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The map label for this gene is hutC [H]

Identifier: 119944791

GI number: 119944791

Start: 1303737

End: 1304441

Strand: Reverse

Name: hutC [H]

Synonym: Ping_1033

Alternate gene names: 119944791

Gene position: 1304441-1303737 (Counterclockwise)

Preceding gene: 119944794

Following gene: 119944790

Centisome position: 28.61

GC content: 42.27

Gene sequence:

>705_bases
ATGAGTAAATCACCACGTTATATCCAAATCAGAGAATTTATAAATGCAAAGATTAGCAGTAATGTCTGGCCGGTGGGCAG
TAAAATCCCAACTGAAATGGCATTAACTGAGCAATTTGGGGTCAGCCGTATGACAGTCAATAAAGCTATTCGAGATTTAG
TGACGGCAGGGTTATTAAAACGAACGGCACGGGTTGGCACTTTTGTTTGCCAGAATAAAATGGAATCCCCATTAATCGAT
ATTCGTAATATCGCCGATGAAATCCGCCAGCGTGGCAAGCAATACAGCAGTAAAGTCCTAACTCAATTAACCCTGCATGC
CGATCCCCAAACGGCAATACGTTTAGGGGTACCGATTGATACACCCATCTACTTTAGTGAGATTGTCCACTTAGAAGATA
ACAGCCCACTACAACTAGAAGTGCGCTGGGTAAACCCATCGTTTGTACCCGATTATATCAAACAGGATTTCAGCCATTCG
ACCCCCAATGAATATCTAACAAAAAATTGCCCGTTAAGCTCGATAGAGCATACCGTTGAAGCTGTGATGGTTAATGAACG
CATTCAGGAATATTTGCACTTATCGACTAACCAACCCTGCCTGCTTTTAAACCGCAGAACATGGAGCAAACAGGATTTGA
TCAGTGTCGCCCTGCTTTATCACCCGGCCGACAAATATAAATTGAGTTTAAAAACTAACCTTTAA

Upstream 100 bases:

>100_bases
CCTACTCCTTCAAGTAATTCGGCTATATCACTTGATTTATCTTGATAAAAAAGAGATTATTTGTATAGTCAATTAATTAT
AATATACATAAGGTAATTTA

Downstream 100 bases:

>100_bases
CCCCTAAGTCACGAGCGATCAGCTGTCTGCGATCTGCGATCAACAGACAGCCGTCAGCAGACAGCTCAAAACCACAAATT
GTTAACATAATGCTTGCGCT

Product: transcriptional regulator, histidine utilization repressor, GntR family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MSKSPRYIQIREFINAKISSNVWPVGSKIPTEMALTEQFGVSRMTVNKAIRDLVTAGLLKRTARVGTFVCQNKMESPLID
IRNIADEIRQRGKQYSSKVLTQLTLHADPQTAIRLGVPIDTPIYFSEIVHLEDNSPLQLEVRWVNPSFVPDYIKQDFSHS
TPNEYLTKNCPLSSIEHTVEAVMVNERIQEYLHLSTNQPCLLLNRRTWSKQDLISVALLYHPADKYKLSLKTNL

Sequences:

>Translated_234_residues
MSKSPRYIQIREFINAKISSNVWPVGSKIPTEMALTEQFGVSRMTVNKAIRDLVTAGLLKRTARVGTFVCQNKMESPLID
IRNIADEIRQRGKQYSSKVLTQLTLHADPQTAIRLGVPIDTPIYFSEIVHLEDNSPLQLEVRWVNPSFVPDYIKQDFSHS
TPNEYLTKNCPLSSIEHTVEAVMVNERIQEYLHLSTNQPCLLLNRRTWSKQDLISVALLYHPADKYKLSLKTNL
>Mature_233_residues
SKSPRYIQIREFINAKISSNVWPVGSKIPTEMALTEQFGVSRMTVNKAIRDLVTAGLLKRTARVGTFVCQNKMESPLIDI
RNIADEIRQRGKQYSSKVLTQLTLHADPQTAIRLGVPIDTPIYFSEIVHLEDNSPLQLEVRWVNPSFVPDYIKQDFSHST
PNEYLTKNCPLSSIEHTVEAVMVNERIQEYLHLSTNQPCLLLNRRTWSKQDLISVALLYHPADKYKLSLKTNL

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=227, Percent_Identity=25.9911894273128, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790118, Length=229, Percent_Identity=24.4541484716157, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1786950, Length=203, Percent_Identity=25.615763546798, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788418, Length=208, Percent_Identity=22.5961538461538, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 26779; Mature: 26648

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSPRYIQIREFINAKISSNVWPVGSKIPTEMALTEQFGVSRMTVNKAIRDLVTAGLLK
CCCCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RTARVGTFVCQNKMESPLIDIRNIADEIRQRGKQYSSKVLTQLTLHADPQTAIRLGVPID
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECCCCC
TPIYFSEIVHLEDNSPLQLEVRWVNPSFVPDYIKQDFSHSTPNEYLTKNCPLSSIEHTVE
CCHHHHHEEEECCCCCEEEEEEECCCCCCHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHH
AVMVNERIQEYLHLSTNQPCLLLNRRTWSKQDLISVALLYHPADKYKLSLKTNL
HHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCC
>Mature Secondary Structure 
SKSPRYIQIREFINAKISSNVWPVGSKIPTEMALTEQFGVSRMTVNKAIRDLVTAGLLK
CCCCCEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
RTARVGTFVCQNKMESPLIDIRNIADEIRQRGKQYSSKVLTQLTLHADPQTAIRLGVPID
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECCCCC
TPIYFSEIVHLEDNSPLQLEVRWVNPSFVPDYIKQDFSHSTPNEYLTKNCPLSSIEHTVE
CCHHHHHEEEECCCCCEEEEEEECCCCCCHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHH
AVMVNERIQEYLHLSTNQPCLLLNRRTWSKQDLISVALLYHPADKYKLSLKTNL
HHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]