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The map label for this gene is trkH [H]

Identifier: 119943984

GI number: 119943984

Start: 248522

End: 249988

Strand: Direct

Name: trkH [H]

Synonym: Ping_0197

Alternate gene names: 119943984

Gene position: 248522-249988 (Clockwise)

Preceding gene: 119943983

Following gene: 119943985

Centisome position: 5.45

GC content: 42.06

Gene sequence:

>1467_bases
GTGGCATTTCGTTCCATAATCAGAATAGTTGGCATGTTAGTCGGCTTGTTTAGCTTGACCATGTTACCGCCTGCATTCAT
CTCAACCTTCTATGAAGGGGCGGCGGGTGAAGATGGAGGTAATTTTTTGGCTGCATTTGTGATGACTTTATTTATTGCTC
TGCTGTTATGGATACCTAATAGGCATGTTAAGAAAGAGCTGAGAGTACGTGAAGGTTTTTTAATTGTGGTCCTCTTTTGG
GTAACCCTGGGCAGTGTAGGAGCCATTCCCTTTATGATGAGTTCGAGCATCGAAATGGATGCCGCTTCCGCTTTTTTTGA
ATCTTTCTCGGGCTTAACCACGACCGGGGCAACGGTTATTGAACAGCTTGATACGCTCCCAAAATCGATCCTTTTTTACC
GGCAAATGCTGCAATGGTTCGGTGGTATGGGGATCATTGTTTTGGCCGTTGCCGTTTTACCCATGTTAGGTATCGGCGGA
ATGCAGCTCTACCGGGCTGAAGCTCCCGGGCCGGTAAAAGACTCAAAAATGACACCGCGTATTGCCGAAACTGCCAAGGC
ATTGTGGAATGTTTATCTCTTTGTGACCGTTGCTTGTATGCTGGCATTTTGGCTTGCCGGCATGAGTTTGTTTGATGCCA
TCGGACATAGTTTTTCAACGGTTTCTATTGGTGGTTTTTCAACTTACAACGAGAGTATTGGCCATTTTGACAGCAATCTT
ATTAACCTTATCACTGTGTTGTTTCTGCTTATTTCCGGGGTCAATTATGCGCTGCATTTTAGTGCCTTTTCCAGCCGAAA
ATTCTCTTTTAATATTTATCGGCAAGATCCGGAACTACGTGCTTTTATTTTTATTCAAGTATTATTAACCACTGTCTGTT
TTATTGGATTGATGGGTCATGAAGTTTATGATTCAATTGAAAATACTTTTTCTCAGGCATTATTTCAGGCTGTTTCTATT
TCCACCACTGCGGGTTTTACAACCACTTCATTTCATGATTGGCCGGCGTTTTTTCCGATTTTATTGATTATGTCCAGCTT
TATTGGTGGTTGTGCCGGGTCAACGGGCGGAGGTATGAAAGTTATTCGCATTTTATTGCTTAATTTACAGGGGATACGTG
AGCTAAAGCGGCTGGTTCACCCCAAAGCGGTTTTTAAAATCAAATTAGCTAATAATGCGCTTCCGGACCGTGTTATTGAA
GCTATTTGGGGATTCTTTTCAACTTATGCCCTGGTATTTGTTGTTTGTATGTTAGCGTTATTATTAACTGGTATGGATGA
GCTGAGTTCCTTTTCTGCGACTGCCGCCATGCTCAATAACTTAGGCCCCGGGCTTGGAGCGGTGGCGCTTCATTTTAATG
AAGTGAGTGCTGCTTCTAAATGGATAATGATCCTTGCTATGTTATTTGGCCGGTTAGAAATTTTTACATTATTAGTTTTA
TTCACTCCTATTTTTTGGAAAAATTAA

Upstream 100 bases:

>100_bases
GTTGATCAACAGTTGTGTCAACAATTTATTGAAAAACTCGACTCCCTGACGCAGGGGCAAGTTATTGCCAAAAAAATTCC
CATTACAGTGAGATAACTCA

Downstream 100 bases:

>100_bases
AAGATGACAATTAAGACCCTTATATTATATTCATCCGTTGATGGACAAACACTGAAAATTATAAACCGGATCATTGAGTT
AGTTGAAGGTGAAGTGACCT

Product: potassium uptake protein, TrkH family protein

Products: Proton [Cytoplasm]; K (I) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MAFRSIIRIVGMLVGLFSLTMLPPAFISTFYEGAAGEDGGNFLAAFVMTLFIALLLWIPNRHVKKELRVREGFLIVVLFW
VTLGSVGAIPFMMSSSIEMDAASAFFESFSGLTTTGATVIEQLDTLPKSILFYRQMLQWFGGMGIIVLAVAVLPMLGIGG
MQLYRAEAPGPVKDSKMTPRIAETAKALWNVYLFVTVACMLAFWLAGMSLFDAIGHSFSTVSIGGFSTYNESIGHFDSNL
INLITVLFLLISGVNYALHFSAFSSRKFSFNIYRQDPELRAFIFIQVLLTTVCFIGLMGHEVYDSIENTFSQALFQAVSI
STTAGFTTTSFHDWPAFFPILLIMSSFIGGCAGSTGGGMKVIRILLLNLQGIRELKRLVHPKAVFKIKLANNALPDRVIE
AIWGFFSTYALVFVVCMLALLLTGMDELSSFSATAAMLNNLGPGLGAVALHFNEVSAASKWIMILAMLFGRLEIFTLLVL
FTPIFWKN

Sequences:

>Translated_488_residues
MAFRSIIRIVGMLVGLFSLTMLPPAFISTFYEGAAGEDGGNFLAAFVMTLFIALLLWIPNRHVKKELRVREGFLIVVLFW
VTLGSVGAIPFMMSSSIEMDAASAFFESFSGLTTTGATVIEQLDTLPKSILFYRQMLQWFGGMGIIVLAVAVLPMLGIGG
MQLYRAEAPGPVKDSKMTPRIAETAKALWNVYLFVTVACMLAFWLAGMSLFDAIGHSFSTVSIGGFSTYNESIGHFDSNL
INLITVLFLLISGVNYALHFSAFSSRKFSFNIYRQDPELRAFIFIQVLLTTVCFIGLMGHEVYDSIENTFSQALFQAVSI
STTAGFTTTSFHDWPAFFPILLIMSSFIGGCAGSTGGGMKVIRILLLNLQGIRELKRLVHPKAVFKIKLANNALPDRVIE
AIWGFFSTYALVFVVCMLALLLTGMDELSSFSATAAMLNNLGPGLGAVALHFNEVSAASKWIMILAMLFGRLEIFTLLVL
FTPIFWKN
>Mature_487_residues
AFRSIIRIVGMLVGLFSLTMLPPAFISTFYEGAAGEDGGNFLAAFVMTLFIALLLWIPNRHVKKELRVREGFLIVVLFWV
TLGSVGAIPFMMSSSIEMDAASAFFESFSGLTTTGATVIEQLDTLPKSILFYRQMLQWFGGMGIIVLAVAVLPMLGIGGM
QLYRAEAPGPVKDSKMTPRIAETAKALWNVYLFVTVACMLAFWLAGMSLFDAIGHSFSTVSIGGFSTYNESIGHFDSNLI
NLITVLFLLISGVNYALHFSAFSSRKFSFNIYRQDPELRAFIFIQVLLTTVCFIGLMGHEVYDSIENTFSQALFQAVSIS
TTAGFTTTSFHDWPAFFPILLIMSSFIGGCAGSTGGGMKVIRILLLNLQGIRELKRLVHPKAVFKIKLANNALPDRVIEA
IWGFFSTYALVFVVCMLALLLTGMDELSSFSATAAMLNNLGPGLGAVALHFNEVSAASKWIMILAMLFGRLEIFTLLVLF
TPIFWKN

Specific function: Low-affinity potassium transport system. Interacts with trk system potassium uptake protein trkA and requires trkE for transport activity [H]

COG id: COG0168

COG function: function code P; Trk-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trkH potassium transport family [H]

Homologues:

Organism=Escherichia coli, GI48994987, Length=492, Percent_Identity=62.8048780487805, Blast_Score=570, Evalue=1e-164,
Organism=Escherichia coli, GI1787626, Length=485, Percent_Identity=40.6185567010309, Blast_Score=366, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003445
- InterPro:   IPR004772 [H]

Pfam domain/function: PF02386 TrkH [H]

EC number: NA

Molecular weight: Translated: 53606; Mature: 53475

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00267 TACHYKININ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFRSIIRIVGMLVGLFSLTMLPPAFISTFYEGAAGEDGGNFLAAFVMTLFIALLLWIPN
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
RHVKKELRVREGFLIVVLFWVTLGSVGAIPFMMSSSIEMDAASAFFESFSGLTTTGATVI
HHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHH
EQLDTLPKSILFYRQMLQWFGGMGIIVLAVAVLPMLGIGGMQLYRAEAPGPVKDSKMTPR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHEEECCCCCCCCCCCCCCH
IAETAKALWNVYLFVTVACMLAFWLAGMSLFDAIGHSFSTVSIGGFSTYNESIGHFDSNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHH
INLITVLFLLISGVNYALHFSAFSSRKFSFNIYRQDPELRAFIFIQVLLTTVCFIGLMGH
HHHHHHHHHHHHCCCHHEEEHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
EVYDSIENTFSQALFQAVSISTTAGFTTTSFHDWPAFFPILLIMSSFIGGCAGSTGGGMK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHH
VIRILLLNLQGIRELKRLVHPKAVFKIKLANNALPDRVIEAIWGFFSTYALVFVVCMLAL
HHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTGMDELSSFSATAAMLNNLGPGLGAVALHFNEVSAASKWIMILAMLFGRLEIFTLLVL
HHHCHHHHHHHHHHHHHHHHCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTPIFWKN
HHHHHCCC
>Mature Secondary Structure 
AFRSIIRIVGMLVGLFSLTMLPPAFISTFYEGAAGEDGGNFLAAFVMTLFIALLLWIPN
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
RHVKKELRVREGFLIVVLFWVTLGSVGAIPFMMSSSIEMDAASAFFESFSGLTTTGATVI
HHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHH
EQLDTLPKSILFYRQMLQWFGGMGIIVLAVAVLPMLGIGGMQLYRAEAPGPVKDSKMTPR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHEEECCCCCCCCCCCCCCH
IAETAKALWNVYLFVTVACMLAFWLAGMSLFDAIGHSFSTVSIGGFSTYNESIGHFDSNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHH
INLITVLFLLISGVNYALHFSAFSSRKFSFNIYRQDPELRAFIFIQVLLTTVCFIGLMGH
HHHHHHHHHHHHCCCHHEEEHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
EVYDSIENTFSQALFQAVSISTTAGFTTTSFHDWPAFFPILLIMSSFIGGCAGSTGGGMK
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHH
VIRILLLNLQGIRELKRLVHPKAVFKIKLANNALPDRVIEAIWGFFSTYALVFVVCMLAL
HHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LLTGMDELSSFSATAAMLNNLGPGLGAVALHFNEVSAASKWIMILAMLFGRLEIFTLLVL
HHHCHHHHHHHHHHHHHHHHCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTPIFWKN
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Periplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Periplasm] = Proton [Cytoplasm] + K (I) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]