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The map label for this gene is phoP [H]

Identifier: 119944067

GI number: 119944067

Start: 369108

End: 369800

Strand: Reverse

Name: phoP [H]

Synonym: Ping_0282

Alternate gene names: 119944067

Gene position: 369800-369108 (Counterclockwise)

Preceding gene: 119944068

Following gene: 119944066

Centisome position: 8.11

GC content: 42.28

Gene sequence:

>693_bases
ATGAGAATACTGTTAGTCGAAGACGATATCAGTCTTCAGAGCAATCTAAAACAACACTTAATCGCTTCTCATTATAGGGT
TGATGCCGCATCCGATGGTGAAGAGGGGCTTTTTCAGGGAATTGAATATAATTATGATGCGGCCATTATCGATCTGGGTT
TACCTAAAATCGACGGTATCACTGTTATTACTCGCCTTCGGGAAAAAAACAGAAATTTTCCAATTTTAATTCTAACGGCC
CGCGACAGTTGGCAGGATAAAGTAGAAGGACTCGATGCCGGTGCCGATGACTATTTGTGCAAACCCTTTTATCCGGAAGA
ACTGGTGGCCAGGCTGAACGCCCTGATTCGCCGTTCAGCGGGTAAAGCGAGTCCGGTTATTAATAATGGCCCCTTCAGCA
TTAATACCAGTAGCCTTGAAGTAAAAAAAGAACATGAATTTATAAGCTTAAGCGCATCTGAGTACAAGATTTTTGAGTAC
TTTATGCTTCACCCTGGCGAAGTTAAATCAAAAACCGTGCTCACGGAACATATTTACGATCAGGATTTTGATCTTGATTC
CAATGTGATCGAAGTCTTTATCCGACGCTTAAGAAAAAAACTCGATCCGGATAATGAATATGGACTTATCGAGACATTAA
GAGGGCAAGGTTACCGCCTTACTCCGTTGCCAACAAGCCAGAGTGATGGCTAA

Upstream 100 bases:

>100_bases
GGGACGGGTGTTTTATCTCTTTGTCGATGCTCAAAACGGCAACATTAGCGGAAAATAGTCACTTAATCAAACAAGCCAAA
ATAATCAAAGGATCCTGTCA

Downstream 100 bases:

>100_bases
TGCCCAAAAGAGCGACAAACTTAAATTCCCTTAAAACGCGTTTGATCGTTAGCGCTCTGTTATTCATATTAGTGCTTATG
CCCTTAATTGGATTGACTCT

Product: two component transcriptional regulator, winged helix family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MRILLVEDDISLQSNLKQHLIASHYRVDAASDGEEGLFQGIEYNYDAAIIDLGLPKIDGITVITRLREKNRNFPILILTA
RDSWQDKVEGLDAGADDYLCKPFYPEELVARLNALIRRSAGKASPVINNGPFSINTSSLEVKKEHEFISLSASEYKIFEY
FMLHPGEVKSKTVLTEHIYDQDFDLDSNVIEVFIRRLRKKLDPDNEYGLIETLRGQGYRLTPLPTSQSDG

Sequences:

>Translated_230_residues
MRILLVEDDISLQSNLKQHLIASHYRVDAASDGEEGLFQGIEYNYDAAIIDLGLPKIDGITVITRLREKNRNFPILILTA
RDSWQDKVEGLDAGADDYLCKPFYPEELVARLNALIRRSAGKASPVINNGPFSINTSSLEVKKEHEFISLSASEYKIFEY
FMLHPGEVKSKTVLTEHIYDQDFDLDSNVIEVFIRRLRKKLDPDNEYGLIETLRGQGYRLTPLPTSQSDG
>Mature_230_residues
MRILLVEDDISLQSNLKQHLIASHYRVDAASDGEEGLFQGIEYNYDAAIIDLGLPKIDGITVITRLREKNRNFPILILTA
RDSWQDKVEGLDAGADDYLCKPFYPEELVARLNALIRRSAGKASPVINNGPFSINTSSLEVKKEHEFISLSASEYKIFEY
FMLHPGEVKSKTVLTEHIYDQDFDLDSNVIEVFIRRLRKKLDPDNEYGLIETLRGQGYRLTPLPTSQSDG

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=44.954128440367, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=37.3333333333333, Blast_Score=157, Evalue=5e-40,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=39.5454545454545, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=38.0733944954128, Blast_Score=150, Evalue=5e-38,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=34.9775784753363, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=37.5, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789809, Length=229, Percent_Identity=31.4410480349345, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=31.6742081447964, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=32.9004329004329, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=31.6742081447964, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=33.920704845815, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=31.0810810810811, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=30.8370044052863, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=26.6094420600858, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790437, Length=134, Percent_Identity=32.8358208955224, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1788550, Length=118, Percent_Identity=27.9661016949153, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26107; Mature: 26107

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILLVEDDISLQSNLKQHLIASHYRVDAASDGEEGLFQGIEYNYDAAIIDLGLPKIDGI
CEEEEEECCCCHHHHHHHHHHHHHHEECCCCCCHHHHHCCCCCCCCEEEEECCCCCCCCH
TVITRLREKNRNFPILILTARDSWQDKVEGLDAGADDYLCKPFYPEELVARLNALIRRSA
HHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GKASPVINNGPFSINTSSLEVKKEHEFISLSASEYKIFEYFMLHPGEVKSKTVLTEHIYD
CCCCCCCCCCCCEEECCCEEEECCCCEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHCC
QDFDLDSNVIEVFIRRLRKKLDPDNEYGLIETLRGQGYRLTPLPTSQSDG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEECCCCCCCCCC
>Mature Secondary Structure
MRILLVEDDISLQSNLKQHLIASHYRVDAASDGEEGLFQGIEYNYDAAIIDLGLPKIDGI
CEEEEEECCCCHHHHHHHHHHHHHHEECCCCCCHHHHHCCCCCCCCEEEEECCCCCCCCH
TVITRLREKNRNFPILILTARDSWQDKVEGLDAGADDYLCKPFYPEELVARLNALIRRSA
HHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
GKASPVINNGPFSINTSSLEVKKEHEFISLSASEYKIFEYFMLHPGEVKSKTVLTEHIYD
CCCCCCCCCCCCEEECCCEEEECCCCEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHCC
QDFDLDSNVIEVFIRRLRKKLDPDNEYGLIETLRGQGYRLTPLPTSQSDG
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA