Click here to switch to the map view.

The map label for this gene is panC

Identifier: 119899435

GI number: 119899435

Start: 3452563

End: 3453390

Strand: Direct

Name: panC

Synonym: azo3145

Alternate gene names: 119899435

Gene position: 3452563-3453390 (Clockwise)

Preceding gene: 119899434

Following gene: 119899436

Centisome position: 78.9

GC content: 69.2

Gene sequence:

>828_bases
ATGCAAATCCACACCACCGTCGCCAGCCTGCGTGCAGCCCGCGCCCGCGCCGGCCGCGTCGCCCTCGTCCCCACCATGGG
CAACCTGCACGATGGCCACATCGCGCTGATGCGCCAGGCTGCCGGCCGGGCGGATTGCGTGATCGCCAGCATCTTCGTAA
ACCGGCTGCAGTTCGGCCCCAACGAAGATTTCGACAAGTACCCGCGCACGCTGCAGGCGGACATCGAGCGCCTGGAGGCA
GCCGGCGTCGCCCATCTGTTCGCGCCTGACGAATCCGAGATGTACCCGCAGCCGCAGCGCTACCACGTCGATCCGGCGCC
GGCGCAGGTTTCCATTCTCGACGGCGAATTCCGCCCCGGCCACTTCCGCGGCGTCGCCACCGTGGTGCTGAAGCTGCTCA
ACATCGTCCAGCCGGACGTCGCGCTGTTCGGCAAGAAGGACTACCAGCAGCTGATGGTGCTGAGCAACATGGTGCGCGAG
TTCGCGCTGCCGATCGAAGTGCTGCCCGGCGACACCGTGCGTGCCGACGACGGCCTCGCGCTGTCCTCGCGCAACGGCTA
CCTCTCCGCCGCAGAACGCGCCGAGGCGCCGCGCCTCTACGCGCTGCTCTGCCGCATCCGCGACGCGGTGCGTGCGGGCG
ACCACGACTTCCTCAAGCTCGAAACCGAGGCGATGGCGCAGCTGGAAGCCCACGGCTGGGCGCCCGACTACATCGCCATC
CGCCGCCAGGCCGACCTCCAGCCGCCGGTGCATGCCGACGATCCGCTCGTGGTGCTGGCCGCCGCCCGCCTCGGCCGCAC
CCGCCTGATCGACAATCTCGAAATCTGA

Upstream 100 bases:

>100_bases
GCCGCCAGCATCGACGCGGCGGTCGCGGCCTATGTCGCCGCCGTGAAGGACGGCAGCTTCCCCGCCGCCGAACACTGCTA
CTGATCCCGCGGACGCCGCC

Downstream 100 bases:

>100_bases
CGCGACGCCCCTGCCCATTCCGGGATCAGGGTTCGCCCGCGTTGCCACTGCAAATTCCTCGGCCCAAGCTATGCTGGAAA
CGTGCTGCTGTGCGGCAGCA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MQIHTTVASLRAARARAGRVALVPTMGNLHDGHIALMRQAAGRADCVIASIFVNRLQFGPNEDFDKYPRTLQADIERLEA
AGVAHLFAPDESEMYPQPQRYHVDPAPAQVSILDGEFRPGHFRGVATVVLKLLNIVQPDVALFGKKDYQQLMVLSNMVRE
FALPIEVLPGDTVRADDGLALSSRNGYLSAAERAEAPRLYALLCRIRDAVRAGDHDFLKLETEAMAQLEAHGWAPDYIAI
RRQADLQPPVHADDPLVVLAAARLGRTRLIDNLEI

Sequences:

>Translated_275_residues
MQIHTTVASLRAARARAGRVALVPTMGNLHDGHIALMRQAAGRADCVIASIFVNRLQFGPNEDFDKYPRTLQADIERLEA
AGVAHLFAPDESEMYPQPQRYHVDPAPAQVSILDGEFRPGHFRGVATVVLKLLNIVQPDVALFGKKDYQQLMVLSNMVRE
FALPIEVLPGDTVRADDGLALSSRNGYLSAAERAEAPRLYALLCRIRDAVRAGDHDFLKLETEAMAQLEAHGWAPDYIAI
RRQADLQPPVHADDPLVVLAAARLGRTRLIDNLEI
>Mature_275_residues
MQIHTTVASLRAARARAGRVALVPTMGNLHDGHIALMRQAAGRADCVIASIFVNRLQFGPNEDFDKYPRTLQADIERLEA
AGVAHLFAPDESEMYPQPQRYHVDPAPAQVSILDGEFRPGHFRGVATVVLKLLNIVQPDVALFGKKDYQQLMVLSNMVRE
FALPIEVLPGDTVRADDGLALSSRNGYLSAAERAEAPRLYALLCRIRDAVRAGDHDFLKLETEAMAQLEAHGWAPDYIAI
RRQADLQPPVHADDPLVVLAAARLGRTRLIDNLEI

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=265, Percent_Identity=48.6792452830189, Blast_Score=237, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6322046, Length=297, Percent_Identity=38.047138047138, Blast_Score=159, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_AZOSB (A1KAA6)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934648.1
- ProteinModelPortal:   A1KAA6
- SMR:   A1KAA6
- STRING:   A1KAA6
- GeneID:   4609493
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo3145
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   A1KAA6
- ProtClustDB:   PRK00380
- BioCyc:   ASP62928:AZO3145-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 30351; Mature: 30351

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 150-150 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIHTTVASLRAARARAGRVALVPTMGNLHDGHIALMRQAAGRADCVIASIFVNRLQFGP
CEEHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCC
NEDFDKYPRTLQADIERLEAAGVAHLFAPDESEMYPQPQRYHVDPAPAQVSILDGEFRPG
CCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCEECCCCCCEEEEECCCCCCC
HFRGVATVVLKLLNIVQPDVALFGKKDYQQLMVLSNMVREFALPIEVLPGDTVRADDGLA
HHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCCCEECCCCEE
LSSRNGYLSAAERAEAPRLYALLCRIRDAVRAGDHDFLKLETEAMAQLEAHGWAPDYIAI
EECCCCCEEHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCCCHHEE
RRQADLQPPVHADDPLVVLAAARLGRTRLIDNLEI
ECCCCCCCCCCCCCCEEEEEHHHHCHHHHHCCCCC
>Mature Secondary Structure
MQIHTTVASLRAARARAGRVALVPTMGNLHDGHIALMRQAAGRADCVIASIFVNRLQFGP
CEEHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCC
NEDFDKYPRTLQADIERLEAAGVAHLFAPDESEMYPQPQRYHVDPAPAQVSILDGEFRPG
CCCHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCEECCCCCCEEEEECCCCCCC
HFRGVATVVLKLLNIVQPDVALFGKKDYQQLMVLSNMVREFALPIEVLPGDTVRADDGLA
HHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHCCCEEECCCCCEECCCCEE
LSSRNGYLSAAERAEAPRLYALLCRIRDAVRAGDHDFLKLETEAMAQLEAHGWAPDYIAI
EECCCCCEEHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHCCCCCCHHEE
RRQADLQPPVHADDPLVVLAAARLGRTRLIDNLEI
ECCCCCCCCCCCCCCEEEEEHHHHCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA