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The map label for this gene is hemN [H]

Identifier: 119943993

GI number: 119943993

Start: 260466

End: 261833

Strand: Reverse

Name: hemN [H]

Synonym: Ping_0207

Alternate gene names: 119943993

Gene position: 261833-260466 (Counterclockwise)

Preceding gene: 119943994

Following gene: 119943992

Centisome position: 5.74

GC content: 38.38

Gene sequence:

>1368_bases
ATGGATAAGTTCGTTTGGGATCAAGCATTAATCGAAAAATATAATTACAGTGGACCAAGATACACCTCGTATCCTACTGC
CTTAGAATTTGACGAAGCTTTTACTTACCAGGAGTCCATTGCGGCAACTGAAGTTTATCCCGAGCGATCGCTTTCTCTGT
ATATCCATATCCCCTTTTGTCATAAAATTTGTTACTTCTGTGGTTGTAATAAAATAATTACACGTCATCAGGAAAAAGCA
GATATTTATCTCGATTATTTAGAAAAAGAAATCAAACAACAAGCCCTCCATTTTAAAAATCGTCATGTCAGTCAGTTACA
CTGGGGCGGGGGAACGCCAACCTTTTTATTACCCGCTCAAATCACCCGTTTAATGACCATGCTTCGTGAAAACTTCAGCT
TTAACCCGAATGCGGAATTAAGTATTGAAGTCGATCCGCGCGAAATTGAATTAAGTACCATAGATCACCTTGCTAACGAA
GGTTTTAACCGTCTCAGCCTTGGCGTACAAGACTTTAACAAAGAAGTCCAAAAGGCGGTCAATCGTGATCAGGACGAGGA
CTTTATTGTTGCGCTATTAAAGCGTGCTAAAGAGCAAGGTTTTCAATCAACAAATCTGGATATGATCTACGGTTTACCAC
TGCAGACAAAACAAAATTTTGCTCATACCTTAGAAAAAGTAGTCGAGCTTGATCCGGCGCGTTTATCTATTTTCAATTAC
GCTCACATGCCGAGTATTTTTCCGGCACAGCGAAAAATCAATGAAGATGATATGCCCAGCCCTGCTGAAAAGCTGGAAAT
TCTACAATATACCATTGAATTTTTAACTCAGGCGGGTTACCAGTTCATCGGGATGGATCATTTTGCAAAACCCACAGATG
AACTTGCTATCGCGCAACAAAAAGGTGTTTTACATCGTAACTTTCAAGGCTACACCACCCAGGAAGATGCAGATCTTTTA
GGAATGGGCGTGTCAGCGATTAGTCAAATTGGTCACAGTTATTCACAAAACCAGAAAAAACTTTCCACCTATTATAAACA
AATTGAACAATCAGGCCATGCGCAATGGCGCGGTGTTGGTTTGAATGAGGATGATTTAATTCGTCGGGAAGTGATTAAAA
AGCTGATTTGTAACTTTAAATTAGATGTTTCTGAGATAGAGAAACAGTTCAATTTAAACTTTAAAAATTATTTTTCTGAA
GATATTAAATTATTACAATGTTTTATTGATGATAAGCTTATTGAAATGACGGATGACAGCATAACAGTCCTAGCCAAGGG
ACGGTTACTGATTCGTAATATCTGTATGTGTTTTGATATTTATTTACGCAACAAAGCACGTCAGCAGCAGTTTTCTCGTG
TTATCTGA

Upstream 100 bases:

>100_bases
GATAAAAAACGTGAAAAATTGGAATCTGAACTTGAACAACAAATAATGACAGAAGCACAACAACTCGCCAATTTTTCAGT
ATAACAATAAAGGCCAAAAC

Downstream 100 bases:

>100_bases
TCCTATTATTGGCAACTATTATATCGGCATTATGTCCGGTACCAGTCTGGATGGGATTGATGTCGCTATTGCCCAGCGCA
CCCGGCATGGTTTTGTACAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MDKFVWDQALIEKYNYSGPRYTSYPTALEFDEAFTYQESIAATEVYPERSLSLYIHIPFCHKICYFCGCNKIITRHQEKA
DIYLDYLEKEIKQQALHFKNRHVSQLHWGGGTPTFLLPAQITRLMTMLRENFSFNPNAELSIEVDPREIELSTIDHLANE
GFNRLSLGVQDFNKEVQKAVNRDQDEDFIVALLKRAKEQGFQSTNLDMIYGLPLQTKQNFAHTLEKVVELDPARLSIFNY
AHMPSIFPAQRKINEDDMPSPAEKLEILQYTIEFLTQAGYQFIGMDHFAKPTDELAIAQQKGVLHRNFQGYTTQEDADLL
GMGVSAISQIGHSYSQNQKKLSTYYKQIEQSGHAQWRGVGLNEDDLIRREVIKKLICNFKLDVSEIEKQFNLNFKNYFSE
DIKLLQCFIDDKLIEMTDDSITVLAKGRLLIRNICMCFDIYLRNKARQQQFSRVI

Sequences:

>Translated_455_residues
MDKFVWDQALIEKYNYSGPRYTSYPTALEFDEAFTYQESIAATEVYPERSLSLYIHIPFCHKICYFCGCNKIITRHQEKA
DIYLDYLEKEIKQQALHFKNRHVSQLHWGGGTPTFLLPAQITRLMTMLRENFSFNPNAELSIEVDPREIELSTIDHLANE
GFNRLSLGVQDFNKEVQKAVNRDQDEDFIVALLKRAKEQGFQSTNLDMIYGLPLQTKQNFAHTLEKVVELDPARLSIFNY
AHMPSIFPAQRKINEDDMPSPAEKLEILQYTIEFLTQAGYQFIGMDHFAKPTDELAIAQQKGVLHRNFQGYTTQEDADLL
GMGVSAISQIGHSYSQNQKKLSTYYKQIEQSGHAQWRGVGLNEDDLIRREVIKKLICNFKLDVSEIEKQFNLNFKNYFSE
DIKLLQCFIDDKLIEMTDDSITVLAKGRLLIRNICMCFDIYLRNKARQQQFSRVI
>Mature_455_residues
MDKFVWDQALIEKYNYSGPRYTSYPTALEFDEAFTYQESIAATEVYPERSLSLYIHIPFCHKICYFCGCNKIITRHQEKA
DIYLDYLEKEIKQQALHFKNRHVSQLHWGGGTPTFLLPAQITRLMTMLRENFSFNPNAELSIEVDPREIELSTIDHLANE
GFNRLSLGVQDFNKEVQKAVNRDQDEDFIVALLKRAKEQGFQSTNLDMIYGLPLQTKQNFAHTLEKVVELDPARLSIFNY
AHMPSIFPAQRKINEDDMPSPAEKLEILQYTIEFLTQAGYQFIGMDHFAKPTDELAIAQQKGVLHRNFQGYTTQEDADLL
GMGVSAISQIGHSYSQNQKKLSTYYKQIEQSGHAQWRGVGLNEDDLIRREVIKKLICNFKLDVSEIEKQFNLNFKNYFSE
DIKLLQCFIDDKLIEMTDDSITVLAKGRLLIRNICMCFDIYLRNKARQQQFSRVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=245, Percent_Identity=23.6734693877551, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI87082341, Length=450, Percent_Identity=69.3333333333333, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI1789325, Length=242, Percent_Identity=29.7520661157025, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 52890; Mature: 52890

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKFVWDQALIEKYNYSGPRYTSYPTALEFDEAFTYQESIAATEVYPERSLSLYIHIPFC
CCCHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEEECHHH
HKICYFCGCNKIITRHQEKADIYLDYLEKEIKQQALHFKNRHVSQLHWGGGTPTFLLPAQ
HHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEECHHH
ITRLMTMLRENFSFNPNAELSIEVDPREIELSTIDHLANEGFNRLSLGVQDFNKEVQKAV
HHHHHHHHHHCCCCCCCCEEEEEECCCEEEHHHHHHHHHCCCHHHHCCHHHHHHHHHHHH
NRDQDEDFIVALLKRAKEQGFQSTNLDMIYGLPLQTKQNFAHTLEKVVELDPARLSIFNY
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHEEHHHH
AHMPSIFPAQRKINEDDMPSPAEKLEILQYTIEFLTQAGYQFIGMDHFAKPTDELAIAQQ
HCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCHHCCCCHHHHHHHHH
KGVLHRNFQGYTTQEDADLLGMGVSAISQIGHSYSQNQKKLSTYYKQIEQSGHAQWRGVG
CCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
LNEDDLIRREVIKKLICNFKLDVSEIEKQFNLNFKNYFSEDIKLLQCFIDDKLIEMTDDS
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHEEECCCC
ITVLAKGRLLIRNICMCFDIYLRNKARQQQFSRVI
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDKFVWDQALIEKYNYSGPRYTSYPTALEFDEAFTYQESIAATEVYPERSLSLYIHIPFC
CCCHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHCCCCCCCEEEEECHHH
HKICYFCGCNKIITRHQEKADIYLDYLEKEIKQQALHFKNRHVSQLHWGGGTPTFLLPAQ
HHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEECHHH
ITRLMTMLRENFSFNPNAELSIEVDPREIELSTIDHLANEGFNRLSLGVQDFNKEVQKAV
HHHHHHHHHHCCCCCCCCEEEEEECCCEEEHHHHHHHHHCCCHHHHCCHHHHHHHHHHHH
NRDQDEDFIVALLKRAKEQGFQSTNLDMIYGLPLQTKQNFAHTLEKVVELDPARLSIFNY
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCHHEEHHHH
AHMPSIFPAQRKINEDDMPSPAEKLEILQYTIEFLTQAGYQFIGMDHFAKPTDELAIAQQ
HCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEECCHHCCCCHHHHHHHHH
KGVLHRNFQGYTTQEDADLLGMGVSAISQIGHSYSQNQKKLSTYYKQIEQSGHAQWRGVG
CCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
LNEDDLIRREVIKKLICNFKLDVSEIEKQFNLNFKNYFSEDIKLLQCFIDDKLIEMTDDS
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHEEECCCC
ITVLAKGRLLIRNICMCFDIYLRNKARQQQFSRVI
EEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7768836; 8346018; 9278503 [H]