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The map label for this gene is lysA2 [H]

Identifier: 119899943

GI number: 119899943

Start: 4013514

End: 4014788

Strand: Direct

Name: lysA2 [H]

Synonym: azo3654

Alternate gene names: 119899943

Gene position: 4013514-4014788 (Clockwise)

Preceding gene: 119899942

Following gene: 119899945

Centisome position: 91.72

GC content: 68.16

Gene sequence:

>1275_bases
ATGAGTTCCACCGCGTCCGCCGCCTATCCGCTGCCTTCCCTGTCCGACGGCCCTGCCGGGCTGATGCTGGAAGAGGTTCC
GCTCGCCACCCTGGCCGAACGCTTCGGAACGCCCACCTACGTCTACTCGCGGGCGGCGCTGACCGCGGCCTTTCGCGACT
GGCAGGCTGCCCTTGCGGGGCGCCGCAGCCTGGTGTGCTATGCGGTAAAGGCGAATGCCAACCTTGGCGTGCTATCGGTG
TTTGCGCAACTCGGCGCCGGGTTTGACATCGTCTCGGGCGGCGAGTTGGCGCGCGTGATCGCAGCAGGTGGTCGCGCCGA
CCGCGTCGTGTTCTCCGGCGTCGGCAAGAGCCGCGCCGAAATGCGCCAGGCCCTTGCCGCCGGAATCCGCTGCTTCAACG
TCGAATCGGCCCCCGAGCTGGAGCGGCTGAACGAGGTGGCCGGCGAACTGGGACAGCGCGCCCCGATCGCACTGCGGGTC
AATCCCGATGTGGATCCGAAGACCCACCCGTACATCTCCACCGGGCTGAAGAGCAACAAGTTCGGCGTCGCGTTCGGCGA
AGCGCTCGAGCTCTACCGTCGCGCCGCAACCCTGCCCCACCTCCGGATCAGCGGCATCGCCTGCCATATCGGCTCGCAGC
TGCTCGATCCCGCGCCCGTCGCGGAAGCTGCGGCCAAGGTCCTCGGGCTCGTCGACCAGTTGTCGGCCGAGGGCATCGTG
CTCGATCACATCGACCTCGGCGGCGGCCTCGGCATCCGCTACCGCGACGAAACGCCGCCCAGCGTGGCCGCGTACCTCGC
ACCGCTGCTGGCCGCCTTCGGCGACCGCCGCGAAGAGATTTGCTTCGAGCCGGGTCGCTCCCTGGTCGGCAACGCCGGTC
TGCTGCTTACCCGGGTGGAGTACCTCAAGCACGGCGAGGAAAAGAACTTCGCGATCGTCGACGCGGCGATGAACGATCTC
GCGCGCCCCGCGCTGTACGACGCCTACCACGAGGCGGTGGCCGTGTGCCGCAGTGACGCTCCGCGGCAACGCTACGAAAT
CGTCGGCCCCATTTGTGAAAGCGGCGACTTCCTCGCCCATGACCGCGAGCTTGCGCTGCGCGACGGCGACCTCGTCGCAC
TGCTGTCGGCCGGCGCCTATGGCATGACGATGAGTTCGAACTACAACACACGCCCGCGCGCCGCCGAAGTGATGGTCGAC
GGCGGGCAGGTGCATCTCGTGCGCGAACGTGAAACGGTCGAGGCGCTCTACGCGGGCGAACACCTGCTTCCCTGA

Upstream 100 bases:

>100_bases
GCCCGCTCTACCACCCGGACCCCGCCAAGACCCGCCCCGCGCCCGCCACTCAGACCCAAGGGGGCGCCGATAATATCAAA
CCGACTCCGCCTACGACCCA

Downstream 100 bases:

>100_bases
CCCGGGCCGGCCCGCTGCGCCCTCAAGCCGGGGGCGGGCGCGGGCCGAGCCTCTCCGCCTCCTCGATCAGCGCCCTGCCG
AAGGCCTTCCAGGCCGGCCC

Product: LysA2 protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSSTASAAYPLPSLSDGPAGLMLEEVPLATLAERFGTPTYVYSRAALTAAFRDWQAALAGRRSLVCYAVKANANLGVLSV
FAQLGAGFDIVSGGELARVIAAGGRADRVVFSGVGKSRAEMRQALAAGIRCFNVESAPELERLNEVAGELGQRAPIALRV
NPDVDPKTHPYISTGLKSNKFGVAFGEALELYRRAATLPHLRISGIACHIGSQLLDPAPVAEAAAKVLGLVDQLSAEGIV
LDHIDLGGGLGIRYRDETPPSVAAYLAPLLAAFGDRREEICFEPGRSLVGNAGLLLTRVEYLKHGEEKNFAIVDAAMNDL
ARPALYDAYHEAVAVCRSDAPRQRYEIVGPICESGDFLAHDRELALRDGDLVALLSAGAYGMTMSSNYNTRPRAAEVMVD
GGQVHLVRERETVEALYAGEHLLP

Sequences:

>Translated_424_residues
MSSTASAAYPLPSLSDGPAGLMLEEVPLATLAERFGTPTYVYSRAALTAAFRDWQAALAGRRSLVCYAVKANANLGVLSV
FAQLGAGFDIVSGGELARVIAAGGRADRVVFSGVGKSRAEMRQALAAGIRCFNVESAPELERLNEVAGELGQRAPIALRV
NPDVDPKTHPYISTGLKSNKFGVAFGEALELYRRAATLPHLRISGIACHIGSQLLDPAPVAEAAAKVLGLVDQLSAEGIV
LDHIDLGGGLGIRYRDETPPSVAAYLAPLLAAFGDRREEICFEPGRSLVGNAGLLLTRVEYLKHGEEKNFAIVDAAMNDL
ARPALYDAYHEAVAVCRSDAPRQRYEIVGPICESGDFLAHDRELALRDGDLVALLSAGAYGMTMSSNYNTRPRAAEVMVD
GGQVHLVRERETVEALYAGEHLLP
>Mature_423_residues
SSTASAAYPLPSLSDGPAGLMLEEVPLATLAERFGTPTYVYSRAALTAAFRDWQAALAGRRSLVCYAVKANANLGVLSVF
AQLGAGFDIVSGGELARVIAAGGRADRVVFSGVGKSRAEMRQALAAGIRCFNVESAPELERLNEVAGELGQRAPIALRVN
PDVDPKTHPYISTGLKSNKFGVAFGEALELYRRAATLPHLRISGIACHIGSQLLDPAPVAEAAAKVLGLVDQLSAEGIVL
DHIDLGGGLGIRYRDETPPSVAAYLAPLLAAFGDRREEICFEPGRSLVGNAGLLLTRVEYLKHGEEKNFAIVDAAMNDLA
RPALYDAYHEAVAVCRSDAPRQRYEIVGPICESGDFLAHDRELALRDGDLVALLSAGAYGMTMSSNYNTRPRAAEVMVDG
GQVHLVRERETVEALYAGEHLLP

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=371, Percent_Identity=24.5283018867925, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI16506287, Length=348, Percent_Identity=24.7126436781609, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789203, Length=417, Percent_Identity=33.0935251798561, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17562780, Length=370, Percent_Identity=24.0540540540541, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322664, Length=378, Percent_Identity=23.2804232804233, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24586472, Length=385, Percent_Identity=24.6753246753247, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45123; Mature: 44992

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTASAAYPLPSLSDGPAGLMLEEVPLATLAERFGTPTYVYSRAALTAAFRDWQAALAG
CCCCCCCCCCCCCCCCCCCCCEEHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
RRSLVCYAVKANANLGVLSVFAQLGAGFDIVSGGELARVIAAGGRADRVVFSGVGKSRAE
CCEEEEEEEECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCHHHH
MRQALAAGIRCFNVESAPELERLNEVAGELGQRAPIALRVNPDVDPKTHPYISTGLKSNK
HHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
FGVAFGEALELYRRAATLPHLRISGIACHIGSQLLDPAPVAEAAAKVLGLVDQLSAEGIV
CCCHHHHHHHHHHHHHCCCCEEECCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
LDHIDLGGGLGIRYRDETPPSVAAYLAPLLAAFGDRREEICFEPGRSLVGNAGLLLTRVE
EEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHCCCHHHHHHHH
YLKHGEEKNFAIVDAAMNDLARPALYDAYHEAVAVCRSDAPRQRYEIVGPICESGDFLAH
HHHCCCCCCEEEEHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHCCCCEEEC
DRELALRDGDLVALLSAGAYGMTMSSNYNTRPRAAEVMVDGGQVHLVRERETVEALYAGE
CCEEEECCCCEEEEEECCCCCEEECCCCCCCCCEEEEEEECCEEEEEECHHHHHHHHCCC
HLLP
CCCC
>Mature Secondary Structure 
SSTASAAYPLPSLSDGPAGLMLEEVPLATLAERFGTPTYVYSRAALTAAFRDWQAALAG
CCCCCCCCCCCCCCCCCCCCEEHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCC
RRSLVCYAVKANANLGVLSVFAQLGAGFDIVSGGELARVIAAGGRADRVVFSGVGKSRAE
CCEEEEEEEECCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCEEEEECCCCHHHH
MRQALAAGIRCFNVESAPELERLNEVAGELGQRAPIALRVNPDVDPKTHPYISTGLKSNK
HHHHHHHCCEEECCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCC
FGVAFGEALELYRRAATLPHLRISGIACHIGSQLLDPAPVAEAAAKVLGLVDQLSAEGIV
CCCHHHHHHHHHHHHHCCCCEEECCEEEHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEE
LDHIDLGGGLGIRYRDETPPSVAAYLAPLLAAFGDRREEICFEPGRSLVGNAGLLLTRVE
EEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHCCCHHHHHHHH
YLKHGEEKNFAIVDAAMNDLARPALYDAYHEAVAVCRSDAPRQRYEIVGPICESGDFLAH
HHHCCCCCCEEEEHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHCCCCEEEC
DRELALRDGDLVALLSAGAYGMTMSSNYNTRPRAAEVMVDGGQVHLVRERETVEALYAGE
CCEEEECCCCEEEEEECCCCCEEECCCCCCCCCEEEEEEECCEEEEEECHHHHHHHHCCC
HLLP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3143046; 10984043 [H]