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The map label for this gene is atoC [H]

Identifier: 119944203

GI number: 119944203

Start: 536389

End: 537744

Strand: Reverse

Name: atoC [H]

Synonym: Ping_0424

Alternate gene names: 119944203

Gene position: 537744-536389 (Counterclockwise)

Preceding gene: 119944204

Following gene: 119944202

Centisome position: 11.79

GC content: 38.57

Gene sequence:

>1356_bases
TTGTCAAAAAACGAAACTAAAACATTATTAATTGTTGAAGATGATATAGGGCTGCAAACGCAGCTTAAATGGCATTTTTC
TGATTACAGTGTTGTTGTTGCAGCAAGCTTAGATAATGCAATTGCTGCTATTCGTTTACATGAACCACAAGTAATGGTGC
AAGATTTAGGTTTGCCCCCTGATCCTGACGGTGTAACCCAAGGTTTTTCTTTGGTACAACAAGCCCTGTCCATAAATCCA
CATATGAAGTTAATTGTGATGACCGGCAATGATTGCAATGAACATGCCTTAAAAGCGGTCAGCCTTGGTGCCTATGATTT
TTACAGTAAACCGGTAAATCCTGATACTTTGGCACTTATCGTACAACGTGCATTTCATATGCACCAACTTGAAACCAAAA
ATAGAATTTTTAATTTATCTAAAAGCAGTCATCTTGAAGGACTAATTACTGCAGATGAACGCATGTTAACTATTTGTAAG
CTAATCGAAAAAGTTGCCCCCACCAGCGCAGCTTGCTTACTCTTAGGTGAAAGTGGTACCGGCAAAGAGGTATTAGCAAA
ATCACTGCATGCATTAAGTACCCGCAATGAACATCCCTTTGTTGCCATTAACTGCGCTGCTCTTCCTGAAAATTTATTTG
AAAGTGAACTGTTTGGCTATGAAAAAGGTGCCTATACAGGGGCAATAAAAAGTACACTCGGTAAATTAGAACTAGCAAAT
GGTGGAACAGTATTTCTCGATGAAATAGGTGAAATGCCACTACTATTACAAGCCAAGTTACTGCGCTTTCTACAAGAAAA
AGTAATTGAACGTATTGGCGGTCGCAAATTAATCCACCTGGACACTCGGATTGTTTGCGCCACTAATAGAAATTTAGAAG
AAATGATGGCTAGCGGTGAATTCCGCGAAGATCTCTATTATCGGATCGCAGAGATACAAATAGATATCCCTCCATTAAGA
GAGCGAGGCTCCGATAAAGTCCTATTAGCCCGCTATCTGCTTCAAAAGTACACTCAAAAAGAAAACCTAAAAGTCACAGG
TTTTACTAAAGATGCAATTAATGCAATAGAAGCGTATTCATGGCCCGGTAATATCCGAGAACTTAACAATAAAATAACTC
GTGCAGCCATTATGTGTGAGCAAAAAAATATAACAGCAGAAGATATCGGATTAAAATCATCTGACAGTAGCCCGCTTAGC
TTAAAAGTGATTAGAGAAAGTGCTGAAATAAACGCACTAAAAACAACACTTAATGCAACTGATAATAACATTTCTGCGGC
CGCAAAATCACTTGGCATAACCAGACCGACACTCTATGACTTAATGAAAAAGCATCATTTAAATACCCCTCTGTAA

Upstream 100 bases:

>100_bases
AAACAAGAAAATATCCAGAAAACCTCTGGTTATGAAGAACAACACTATACAAGCAGAATTGCTTATAAATACTGAAGCAA
TTAATTTTTAAGGAACTATT

Downstream 100 bases:

>100_bases
TACTGGCTATATATTAAAGCCAATTTGAATAGGTAAGATAAATATGAAATTAAAATTTTTTAATCTTCAAATAGACAAAG
CATTAACGATATCAATGCTT

Product: two component, sigma54 specific, transcriptional regulator, Fis family protein

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSKNETKTLLIVEDDIGLQTQLKWHFSDYSVVVAASLDNAIAAIRLHEPQVMVQDLGLPPDPDGVTQGFSLVQQALSINP
HMKLIVMTGNDCNEHALKAVSLGAYDFYSKPVNPDTLALIVQRAFHMHQLETKNRIFNLSKSSHLEGLITADERMLTICK
LIEKVAPTSAACLLLGESGTGKEVLAKSLHALSTRNEHPFVAINCAALPENLFESELFGYEKGAYTGAIKSTLGKLELAN
GGTVFLDEIGEMPLLLQAKLLRFLQEKVIERIGGRKLIHLDTRIVCATNRNLEEMMASGEFREDLYYRIAEIQIDIPPLR
ERGSDKVLLARYLLQKYTQKENLKVTGFTKDAINAIEAYSWPGNIRELNNKITRAAIMCEQKNITAEDIGLKSSDSSPLS
LKVIRESAEINALKTTLNATDNNISAAAKSLGITRPTLYDLMKKHHLNTPL

Sequences:

>Translated_451_residues
MSKNETKTLLIVEDDIGLQTQLKWHFSDYSVVVAASLDNAIAAIRLHEPQVMVQDLGLPPDPDGVTQGFSLVQQALSINP
HMKLIVMTGNDCNEHALKAVSLGAYDFYSKPVNPDTLALIVQRAFHMHQLETKNRIFNLSKSSHLEGLITADERMLTICK
LIEKVAPTSAACLLLGESGTGKEVLAKSLHALSTRNEHPFVAINCAALPENLFESELFGYEKGAYTGAIKSTLGKLELAN
GGTVFLDEIGEMPLLLQAKLLRFLQEKVIERIGGRKLIHLDTRIVCATNRNLEEMMASGEFREDLYYRIAEIQIDIPPLR
ERGSDKVLLARYLLQKYTQKENLKVTGFTKDAINAIEAYSWPGNIRELNNKITRAAIMCEQKNITAEDIGLKSSDSSPLS
LKVIRESAEINALKTTLNATDNNISAAAKSLGITRPTLYDLMKKHHLNTPL
>Mature_450_residues
SKNETKTLLIVEDDIGLQTQLKWHFSDYSVVVAASLDNAIAAIRLHEPQVMVQDLGLPPDPDGVTQGFSLVQQALSINPH
MKLIVMTGNDCNEHALKAVSLGAYDFYSKPVNPDTLALIVQRAFHMHQLETKNRIFNLSKSSHLEGLITADERMLTICKL
IEKVAPTSAACLLLGESGTGKEVLAKSLHALSTRNEHPFVAINCAALPENLFESELFGYEKGAYTGAIKSTLGKLELANG
GTVFLDEIGEMPLLLQAKLLRFLQEKVIERIGGRKLIHLDTRIVCATNRNLEEMMASGEFREDLYYRIAEIQIDIPPLRE
RGSDKVLLARYLLQKYTQKENLKVTGFTKDAINAIEAYSWPGNIRELNNKITRAAIMCEQKNITAEDIGLKSSDSSPLSL
KVIRESAEINALKTTLNATDNNISAAAKSLGITRPTLYDLMKKHHLNTPL

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=457, Percent_Identity=38.074398249453, Blast_Score=292, Evalue=3e-80,
Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=36.0544217687075, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1788905, Length=444, Percent_Identity=36.2612612612613, Blast_Score=271, Evalue=8e-74,
Organism=Escherichia coli, GI1790299, Length=341, Percent_Identity=36.6568914956012, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1789233, Length=344, Percent_Identity=39.5348837209302, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87082117, Length=316, Percent_Identity=39.2405063291139, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1789087, Length=309, Percent_Identity=40.7766990291262, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87082152, Length=340, Percent_Identity=37.9411764705882, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87081872, Length=311, Percent_Identity=38.5852090032154, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1786524, Length=301, Percent_Identity=39.8671096345515, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI1787583, Length=315, Percent_Identity=33.6507936507937, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1789828, Length=313, Percent_Identity=33.8658146964856, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87081858, Length=340, Percent_Identity=30.2941176470588, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49961; Mature: 49830

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKNETKTLLIVEDDIGLQTQLKWHFSDYSVVVAASLDNAIAAIRLHEPQVMVQDLGLPP
CCCCCCEEEEEEECCCCCEEEEEEEECCCEEEEEEECCCCEEEEEECCCHHHHHHCCCCC
DPDGVTQGFSLVQQALSINPHMKLIVMTGNDCNEHALKAVSLGAYDFYSKPVNPDTLALI
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHCCCCCCHHHHHHH
VQRAFHMHQLETKNRIFNLSKSSHLEGLITADERMLTICKLIEKVAPTSAACLLLGESGT
HHHHHHHHHHHHHHHEEECCCCCCCCEEEECHHHHHHHHHHHHHHCCCCEEEEEEECCCC
GKEVLAKSLHALSTRNEHPFVAINCAALPENLFESELFGYEKGAYTGAIKSTLGKLELAN
CHHHHHHHHHHHHCCCCCCEEEEEHHHCCHHHHHHHHCCCCCCCCHHHHHHHHCCEEECC
GGTVFLDEIGEMPLLLQAKLLRFLQEKVIERIGGRKLIHLDTRIVCATNRNLEEMMASGE
CCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCHHHHHHCCC
FREDLYYRIAEIQIDIPPLRERGSDKVLLARYLLQKYTQKENLKVTGFTKDAINAIEAYS
HHHHHHEEEEEEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCC
WPGNIRELNNKITRAAIMCEQKNITAEDIGLKSSDSSPLSLKVIRESAEINALKTTLNAT
CCCHHHHHHHHHHHHHHEEECCCCCHHHCCCCCCCCCCEEEEEECCCHHHHHHHHEECCC
DNNISAAAKSLGITRPTLYDLMKKHHLNTPL
CCCHHHHHHHCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SKNETKTLLIVEDDIGLQTQLKWHFSDYSVVVAASLDNAIAAIRLHEPQVMVQDLGLPP
CCCCCEEEEEEECCCCCEEEEEEEECCCEEEEEEECCCCEEEEEECCCHHHHHHCCCCC
DPDGVTQGFSLVQQALSINPHMKLIVMTGNDCNEHALKAVSLGAYDFYSKPVNPDTLALI
CCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHCCCCHHHCCCCCCHHHHHHH
VQRAFHMHQLETKNRIFNLSKSSHLEGLITADERMLTICKLIEKVAPTSAACLLLGESGT
HHHHHHHHHHHHHHHEEECCCCCCCCEEEECHHHHHHHHHHHHHHCCCCEEEEEEECCCC
GKEVLAKSLHALSTRNEHPFVAINCAALPENLFESELFGYEKGAYTGAIKSTLGKLELAN
CHHHHHHHHHHHHCCCCCCEEEEEHHHCCHHHHHHHHCCCCCCCCHHHHHHHHCCEEECC
GGTVFLDEIGEMPLLLQAKLLRFLQEKVIERIGGRKLIHLDTRIVCATNRNLEEMMASGE
CCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCHHHHHHCCC
FREDLYYRIAEIQIDIPPLRERGSDKVLLARYLLQKYTQKENLKVTGFTKDAINAIEAYS
HHHHHHEEEEEEEECCCCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHCC
WPGNIRELNNKITRAAIMCEQKNITAEDIGLKSSDSSPLSLKVIRESAEINALKTTLNAT
CCCHHHHHHHHHHHHHHEEECCCCCHHHCCCCCCCCCCEEEEEECCCHHHHHHHHEECCC
DNNISAAAKSLGITRPTLYDLMKKHHLNTPL
CCCHHHHHHHCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]