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The map label for this gene is pdhC [H]

Identifier: 119900159

GI number: 119900159

Start: 4242513

End: 4243226

Strand: Direct

Name: pdhC [H]

Synonym: azo3870

Alternate gene names: 119900159

Gene position: 4242513-4243226 (Clockwise)

Preceding gene: 119900158

Following gene: 119900160

Centisome position: 96.95

GC content: 73.81

Gene sequence:

>714_bases
ATGGCTGCGAGCGTGGCGGCTGAAACCGCCTCCCCCGCGGCGGCGCCGGAACGCCGCACGGTGCCGCTGACCGGTCTGCG
CGGCGCCATCGCCCGCAACATGGGCCAGGGCTGGCAGGTGCCGCGGGTGGCGCACTCGGTGGACGTGGATCTCACCCGCG
TCGAAGCGCTGCGCGCCGAGCGCGCCGCCGCCGGCGACAAGCTCAGCGTGAATGCCTTCGTGCTGCACGCGGTGGCGCAG
GCGCTGCGCGCCCATCCGCGGCTGAACGCGCTGATGCGCGAGAAGGAAGTCGAGCTGGTCGACGACATCAACATCGGCGT
CGCGGTGGCGCTGGACGACGGCCTGATGGTGCCGGTGATCCGCCAGGCGGACACCAAGCCGGTGGCGGCGCTGGCGGCGG
AAACCCGCCAGCTCGCCGAGGGCGCCCGCGCCGGCGCGCTCACCGGCGGCGCCTACCAGCGCGGCACCTTCACCGTCACC
AACCTCGGCAGCACGCCGGTGGACCGCTTCAGCCCGATCATCAACCCGCCGCAGGTGGCCATCCTCGGCGTCGGCCGCAC
CCGCCAGCAGGCGGTGGTGAAGGACGGCGCCATCGTCGCCGCGCCGGTGGTCAACCTGACCCTGGTGTTCGACCACCGCG
CGGTGGACGGCTACCCGGCGGCGCTCTTCCTCGGCGAGATCGCGCGCCGGCTGGAACAGGCGGAGTTCGACTGA

Upstream 100 bases:

>100_bases
GATCTTCGCGCCCTCGGCCGGCCGCATCGCCAAGCTCAACGTGGCCGAGCAGGACACCTTCGGCCGCGGCGCGGTGCTCG
CGCTGCTGGAGGCCTGAGCC

Downstream 100 bases:

>100_bases
TGCCCGCCGCCGCCCTCGCCCCTTCGACCCACGGCCGCCGCCTGACGACCAGCGGCAGCGCGCTGACGCTGGCGCGCGCC
GCCGCCGAGCAGGACTGGAA

Product: hypothetical protein

Products: NA

Alternate protein names: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2 [H]

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MAASVAAETASPAAAPERRTVPLTGLRGAIARNMGQGWQVPRVAHSVDVDLTRVEALRAERAAAGDKLSVNAFVLHAVAQ
ALRAHPRLNALMREKEVELVDDINIGVAVALDDGLMVPVIRQADTKPVAALAAETRQLAEGARAGALTGGAYQRGTFTVT
NLGSTPVDRFSPIINPPQVAILGVGRTRQQAVVKDGAIVAAPVVNLTLVFDHRAVDGYPAALFLGEIARRLEQAEFD

Sequences:

>Translated_237_residues
MAASVAAETASPAAAPERRTVPLTGLRGAIARNMGQGWQVPRVAHSVDVDLTRVEALRAERAAAGDKLSVNAFVLHAVAQ
ALRAHPRLNALMREKEVELVDDINIGVAVALDDGLMVPVIRQADTKPVAALAAETRQLAEGARAGALTGGAYQRGTFTVT
NLGSTPVDRFSPIINPPQVAILGVGRTRQQAVVKDGAIVAAPVVNLTLVFDHRAVDGYPAALFLGEIARRLEQAEFD
>Mature_236_residues
AASVAAETASPAAAPERRTVPLTGLRGAIARNMGQGWQVPRVAHSVDVDLTRVEALRAERAAAGDKLSVNAFVLHAVAQA
LRAHPRLNALMREKEVELVDDINIGVAVALDDGLMVPVIRQADTKPVAALAAETRQLAEGARAGALTGGAYQRGTFTVTN
LGSTPVDRFSPIINPPQVAILGVGRTRQQAVVKDGAIVAAPVVNLTLVFDHRAVDGYPAALFLGEIARRLEQAEFD

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0508

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI31711992, Length=219, Percent_Identity=34.2465753424658, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI203098753, Length=221, Percent_Identity=32.579185520362, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI203098816, Length=221, Percent_Identity=32.579185520362, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI110671329, Length=232, Percent_Identity=28.448275862069, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI19923748, Length=192, Percent_Identity=34.8958333333333, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI260898739, Length=138, Percent_Identity=36.9565217391304, Blast_Score=87, Evalue=1e-17,
Organism=Escherichia coli, GI1786305, Length=208, Percent_Identity=36.5384615384615, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786946, Length=222, Percent_Identity=31.5315315315315, Blast_Score=101, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17538894, Length=222, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17560088, Length=224, Percent_Identity=30.8035714285714, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI25146366, Length=171, Percent_Identity=36.2573099415205, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17537937, Length=220, Percent_Identity=25.9090909090909, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324258, Length=224, Percent_Identity=30.3571428571429, Blast_Score=102, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320352, Length=168, Percent_Identity=33.9285714285714, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI20129315, Length=220, Percent_Identity=33.1818181818182, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24582497, Length=220, Percent_Identity=33.1818181818182, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI18859875, Length=238, Percent_Identity=29.8319327731092, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645909, Length=181, Percent_Identity=34.8066298342541, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 912 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 4,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003016
- InterPro:   IPR001078
- InterPro:   IPR000089
- InterPro:   IPR023213
- InterPro:   IPR004167
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]

EC number: =2.3.1.12 [H]

Molecular weight: Translated: 24943; Mature: 24812

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASVAAETASPAAAPERRTVPLTGLRGAIARNMGQGWQVPRVAHSVDVDLTRVEALRAE
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHH
RAAAGDKLSVNAFVLHAVAQALRAHPRLNALMREKEVELVDDINIGVAVALDDGLMVPVI
HHCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCCEEEEECCCCEEEHH
RQADTKPVAALAAETRQLAEGARAGALTGGAYQRGTFTVTNLGSTPVDRFSPIINPPQVA
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHCCCCCCCCEE
ILGVGRTRQQAVVKDGAIVAAPVVNLTLVFDHRAVDGYPAALFLGEIARRLEQAEFD
EEECCCCHHHHHHHCCCEEEECEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AASVAAETASPAAAPERRTVPLTGLRGAIARNMGQGWQVPRVAHSVDVDLTRVEALRAE
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHH
RAAAGDKLSVNAFVLHAVAQALRAHPRLNALMREKEVELVDDINIGVAVALDDGLMVPVI
HHCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHEECCCCCEEEEECCCCEEEHH
RQADTKPVAALAAETRQLAEGARAGALTGGAYQRGTFTVTNLGSTPVDRFSPIINPPQVA
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCHHHHCCCCCCCCEE
ILGVGRTRQQAVVKDGAIVAAPVVNLTLVFDHRAVDGYPAALFLGEIARRLEQAEFD
EEECCCCHHHHHHHCCCEEEECEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 3421911; 1915365; 8445635; 8450544; 8805537 [H]