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The map label for this gene is fabG [C]

Identifier: 119899604

GI number: 119899604

Start: 3652517

End: 3653299

Strand: Direct

Name: fabG [C]

Synonym: azo3315

Alternate gene names: 119899604

Gene position: 3652517-3653299 (Clockwise)

Preceding gene: 119899603

Following gene: 119899605

Centisome position: 83.47

GC content: 71.14

Gene sequence:

>783_bases
GTGATCGGACGCCCGCTCAATCCGCCGCTGACCGACTGGCGGGGCCGCCGGGTGTGGCTGGTGGGCGCATCCACCGGCAT
CGGCGCGGCGCTCGCACGGGCGCTTGCCGCACGCGGCGCGCAGCTCGCGCTGTCGGCGCGCCATCCGGACAAGCTGGCCG
AAGCGGCCGCGGCCTGCCCGGACGCGCTGCTGCTGCCGCTCGACCTGAGCCACGAAAACCAGTTCGCCGCCGTGCATCAA
CGCCTGCTGGCGCAGTGGGGCGCGATCGATGTGGTGATGTTCGTCGCCGGCACCTACCGCCCGCTGCGCGCGTGGGAGCT
GGACGCAGCCGCGGTCTACGAGACGATGGCGGTGAACCTGACCGGCACCTTGTGCGGTGTCGCCACCGTGCTGCCGCCGA
TGCTGGCACGCGGCGCCGGTTCGATCGTGCTGGTGGCCAGCGTGGCGGGCTACCGCGGCCTGCCGCGCGCGCTGCTCTAC
GGCAGTTCGAAAGCGGCGCTGATCAACTTCGCCGAAACGCTGTACCTCGACCTCGCGCCGCGCGGACTCGGCGTCTATCT
GGTCGATCCCGGCTTTGTCGCGACCCCGCTCACCGCCGCCAACGACTTCCGCATGCCGGCGCTGATCGACGCCGACACCG
CGGCGCGCGAAATCCTCACCGGCATGGCACGCGGCGAGTTCGAAATCCATTTCCCCAAGCGCTTCACCCGGGTGATGAAG
GCCCTGGCGCTGCTGCCGCGGCGCTGCTACTTCCCGCTGATACGGCGGATTACCGGAGCCTGA

Upstream 100 bases:

>100_bases
ATGGACGAGCGCGTGATGCTGAACCGCTCGGTGATGAGCAAGTGGGGCTTCCGCCTGGGCGAGGTCACGCTGTCCTTCTA
CAAGCAGACGGAGTGAGATC

Downstream 100 bases:

>100_bases
TCCGATGGCCGCGGCCCCCGACCTCGACGCCGCCTGCGAGCGCGTCGCGCACTTCTACGAAACGCTCAGCCCGCTCACGC
TGCCGCATCTGGACACGGTC

Product: short-chain dehydrogenase family protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MIGRPLNPPLTDWRGRRVWLVGASTGIGAALARALAARGAQLALSARHPDKLAEAAAACPDALLLPLDLSHENQFAAVHQ
RLLAQWGAIDVVMFVAGTYRPLRAWELDAAAVYETMAVNLTGTLCGVATVLPPMLARGAGSIVLVASVAGYRGLPRALLY
GSSKAALINFAETLYLDLAPRGLGVYLVDPGFVATPLTAANDFRMPALIDADTAAREILTGMARGEFEIHFPKRFTRVMK
ALALLPRRCYFPLIRRITGA

Sequences:

>Translated_260_residues
MIGRPLNPPLTDWRGRRVWLVGASTGIGAALARALAARGAQLALSARHPDKLAEAAAACPDALLLPLDLSHENQFAAVHQ
RLLAQWGAIDVVMFVAGTYRPLRAWELDAAAVYETMAVNLTGTLCGVATVLPPMLARGAGSIVLVASVAGYRGLPRALLY
GSSKAALINFAETLYLDLAPRGLGVYLVDPGFVATPLTAANDFRMPALIDADTAAREILTGMARGEFEIHFPKRFTRVMK
ALALLPRRCYFPLIRRITGA
>Mature_260_residues
MIGRPLNPPLTDWRGRRVWLVGASTGIGAALARALAARGAQLALSARHPDKLAEAAAACPDALLLPLDLSHENQFAAVHQ
RLLAQWGAIDVVMFVAGTYRPLRAWELDAAAVYETMAVNLTGTLCGVATVLPPMLARGAGSIVLVASVAGYRGLPRALLY
GSSKAALINFAETLYLDLAPRGLGVYLVDPGFVATPLTAANDFRMPALIDADTAAREILTGMARGEFEIHFPKRFTRVMK
ALALLPRRCYFPLIRRITGA

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7706318, Length=204, Percent_Identity=31.8627450980392, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI210032110, Length=241, Percent_Identity=26.9709543568465, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI32483357, Length=191, Percent_Identity=31.9371727748691, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI4503817, Length=232, Percent_Identity=26.2931034482759, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI226371731, Length=197, Percent_Identity=27.4111675126904, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI210032112, Length=172, Percent_Identity=27.3255813953488, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI109715829, Length=202, Percent_Identity=28.7128712871287, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI223718074, Length=190, Percent_Identity=35.7894736842105, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI126723750, Length=200, Percent_Identity=31.5, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI142976729, Length=251, Percent_Identity=24.3027888446215, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI126723191, Length=185, Percent_Identity=32.4324324324324, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI5031737, Length=185, Percent_Identity=29.1891891891892, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=194, Percent_Identity=29.3814432989691, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789378, Length=195, Percent_Identity=31.7948717948718, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1786812, Length=188, Percent_Identity=32.4468085106383, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082100, Length=187, Percent_Identity=29.9465240641711, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790717, Length=194, Percent_Identity=25.7731958762887, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787820, Length=179, Percent_Identity=26.8156424581006, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786701, Length=186, Percent_Identity=28.494623655914, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=267, Percent_Identity=25.4681647940075, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=186, Percent_Identity=29.5698924731183, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17567345, Length=210, Percent_Identity=27.1428571428571, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=226, Percent_Identity=26.5486725663717, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17564282, Length=248, Percent_Identity=24.5967741935484, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=185, Percent_Identity=29.1891891891892, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17565030, Length=196, Percent_Identity=29.5918367346939, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322067, Length=182, Percent_Identity=29.1208791208791, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI23397609, Length=235, Percent_Identity=34.468085106383, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357041, Length=191, Percent_Identity=32.9842931937173, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28571526, Length=215, Percent_Identity=31.1627906976744, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21358495, Length=196, Percent_Identity=30.6122448979592, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24644339, Length=193, Percent_Identity=32.1243523316062, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356301, Length=232, Percent_Identity=30.1724137931034, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643142, Length=194, Percent_Identity=34.5360824742268, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24580925, Length=226, Percent_Identity=26.9911504424779, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737361, Length=194, Percent_Identity=26.2886597938144, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641232, Length=201, Percent_Identity=26.865671641791, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 27825; Mature: 27825

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGRPLNPPLTDWRGRRVWLVGASTGIGAALARALAARGAQLALSARHPDKLAEAAAACP
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCC
DALLLPLDLSHENQFAAVHQRLLAQWGAIDVVMFVAGTYRPLRAWELDAAAVYETMAVNL
CCEEEEEECCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHEEC
TGTLCGVATVLPPMLARGAGSIVLVASVAGYRGLPRALLYGSSKAALINFAETLYLDLAP
HHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCHHHHCCCCCHHHHHHHHHHEEEECC
RGLGVYLVDPGFVATPLTAANDFRMPALIDADTAAREILTGMARGEFEIHFPKRFTRVMK
CCCEEEEECCCCEECCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCEEEECCHHHHHHHH
ALALLPRRCYFPLIRRITGA
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIGRPLNPPLTDWRGRRVWLVGASTGIGAALARALAARGAQLALSARHPDKLAEAAAACP
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCC
DALLLPLDLSHENQFAAVHQRLLAQWGAIDVVMFVAGTYRPLRAWELDAAAVYETMAVNL
CCEEEEEECCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHEEC
TGTLCGVATVLPPMLARGAGSIVLVASVAGYRGLPRALLYGSSKAALINFAETLYLDLAP
HHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCHHHHCCCCCHHHHHHHHHHEEEECC
RGLGVYLVDPGFVATPLTAANDFRMPALIDADTAAREILTGMARGEFEIHFPKRFTRVMK
CCCEEEEECCCCEECCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCEEEECCHHHHHHHH
ALALLPRRCYFPLIRRITGA
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1730672 [H]