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The map label for this gene is fabF2 [H]

Identifier: 119900200

GI number: 119900200

Start: 4291053

End: 4292258

Strand: Direct

Name: fabF2 [H]

Synonym: azo3911

Alternate gene names: 119900200

Gene position: 4291053-4292258 (Clockwise)

Preceding gene: 119900196

Following gene: 119900201

Centisome position: 98.06

GC content: 71.31

Gene sequence:

>1206_bases
TTGAAGCCGCTTCAGCAGCCCCTTCTCCTGTCCTGTTACACCGCCACCAGCTGTATCGGCACCGGGCTCGCGGCAACGCG
GCAGGCGCTGGCGGAAGGCCGCAGCGGGCTCGCGCCCTGCGACTTCGAGACCGTGACCCTGCCCACCTGGATCGGGCGCG
TGCCGCAGCTCGAAGAGGTGGTGCTCTCACCGGCCCTCATCGACTACGACTGTCGTAATAATCGCCTGGCGCTGCTCGGG
CTGCTGCAGGACGGCTTCGTCGACGCCGCGCTGGCGGCCGTGAAACGCTATGGCGCGGCGCGAGTGGCCGTACTGCTGGG
CACCAGCACCTCGGGCATCCTCGAAACCGAACTCGCCTACCGCGCGCGCGACCCGCACACCGGCGCGCTGCCGCCGGCCT
TCCACTATCGCGGCAGCCATAACATCTTCTCGGTCGCGGAGTTCGTGCGCCACGTGATCGGCGCCACCGGCCCCGCATGG
GTCACCTCCACCGCCTGCTCGTCGAGTGCCAAGGTGTTCGCCAGCGCTGCGCGACTGATCGCCACCGGCGTGATCGACGC
GGCGGTGGTCGGCGGCGTCGATTCGCTGTGCCTCACCACGCTGTACGGCTTCAACTCGCTCGAACTGGTGTCGTCCGCGC
CCTGCCGCCCTTACGACGCGGCCCGCAACGGCATCTCCGTGGGCGAGGCGGCGGCGTTCGCGCTGCTGGAACGCGCGCCG
GCGCAGCCCGCCAGCGGCGCGGTGCTGCTCAGCGGCAGCGGCGAATCCAGCGATGCGCACCATATGTCGTCGCCGCATCC
GCAGGGCCTGGGTGCGCGCCTGGCGATGGAACAGGCCCTGGCAACGGCAGGACTCACGGCCGCCGACATCGACTACATCA
ACCTGCACGGCACCGCCACCCCCAGCAACGACGCAGCCGAAGGGCAGGCGGTGCAGGCGCTGTTCGGCGCCGCCACGCCG
GCCAGCTCCACCAAGGGCGCCACCGGCCACACGCTCGGCGCCGCCGGCGGGCTCGAAGCCGTGTTCAGCGCGATCGCGCT
CGCCGACGGCCTCATCCCGGGCAGCCCGGGCACCGGGACCCTCGACCCCGCGATCGCGATCGACTACCAGCGCCGCCCCC
GCCCGGCCGCGCTGCGCCATGTGCTCAGCAATTCCTTCGGTTTCGGCGGCACCAATTGCAGCCTCGTGTTCTCGCGCGCC
GGATGA

Upstream 100 bases:

>100_bases
GCGGGATACTAGGGTGGCCGCCGTAAACATGTCAAACCGCATAGCCGGCCGGGCGTGCCAAGTTTGTTAGAATCGGCCGA
AATCTCACCGGATACCGCGT

Downstream 100 bases:

>100_bases
CCCCATGACCCAGCCTTCACACCCGGCCCCTCCGTACGCCCTGCCCGCCGCCCGCATCAGCGGCATCGGCCTGACCGGCC
CCGCGCTGGACGACTGGCCC

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MKPLQQPLLLSCYTATSCIGTGLAATRQALAEGRSGLAPCDFETVTLPTWIGRVPQLEEVVLSPALIDYDCRNNRLALLG
LLQDGFVDAALAAVKRYGAARVAVLLGTSTSGILETELAYRARDPHTGALPPAFHYRGSHNIFSVAEFVRHVIGATGPAW
VTSTACSSSAKVFASAARLIATGVIDAAVVGGVDSLCLTTLYGFNSLELVSSAPCRPYDAARNGISVGEAAAFALLERAP
AQPASGAVLLSGSGESSDAHHMSSPHPQGLGARLAMEQALATAGLTAADIDYINLHGTATPSNDAAEGQAVQALFGAATP
ASSTKGATGHTLGAAGGLEAVFSAIALADGLIPGSPGTGTLDPAIAIDYQRRPRPAALRHVLSNSFGFGGTNCSLVFSRA
G

Sequences:

>Translated_401_residues
MKPLQQPLLLSCYTATSCIGTGLAATRQALAEGRSGLAPCDFETVTLPTWIGRVPQLEEVVLSPALIDYDCRNNRLALLG
LLQDGFVDAALAAVKRYGAARVAVLLGTSTSGILETELAYRARDPHTGALPPAFHYRGSHNIFSVAEFVRHVIGATGPAW
VTSTACSSSAKVFASAARLIATGVIDAAVVGGVDSLCLTTLYGFNSLELVSSAPCRPYDAARNGISVGEAAAFALLERAP
AQPASGAVLLSGSGESSDAHHMSSPHPQGLGARLAMEQALATAGLTAADIDYINLHGTATPSNDAAEGQAVQALFGAATP
ASSTKGATGHTLGAAGGLEAVFSAIALADGLIPGSPGTGTLDPAIAIDYQRRPRPAALRHVLSNSFGFGGTNCSLVFSRA
G
>Mature_401_residues
MKPLQQPLLLSCYTATSCIGTGLAATRQALAEGRSGLAPCDFETVTLPTWIGRVPQLEEVVLSPALIDYDCRNNRLALLG
LLQDGFVDAALAAVKRYGAARVAVLLGTSTSGILETELAYRARDPHTGALPPAFHYRGSHNIFSVAEFVRHVIGATGPAW
VTSTACSSSAKVFASAARLIATGVIDAAVVGGVDSLCLTTLYGFNSLELVSSAPCRPYDAARNGISVGEAAAFALLERAP
AQPASGAVLLSGSGESSDAHHMSSPHPQGLGARLAMEQALATAGLTAADIDYINLHGTATPSNDAAEGQAVQALFGAATP
ASSTKGATGHTLGAAGGLEAVFSAIALADGLIPGSPGTGTLDPAIAIDYQRRPRPAALRHVLSNSFGFGGTNCSLVFSRA
G

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=256, Percent_Identity=39.0625, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI223972627, Length=145, Percent_Identity=42.7586206896552, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI41872631, Length=253, Percent_Identity=26.4822134387352, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1787337, Length=263, Percent_Identity=39.5437262357414, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1788663, Length=255, Percent_Identity=34.5098039215686, Blast_Score=119, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71983541, Length=413, Percent_Identity=29.7820823244552, Blast_Score=134, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71983535, Length=253, Percent_Identity=33.9920948616601, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI212642053, Length=336, Percent_Identity=25.297619047619, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17550940, Length=305, Percent_Identity=24.5901639344262, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320904, Length=258, Percent_Identity=36.046511627907, Blast_Score=123, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24644341, Length=273, Percent_Identity=39.5604395604396, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI24581345, Length=342, Percent_Identity=26.9005847953216, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19920632, Length=339, Percent_Identity=25.3687315634218, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI221330659, Length=339, Percent_Identity=25.3687315634218, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 40849; Mature: 40849

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLQQPLLLSCYTATSCIGTGLAATRQALAEGRSGLAPCDFETVTLPTWIGRVPQLEEV
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCHHHCCCCCHHHH
VLSPALIDYDCRNNRLALLGLLQDGFVDAALAAVKRYGAARVAVLLGTSTSGILETELAY
HHCCHHEEECCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHH
RARDPHTGALPPAFHYRGSHNIFSVAEFVRHVIGATGPAWVTSTACSSSAKVFASAARLI
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHH
ATGVIDAAVVGGVDSLCLTTLYGFNSLELVSSAPCRPYDAARNGISVGEAAAFALLERAP
HHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCC
AQPASGAVLLSGSGESSDAHHMSSPHPQGLGARLAMEQALATAGLTAADIDYINLHGTAT
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
PSNDAAEGQAVQALFGAATPASSTKGATGHTLGAAGGLEAVFSAIALADGLIPGSPGTGT
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
LDPAIAIDYQRRPRPAALRHVLSNSFGFGGTNCSLVFSRAG
CCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MKPLQQPLLLSCYTATSCIGTGLAATRQALAEGRSGLAPCDFETVTLPTWIGRVPQLEEV
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCEEECCHHHCCCCCHHHH
VLSPALIDYDCRNNRLALLGLLQDGFVDAALAAVKRYGAARVAVLLGTSTSGILETELAY
HHCCHHEEECCCCCCEEEEEEHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHH
RARDPHTGALPPAFHYRGSHNIFSVAEFVRHVIGATGPAWVTSTACSSSAKVFASAARLI
HCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHH
ATGVIDAAVVGGVDSLCLTTLYGFNSLELVSSAPCRPYDAARNGISVGEAAAFALLERAP
HHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCC
AQPASGAVLLSGSGESSDAHHMSSPHPQGLGARLAMEQALATAGLTAADIDYINLHGTAT
CCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
PSNDAAEGQAVQALFGAATPASSTKGATGHTLGAAGGLEAVFSAIALADGLIPGSPGTGT
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
LDPAIAIDYQRRPRPAALRHVLSNSFGFGGTNCSLVFSRAG
CCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]