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The map label for this gene is purM

Identifier: 119899426

GI number: 119899426

Start: 3444879

End: 3445937

Strand: Reverse

Name: purM

Synonym: azo3136

Alternate gene names: 119899426

Gene position: 3445937-3444879 (Counterclockwise)

Preceding gene: 119899437

Following gene: 119899425

Centisome position: 78.75

GC content: 66.67

Gene sequence:

>1059_bases
TTGAGCGTCTCCAATTCCGCTTCCCCCAGCTCCCTTTCCTATCGCGACGCCGGTGTCGACATCGAGGCGGGCGACGCCCT
CGTCGACCGCATCAAGCCGTTTGCCAAGCGCACGATGCGGCCGGAAGTGCTCGGCGGCATCGGCGGCTTCGGCGCGCTGT
TCGAGCTGTCGAAGAAGTTCAAGGAGCCGGTGCTGGTGTCGGGTACCGACGGCGTCGGCACCAAGCTCAAGCTCGCCTTC
CAGCTGAACAAGCACGACACGGTCGGTCAGGATCTGGTGGCGATGAGCGTCAATGACATCCTGGTGCAGGGCGCCGAGCC
GCTGTTCTTCCTCGACTATTTCGCCTGCGGCAAGCTCGATGTGGATACCGCGGCCGACGTGGTCAAGGGCATTGCCCACG
GCTGCGAACTCGCCGGCTGCGCGCTGATCGGCGGCGAAACCGCCGAGATGCCGAGCATGTACCCGGAAGGCGAATACGAT
CTCGCCGGCTTCGCCGTCGGCGCGGTTGAAAAGGCGGACATCATCGACGGCTCGAAGATCGTGCCGGGCGACGTGGTGCT
CGGGCTGGCTTCCAGCGGCGCGCATTCCAACGGCTATTCGCTGGTGCGCAAGATCATCGAAGTCGCCAAGCCCGACCTCG
ACGCCGACTTCCACGGCCGCACGTTCCGCGACGTGGTGATGGAACCCACCCGCATCTACGTGAAGCCGCTGCTCGCGCTG
ATGCAGGCGATGCCGGGCGTGGTGAAGGGCATGGCCCACATCACCGGCGGCGGCATCACCGAAAACGTGCCGCGCATCCT
GCGCGACGAACTCACCGCCCGCATCGACGCCGCGAGCTGGACGCTGCCGCCGCTGTTCCAGTGGCTGCAGCAGGCCGGCA
ACGTCGATACCCAGGAAATGTACCGGGTGTTCAACTGCGGCATCGGCATGGCCGTGGTGGTCGCTGCCGACGTTGCCGAC
GCGGTGGCGGCCCAGCTGACCGCCGCCGGCGAGACGGTGTACCGCATCGGCCGCATCGACAGCCGCAAGGACGGCGAGGC
GCAGACCATCGTCGCCTGA

Upstream 100 bases:

>100_bases
CCCTGCGGACCCGTAACTGTAGCCAGTTGGCGTTGCAGCCTCAAGCCTTATGCATCCGGGCTGGCGCCGACCCCGCATCC
TGCTAGTCAGAGGACCGATC

Downstream 100 bases:

>100_bases
GGGCGCAGTCCCGCCCGCGCGGTGCAACTTGCGCCGTGGCGGGCTGTCTCGGCTTGAGTGCCGGCGACGCGCGCACCGCG
CGCCGGCTTTCCGTTTCCGC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSVSNSASPSSLSYRDAGVDIEAGDALVDRIKPFAKRTMRPEVLGGIGGFGALFELSKKFKEPVLVSGTDGVGTKLKLAF
QLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAADVVKGIAHGCELAGCALIGGETAEMPSMYPEGEYD
LAGFAVGAVEKADIIDGSKIVPGDVVLGLASSGAHSNGYSLVRKIIEVAKPDLDADFHGRTFRDVVMEPTRIYVKPLLAL
MQAMPGVVKGMAHITGGGITENVPRILRDELTARIDAASWTLPPLFQWLQQAGNVDTQEMYRVFNCGIGMAVVVAADVAD
AVAAQLTAAGETVYRIGRIDSRKDGEAQTIVA

Sequences:

>Translated_352_residues
MSVSNSASPSSLSYRDAGVDIEAGDALVDRIKPFAKRTMRPEVLGGIGGFGALFELSKKFKEPVLVSGTDGVGTKLKLAF
QLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAADVVKGIAHGCELAGCALIGGETAEMPSMYPEGEYD
LAGFAVGAVEKADIIDGSKIVPGDVVLGLASSGAHSNGYSLVRKIIEVAKPDLDADFHGRTFRDVVMEPTRIYVKPLLAL
MQAMPGVVKGMAHITGGGITENVPRILRDELTARIDAASWTLPPLFQWLQQAGNVDTQEMYRVFNCGIGMAVVVAADVAD
AVAAQLTAAGETVYRIGRIDSRKDGEAQTIVA
>Mature_351_residues
SVSNSASPSSLSYRDAGVDIEAGDALVDRIKPFAKRTMRPEVLGGIGGFGALFELSKKFKEPVLVSGTDGVGTKLKLAFQ
LNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTAADVVKGIAHGCELAGCALIGGETAEMPSMYPEGEYDL
AGFAVGAVEKADIIDGSKIVPGDVVLGLASSGAHSNGYSLVRKIIEVAKPDLDADFHGRTFRDVVMEPTRIYVKPLLALM
QAMPGVVKGMAHITGGGITENVPRILRDELTARIDAASWTLPPLFQWLQQAGNVDTQEMYRVFNCGIGMAVVVAADVADA
VAAQLTAAGETVYRIGRIDSRKDGEAQTIVA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=352, Percent_Identity=51.9886363636364, Blast_Score=358, Evalue=4e-99,
Organism=Homo sapiens, GI209869995, Length=352, Percent_Identity=51.9886363636364, Blast_Score=358, Evalue=4e-99,
Organism=Homo sapiens, GI209869993, Length=352, Percent_Identity=51.9886363636364, Blast_Score=358, Evalue=4e-99,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=58.600583090379, Blast_Score=408, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17567511, Length=352, Percent_Identity=45.4545454545455, Blast_Score=281, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6321203, Length=347, Percent_Identity=48.1268011527378, Blast_Score=328, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24582400, Length=302, Percent_Identity=43.046357615894, Blast_Score=251, Evalue=8e-67,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_AZOSB (A1KA97)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934639.1
- ProteinModelPortal:   A1KA97
- SMR:   A1KA97
- STRING:   A1KA97
- GeneID:   4607812
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo3136
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- PhylomeDB:   A1KA97
- ProtClustDB:   PRK05385
- BioCyc:   ASP62928:AZO3136-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37206; Mature: 37075

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSNSASPSSLSYRDAGVDIEAGDALVDRIKPFAKRTMRPEVLGGIGGFGALFELSKKF
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHH
KEPVLVSGTDGVGTKLKLAFQLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLD
CCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCC
VDTAADVVKGIAHGCELAGCALIGGETAEMPSMYPEGEYDLAGFAVGAVEKADIIDGSKI
CHHHHHHHHHHHHCCCHHCEEEECCCCCCCCCCCCCCCCCCHHEEECCCCHHHCCCCCCC
VPGDVVLGLASSGAHSNGYSLVRKIIEVAKPDLDADFHGRTFRDVVMEPTRIYVKPLLAL
CCCHHEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHH
MQAMPGVVKGMAHITGGGITENVPRILRDELTARIDAASWTLPPLFQWLQQAGNVDTQEM
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHH
YRVFNCGIGMAVVVAADVADAVAAQLTAAGETVYRIGRIDSRKDGEAQTIVA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SVSNSASPSSLSYRDAGVDIEAGDALVDRIKPFAKRTMRPEVLGGIGGFGALFELSKKF
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHH
KEPVLVSGTDGVGTKLKLAFQLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLD
CCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCC
VDTAADVVKGIAHGCELAGCALIGGETAEMPSMYPEGEYDLAGFAVGAVEKADIIDGSKI
CHHHHHHHHHHHHCCCHHCEEEECCCCCCCCCCCCCCCCCCHHEEECCCCHHHCCCCCCC
VPGDVVLGLASSGAHSNGYSLVRKIIEVAKPDLDADFHGRTFRDVVMEPTRIYVKPLLAL
CCCHHEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHH
MQAMPGVVKGMAHITGGGITENVPRILRDELTARIDAASWTLPPLFQWLQQAGNVDTQEM
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHH
YRVFNCGIGMAVVVAADVADAVAAQLTAAGETVYRIGRIDSRKDGEAQTIVA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA