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The map label for this gene is tyrA [H]

Identifier: 119944072

GI number: 119944072

Start: 374087

End: 375214

Strand: Direct

Name: tyrA [H]

Synonym: Ping_0287

Alternate gene names: 119944072

Gene position: 374087-375214 (Clockwise)

Preceding gene: 119944071

Following gene: 119944074

Centisome position: 8.2

GC content: 42.82

Gene sequence:

>1128_bases
ATGCCTTTAAGTAAATTAAGAGATCAAATTGATGCCGTTGATCAGCAGATAATTGACCTGCTTGCTGAGCGTCTGCGTTT
GGTTGGTGAAGTGGGTGAGGTTAAAGCCAAGCATGGTTTACCTATTTATGTTCCTGAGCGTGAAGCGGCTATGCTGGCTA
AACGCCGCGAGGAAGCATCATCTAAAGGCGTGCCGGCCAATTTAATCGAGGATATCCTGCGCCGTACAATGCGCGAATCC
TACGCCAGTGAAAATGATACTGGCTTTAAAACGGTTAATCCAAAGATGAAAAGAATTGTTATCATTGGTGGGAACGGCTT
ATTAGGTCAGCGTTTTGTGGAAATGTTTAAGCTATCAGGCTATGAAGTTGATATTCTAGGACGTGCTAATTGGGACAAGG
CAGAGGAGATATGCAGTCATGCAGGTCTGGTTATTGTCGGTTCACCCATTGATGTCACTGTCTCAGTTATCGAGCAACTG
AGCTATCTCCCCGAAGATTGTATATTAGCTGATATTACCAGCGTAAAAGATGGACCGTTACAGGCAATGCTGAAGGTGCA
TAAAGGACCGGTTGTTGGTTTACATCCTATGTTTGGTCCTGATATTAGCAGTTTTGCCAAGCAGGTTGTTGTTTATTGTA
ATGGTCGGGGTGAAGAGAAGTACCAGTGGTTAATCGAACAGATGAAAATCTGGGGAGCGCATCTTTATAACGTTGACTCG
ACAGTTCACGATGAGTCGATGACCCTGATTCAAGCATTACGACACTTTACGAGTTTTGTCTACGGAAGCCATTTAAAAGA
AGTTAATGCTGATTTAAAACAGTTGTTAGATTTAAGCTCCCCAATTTATCGTTTGGAGCTGGCGATGGTCGGACGCTTGT
TTGCGCAGGATCCTGCTTTATATGCCGATATTATTCTTTCACAAAAAAATAATCTGGTGATGATCAAACGTTATCATCAG
CATTTTGCCGAGGCGATTGAGTTACTTGAAAATGCGGATCGGGAGCAGTTTATTAAACGTTTTGAATCGGTAACCGAATG
GATGGGGGATTACTCTTCTCTTTTTCTTGATGAAAGTCGTTCGCTACTGCAGCAGGCCCATGATAATCGCCATTACGAAG
ATAAATAA

Upstream 100 bases:

>100_bases
AGTCACTGATGCCTGTATTGATTGGGAAACAACGAGTCAACTTCTTGCTGAAGCTGTCAATGTATTAAAAGATACTTTAA
AAACAAGATAAGAAGGGTTT

Downstream 100 bases:

>100_bases
AGAACAATTTATAACCTTTTTTCCAGGTAATAAAAAAGGAGGTTTTTAACCTCCTTTTTTATTTACTTACTTGCCTTGTA
TCAGTTTTATGCTGCGAACT

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MPLSKLRDQIDAVDQQIIDLLAERLRLVGEVGEVKAKHGLPIYVPEREAAMLAKRREEASSKGVPANLIEDILRRTMRES
YASENDTGFKTVNPKMKRIVIIGGNGLLGQRFVEMFKLSGYEVDILGRANWDKAEEICSHAGLVIVGSPIDVTVSVIEQL
SYLPEDCILADITSVKDGPLQAMLKVHKGPVVGLHPMFGPDISSFAKQVVVYCNGRGEEKYQWLIEQMKIWGAHLYNVDS
TVHDESMTLIQALRHFTSFVYGSHLKEVNADLKQLLDLSSPIYRLELAMVGRLFAQDPALYADIILSQKNNLVMIKRYHQ
HFAEAIELLENADREQFIKRFESVTEWMGDYSSLFLDESRSLLQQAHDNRHYEDK

Sequences:

>Translated_375_residues
MPLSKLRDQIDAVDQQIIDLLAERLRLVGEVGEVKAKHGLPIYVPEREAAMLAKRREEASSKGVPANLIEDILRRTMRES
YASENDTGFKTVNPKMKRIVIIGGNGLLGQRFVEMFKLSGYEVDILGRANWDKAEEICSHAGLVIVGSPIDVTVSVIEQL
SYLPEDCILADITSVKDGPLQAMLKVHKGPVVGLHPMFGPDISSFAKQVVVYCNGRGEEKYQWLIEQMKIWGAHLYNVDS
TVHDESMTLIQALRHFTSFVYGSHLKEVNADLKQLLDLSSPIYRLELAMVGRLFAQDPALYADIILSQKNNLVMIKRYHQ
HFAEAIELLENADREQFIKRFESVTEWMGDYSSLFLDESRSLLQQAHDNRHYEDK
>Mature_374_residues
PLSKLRDQIDAVDQQIIDLLAERLRLVGEVGEVKAKHGLPIYVPEREAAMLAKRREEASSKGVPANLIEDILRRTMRESY
ASENDTGFKTVNPKMKRIVIIGGNGLLGQRFVEMFKLSGYEVDILGRANWDKAEEICSHAGLVIVGSPIDVTVSVIEQLS
YLPEDCILADITSVKDGPLQAMLKVHKGPVVGLHPMFGPDISSFAKQVVVYCNGRGEEKYQWLIEQMKIWGAHLYNVDST
VHDESMTLIQALRHFTSFVYGSHLKEVNADLKQLLDLSSPIYRLELAMVGRLFAQDPALYADIILSQKNNLVMIKRYHQH
FAEAIELLENADREQFIKRFESVTEWMGDYSSLFLDESRSLLQQAHDNRHYEDK

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=369, Percent_Identity=61.7886178861789, Blast_Score=485, Evalue=1e-138,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42542; Mature: 42411

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSKLRDQIDAVDQQIIDLLAERLRLVGEVGEVKAKHGLPIYVPEREAAMLAKRREEAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHH
SKGVPANLIEDILRRTMRESYASENDTGFKTVNPKMKRIVIIGGNGLLGQRFVEMFKLSG
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHCC
YEVDILGRANWDKAEEICSHAGLVIVGSPIDVTVSVIEQLSYLPEDCILADITSVKDGPL
CEEEEECCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHH
QAMLKVHKGPVVGLHPMFGPDISSFAKQVVVYCNGRGEEKYQWLIEQMKIWGAHLYNVDS
HHHHHHHCCCEEEECCCCCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCC
TVHDESMTLIQALRHFTSFVYGSHLKEVNADLKQLLDLSSPIYRLELAMVGRLFAQDPAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHH
YADIILSQKNNLVMIKRYHQHFAEAIELLENADREQFIKRFESVTEWMGDYSSLFLDESR
HHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLLQQAHDNRHYEDK
HHHHHHHCCCCCCCC
>Mature Secondary Structure 
PLSKLRDQIDAVDQQIIDLLAERLRLVGEVGEVKAKHGLPIYVPEREAAMLAKRREEAS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHH
SKGVPANLIEDILRRTMRESYASENDTGFKTVNPKMKRIVIIGGNGLLGQRFVEMFKLSG
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHHCC
YEVDILGRANWDKAEEICSHAGLVIVGSPIDVTVSVIEQLSYLPEDCILADITSVKDGPL
CEEEEECCCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHH
QAMLKVHKGPVVGLHPMFGPDISSFAKQVVVYCNGRGEEKYQWLIEQMKIWGAHLYNVDS
HHHHHHHCCCEEEECCCCCCCHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCC
TVHDESMTLIQALRHFTSFVYGSHLKEVNADLKQLLDLSSPIYRLELAMVGRLFAQDPAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHH
YADIILSQKNNLVMIKRYHQHFAEAIELLENADREQFIKRFESVTEWMGDYSSLFLDESR
HHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLLQQAHDNRHYEDK
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396419; 9205837; 9278503 [H]