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The map label for this gene is yeaU [H]

Identifier: 119900149

GI number: 119900149

Start: 4232582

End: 4233661

Strand: Direct

Name: yeaU [H]

Synonym: azo3860

Alternate gene names: 119900149

Gene position: 4232582-4233661 (Clockwise)

Preceding gene: 119900145

Following gene: 119900152

Centisome position: 96.72

GC content: 65.83

Gene sequence:

>1080_bases
ATGACCACCCCCCACCGCATCGCAGTCATCGCCGGCGACGGCATCGGCCAGGAAGTGATGCCGGAAGGCCTGCGCGCCGT
GCAGGCCGCCGCCGCGAAATTCGACATCGCGCTGGAATTCACCCACTTCGACTGGGCCCACTGCGACTACTACCTGCAGC
ACGGCAAGATGATGCCGGACGACTGGTTCGAGCAATTGAAGGGCTTCGACGCCATCTTCTTCGGCGCGGTCGGCTGGCCG
GACAAGGTGCCCGACCACATCTCGCTGTGGGGTTCGCTGCTCAAGTTCCGCCGCGACTTCGACCAGTATGTGAACCTGCG
CCCGGTGCGGCTGATGCCCGGGGTGCCCTGCCCGCTGGCCAACAAGAAGGTGGGCGACATCGACTTCTACGTGGTGCGCG
AGAACACCGAGGGCGAGTACTCCTCGGTGGGCGGCAAGATGTACGAGGGCACCGAGCGCGAGACCGTGCTGCAGGAATCC
ATCTTCACCCGCAAGGGCGTGGACCGCATCCTCAAGTACGCCTTTGAACTGGCGCAGAAGCGGCCGAAGAAGCACCTCAC
CTCCGCCACCAAGTCCAACGGCATCGCCATCAGCATGCCCTACTGGGACGGCCGGGTTAAGGAGATGGGCAAGGCCTACC
CCGAGGTGAAGTGGGACCAGTACCACATCGACATCCTCACCGCGCGCTTCGTCCTCAGCCCGGAACGCTTCGACGTGGTG
GTGGCCTCCAACCTGTTCGGCGACATCCTCTCCGACCTCGGTCCGGCCTGCGCTGGCACCATCGGCATCGCGCCCTCGGC
CAACCTCAATCCGGACCGGACCTTCCCCTCGCTGTTCGAGCCGGTGCATGGCTCGGCGCCGGACATCTACGGCCGCAACA
TCGCCAACCCGGTGGCCATGATCTGGTCGGGTGCGATGATGCTGGACTTCCTCGGCAATGGCGACGCGCGCTACACCGCC
GCCCACGACGCCATCGTCAAGGCCATCGAAACCGTGCTGGTGGAAGGCCCGCGCACCCCGGACATGGGCGGCACGGCGAA
CACCACCGAAGTCGGCAAGGCGGTGGCCGCCGCGATCTGA

Upstream 100 bases:

>100_bases
AGCTTCGCGCCATCATTCAACAGGCGGTCGGCATTGCCGCCGAAACTCCTGCCCCCAGAAGAGAAGCGCGCAAGGACCGC
CACCCACAGGAGACATCCCC

Downstream 100 bases:

>100_bases
AGCGGCGGAGCCGGGGGCGTCCGCCGCAGCGGCGGGCGATGCGTGCCGCGCCGACGCTTCGGGCGCAATCGCCGCCCGAT
GCTACGCGCGCGGTCGGCGC

Product: tartrate dehydrogenase

Products: NA

Alternate protein names: D-malate degradation protein A; D-malate oxidase [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTTPHRIAVIAGDGIGQEVMPEGLRAVQAAAAKFDIALEFTHFDWAHCDYYLQHGKMMPDDWFEQLKGFDAIFFGAVGWP
DKVPDHISLWGSLLKFRRDFDQYVNLRPVRLMPGVPCPLANKKVGDIDFYVVRENTEGEYSSVGGKMYEGTERETVLQES
IFTRKGVDRILKYAFELAQKRPKKHLTSATKSNGIAISMPYWDGRVKEMGKAYPEVKWDQYHIDILTARFVLSPERFDVV
VASNLFGDILSDLGPACAGTIGIAPSANLNPDRTFPSLFEPVHGSAPDIYGRNIANPVAMIWSGAMMLDFLGNGDARYTA
AHDAIVKAIETVLVEGPRTPDMGGTANTTEVGKAVAAAI

Sequences:

>Translated_359_residues
MTTPHRIAVIAGDGIGQEVMPEGLRAVQAAAAKFDIALEFTHFDWAHCDYYLQHGKMMPDDWFEQLKGFDAIFFGAVGWP
DKVPDHISLWGSLLKFRRDFDQYVNLRPVRLMPGVPCPLANKKVGDIDFYVVRENTEGEYSSVGGKMYEGTERETVLQES
IFTRKGVDRILKYAFELAQKRPKKHLTSATKSNGIAISMPYWDGRVKEMGKAYPEVKWDQYHIDILTARFVLSPERFDVV
VASNLFGDILSDLGPACAGTIGIAPSANLNPDRTFPSLFEPVHGSAPDIYGRNIANPVAMIWSGAMMLDFLGNGDARYTA
AHDAIVKAIETVLVEGPRTPDMGGTANTTEVGKAVAAAI
>Mature_358_residues
TTPHRIAVIAGDGIGQEVMPEGLRAVQAAAAKFDIALEFTHFDWAHCDYYLQHGKMMPDDWFEQLKGFDAIFFGAVGWPD
KVPDHISLWGSLLKFRRDFDQYVNLRPVRLMPGVPCPLANKKVGDIDFYVVRENTEGEYSSVGGKMYEGTERETVLQESI
FTRKGVDRILKYAFELAQKRPKKHLTSATKSNGIAISMPYWDGRVKEMGKAYPEVKWDQYHIDILTARFVLSPERFDVVV
ASNLFGDILSDLGPACAGTIGIAPSANLNPDRTFPSLFEPVHGSAPDIYGRNIANPVAMIWSGAMMLDFLGNGDARYTAA
HDAIVKAIETVLVEGPRTPDMGGTANTTEVGKAVAAAI

Specific function: Catalyzes the NAD(+)-dependent oxidative decarboxylation of D-malate into pyruvate. Is essential for aerobic growth on D- malate as the sole carbon source. But is not required for anaerobic D-malate utilization, although DmlA is expressed and active in th

COG id: COG0473

COG function: function code CE; Isocitrate/isopropylmalate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=358, Percent_Identity=30.1675977653631, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI4758582, Length=348, Percent_Identity=29.5977011494253, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI28178816, Length=355, Percent_Identity=28.169014084507, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI28178821, Length=351, Percent_Identity=28.2051282051282, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI28178838, Length=340, Percent_Identity=28.8235294117647, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI28178819, Length=197, Percent_Identity=33.502538071066, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1788101, Length=359, Percent_Identity=74.3732590529248, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI87081683, Length=368, Percent_Identity=38.3152173913043, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1787381, Length=400, Percent_Identity=26.25, Blast_Score=103, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71986051, Length=362, Percent_Identity=30.1104972375691, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17550882, Length=353, Percent_Identity=28.8951841359773, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144293, Length=354, Percent_Identity=26.271186440678, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=272, Percent_Identity=30.8823529411765, Blast_Score=110, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6322097, Length=365, Percent_Identity=35.8904109589041, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319830, Length=379, Percent_Identity=34.0369393139842, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324709, Length=362, Percent_Identity=31.4917127071823, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324291, Length=353, Percent_Identity=31.4447592067989, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24643268, Length=361, Percent_Identity=31.0249307479224, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24643270, Length=361, Percent_Identity=31.0249307479224, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24661184, Length=359, Percent_Identity=30.3621169916435, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI161078633, Length=260, Percent_Identity=30.7692307692308, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24650122, Length=260, Percent_Identity=30.7692307692308, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI161078635, Length=258, Percent_Identity=31.0077519379845, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI161078639, Length=260, Percent_Identity=30.7692307692308, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI161078637, Length=258, Percent_Identity=31.0077519379845, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI281362242, Length=355, Percent_Identity=28.169014084507, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24648872, Length=355, Percent_Identity=28.169014084507, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI20130355, Length=360, Percent_Identity=25.2777777777778, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR011829 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.83 [H]

Molecular weight: Translated: 39620; Mature: 39488

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPHRIAVIAGDGIGQEVMPEGLRAVQAAAAKFDIALEFTHFDWAHCDYYLQHGKMMPD
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHCCCCCCH
DWFEQLKGFDAIFFGAVGWPDKVPDHISLWGSLLKFRRDFDQYVNLRPVRLMPGVPCPLA
HHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
NKKVGDIDFYVVRENTEGEYSSVGGKMYEGTERETVLQESIFTRKGVDRILKYAFELAQK
CCCCCCEEEEEEECCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPKKHLTSATKSNGIAISMPYWDGRVKEMGKAYPEVKWDQYHIDILTARFVLSPERFDVV
CHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCEEEEEEEEEHEEECCCHHEEE
VASNLFGDILSDLGPACAGTIGIAPSANLNPDRTFPSLFEPVHGSAPDIYGRNIANPVAM
EHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHH
IWSGAMMLDFLGNGDARYTAAHDAIVKAIETVLVEGPRTPDMGGTANTTEVGKAVAAAI
HHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TTPHRIAVIAGDGIGQEVMPEGLRAVQAAAAKFDIALEFTHFDWAHCDYYLQHGKMMPD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCCHHHHHHHHHCCCCCCH
DWFEQLKGFDAIFFGAVGWPDKVPDHISLWGSLLKFRRDFDQYVNLRPVRLMPGVPCPLA
HHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
NKKVGDIDFYVVRENTEGEYSSVGGKMYEGTERETVLQESIFTRKGVDRILKYAFELAQK
CCCCCCEEEEEEECCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPKKHLTSATKSNGIAISMPYWDGRVKEMGKAYPEVKWDQYHIDILTARFVLSPERFDVV
CHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCEEEEEEEEEHEEECCCHHEEE
VASNLFGDILSDLGPACAGTIGIAPSANLNPDRTFPSLFEPVHGSAPDIYGRNIANPVAM
EHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHH
IWSGAMMLDFLGNGDARYTAAHDAIVKAIETVLVEGPRTPDMGGTANTTEVGKAVAAAI
HHCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]