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The map label for this gene is algD [H]

Identifier: 119899558

GI number: 119899558

Start: 3603654

End: 3604970

Strand: Reverse

Name: algD [H]

Synonym: azo3269

Alternate gene names: 119899558

Gene position: 3604970-3603654 (Counterclockwise)

Preceding gene: 119899559

Following gene: 119899557

Centisome position: 82.38

GC content: 65.3

Gene sequence:

>1317_bases
ATGAAGATCAGCATTTTCGGCCTGGGCTATGTCGGCGCGGTATCGCTCGCCTGCCTTGCGCGCGACGGCCACCAGGTTGT
GGGCGTGGATATCGACGCCACCAAGCTCGAACTCATCCGCTCCGGCACCACGCCGGTGGTTGAAGAAGGCATGGTGGAGC
TGATGGCGAACGTCGCCGCCAGCGGCCGTGTGAGCGTCACCACCGATGTGCGCCAGGCGGTCCTCGATACCGAAATCTCG
TTGATCTGCGTCGGCACGCCGTCCGCCCCCAATGGCAGCCAGGACCAGGGCGCGGTGCTGCGGCTGGCACGTGACCTCGG
CCGCGCGCTGGCCGAGAAGTCTGCACCGCACGTGCTGGTGTTCCGCTCCACGCTGGTGCCCGGCACGGTCGAGGGCAGCC
TCAAGCCGATCATCGAAACCGAATCCGGCAAGCGCGACGGCGAGGATTTCCACCTCTGCTTCCAGCCGGAGTTCCTGCGC
GAGGGCTCGTCGATCCGCGACTACGACAAGCCGCCGTTTACCGTGGTCGGCGCCAACCACGCCTACCCGGCCGAACGCCT
GCGCGAGCTGTTCGGCCATCTGCCGTGCAAGTTCCTCGAAACCTCGGTGCGCGCGGCCGAGATGATGAAGTACTGCTGCA
ACAACTTCCACGCGCTGAAGATCACCTTCGCCAACGAGACCGCGCGCCTGTGCAGCGCGCTTGGGGTCAATCCGTTCGAG
GTCATGGAACTGGTGTGCCAGGACACCCAGCTCAACATCTCGCGGGCCTACCTCAAGCCCGGCTTCGCCTTCGGCGGTTC
CTGCCTGCCCAAGGACCTGCGTGCCACCAGCTACCTGGCCAAGACCCACGACGTCGAACTGCCGATGCTGAACGGCATCC
TGCAGTCCAACCGTCACCACGTCGAAGAGGCGATCCAGAAGGTGCTTGCGTCCGGCTGCCGGCGGGTGGGCATGCTGGGA
CTGTCGTTCAAGACCGGCACCGACGACCTGCGTGAAAGTCCGCTGGTGACGCTGGCCGAGCAACTGATCGGCAAGGGCAT
GCAGCTCTCTATCTATGACCCGGATGTGCAGCTCTCACGCCTGCTCGGTGCCAACCGGCGATTCATCGAAACCCAGTTGC
CCCACATCGGCGAACTGCTGAAGCCGGAACTCGATGCGGTGATCGGCGAGGCCGAAGTGCTGATCGTGGGCGTCTCCAGC
CCCGCCATCTTCGATGCGCTCGCTACCCACAGCCGGCCCGAGCAGAAGGTGCTTGACCTGGTCCGCCTGCCCAACCCGCA
GGCGCTGCGGGCCGAGGTTGAAGGGCTGTGCTGGTAA

Upstream 100 bases:

>100_bases
GCATGCTGTCGCATCACGCCTGGCCGCGCTCGATGGAACGCCTGGACGGCATCATCGGGCGCTGCCTGAAGGAATTTCAC
GGTAACGAGGAAACGACGCA

Downstream 100 bases:

>100_bases
GGCTGGCGTCCGTTGCGCCCCGGCCCCGTCGCGCGGCGGAGGTCTGAGTGCGTCGCGTGCTACTGTTTTCCTCGCTGTTT
CCGAACGCCGAGCAGCCGCG

Product: GDP-mannose 6-dehydrogenase

Products: NA

Alternate protein names: GMD [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MKISIFGLGYVGAVSLACLARDGHQVVGVDIDATKLELIRSGTTPVVEEGMVELMANVAASGRVSVTTDVRQAVLDTEIS
LICVGTPSAPNGSQDQGAVLRLARDLGRALAEKSAPHVLVFRSTLVPGTVEGSLKPIIETESGKRDGEDFHLCFQPEFLR
EGSSIRDYDKPPFTVVGANHAYPAERLRELFGHLPCKFLETSVRAAEMMKYCCNNFHALKITFANETARLCSALGVNPFE
VMELVCQDTQLNISRAYLKPGFAFGGSCLPKDLRATSYLAKTHDVELPMLNGILQSNRHHVEEAIQKVLASGCRRVGMLG
LSFKTGTDDLRESPLVTLAEQLIGKGMQLSIYDPDVQLSRLLGANRRFIETQLPHIGELLKPELDAVIGEAEVLIVGVSS
PAIFDALATHSRPEQKVLDLVRLPNPQALRAEVEGLCW

Sequences:

>Translated_438_residues
MKISIFGLGYVGAVSLACLARDGHQVVGVDIDATKLELIRSGTTPVVEEGMVELMANVAASGRVSVTTDVRQAVLDTEIS
LICVGTPSAPNGSQDQGAVLRLARDLGRALAEKSAPHVLVFRSTLVPGTVEGSLKPIIETESGKRDGEDFHLCFQPEFLR
EGSSIRDYDKPPFTVVGANHAYPAERLRELFGHLPCKFLETSVRAAEMMKYCCNNFHALKITFANETARLCSALGVNPFE
VMELVCQDTQLNISRAYLKPGFAFGGSCLPKDLRATSYLAKTHDVELPMLNGILQSNRHHVEEAIQKVLASGCRRVGMLG
LSFKTGTDDLRESPLVTLAEQLIGKGMQLSIYDPDVQLSRLLGANRRFIETQLPHIGELLKPELDAVIGEAEVLIVGVSS
PAIFDALATHSRPEQKVLDLVRLPNPQALRAEVEGLCW
>Mature_438_residues
MKISIFGLGYVGAVSLACLARDGHQVVGVDIDATKLELIRSGTTPVVEEGMVELMANVAASGRVSVTTDVRQAVLDTEIS
LICVGTPSAPNGSQDQGAVLRLARDLGRALAEKSAPHVLVFRSTLVPGTVEGSLKPIIETESGKRDGEDFHLCFQPEFLR
EGSSIRDYDKPPFTVVGANHAYPAERLRELFGHLPCKFLETSVRAAEMMKYCCNNFHALKITFANETARLCSALGVNPFE
VMELVCQDTQLNISRAYLKPGFAFGGSCLPKDLRATSYLAKTHDVELPMLNGILQSNRHHVEEAIQKVLASGCRRVGMLG
LSFKTGTDDLRESPLVTLAEQLIGKGMQLSIYDPDVQLSRLLGANRRFIETQLPHIGELLKPELDAVIGEAEVLIVGVSS
PAIFDALATHSRPEQKVLDLVRLPNPQALRAEVEGLCW

Specific function: Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and ant

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=373, Percent_Identity=25.7372654155496, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI296040438, Length=276, Percent_Identity=26.0869565217391, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI296040443, Length=217, Percent_Identity=29.0322580645161, Blast_Score=93, Evalue=5e-19,
Organism=Escherichia coli, GI1788340, Length=361, Percent_Identity=27.4238227146814, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI48994968, Length=357, Percent_Identity=26.3305322128852, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17560350, Length=382, Percent_Identity=27.2251308900524, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI17136908, Length=380, Percent_Identity=26.3157894736842, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.132 [H]

Molecular weight: Translated: 47609; Mature: 47609

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISIFGLGYVGAVSLACLARDGHQVVGVDIDATKLELIRSGTTPVVEEGMVELMANVAA
CEEEEEECCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHC
SGRVSVTTDVRQAVLDTEISLICVGTPSAPNGSQDQGAVLRLARDLGRALAEKSAPHVLV
CCCEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
FRSTLVPGTVEGSLKPIIETESGKRDGEDFHLCFQPEFLREGSSIRDYDKPPFTVVGANH
EECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCHHHHCCCCCCCCCCCCEEEEECCC
AYPAERLRELFGHLPCKFLETSVRAAEMMKYCCNNFHALKITFANETARLCSALGVNPFE
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCHHH
VMELVCQDTQLNISRAYLKPGFAFGGSCLPKDLRATSYLAKTHDVELPMLNGILQSNRHH
HHHHHHCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHH
VEEAIQKVLASGCRRVGMLGLSFKTGTDDLRESPLVTLAEQLIGKGMQLSIYDPDVQLSR
HHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHH
LLGANRRFIETQLPHIGELLKPELDAVIGEAEVLIVGVSSPAIFDALATHSRPEQKVLDL
HHCCCCHHHHHCCCHHHHHHCHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHH
VRLPNPQALRAEVEGLCW
HHCCCCHHHHHHHCCCCC
>Mature Secondary Structure
MKISIFGLGYVGAVSLACLARDGHQVVGVDIDATKLELIRSGTTPVVEEGMVELMANVAA
CEEEEEECCHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHC
SGRVSVTTDVRQAVLDTEISLICVGTPSAPNGSQDQGAVLRLARDLGRALAEKSAPHVLV
CCCEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEE
FRSTLVPGTVEGSLKPIIETESGKRDGEDFHLCFQPEFLREGSSIRDYDKPPFTVVGANH
EECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCHHHHCCCCCCCCCCCCEEEEECCC
AYPAERLRELFGHLPCKFLETSVRAAEMMKYCCNNFHALKITFANETARLCSALGVNPFE
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHCCCHHH
VMELVCQDTQLNISRAYLKPGFAFGGSCLPKDLRATSYLAKTHDVELPMLNGILQSNRHH
HHHHHHCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCHHH
VEEAIQKVLASGCRRVGMLGLSFKTGTDDLRESPLVTLAEQLIGKGMQLSIYDPDVQLSR
HHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHH
LLGANRRFIETQLPHIGELLKPELDAVIGEAEVLIVGVSSPAIFDALATHSRPEQKVLDL
HHCCCCHHHHHCCCHHHHHHCHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCHHHHHHH
VRLPNPQALRAEVEGLCW
HHCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3108855; 10984043; 2470755; 1370473; 8294014; 12135385; 12705829 [H]