Click here to switch to the map view.

The map label for this gene is obgE

Identifier: 119899459

GI number: 119899459

Start: 3476915

End: 3478141

Strand: Direct

Name: obgE

Synonym: azo3169

Alternate gene names: 119899459

Gene position: 3476915-3478141 (Clockwise)

Preceding gene: 119899458

Following gene: 119899460

Centisome position: 79.45

GC content: 68.3

Gene sequence:

>1227_bases
ATGAAATTCTTTGACGAAGCCCGCATCGAGGTCGTCGCCGGCGACGGCGGAAACGGCGCAGCCACCTTCCGCCGCGAAAA
GTTCATTCCCCGCGGCGGCCCCGACGGCGGCGACGGCGGACGGGGCGGCAGCGTCTATGCAGTGGCCGACCGCAATCTGA
ACACGCTGGTCGAATACCGCTTCAAACGCAGCTTCCGCGCCGAACGCGGCGAGAACGGGGGCAGCAAGGACTGCTACGGC
AAGGGTGGCGAGGACATCACGCTGCACTTCCCGGTGGGCACGGTGATCAGCGATCTCGACAGCGGCGAGCCGATCGCCGA
CCTCGACGTCGATGGCAAGCGCGTCCTGCTCGCTCAGGGCGGCCGCGGCGGGCTTGGCAATCTGCACTTCAAGTCCAGCG
TGAACCGCGCCCCGCGCAAGCGCACGATGGGGCAGGAAGGCGAGCGCCGCAATCTGCACCTCGAACTGAAGGTGCTTGCC
GACGTCGGCCTGCTCGGCATGCCGAACGCAGGCAAGTCGACGTTCATCCGCGCGGTGTCCGCGGCGCGGCCCAAGGTGGG
CGATTACCCGTTCACGACCCTGCAGCCCAATCTCGGCGTGGTTCGTACCGACGAAAACCGCAGCTTCGTCATCGCCGACA
TCCCCGGCCTGATCGAGGGCGCGGCCGAGGGTGCCGGTCTCGGCCATCAGTTCCTGCGCCACCTGCAACGCACCCACGTG
CTGCTGCACCTGGTGGATCTCGCGCCTTTCGACCCCGAAGTCGACCCGGTGCGTGACGCGCTCGCCATCGTCGAAGAACT
GCGCAAGTACGACGAAAGCCTCTACAACAAGCCGCGCTGGCTGGTGCTGAACAAGCTCGACCTGCTCGAACCCGAAGACC
GGGCGCCGCGCGTCGCGGCTTTCCTCGAAGCGTATGGCGAAGTCGAGCGTCACTTCGAGATATCGGCGTTGCAGGGTGAG
GGCTGCCGCGGGTTGATCTTCGCGCTGCAGGACTTCCTCGACAGCGAACGGGCGAACATCCACGCCCAGCAGGCCGCCCG
CGAGGCAGAAGAGCGCCAGCGGCTGGCTGCCGCGCAGTCCGCCCGTAGCGCCGCGGAGGCAGAAGCGCTGGAGGCCGATC
TGGCCGAGGACGCGCTGGCCGAGGACGCGCTGGCCGAGGACGCGCTGGCCGAGGACGCGCTGGACGACGACGCCGACGGC
GAGGACGCCGACCCGAACGCCCGCTGA

Upstream 100 bases:

>100_bases
GCCGCGCAGGAAGCTGCCGCCGCCTGATCCCCGCGTCGTGCAAGAAAAAGCCCTATCCTTGCGGTAGGGCTTTTTTGTTT
ATGCCCACAGGCAAACGAAC

Downstream 100 bases:

>100_bases
ACACCTGCGCCGAATCGACATCATGAGAGACAAGATCAAGAATGCGCGCCGGCTTATCGTGAAAGTCGGCAGCGCCCTCG
TGACCAACAACGGCGCGGGG

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MKFFDEARIEVVAGDGGNGAATFRREKFIPRGGPDGGDGGRGGSVYAVADRNLNTLVEYRFKRSFRAERGENGGSKDCYG
KGGEDITLHFPVGTVISDLDSGEPIADLDVDGKRVLLAQGGRGGLGNLHFKSSVNRAPRKRTMGQEGERRNLHLELKVLA
DVGLLGMPNAGKSTFIRAVSAARPKVGDYPFTTLQPNLGVVRTDENRSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTHV
LLHLVDLAPFDPEVDPVRDALAIVEELRKYDESLYNKPRWLVLNKLDLLEPEDRAPRVAAFLEAYGEVERHFEISALQGE
GCRGLIFALQDFLDSERANIHAQQAAREAEERQRLAAAQSARSAAEAEALEADLAEDALAEDALAEDALAEDALDDDADG
EDADPNAR

Sequences:

>Translated_408_residues
MKFFDEARIEVVAGDGGNGAATFRREKFIPRGGPDGGDGGRGGSVYAVADRNLNTLVEYRFKRSFRAERGENGGSKDCYG
KGGEDITLHFPVGTVISDLDSGEPIADLDVDGKRVLLAQGGRGGLGNLHFKSSVNRAPRKRTMGQEGERRNLHLELKVLA
DVGLLGMPNAGKSTFIRAVSAARPKVGDYPFTTLQPNLGVVRTDENRSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTHV
LLHLVDLAPFDPEVDPVRDALAIVEELRKYDESLYNKPRWLVLNKLDLLEPEDRAPRVAAFLEAYGEVERHFEISALQGE
GCRGLIFALQDFLDSERANIHAQQAAREAEERQRLAAAQSARSAAEAEALEADLAEDALAEDALAEDALAEDALDDDADG
EDADPNAR
>Mature_408_residues
MKFFDEARIEVVAGDGGNGAATFRREKFIPRGGPDGGDGGRGGSVYAVADRNLNTLVEYRFKRSFRAERGENGGSKDCYG
KGGEDITLHFPVGTVISDLDSGEPIADLDVDGKRVLLAQGGRGGLGNLHFKSSVNRAPRKRTMGQEGERRNLHLELKVLA
DVGLLGMPNAGKSTFIRAVSAARPKVGDYPFTTLQPNLGVVRTDENRSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTHV
LLHLVDLAPFDPEVDPVRDALAIVEELRKYDESLYNKPRWLVLNKLDLLEPEDRAPRVAAFLEAYGEVERHFEISALQGE
GCRGLIFALQDFLDSERANIHAQQAAREAEERQRLAAAQSARSAAEAEALEADLAEDALAEDALAEDALAEDALDDDADG
EDADPNAR

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=335, Percent_Identity=40.8955223880597, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI111955139, Length=348, Percent_Identity=34.4827586206897, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI111955063, Length=265, Percent_Identity=30.9433962264151, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI58761500, Length=135, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1789574, Length=347, Percent_Identity=59.0778097982709, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=33.59375, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508313, Length=335, Percent_Identity=37.6119402985075, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17552324, Length=310, Percent_Identity=30, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=35.2517985611511, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321962, Length=189, Percent_Identity=40.2116402116402, Blast_Score=124, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24585318, Length=292, Percent_Identity=38.6986301369863, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20129375, Length=294, Percent_Identity=40.4761904761905, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24640873, Length=149, Percent_Identity=36.241610738255, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24640877, Length=149, Percent_Identity=36.241610738255, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24640875, Length=149, Percent_Identity=36.241610738255, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_AZOSB (A1KAD0)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934672.1
- STRING:   A1KAD0
- GeneID:   4609785
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo3169
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   YIQADEN
- PhylomeDB:   A1KAD0
- ProtClustDB:   PRK12298
- BioCyc:   ASP62928:AZO3169-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 44258; Mature: 44258

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFDEARIEVVAGDGGNGAATFRREKFIPRGGPDGGDGGRGGSVYAVADRNLNTLVEYR
CCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHH
FKRSFRAERGENGGSKDCYGKGGEDITLHFPVGTVISDLDSGEPIADLDVDGKRVLLAQG
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHCCCCCCEEECCCCCCEEEEEEC
GRGGLGNLHFKSSVNRAPRKRTMGQEGERRNLHLELKVLADVGLLGMPNAGKSTFIRAVS
CCCCCCCEEEHHHHHHCHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHH
AARPKVGDYPFTTLQPNLGVVRTDENRSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTHV
HCCCCCCCCCCEEECCCCCEEEECCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHH
LLHLVDLAPFDPEVDPVRDALAIVEELRKYDESLYNKPRWLVLNKLDLLEPEDRAPRVAA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHH
FLEAYGEVERHFEISALQGEGCRGLIFALQDFLDSERANIHAQQAAREAEERQRLAAAQS
HHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARSAAEAEALEADLAEDALAEDALAEDALAEDALDDDADGEDADPNAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKFFDEARIEVVAGDGGNGAATFRREKFIPRGGPDGGDGGRGGSVYAVADRNLNTLVEYR
CCCCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHH
FKRSFRAERGENGGSKDCYGKGGEDITLHFPVGTVISDLDSGEPIADLDVDGKRVLLAQG
HHHHHHHHCCCCCCCCCCCCCCCCEEEEEECHHHHHHHCCCCCCEEECCCCCCEEEEEEC
GRGGLGNLHFKSSVNRAPRKRTMGQEGERRNLHLELKVLADVGLLGMPNAGKSTFIRAVS
CCCCCCCEEEHHHHHHCHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHH
AARPKVGDYPFTTLQPNLGVVRTDENRSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTHV
HCCCCCCCCCCEEECCCCCEEEECCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHH
LLHLVDLAPFDPEVDPVRDALAIVEELRKYDESLYNKPRWLVLNKLDLLEPEDRAPRVAA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHH
FLEAYGEVERHFEISALQGEGCRGLIFALQDFLDSERANIHAQQAAREAEERQRLAAAQS
HHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ARSAAEAEALEADLAEDALAEDALAEDALAEDALDDDADGEDADPNAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA