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The map label for this gene is patB [H]

Identifier: 119899669

GI number: 119899669

Start: 3714479

End: 3715621

Strand: Direct

Name: patB [H]

Synonym: azo3380

Alternate gene names: 119899669

Gene position: 3714479-3715621 (Clockwise)

Preceding gene: 119899661

Following gene: 119899676

Centisome position: 84.88

GC content: 70.69

Gene sequence:

>1143_bases
ATGCAATTCGACTTTGACCGACACCCCGACCGGCGCCAGGTTCCCGGTGAAAAGTGGGGCCGCTACGCGGGCCGTGACGT
GCTGCCCTTGTGGGTTGCCGACATGGATTTCAGTGCGCCGCCGCCCGTGCTCGAAGCCCTGCGCCGCCGTCTCGACCACG
GCGTGTTCGGCTACACCGATGCCCCCCCGTCGCTGGCCGAGGCGGTGGTCGAGGGCCTGCGGCGCGACCACGACTGGCAC
ATCCAGCCTGAATGGCTGGTGTGGCTGCCGGGTGTGGTTACCGGGTTCAACCTCGCCTGCCGCGCGGTGGGCGAAGCGGG
CGACAGCGTGTTTACCGCCACCCCGGTCTACCCGCCCTTCCTGACCGCACCGGAAAACAGCGGTCGCCGCCTGGTGAGTT
GCGCGCTGGTGGAGCGCAACGGGCGCTGGGAATGGGACCGCGCCGCAGTGGAGGCGGCAATCGAGCCGCGCACCCGCGTC
TTCATGCTGTGCAATCCGCACAACCCGGTCGGGCGCGCGTTCGATCGCGAGGAGCTGCGCTGGATTGCGGATCTCGCGGA
AAGCCGCGACCTGGTGGTCTGCAGCGACGAGATCCACTGCGGCCTGGTCCTCGATGCGGCGCGCCCACACCTGCCGATCG
CCGCGCTCGACGAGCGCATCGCGCGGCGCAGCATCACGCTGATGGCGCCCTCCAAGACCTGGAACATCCCCGCGCTGTAC
TGTGCTTTCGCGGTCATCCCGGACGCCGGCCTGCGGCGCCGCTACCAGCGCGAGATGCGCGGCATCGTGCCGCACGTGAA
TGTGATGGGTCTGGTCGCCGCCGAGGCGGCCTACCGCCATGGCGGCCCCTGGCGCGCCGCGCTGCTGGACTATCTGCGCG
ACAACCGAGAGCGCGTGCTCGACGCGGTGGCGACGATGCCCGGCCTGCGCACGACGCGGCCGGAAGCCACCTATCTGGCC
TGGATCGACTGTCGCGACGCCGGACTCGACGACCCGGCCGCGTTCTTCGAAGCAGGCGGCGTCGGCCTGTCCGACGGACG
CGCGTTCGGCATGCCGGGTTTCGTGCGGCTCAACTTCGGCTGCAGCCGGGCGACGCTGGACGAAGCGCTGGCACGCATGC
GGCGCGCGCTCACCGCGCGCTGA

Upstream 100 bases:

>100_bases
GTTCGATTGATTTTGCGCAATTATATCTGCCCCACCCGGCGGTCCCGGGCCATCACAAGCGACGTTACACTACCGGCCTC
GCTAACCTGCGGTAGCCGCC

Downstream 100 bases:

>100_bases
GGGTTTAGCGCAGCCGCAGGAAGCGCGCCTCGAATTCGTCCGCCGGCAGCGGCGGGCTGCACAGGTAGCCCTGGTAGCTG
CCACAGCCCAGTCCGCGCAG

Product: putative transaminase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MQFDFDRHPDRRQVPGEKWGRYAGRDVLPLWVADMDFSAPPPVLEALRRRLDHGVFGYTDAPPSLAEAVVEGLRRDHDWH
IQPEWLVWLPGVVTGFNLACRAVGEAGDSVFTATPVYPPFLTAPENSGRRLVSCALVERNGRWEWDRAAVEAAIEPRTRV
FMLCNPHNPVGRAFDREELRWIADLAESRDLVVCSDEIHCGLVLDAARPHLPIAALDERIARRSITLMAPSKTWNIPALY
CAFAVIPDAGLRRRYQREMRGIVPHVNVMGLVAAEAAYRHGGPWRAALLDYLRDNRERVLDAVATMPGLRTTRPEATYLA
WIDCRDAGLDDPAAFFEAGGVGLSDGRAFGMPGFVRLNFGCSRATLDEALARMRRALTAR

Sequences:

>Translated_380_residues
MQFDFDRHPDRRQVPGEKWGRYAGRDVLPLWVADMDFSAPPPVLEALRRRLDHGVFGYTDAPPSLAEAVVEGLRRDHDWH
IQPEWLVWLPGVVTGFNLACRAVGEAGDSVFTATPVYPPFLTAPENSGRRLVSCALVERNGRWEWDRAAVEAAIEPRTRV
FMLCNPHNPVGRAFDREELRWIADLAESRDLVVCSDEIHCGLVLDAARPHLPIAALDERIARRSITLMAPSKTWNIPALY
CAFAVIPDAGLRRRYQREMRGIVPHVNVMGLVAAEAAYRHGGPWRAALLDYLRDNRERVLDAVATMPGLRTTRPEATYLA
WIDCRDAGLDDPAAFFEAGGVGLSDGRAFGMPGFVRLNFGCSRATLDEALARMRRALTAR
>Mature_380_residues
MQFDFDRHPDRRQVPGEKWGRYAGRDVLPLWVADMDFSAPPPVLEALRRRLDHGVFGYTDAPPSLAEAVVEGLRRDHDWH
IQPEWLVWLPGVVTGFNLACRAVGEAGDSVFTATPVYPPFLTAPENSGRRLVSCALVERNGRWEWDRAAVEAAIEPRTRV
FMLCNPHNPVGRAFDREELRWIADLAESRDLVVCSDEIHCGLVLDAARPHLPIAALDERIARRSITLMAPSKTWNIPALY
CAFAVIPDAGLRRRYQREMRGIVPHVNVMGLVAAEAAYRHGGPWRAALLDYLRDNRERVLDAVATMPGLRTTRPEATYLA
WIDCRDAGLDDPAAFFEAGGVGLSDGRAFGMPGFVRLNFGCSRATLDEALARMRRALTAR

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787909, Length=392, Percent_Identity=34.4387755102041, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1788627, Length=346, Percent_Identity=23.6994219653179, Blast_Score=72, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322401, Length=223, Percent_Identity=23.7668161434978, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42513; Mature: 42513

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFDFDRHPDRRQVPGEKWGRYAGRDVLPLWVADMDFSAPPPVLEALRRRLDHGVFGYTD
CCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCC
APPSLAEAVVEGLRRDHDWHIQPEWLVWLPGVVTGFNLACRAVGEAGDSVFTATPVYPPF
CCHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
LTAPENSGRRLVSCALVERNGRWEWDRAAVEAAIEPRTRVFMLCNPHNPVGRAFDREELR
EECCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHH
WIADLAESRDLVVCSDEIHCGLVLDAARPHLPIAALDERIARRSITLMAPSKTWNIPALY
HHHHHHCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCCCCHHHH
CAFAVIPDAGLRRRYQREMRGIVPHVNVMGLVAAEAAYRHGGPWRAALLDYLRDNRERVL
HHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHH
DAVATMPGLRTTRPEATYLAWIDCRDAGLDDPAAFFEAGGVGLSDGRAFGMPGFVRLNFG
HHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCEECCCCEEEEECC
CSRATLDEALARMRRALTAR
CCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQFDFDRHPDRRQVPGEKWGRYAGRDVLPLWVADMDFSAPPPVLEALRRRLDHGVFGYTD
CCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCC
APPSLAEAVVEGLRRDHDWHIQPEWLVWLPGVVTGFNLACRAVGEAGDSVFTATPVYPPF
CCHHHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCC
LTAPENSGRRLVSCALVERNGRWEWDRAAVEAAIEPRTRVFMLCNPHNPVGRAFDREELR
EECCCCCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHH
WIADLAESRDLVVCSDEIHCGLVLDAARPHLPIAALDERIARRSITLMAPSKTWNIPALY
HHHHHHCCCCEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCEEEEEECCCCCCCHHHH
CAFAVIPDAGLRRRYQREMRGIVPHVNVMGLVAAEAAYRHGGPWRAALLDYLRDNRERVL
HHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHH
DAVATMPGLRTTRPEATYLAWIDCRDAGLDDPAAFFEAGGVGLSDGRAFGMPGFVRLNFG
HHHHHCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCEECCCCEEEEECC
CSRATLDEALARMRRALTAR
CCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]