Click here to switch to the map view.

The map label for this gene is arcA [H]

Identifier: 119944948

GI number: 119944948

Start: 1489165

End: 1489881

Strand: Reverse

Name: arcA [H]

Synonym: Ping_1195

Alternate gene names: 119944948

Gene position: 1489881-1489165 (Counterclockwise)

Preceding gene: 119944956

Following gene: 119944944

Centisome position: 32.68

GC content: 35.43

Gene sequence:

>717_bases
ATGTCAACCGCAAACATACTTATTGTTGAAGATGAGTTAGTCACACGTAACATGTTAAAAAGTGTTTTTGAAGCAGAAGG
ATATAATGTTTTGGAAGCGAATGATGGTAATGAGATGCACCAGGCCATCAAGGAAAATAATATTAACTTGATTATTATGG
ATATTAATTTACCTGGTAAAAATGGTCTGTTATTAGCGCGAGAGTTACGTGAACATGAAAATATTGCGCTTATTTTTTTA
ACGGGTCGTGATAATGAAGTTGATAAAATACTGGGATTGGAAATTGGTGCCGATGATTACATCACTAAACCTTTTAATCC
TCGTGAATTAACCATACGTACACGAAACCTGTTAACACGTACTATGCAAGATAATATTTATTTTGAAGAAACAGGTAAAA
AAGTAGAAAATTACAAATTTAACGGTTGGACACTTGAAATAGAAAGTCGCTCACTGATTAGCCCTGATGGTAATATCTGT
AAATTACCACGCAGTGAATTCAGAGCTATATTACATTTCATTGAAAATCCGGGAAAAATTCAAACACGCGCAGATTTATT
AATGAAAATGACCGGACGAGAATTAAAAGCACAGGATCGTACTGTTGACGTTACTATCCGCCGTATCCGCAAACATTTTG
AGAGTATTCCTGATGCACCTGAAATTATTGCGACCATTCATGGTGAAGGTTACCGCTTCTGTGGTGATGTAGAATAA

Upstream 100 bases:

>100_bases
GTATATTTCCACGAACAATCAAAAAACATGAGATATAAAAAACATCTTCACGCCGAATAAGGCAAAGGGATATAAAGATT
CGAAAATAGAGAGGTACCTA

Downstream 100 bases:

>100_bases
AAACAGCAGACTTTATAGCAAAACATATATCAAGGTACACTAAGTGCCTTTTTTATTGCCTAAAATCGATTACAGCCATA
AAACAGTGGTTGTTAATAGC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 237

Protein sequence:

>238_residues
MSTANILIVEDELVTRNMLKSVFEAEGYNVLEANDGNEMHQAIKENNINLIIMDINLPGKNGLLLARELREHENIALIFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRTRNLLTRTMQDNIYFEETGKKVENYKFNGWTLEIESRSLISPDGNIC
KLPRSEFRAILHFIENPGKIQTRADLLMKMTGRELKAQDRTVDVTIRRIRKHFESIPDAPEIIATIHGEGYRFCGDVE

Sequences:

>Translated_238_residues
MSTANILIVEDELVTRNMLKSVFEAEGYNVLEANDGNEMHQAIKENNINLIIMDINLPGKNGLLLARELREHENIALIFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRTRNLLTRTMQDNIYFEETGKKVENYKFNGWTLEIESRSLISPDGNIC
KLPRSEFRAILHFIENPGKIQTRADLLMKMTGRELKAQDRTVDVTIRRIRKHFESIPDAPEIIATIHGEGYRFCGDVE
>Mature_237_residues
STANILIVEDELVTRNMLKSVFEAEGYNVLEANDGNEMHQAIKENNINLIIMDINLPGKNGLLLARELREHENIALIFLT
GRDNEVDKILGLEIGADDYITKPFNPRELTIRTRNLLTRTMQDNIYFEETGKKVENYKFNGWTLEIESRSLISPDGNICK
LPRSEFRAILHFIENPGKIQTRADLLMKMTGRELKAQDRTVDVTIRRIRKHFESIPDAPEIIATIHGEGYRFCGDVE

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=79.4117647058823, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=41.025641025641, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=34.3347639484979, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1788394, Length=235, Percent_Identity=31.9148936170213, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786599, Length=233, Percent_Identity=34.3347639484979, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=33.1896551724138, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790860, Length=236, Percent_Identity=30.9322033898305, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=31.304347826087, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI87082012, Length=232, Percent_Identity=31.0344827586207, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=29.1304347826087, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=28.755364806867, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1786784, Length=231, Percent_Identity=28.1385281385281, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789402, Length=227, Percent_Identity=25.5506607929515, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1790552, Length=116, Percent_Identity=37.9310344827586, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27315; Mature: 27183

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTANILIVEDELVTRNMLKSVFEAEGYNVLEANDGNEMHQAIKENNINLIIMDINLPGK
CCCCEEEEEEHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCEEEEEEEECCCC
NGLLLARELREHENIALIFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRTRNLLTR
CCEEEEHHHHCCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEEHHHHHHH
TMQDNIYFEETGKKVENYKFNGWTLEIESRSLISPDGNICKLPRSEFRAILHFIENPGKI
HHHCCEEEECCCCCHHCEEECCEEEEECCCEEECCCCCEEECCHHHHHHHHHHHCCCCCC
QTRADLLMKMTGRELKAQDRTVDVTIRRIRKHFESIPDAPEIIATIHGEGYRFCGDVE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCC
>Mature Secondary Structure 
STANILIVEDELVTRNMLKSVFEAEGYNVLEANDGNEMHQAIKENNINLIIMDINLPGK
CCCEEEEEEHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCEEEEEEEECCCC
NGLLLARELREHENIALIFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRTRNLLTR
CCEEEEHHHHCCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEEEHHHHHHH
TMQDNIYFEETGKKVENYKFNGWTLEIESRSLISPDGNICKLPRSEFRAILHFIENPGKI
HHHCCEEEECCCCCHHCEEECCEEEEECCCEEECCCCCEEECCHHHHHHHHHHHCCCCCC
QTRADLLMKMTGRELKAQDRTVDVTIRRIRKHFESIPDAPEIIATIHGEGYRFCGDVE
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]