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The map label for this gene is fadD [C]

Identifier: 119899462

GI number: 119899462

Start: 3480540

End: 3482300

Strand: Direct

Name: fadD [C]

Synonym: azo3172

Alternate gene names: 119899462

Gene position: 3480540-3482300 (Clockwise)

Preceding gene: 119899461

Following gene: 119899463

Centisome position: 79.54

GC content: 67.52

Gene sequence:

>1761_bases
GTGAGTGTTGCCAACCCGCCCCAGACGCTGCCCGGCCGGCTTCGCCAGCGCGTCTCCGTCACCCCGTCGGCGCCGGCATT
CCTGTTGCGCAACGCGGACGGCGACTGGCAGCCCATGCCGTGGAGCGCGCTGCTGGAACGGGCCGAGCACCTTGCCACCC
ACTTCGTACGCCTTGGCGTCCGCCCGGGAGACCGCGTCGCGATCATGCTGCCGACCGGTCCGGACTGGGAGTGCTGCCAG
TACGCGGCGCTTCTCGCCGGTGCCGCGGTGGTTGGCATCGACGCCCACGACGCGCCGCAGAACCTGCGCCACATCCTCGC
AATCGCGAGCCCCGCGCTCGTGGTCGCACCCGACGCGGAACGGCTCGAACAACTCCGCTCGCTCCACCCGGGCGACTGGC
ACGCCATCGTGCAAGCCGAGGCTCCGTCCGACACCGGCCTACCCTGCCTCTCACAGCTCACCACGCCATGCGAGGCCTTA
CTCCCGGAACCCGCTGCCGACGACATCGCGACCCTGGTCTTCACGTCGGGCAGCACCGGCAAACCCAAGGGCATTGCCTA
CAGCCACCGTCAGATACTGCTCGCCTGCGACACCATCCTCGACCGTTTCCCGGCAATCCGGGACGACGCACGGCTGGTGT
GCTGGCTACCCCTGTCCAACCTCTTCCAGCGCATGATCAACTTCTGCGCACTCACCTGCGGCGCACGCTCCTACATGGTC
GACAAGCCGGACCAGATCGCCCGTCTGCTGCCGGAAATCGAGCCGACGCTCTTCATCGGCGTGCCGCGCTTCTTCGAAAA
GCTCTATGCCGGCATCAGGGCGGAACTCGCCCGGCAACCGCGGCTGGTGCGCCTGCTCGTCGCCGCCTCCTGGTCGGTCG
GTGAACGGATTGCGCGTGCACGGCGCGCCGGACGCGAACCGGCGCTCGCCTGGCGCATGCTGCAACCGCTGGCCGATGCG
GTGCTGGTGCGCCTGCGGGCAGTCATGGGACGCAACCTGCAGTTCATGGTCAGCGGGTCGGCGCCCTTGCCGGGCTGGCT
GATGGAGCGCTTCCATGGCCTCGGCTGGCTCGTGCTGGAAGCCTATGGCATCAGCGAGAACGTGATGCCAGTCGCGCTCA
ACACGCTCGACGCATACCGCTTCGGGAGCGTCGGGCATCCGTTGCCGGGCAATGAAGTGAAAATCGCCGAGGATCGCGAG
TTGCTCGTGCGTGGCGCGGGCGTGTTCTCGGGGTATGTCGGCGGCGACGGAAGCTCGCCCATCGACGCCGAGGGCTTCCT
CCATACGGGTGACTACGCCCGACTCGATGAAGATGGATTCGTCTGGCTCGAAGGCCGGAAGAGCGAGGTCTTCAAGAGCT
CGACCGGGCGGCGCATCGCCCCCGCCCCGATCGAAGCGGCGTTGAAGCAGATCGAGTATGTCGACCATGCCGTGCTTACC
GGCAGTCAGCGCCCCTATACCGTGGCCATCCTCGCGCTGCGCCCCGACCATCCATTGAGCAGTACCGTGCACGACCCCGA
CGCCCAGCAACGCATCACCGCCGACGTCGCCGCCGCAGTCCGCGACTTCAACGAGTACCAGCGCCCGGGTGCCATCGTCG
TCGCGGCAAAGCCGTTCACGATTGCCGACGGCGAATTGACCGCCAACCTCAAGATCCGCCGCAAGGCCATCGAGGAACGC
TTTGCCGACGTGCTTGCGCAGGCGTATTCCCGTCCAGCCACCGACGCCTCTTCCCGTTCCGCCGTGATCATCGCGCCATG
A

Upstream 100 bases:

>100_bases
TCCGGCGCAGCATGGCATGGCTGGACCTGAAGGACGAAGACCTCCGCATCACGCTACCCCGCGGCGCCTACGATCCCCCG
CTGGTGCAGGGCCGGATGCC

Downstream 100 bases:

>100_bases
CCAAGACCTACTTCGTGACCGGCGCCTCCGGCGCCGTCGGCAGCGCCATCGTCCCGCTGCTTTGCAAGGACGCCGAAACC
CGCGTGCGCCTCCTGCTGCG

Product: putative long chain fatty acid CoA ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 586; Mature: 585

Protein sequence:

>586_residues
MSVANPPQTLPGRLRQRVSVTPSAPAFLLRNADGDWQPMPWSALLERAEHLATHFVRLGVRPGDRVAIMLPTGPDWECCQ
YAALLAGAAVVGIDAHDAPQNLRHILAIASPALVVAPDAERLEQLRSLHPGDWHAIVQAEAPSDTGLPCLSQLTTPCEAL
LPEPAADDIATLVFTSGSTGKPKGIAYSHRQILLACDTILDRFPAIRDDARLVCWLPLSNLFQRMINFCALTCGARSYMV
DKPDQIARLLPEIEPTLFIGVPRFFEKLYAGIRAELARQPRLVRLLVAASWSVGERIARARRAGREPALAWRMLQPLADA
VLVRLRAVMGRNLQFMVSGSAPLPGWLMERFHGLGWLVLEAYGISENVMPVALNTLDAYRFGSVGHPLPGNEVKIAEDRE
LLVRGAGVFSGYVGGDGSSPIDAEGFLHTGDYARLDEDGFVWLEGRKSEVFKSSTGRRIAPAPIEAALKQIEYVDHAVLT
GSQRPYTVAILALRPDHPLSSTVHDPDAQQRITADVAAAVRDFNEYQRPGAIVVAAKPFTIADGELTANLKIRRKAIEER
FADVLAQAYSRPATDASSRSAVIIAP

Sequences:

>Translated_586_residues
MSVANPPQTLPGRLRQRVSVTPSAPAFLLRNADGDWQPMPWSALLERAEHLATHFVRLGVRPGDRVAIMLPTGPDWECCQ
YAALLAGAAVVGIDAHDAPQNLRHILAIASPALVVAPDAERLEQLRSLHPGDWHAIVQAEAPSDTGLPCLSQLTTPCEAL
LPEPAADDIATLVFTSGSTGKPKGIAYSHRQILLACDTILDRFPAIRDDARLVCWLPLSNLFQRMINFCALTCGARSYMV
DKPDQIARLLPEIEPTLFIGVPRFFEKLYAGIRAELARQPRLVRLLVAASWSVGERIARARRAGREPALAWRMLQPLADA
VLVRLRAVMGRNLQFMVSGSAPLPGWLMERFHGLGWLVLEAYGISENVMPVALNTLDAYRFGSVGHPLPGNEVKIAEDRE
LLVRGAGVFSGYVGGDGSSPIDAEGFLHTGDYARLDEDGFVWLEGRKSEVFKSSTGRRIAPAPIEAALKQIEYVDHAVLT
GSQRPYTVAILALRPDHPLSSTVHDPDAQQRITADVAAAVRDFNEYQRPGAIVVAAKPFTIADGELTANLKIRRKAIEER
FADVLAQAYSRPATDASSRSAVIIAP
>Mature_585_residues
SVANPPQTLPGRLRQRVSVTPSAPAFLLRNADGDWQPMPWSALLERAEHLATHFVRLGVRPGDRVAIMLPTGPDWECCQY
AALLAGAAVVGIDAHDAPQNLRHILAIASPALVVAPDAERLEQLRSLHPGDWHAIVQAEAPSDTGLPCLSQLTTPCEALL
PEPAADDIATLVFTSGSTGKPKGIAYSHRQILLACDTILDRFPAIRDDARLVCWLPLSNLFQRMINFCALTCGARSYMVD
KPDQIARLLPEIEPTLFIGVPRFFEKLYAGIRAELARQPRLVRLLVAASWSVGERIARARRAGREPALAWRMLQPLADAV
LVRLRAVMGRNLQFMVSGSAPLPGWLMERFHGLGWLVLEAYGISENVMPVALNTLDAYRFGSVGHPLPGNEVKIAEDREL
LVRGAGVFSGYVGGDGSSPIDAEGFLHTGDYARLDEDGFVWLEGRKSEVFKSSTGRRIAPAPIEAALKQIEYVDHAVLTG
SQRPYTVAILALRPDHPLSSTVHDPDAQQRITADVAAAVRDFNEYQRPGAIVVAAKPFTIADGELTANLKIRRKAIEERF
ADVLAQAYSRPATDASSRSAVIIAP

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI83745141, Length=622, Percent_Identity=24.4372990353698, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI27477105, Length=600, Percent_Identity=26.8333333333333, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI42794756, Length=621, Percent_Identity=23.1884057971014, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI42794760, Length=621, Percent_Identity=23.1884057971014, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI42794758, Length=621, Percent_Identity=23.1884057971014, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI57165412, Length=616, Percent_Identity=24.1883116883117, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI40807491, Length=616, Percent_Identity=22.2402597402597, Blast_Score=139, Evalue=8e-33,
Organism=Homo sapiens, GI42794754, Length=623, Percent_Identity=22.1508828250401, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI42794752, Length=623, Percent_Identity=22.1508828250401, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI57165410, Length=617, Percent_Identity=23.5008103727715, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI4758332, Length=604, Percent_Identity=20.8609271523179, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI12669909, Length=604, Percent_Identity=20.8609271523179, Blast_Score=128, Evalue=2e-29,
Organism=Escherichia coli, GI1788107, Length=510, Percent_Identity=24.7058823529412, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI221142682, Length=183, Percent_Identity=26.775956284153, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786801, Length=492, Percent_Identity=25.2032520325203, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17556552, Length=597, Percent_Identity=22.2780569514238, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17510401, Length=607, Percent_Identity=24.0527182866557, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17541856, Length=611, Percent_Identity=22.7495908346972, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17564090, Length=449, Percent_Identity=24.7216035634744, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25147511, Length=602, Percent_Identity=23.421926910299, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI193204819, Length=628, Percent_Identity=21.4968152866242, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17553312, Length=572, Percent_Identity=22.3776223776224, Blast_Score=105, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17558820, Length=469, Percent_Identity=23.2409381663113, Blast_Score=99, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320852, Length=453, Percent_Identity=25.60706401766, Blast_Score=111, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324893, Length=359, Percent_Identity=22.2841225626741, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6323903, Length=439, Percent_Identity=22.5512528473804, Blast_Score=91, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6322182, Length=439, Percent_Identity=19.5899772209567, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17933690, Length=634, Percent_Identity=22.8706624605678, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI19921316, Length=651, Percent_Identity=25.4992319508449, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI281366413, Length=612, Percent_Identity=24.5098039215686, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI24666501, Length=612, Percent_Identity=24.5098039215686, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24666497, Length=612, Percent_Identity=24.5098039215686, Blast_Score=149, Evalue=7e-36,
Organism=Drosophila melanogaster, GI62471679, Length=453, Percent_Identity=22.075055187638, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62471683, Length=453, Percent_Identity=22.075055187638, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62471685, Length=453, Percent_Identity=22.075055187638, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24586636, Length=453, Percent_Identity=22.075055187638, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI62471681, Length=453, Percent_Identity=22.075055187638, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI62471687, Length=453, Percent_Identity=22.075055187638, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24586634, Length=453, Percent_Identity=22.075055187638, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI22026970, Length=453, Percent_Identity=22.075055187638, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI62471689, Length=453, Percent_Identity=22.075055187638, Blast_Score=117, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 63856; Mature: 63725

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVANPPQTLPGRLRQRVSVTPSAPAFLLRNADGDWQPMPWSALLERAEHLATHFVRLGV
CCCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
RPGDRVAIMLPTGPDWECCQYAALLAGAAVVGIDAHDAPQNLRHILAIASPALVVAPDAE
CCCCEEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCEEECCCHH
RLEQLRSLHPGDWHAIVQAEAPSDTGLPCLSQLTTPCEALLPEPAADDIATLVFTSGSTG
HHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHCCCHHHHCCCCCCCCEEEEEEECCCCC
KPKGIAYSHRQILLACDTILDRFPAIRDDARLVCWLPLSNLFQRMINFCALTCGARSYMV
CCCCEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCC
DKPDQIARLLPEIEPTLFIGVPRFFEKLYAGIRAELARQPRLVRLLVAASWSVGERIARA
CCHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCHHEEHHHHHCCHHHHHHHHH
RRAGREPALAWRMLQPLADAVLVRLRAVMGRNLQFMVSGSAPLPGWLMERFHGLGWLVLE
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCEEEEE
AYGISENVMPVALNTLDAYRFGSVGHPLPGNEVKIAEDRELLVRGAGVFSGYVGGDGSSP
EECCCCCCCEEEHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEECCCCEECCCCCCCCCC
IDAEGFLHTGDYARLDEDGFVWLEGRKSEVFKSSTGRRIAPAPIEAALKQIEYVDHAVLT
CCCCCCEECCCCCEECCCCEEEEECCHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHC
GSQRPYTVAILALRPDHPLSSTVHDPDAQQRITADVAAAVRDFNEYQRPGAIVVAAKPFT
CCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEE
IADGELTANLKIRRKAIEERFADVLAQAYSRPATDASSRSAVIIAP
EECCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
>Mature Secondary Structure 
SVANPPQTLPGRLRQRVSVTPSAPAFLLRNADGDWQPMPWSALLERAEHLATHFVRLGV
CCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
RPGDRVAIMLPTGPDWECCQYAALLAGAAVVGIDAHDAPQNLRHILAIASPALVVAPDAE
CCCCEEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCEEECCCHH
RLEQLRSLHPGDWHAIVQAEAPSDTGLPCLSQLTTPCEALLPEPAADDIATLVFTSGSTG
HHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHCCCHHHHCCCCCCCCEEEEEEECCCCC
KPKGIAYSHRQILLACDTILDRFPAIRDDARLVCWLPLSNLFQRMINFCALTCGARSYMV
CCCCEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCC
DKPDQIARLLPEIEPTLFIGVPRFFEKLYAGIRAELARQPRLVRLLVAASWSVGERIARA
CCHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCHHEEHHHHHCCHHHHHHHHH
RRAGREPALAWRMLQPLADAVLVRLRAVMGRNLQFMVSGSAPLPGWLMERFHGLGWLVLE
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCCCEEEEE
AYGISENVMPVALNTLDAYRFGSVGHPLPGNEVKIAEDRELLVRGAGVFSGYVGGDGSSP
EECCCCCCCEEEHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEECCCCEECCCCCCCCCC
IDAEGFLHTGDYARLDEDGFVWLEGRKSEVFKSSTGRRIAPAPIEAALKQIEYVDHAVLT
CCCCCCEECCCCCEECCCCEEEEECCHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHC
GSQRPYTVAILALRPDHPLSSTVHDPDAQQRITADVAAAVRDFNEYQRPGAIVVAAKPFT
CCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEE
IADGELTANLKIRRKAIEERFADVLAQAYSRPATDASSRSAVIIAP
EECCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]