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The map label for this gene is lysA [H]

Identifier: 119943834

GI number: 119943834

Start: 59442

End: 60707

Strand: Reverse

Name: lysA [H]

Synonym: Ping_0041

Alternate gene names: 119943834

Gene position: 60707-59442 (Counterclockwise)

Preceding gene: 119943838

Following gene: 119943833

Centisome position: 1.33

GC content: 41.79

Gene sequence:

>1266_bases
TTGGATCACTTTAATTATCAAAATGATGGCCGTCTTTTTGTTGAAGGATTACCTGTAGAGCAAGTTGTTAAAAAAACAGG
GACACCTGCCTATATCTACTCACGTGCAACTATCGAGCGTCATTGGCAAGCTTTTGATAGCGCAGCAGGAAAACACCCCC
ATCTAATCTGTTACGCCGTTAAAGCAAACTCTAACTTGGCTGTATTAAACCTGATGGCTAGAATGGGATCCGGATTTGAT
ATCGTTTCTGTCGGTGAATTAATGCGGGTGATTCAAGCCGGTGGAGATCCGAAAAAAATCGTCTTCTCAGGCGTAGGTAA
AACGGAAATCGAAATATCAGCGGCACTGCAAGCAAATATTATGTGTTTTAATGTTGAATCTATTTCGGAACTGTACCGCA
TTAATAGTGTTGCCAAAGCGCTAAATGTTAAAGCTCCCATCTCAATCCGCATTAATCCTAATATTGATGCAGGGACTCAT
CCTTATATCTCTACCGGTTTAAAAGAGAATAAATTTGGTATCGAAATTGAACAAGCGCTAGACGTTTATAAAATAGCGAG
CGATCTTGAATTTTTAGAAATAAAAGGCGTAGATTGCCATATCGGTTCGCAGTTAACTGAAATAGCGCCCTTTATTGAAG
CCTTAGACAAATTGTTAATTTTAATCGATTTATTAGCGGAAAAAGGCATTACTATCTCTCATCTGGATTTAGGAGGTGGG
TTAGGTGTGCCTTATGATGACGAAACGCCACCAGAGCCGGCTGAATATATGACCGCAATCATTAATAGAATGGCCGGTCG
CAGTCTCAAACTTATTTTTGAACCTGGCCGCGCTATTATGGCCAATGCGGGTGTACTGGTAACTAAAGTTGAATTTTTAA
AACTGAATGACTACAAAAACTTTGCCATTGTCGATGCAGCGATGAACGATTTAATCCGTCCGGCGTTATACAGTGCATGG
CAAAATATTATCCCGCTAAATACGGACTATCAGGATGGCCAAGATCGCCCCGTACGCAGCTACGACATTGTTGGTCCTAT
TTGTGAAACGGGTGATTTTTTAGGCAAAGAACGTCAGCTTGCTTTAGCTGAAGGTGATTATCTGGTTATCCGCAGTACAG
GCGCCTATGGTTCAACCATGAGCTCTAACTACAACTCACGTTGCCGCGCTGCCGAAATATTAGTCGATGGCGAAAAAGCC
TTTATCGTGCGTGAACGCGAAGAGCTTAAAGATTTATGGCGCGGAGAGCACATTTTACCAATATAA

Upstream 100 bases:

>100_bases
CTGACAGCGACACCACAAAAATCAATGCAAGCGAATAAAAGAAACTTGCTTTTTTAATACATTGATTTTACATATTTAAG
TAAATAAAAAGGATTTACAA

Downstream 100 bases:

>100_bases
TAGATTTAACAAAGTGAAACCTGCTTTGGCTTAATTTCAACAACGAGAAATAATGAATATTCAATTTTCAAAAATGCACG
GCTTGGGTAATGACTTTATG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDHFNYQNDGRLFVEGLPVEQVVKKTGTPAYIYSRATIERHWQAFDSAAGKHPHLICYAVKANSNLAVLNLMARMGSGFD
IVSVGELMRVIQAGGDPKKIVFSGVGKTEIEISAALQANIMCFNVESISELYRINSVAKALNVKAPISIRINPNIDAGTH
PYISTGLKENKFGIEIEQALDVYKIASDLEFLEIKGVDCHIGSQLTEIAPFIEALDKLLILIDLLAEKGITISHLDLGGG
LGVPYDDETPPEPAEYMTAIINRMAGRSLKLIFEPGRAIMANAGVLVTKVEFLKLNDYKNFAIVDAAMNDLIRPALYSAW
QNIIPLNTDYQDGQDRPVRSYDIVGPICETGDFLGKERQLALAEGDYLVIRSTGAYGSTMSSNYNSRCRAAEILVDGEKA
FIVREREELKDLWRGEHILPI

Sequences:

>Translated_421_residues
MDHFNYQNDGRLFVEGLPVEQVVKKTGTPAYIYSRATIERHWQAFDSAAGKHPHLICYAVKANSNLAVLNLMARMGSGFD
IVSVGELMRVIQAGGDPKKIVFSGVGKTEIEISAALQANIMCFNVESISELYRINSVAKALNVKAPISIRINPNIDAGTH
PYISTGLKENKFGIEIEQALDVYKIASDLEFLEIKGVDCHIGSQLTEIAPFIEALDKLLILIDLLAEKGITISHLDLGGG
LGVPYDDETPPEPAEYMTAIINRMAGRSLKLIFEPGRAIMANAGVLVTKVEFLKLNDYKNFAIVDAAMNDLIRPALYSAW
QNIIPLNTDYQDGQDRPVRSYDIVGPICETGDFLGKERQLALAEGDYLVIRSTGAYGSTMSSNYNSRCRAAEILVDGEKA
FIVREREELKDLWRGEHILPI
>Mature_421_residues
MDHFNYQNDGRLFVEGLPVEQVVKKTGTPAYIYSRATIERHWQAFDSAAGKHPHLICYAVKANSNLAVLNLMARMGSGFD
IVSVGELMRVIQAGGDPKKIVFSGVGKTEIEISAALQANIMCFNVESISELYRINSVAKALNVKAPISIRINPNIDAGTH
PYISTGLKENKFGIEIEQALDVYKIASDLEFLEIKGVDCHIGSQLTEIAPFIEALDKLLILIDLLAEKGITISHLDLGGG
LGVPYDDETPPEPAEYMTAIINRMAGRSLKLIFEPGRAIMANAGVLVTKVEFLKLNDYKNFAIVDAAMNDLIRPALYSAW
QNIIPLNTDYQDGQDRPVRSYDIVGPICETGDFLGKERQLALAEGDYLVIRSTGAYGSTMSSNYNSRCRAAEILVDGEKA
FIVREREELKDLWRGEHILPI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=349, Percent_Identity=25.5014326647564, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI22538418, Length=377, Percent_Identity=26.2599469496021, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI21361583, Length=377, Percent_Identity=26.2599469496021, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1789203, Length=435, Percent_Identity=31.264367816092, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789307, Length=311, Percent_Identity=24.7588424437299, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562780, Length=359, Percent_Identity=23.9554317548747, Blast_Score=75, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322664, Length=372, Percent_Identity=26.3440860215054, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24586472, Length=343, Percent_Identity=25.9475218658892, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24586474, Length=342, Percent_Identity=25.7309941520468, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 46452; Mature: 46452

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFNYQNDGRLFVEGLPVEQVVKKTGTPAYIYSRATIERHWQAFDSAAGKHPHLICYAV
CCCCCCCCCCEEEEECCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEEEE
KANSNLAVLNLMARMGSGFDIVSVGELMRVIQAGGDPKKIVFSGVGKTEIEISAALQANI
ECCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEEEEE
MCFNVESISELYRINSVAKALNVKAPISIRINPNIDAGTHPYISTGLKENKFGIEIEQAL
EEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHCCCCCCCCCEEHHHHH
DVYKIASDLEFLEIKGVDCHIGSQLTEIAPFIEALDKLLILIDLLAEKGITISHLDLGGG
HHHHHHCCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
LGVPYDDETPPEPAEYMTAIINRMAGRSLKLIFEPGRAIMANAGVLVTKVEFLKLNDYKN
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCEEEEEEEEEEECCCCC
FAIVDAAMNDLIRPALYSAWQNIIPLNTDYQDGQDRPVRSYDIVGPICETGDFLGKERQL
EEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCHHHCHHHCCCCCEE
ALAEGDYLVIRSTGAYGSTMSSNYNSRCRAAEILVDGEKAFIVREREELKDLWRGEHILP
EEECCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEEEECHHHHHHHHCCCCCCC
I
C
>Mature Secondary Structure
MDHFNYQNDGRLFVEGLPVEQVVKKTGTPAYIYSRATIERHWQAFDSAAGKHPHLICYAV
CCCCCCCCCCEEEEECCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEEEE
KANSNLAVLNLMARMGSGFDIVSVGELMRVIQAGGDPKKIVFSGVGKTEIEISAALQANI
ECCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEEEEEE
MCFNVESISELYRINSVAKALNVKAPISIRINPNIDAGTHPYISTGLKENKFGIEIEQAL
EEEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHCCCCCCCCCEEHHHHH
DVYKIASDLEFLEIKGVDCHIGSQLTEIAPFIEALDKLLILIDLLAEKGITISHLDLGGG
HHHHHHCCCEEEEEECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCC
LGVPYDDETPPEPAEYMTAIINRMAGRSLKLIFEPGRAIMANAGVLVTKVEFLKLNDYKN
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCEEEEEEEEEEECCCCC
FAIVDAAMNDLIRPALYSAWQNIIPLNTDYQDGQDRPVRSYDIVGPICETGDFLGKERQL
EEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCHHHCHHHCCCCCEE
ALAEGDYLVIRSTGAYGSTMSSNYNSRCRAAEILVDGEKAFIVREREELKDLWRGEHILP
EEECCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCEEEEEECHHHHHHHHCCCCCCC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]