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The map label for this gene is fmt

Identifier: 119943872

GI number: 119943872

Start: 105437

End: 106387

Strand: Direct

Name: fmt

Synonym: Ping_0079

Alternate gene names: 119943872

Gene position: 105437-106387 (Clockwise)

Preceding gene: 119943871

Following gene: 119943873

Centisome position: 2.31

GC content: 44.48

Gene sequence:

>951_bases
TTGGAAAAACTAAATATAATTTTTGCCGGCACGCCTGATTTTGCAGCTAAGCATCTTAGTGCATTGATAAACTCCGAGCA
TAATGTGATTGCCGTTTATACACAACCGGATCGCCCGGCAGGACGCGGTAAAAGATTAACCGCGAGTGCCGTCAAAGAGC
TTGCTATGGAGCAACAGATTCCTGTTTACCAGCCCGCTAACTTCAAAGAGGTTGACAGTACTAAGCAACTTGCCGCGTTA
AATGCCGATCTTATGATTGTGGTTGCCTACGGTTTATTATTACCGCAATTGGTATTAGGGATACCTCGTTTGGGCTGTTT
AAATGTACATGGCTCCTTATTGCCTCGCTGGCGGGGTGCTGCACCCATTCAGCGTGCAATTTGGGCGGGTGATACAGAGA
CGGGTGTGACTATCATGCAAATGGATGAAGGTCTGGATACCGGTGATATGTTAGCTAAAGTGAGTTGTCCAATTGAGAGA
GATGAAACCAGTGCTTCGCTCTATGAAAAACTTGCCCTGCAAGCGCCTGATGTATTAGTTGATACTATTAATAAACTCGT
TAAGGGGGAATTAAAGGCTGAAAAACAAGATCCGCAATTAGCCTGTTACGCTAAAAAATTGAGTAAAAGTGAGGCATTGA
TTGATTGGTCCAAGGATGCCGTCTTTATTGAGCGCTGTATCCGGGCATTTAATCCCTGGCCGGTCAGTTATTTTGTGCTT
GACGATAAAGTCATAAAAGTGCGCCAGGCAGGTTTACTTGCGACCAAAAGTGAACAGACCGCGGGTACTATTATTACAGC
GAGTAAAAATGGCATTCAAGTCGCCACGGGTGAAGGTATTATAAACCTTGAAGTGCTTCAGTTGGCGGGAAAAAAAGCGC
TGCCGGTACAAGATATTTTAAATTCTCGTCGTGAATTGTTTGCGCAGGGTACTTTACTACAGCAAGGTTAA

Upstream 100 bases:

>100_bases
GTATAGGGTTGGCGATACTTTTTTCGGCTGATAATCAGAGTCGAATAGAGTGCAATATAACAACCAAAAAATATTTATCA
TTTTTACTTTAAGGTTTCTC

Downstream 100 bases:

>100_bases
TTACATGAATGTAAGAGCATTAGCAGCTAAAATTTTAAATCAAGTGGTAGAGCAGGGGCAATCATTATCCAATGTCTTAC
CCCCTGTCCAACAGGATCTT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 316

Protein sequence:

>316_residues
MEKLNIIFAGTPDFAAKHLSALINSEHNVIAVYTQPDRPAGRGKRLTASAVKELAMEQQIPVYQPANFKEVDSTKQLAAL
NADLMIVVAYGLLLPQLVLGIPRLGCLNVHGSLLPRWRGAAPIQRAIWAGDTETGVTIMQMDEGLDTGDMLAKVSCPIER
DETSASLYEKLALQAPDVLVDTINKLVKGELKAEKQDPQLACYAKKLSKSEALIDWSKDAVFIERCIRAFNPWPVSYFVL
DDKVIKVRQAGLLATKSEQTAGTIITASKNGIQVATGEGIINLEVLQLAGKKALPVQDILNSRRELFAQGTLLQQG

Sequences:

>Translated_316_residues
MEKLNIIFAGTPDFAAKHLSALINSEHNVIAVYTQPDRPAGRGKRLTASAVKELAMEQQIPVYQPANFKEVDSTKQLAAL
NADLMIVVAYGLLLPQLVLGIPRLGCLNVHGSLLPRWRGAAPIQRAIWAGDTETGVTIMQMDEGLDTGDMLAKVSCPIER
DETSASLYEKLALQAPDVLVDTINKLVKGELKAEKQDPQLACYAKKLSKSEALIDWSKDAVFIERCIRAFNPWPVSYFVL
DDKVIKVRQAGLLATKSEQTAGTIITASKNGIQVATGEGIINLEVLQLAGKKALPVQDILNSRRELFAQGTLLQQG
>Mature_316_residues
MEKLNIIFAGTPDFAAKHLSALINSEHNVIAVYTQPDRPAGRGKRLTASAVKELAMEQQIPVYQPANFKEVDSTKQLAAL
NADLMIVVAYGLLLPQLVLGIPRLGCLNVHGSLLPRWRGAAPIQRAIWAGDTETGVTIMQMDEGLDTGDMLAKVSCPIER
DETSASLYEKLALQAPDVLVDTINKLVKGELKAEKQDPQLACYAKKLSKSEALIDWSKDAVFIERCIRAFNPWPVSYFVL
DDKVIKVRQAGLLATKSEQTAGTIITASKNGIQVATGEGIINLEVLQLAGKKALPVQDILNSRRELFAQGTLLQQG

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI164663775, Length=223, Percent_Identity=33.1838565022422, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI21614513, Length=240, Percent_Identity=27.5, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI238814322, Length=312, Percent_Identity=23.0769230769231, Blast_Score=92, Evalue=4e-19,
Organism=Escherichia coli, GI1789683, Length=312, Percent_Identity=60.5769230769231, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788589, Length=280, Percent_Identity=26.7857142857143, Blast_Score=124, Evalue=7e-30,
Organism=Caenorhabditis elegans, GI133930964, Length=252, Percent_Identity=25.7936507936508, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6319458, Length=183, Percent_Identity=31.1475409836066, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550868, Length=304, Percent_Identity=30.9210526315789, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28571984, Length=227, Percent_Identity=34.3612334801762, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24585660, Length=213, Percent_Identity=28.169014084507, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_PSYIN (A1SR38)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941552.1
- ProteinModelPortal:   A1SR38
- SMR:   A1SR38
- STRING:   A1SR38
- GeneID:   4626633
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0079
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- PhylomeDB:   A1SR38
- BioCyc:   PING357804:PING_0079-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 34425; Mature: 34425

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLNIIFAGTPDFAAKHLSALINSEHNVIAVYTQPDRPAGRGKRLTASAVKELAMEQQI
CCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHHCC
PVYQPANFKEVDSTKQLAALNADLMIVVAYGLLLPQLVLGIPRLGCLNVHGSLLPRWRGA
CCCCCCCCCHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCC
APIQRAIWAGDTETGVTIMQMDEGLDTGDMLAKVSCPIERDETSASLYEKLALQAPDVLV
CCHHHHHCCCCCCCCEEEEEECCCCCHHHHHEEECCCCCCCCHHHHHHHHHHHCCCHHHH
DTINKLVKGELKAEKQDPQLACYAKKLSKSEALIDWSKDAVFIERCIRAFNPWPVSYFVL
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHCCCCCEEEEEE
DDKVIKVRQAGLLATKSEQTAGTIITASKNGIQVATGEGIINLEVLQLAGKKALPVQDIL
CCCEEEHHHCCCEEECCCCCCCEEEEECCCCEEEEECCCEEEEHEEECCCCCCCCHHHHH
NSRRELFAQGTLLQQG
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MEKLNIIFAGTPDFAAKHLSALINSEHNVIAVYTQPDRPAGRGKRLTASAVKELAMEQQI
CCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHHCC
PVYQPANFKEVDSTKQLAALNADLMIVVAYGLLLPQLVLGIPRLGCLNVHGSLLPRWRGA
CCCCCCCCCHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCC
APIQRAIWAGDTETGVTIMQMDEGLDTGDMLAKVSCPIERDETSASLYEKLALQAPDVLV
CCHHHHHCCCCCCCCEEEEEECCCCCHHHHHEEECCCCCCCCHHHHHHHHHHHCCCHHHH
DTINKLVKGELKAEKQDPQLACYAKKLSKSEALIDWSKDAVFIERCIRAFNPWPVSYFVL
HHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHEEECCCCHHHHHHHHHHCCCCCEEEEEE
DDKVIKVRQAGLLATKSEQTAGTIITASKNGIQVATGEGIINLEVLQLAGKKALPVQDIL
CCCEEEHHHCCCEEECCCCCCCEEEEECCCCEEEEECCCEEEEHEEECCCCCCCCHHHHH
NSRRELFAQGTLLQQG
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA