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The map label for this gene is gltP [H]

Identifier: 119945082

GI number: 119945082

Start: 1658439

End: 1659776

Strand: Direct

Name: gltP [H]

Synonym: Ping_1338

Alternate gene names: 119945082

Gene position: 1658439-1659776 (Clockwise)

Preceding gene: 119945081

Following gene: 119945085

Centisome position: 36.37

GC content: 41.41

Gene sequence:

>1338_bases
ATGACAGAAAAAAAACAAAAAATGTCACTCACTAAACGTGTTCTACTTGGTATGCTTATTGGCATCATAACGGGTTTTTT
AATCCGTACATTTTTACCTGACAACGCATTTGTTAATGAATATATTGTGAATGGATTCTTTGAAGTGGGCGGAAAAATAT
TCATCGCCAGCTTGAAGATGTTAGTCGTACCGCTTATTTTTGTCTCATTAGTCTGCGGAACCAGTTCATTAAAAGATATT
TCAACCCTGGGGCGTTTGGGCGGGAAAACCATCGCCTTTTATCTGATGACTACAGCGATTGCTATTACCTTTGCAATCAT
TATGGGTAATATTTTTGAACCGGGTGTTGGGACTGACCTTTCTACCGCAACAACTTACGCATCGTCAGAAGCGCCTTCAT
TAGCCTCTGTTATTATTAACATGTTCCCTACCAATCCCGTTAACGCTATGGCCGAGGGCAACACCTTACAAATTATTGTG
TTTGCCATTTTATTTGGTATCGCTGTCAGTGCTTCCGGACAATCTGGTGCACGCATCGCAGCCTTTTTTGTTGATCTTAA
TGAAGTGATTATGAAGCTGGTGGTAATGTTAATGAATATTGCACCCTACGGTGTGTTTTTCTTAATGGCTAAATTATTTA
CGGAAATCGGATTAGATGCGATTAGCAATTTATTAAGTTATTTTTTAGTGCTATCTGCCACTTTGTTACTGCATGGTTTA
ATCACTTACGGTATTTGTTTTAAAGTCTTTACCGGTCTTAATCCCATTACCTTTTTAAAGAAAATGGAAACGGCCATCAC
CTTTGCTTTTTCAACGGCATCATCAAATGCAACCATTCCTGTCACGCTTGAAACCGCGACTAAGCATCTCGGTATTTCAA
ATAAAGTGGCCTCCTTTACGGTGCCGCTGGGCGCTACCATCAATATGGATGGTACTGCCATTATGCAGGGGGTTGCGACG
GTATTTATCGCACAAGCCTTTAATATTGATTTGTCTTTAGCTGACTACGGTGCGGTAATACTCACTGCAACACTTGCATC
CGTTGGCACAGCCGGGGTGCCCGGTGTTGGACTGATCATGCTGGCCATGGTACTTAATCAAGTGGGTCTGCCGGTTGAAG
GGATCGCCATTATTATGGGTGTCGACAGATTGTTAGATATGATCCGTACCGCGGTTAATATCACGGGCGACTGTGTTGTT
ACTTGTATTGTCGCTAAATCCGAAGGTGAAATGAATATTGATGTATTTAATGATCCTAAGGCGGGTGATAAAGACGAAGA
ATTACGTCTTCATAAATTAGGGTTAGAAGCTGAAGCTGAAAGAGTCAGAAACGCGTAA

Upstream 100 bases:

>100_bases
ACTTATGTTAATGCAGAGAGAATTAACAATTAATCAATGTCTTTAACCTACAATACGGCATATTTTGCCGACAATAATAA
TGAATTTACAAGGAGTTAGC

Downstream 100 bases:

>100_bases
ATTCTTTGAAAATAACAGCCCCTTTATTTTTATTTTTAGCTAAAGGGGCTTTTTTTTAACTTTGATTCTTTAACCTTTAT
TCCTTAACTTTTATCCCTTA

Product: proton/glutamate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 445; Mature: 444

Protein sequence:

>445_residues
MTEKKQKMSLTKRVLLGMLIGIITGFLIRTFLPDNAFVNEYIVNGFFEVGGKIFIASLKMLVVPLIFVSLVCGTSSLKDI
STLGRLGGKTIAFYLMTTAIAITFAIIMGNIFEPGVGTDLSTATTYASSEAPSLASVIINMFPTNPVNAMAEGNTLQIIV
FAILFGIAVSASGQSGARIAAFFVDLNEVIMKLVVMLMNIAPYGVFFLMAKLFTEIGLDAISNLLSYFLVLSATLLLHGL
ITYGICFKVFTGLNPITFLKKMETAITFAFSTASSNATIPVTLETATKHLGISNKVASFTVPLGATINMDGTAIMQGVAT
VFIAQAFNIDLSLADYGAVILTATLASVGTAGVPGVGLIMLAMVLNQVGLPVEGIAIIMGVDRLLDMIRTAVNITGDCVV
TCIVAKSEGEMNIDVFNDPKAGDKDEELRLHKLGLEAEAERVRNA

Sequences:

>Translated_445_residues
MTEKKQKMSLTKRVLLGMLIGIITGFLIRTFLPDNAFVNEYIVNGFFEVGGKIFIASLKMLVVPLIFVSLVCGTSSLKDI
STLGRLGGKTIAFYLMTTAIAITFAIIMGNIFEPGVGTDLSTATTYASSEAPSLASVIINMFPTNPVNAMAEGNTLQIIV
FAILFGIAVSASGQSGARIAAFFVDLNEVIMKLVVMLMNIAPYGVFFLMAKLFTEIGLDAISNLLSYFLVLSATLLLHGL
ITYGICFKVFTGLNPITFLKKMETAITFAFSTASSNATIPVTLETATKHLGISNKVASFTVPLGATINMDGTAIMQGVAT
VFIAQAFNIDLSLADYGAVILTATLASVGTAGVPGVGLIMLAMVLNQVGLPVEGIAIIMGVDRLLDMIRTAVNITGDCVV
TCIVAKSEGEMNIDVFNDPKAGDKDEELRLHKLGLEAEAERVRNA
>Mature_444_residues
TEKKQKMSLTKRVLLGMLIGIITGFLIRTFLPDNAFVNEYIVNGFFEVGGKIFIASLKMLVVPLIFVSLVCGTSSLKDIS
TLGRLGGKTIAFYLMTTAIAITFAIIMGNIFEPGVGTDLSTATTYASSEAPSLASVIINMFPTNPVNAMAEGNTLQIIVF
AILFGIAVSASGQSGARIAAFFVDLNEVIMKLVVMLMNIAPYGVFFLMAKLFTEIGLDAISNLLSYFLVLSATLLLHGLI
TYGICFKVFTGLNPITFLKKMETAITFAFSTASSNATIPVTLETATKHLGISNKVASFTVPLGATINMDGTAIMQGVATV
FIAQAFNIDLSLADYGAVILTATLASVGTAGVPGVGLIMLAMVLNQVGLPVEGIAIIMGVDRLLDMIRTAVNITGDCVVT
CIVAKSEGEMNIDVFNDPKAGDKDEELRLHKLGLEAEAERVRNA

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=456, Percent_Identity=31.7982456140351, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI21314632, Length=390, Percent_Identity=32.8205128205128, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI66773030, Length=451, Percent_Identity=31.9290465631929, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI40254478, Length=470, Percent_Identity=32.5531914893617, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI5032093, Length=372, Percent_Identity=34.4086021505376, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI4827012, Length=297, Percent_Identity=36.026936026936, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI194239697, Length=258, Percent_Identity=38.7596899224806, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI223468566, Length=256, Percent_Identity=39.0625, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI223468564, Length=247, Percent_Identity=38.8663967611336, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI262359914, Length=379, Percent_Identity=29.5514511873351, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI301601644, Length=146, Percent_Identity=37.6712328767123, Blast_Score=108, Evalue=1e-23,
Organism=Escherichia coli, GI1790514, Length=437, Percent_Identity=33.8672768878719, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI1789947, Length=435, Percent_Identity=30.1149425287356, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1788024, Length=448, Percent_Identity=29.2410714285714, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1789473, Length=374, Percent_Identity=25.9358288770053, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI71983106, Length=475, Percent_Identity=32.6315789473684, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI71983099, Length=475, Percent_Identity=32.6315789473684, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI193206505, Length=438, Percent_Identity=34.703196347032, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17537407, Length=477, Percent_Identity=33.7526205450734, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71996953, Length=446, Percent_Identity=30.0448430493274, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI193206654, Length=435, Percent_Identity=32.6436781609195, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17541374, Length=485, Percent_Identity=30.1030927835052, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24583025, Length=437, Percent_Identity=31.1212814645309, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17137668, Length=437, Percent_Identity=31.1212814645309, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24583023, Length=437, Percent_Identity=31.1212814645309, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI281360481, Length=452, Percent_Identity=26.9911504424779, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI281360483, Length=452, Percent_Identity=26.9911504424779, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI17137666, Length=452, Percent_Identity=26.9911504424779, Blast_Score=118, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47235; Mature: 47103

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKKQKMSLTKRVLLGMLIGIITGFLIRTFLPDNAFVNEYIVNGFFEVGGKIFIASLKM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
LVVPLIFVSLVCGTSSLKDISTLGRLGGKTIAFYLMTTAIAITFAIIMGNIFEPGVGTDL
HHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
STATTYASSEAPSLASVIINMFPTNPVNAMAEGNTLQIIVFAILFGIAVSASGQSGARIA
CHHHHCCCCCCCHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHH
AFFVDLNEVIMKLVVMLMNIAPYGVFFLMAKLFTEIGLDAISNLLSYFLVLSATLLLHGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
ITYGICFKVFTGLNPITFLKKMETAITFAFSTASSNATIPVTLETATKHLGISNKVASFT
HHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCCCEEEEEEEHHHHHCCCCCCHHEEE
VPLGATINMDGTAIMQGVATVFIAQAFNIDLSLADYGAVILTATLASVGTAGVPGVGLIM
ECCCCEECCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LAMVLNQVGLPVEGIAIIMGVDRLLDMIRTAVNITGDCVVTCIVAKSEGEMNIDVFNDPK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEEECCCC
AGDKDEELRLHKLGLEAEAERVRNA
CCCCHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
TEKKQKMSLTKRVLLGMLIGIITGFLIRTFLPDNAFVNEYIVNGFFEVGGKIFIASLKM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
LVVPLIFVSLVCGTSSLKDISTLGRLGGKTIAFYLMTTAIAITFAIIMGNIFEPGVGTDL
HHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
STATTYASSEAPSLASVIINMFPTNPVNAMAEGNTLQIIVFAILFGIAVSASGQSGARIA
CHHHHCCCCCCCHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCHH
AFFVDLNEVIMKLVVMLMNIAPYGVFFLMAKLFTEIGLDAISNLLSYFLVLSATLLLHGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
ITYGICFKVFTGLNPITFLKKMETAITFAFSTASSNATIPVTLETATKHLGISNKVASFT
HHHHHHHHHHHCCCHHHHHHHHHHHHEEEEEECCCCCEEEEEEEHHHHHCCCCCCHHEEE
VPLGATINMDGTAIMQGVATVFIAQAFNIDLSLADYGAVILTATLASVGTAGVPGVGLIM
ECCCCEECCCHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHCCCCCCCHHHHHH
LAMVLNQVGLPVEGIAIIMGVDRLLDMIRTAVNITGDCVVTCIVAKSEGEMNIDVFNDPK
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCEEEEEECCCC
AGDKDEELRLHKLGLEAEAERVRNA
CCCCHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]