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The map label for this gene is hslU

Identifier: 119943797

GI number: 119943797

Start: 7861

End: 9195

Strand: Reverse

Name: hslU

Synonym: Ping_0003

Alternate gene names: 119943797

Gene position: 9195-7861 (Counterclockwise)

Preceding gene: 119943798

Following gene: 119943796

Centisome position: 0.2

GC content: 38.58

Gene sequence:

>1335_bases
ATGTCAAATATGACACCAAAAGAAATTAAACATGAGTTAGATCGCCATATCATTGGACAAGACAATGCCAAACGAGCTGT
TGCTATTGCACTTCGTAATCGCTGGCGCCGTATGCAGCTTGATAAAGAAATGCGTCAAGAAGTCACCCCAAAGAATATTT
TAATGATCGGTCCTACCGGTGTAGGTAAAACAGAGATTGCGCGCCGTTTAGCAAAACTCGCTAATGCTCCTTTTATCAAA
GTTGAAGCAACTAAATTTACAGAAGTAGGGTATGTTGGTAAAGAGGTCGAATCTATCGTTCGTGATTTAGTCGATGTAGC
CATTAAACTGACTCGCGAAGAAGAAATGGCAAAGGTTGCCCATAAGGCAGAAGATTTAGCTGAGGATAGGATCTTAGATA
TCCTTATTCCACCTGCTAAAACAGGCAATGATTGGGAAACTGTAAAAACAGAAGATAGTGCGACAAGGCAGTCTTTCCGT
AAAAAACTGCGTGAAGGTAAATTGGATGATAAAGAGGTTGAGATAGATCTCCCTGCTCCACAAATAGGTGTGGAAATAAT
GGCTCCTCCCGGCATGGAAGAAATGACTAATCAATTGCAGGGCATGTTTCAAAGTATGTCAGGTAAAGATAAAACTAAAA
AACGCAAAATGAAAATAAAAGAGGCGTTGAAAGTACTGATCGAATCGGAAGCTGCAAAATTAGTGAATGAAGAAGACATT
AAAGAAAAAGCACTCTTTTCAGCAGAAAATAACGGTATTATATTTATCGACGAAATAGATAAAATTTGTAAGCGTGGTGA
TAGTGCCGGTCCTGACGTATCAAGAGAAGGTGTACAGCGTGATTTATTACCTTTAATTGAAGGTTCTACCGTCAGCACTA
AGCATGGGATGGTGAAAACTGACCATATGTTATTTATTGCATCGGGTGCATTTCAAGTTGCTAAACCCTCAGATCTTATT
CCCGAATTACAGGGCCGCTTACCAATTAGGGTTGAGTTAGAAGCACTGACAGAAGAAGATCTGGCAAAAATATTAACTGA
GCCTAAAGCTTCCTTAAGTGAACAGTATAAAGCGCTGTTAGCAACCGAAGGTATAACGCTTCAATTTAGCAAAGATGGTA
TAGATAAAATTGCTAAATCTGCCTGGCATGTGAATGAAACCACCGAAAATATAGGTGCACGTCGTTTACACACATTAATG
GAACGCATTCTTGATGAACTTTCCTATGAAGCTTCAGAACGGAAAGGTGAATCAATTACTATTGATGAAAATTACGTTGC
TAATACGTTAGATGATTTGCTTGAAAATGAAGATTTAAGCCGATATATTTTATAA

Upstream 100 bases:

>100_bases
CAGGCAATATTTGTGTTTTTACTAATGAAACTCACACTATTGAATGCATTGATTTCTCTGATGAAATTACTACTGAAAGT
AAAAAATAGGGTATATAACT

Downstream 100 bases:

>100_bases
AACATTAAGTTATTAAACAAAAAAGGATCCTATATGGATCCTTTTTTATACTTCTGGCGCGTGCAGATCAACTGCGTAAT
AAGCCGTCATAAAACTCAGT

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MSNMTPKEIKHELDRHIIGQDNAKRAVAIALRNRWRRMQLDKEMRQEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIK
VEATKFTEVGYVGKEVESIVRDLVDVAIKLTREEEMAKVAHKAEDLAEDRILDILIPPAKTGNDWETVKTEDSATRQSFR
KKLREGKLDDKEVEIDLPAPQIGVEIMAPPGMEEMTNQLQGMFQSMSGKDKTKKRKMKIKEALKVLIESEAAKLVNEEDI
KEKALFSAENNGIIFIDEIDKICKRGDSAGPDVSREGVQRDLLPLIEGSTVSTKHGMVKTDHMLFIASGAFQVAKPSDLI
PELQGRLPIRVELEALTEEDLAKILTEPKASLSEQYKALLATEGITLQFSKDGIDKIAKSAWHVNETTENIGARRLHTLM
ERILDELSYEASERKGESITIDENYVANTLDDLLENEDLSRYIL

Sequences:

>Translated_444_residues
MSNMTPKEIKHELDRHIIGQDNAKRAVAIALRNRWRRMQLDKEMRQEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIK
VEATKFTEVGYVGKEVESIVRDLVDVAIKLTREEEMAKVAHKAEDLAEDRILDILIPPAKTGNDWETVKTEDSATRQSFR
KKLREGKLDDKEVEIDLPAPQIGVEIMAPPGMEEMTNQLQGMFQSMSGKDKTKKRKMKIKEALKVLIESEAAKLVNEEDI
KEKALFSAENNGIIFIDEIDKICKRGDSAGPDVSREGVQRDLLPLIEGSTVSTKHGMVKTDHMLFIASGAFQVAKPSDLI
PELQGRLPIRVELEALTEEDLAKILTEPKASLSEQYKALLATEGITLQFSKDGIDKIAKSAWHVNETTENIGARRLHTLM
ERILDELSYEASERKGESITIDENYVANTLDDLLENEDLSRYIL
>Mature_443_residues
SNMTPKEIKHELDRHIIGQDNAKRAVAIALRNRWRRMQLDKEMRQEVTPKNILMIGPTGVGKTEIARRLAKLANAPFIKV
EATKFTEVGYVGKEVESIVRDLVDVAIKLTREEEMAKVAHKAEDLAEDRILDILIPPAKTGNDWETVKTEDSATRQSFRK
KLREGKLDDKEVEIDLPAPQIGVEIMAPPGMEEMTNQLQGMFQSMSGKDKTKKRKMKIKEALKVLIESEAAKLVNEEDIK
EKALFSAENNGIIFIDEIDKICKRGDSAGPDVSREGVQRDLLPLIEGSTVSTKHGMVKTDHMLFIASGAFQVAKPSDLIP
ELQGRLPIRVELEALTEEDLAKILTEPKASLSEQYKALLATEGITLQFSKDGIDKIAKSAWHVNETTENIGARRLHTLME
RILDELSYEASERKGESITIDENYVANTLDDLLENEDLSRYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Escherichia coli, GI1790366, Length=446, Percent_Identity=71.7488789237668, Blast_Score=667, Evalue=0.0,
Organism=Escherichia coli, GI1786642, Length=231, Percent_Identity=35.4978354978355, Blast_Score=101, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319704, Length=511, Percent_Identity=22.5048923679061, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_PSYIN (A1SQW3)

Other databases:

- EMBL:   CP000510
- RefSeq:   YP_941477.1
- ProteinModelPortal:   A1SQW3
- SMR:   A1SQW3
- STRING:   A1SQW3
- GeneID:   4625092
- GenomeReviews:   CP000510_GR
- KEGG:   pin:Ping_0003
- eggNOG:   COG1220
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- PhylomeDB:   A1SQW3
- ProtClustDB:   PRK05201
- BioCyc:   PING357804:PING_0003-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 49907; Mature: 49776

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: BINDING 18-18 BINDING 257-257 BINDING 322-322 BINDING 394-394

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNMTPKEIKHELDRHIIGQDNAKRAVAIALRNRWRRMQLDKEMRQEVTPKNILMIGPTG
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVESIVRDLVDVAIKLTREEEMAKVA
CCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKAEDLAEDRILDILIPPAKTGNDWETVKTEDSATRQSFRKKLREGKLDDKEVEIDLPAP
HHHHHHHHHCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
QIGVEIMAPPGMEEMTNQLQGMFQSMSGKDKTKKRKMKIKEALKVLIESEAAKLVNEEDI
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KEKALFSAENNGIIFIDEIDKICKRGDSAGPDVSREGVQRDLLPLIEGSTVSTKHGMVKT
HHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEE
DHMLFIASGAFQVAKPSDLIPELQGRLPIRVELEALTEEDLAKILTEPKASLSEQYKALL
CCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEHHHHCHHHHHHHHHCCHHHHHHHHHHHH
ATEGITLQFSKDGIDKIAKSAWHVNETTENIGARRLHTLMERILDELSYEASERKGESIT
HCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEE
IDENYVANTLDDLLENEDLSRYIL
ECCCHHHHHHHHHHCCCCHHHHCC
>Mature Secondary Structure 
SNMTPKEIKHELDRHIIGQDNAKRAVAIALRNRWRRMQLDKEMRQEVTPKNILMIGPTG
CCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
VGKTEIARRLAKLANAPFIKVEATKFTEVGYVGKEVESIVRDLVDVAIKLTREEEMAKVA
CCHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HKAEDLAEDRILDILIPPAKTGNDWETVKTEDSATRQSFRKKLREGKLDDKEVEIDLPAP
HHHHHHHHHCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCC
QIGVEIMAPPGMEEMTNQLQGMFQSMSGKDKTKKRKMKIKEALKVLIESEAAKLVNEEDI
CCCEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
KEKALFSAENNGIIFIDEIDKICKRGDSAGPDVSREGVQRDLLPLIEGSTVSTKHGMVKT
HHHHHHCCCCCCEEEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEE
DHMLFIASGAFQVAKPSDLIPELQGRLPIRVELEALTEEDLAKILTEPKASLSEQYKALL
CCEEEEECCCCCCCCCHHHHHHHHCCCCEEEEHHHHCHHHHHHHHHCCHHHHHHHHHHHH
ATEGITLQFSKDGIDKIAKSAWHVNETTENIGARRLHTLMERILDELSYEASERKGESIT
HCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEE
IDENYVANTLDDLLENEDLSRYIL
ECCCHHHHHHHHHHCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA