Click here to switch to the map view.

The map label for this gene is lrp1 [H]

Identifier: 119899354

GI number: 119899354

Start: 3373359

End: 3373826

Strand: Direct

Name: lrp1 [H]

Synonym: azo3064

Alternate gene names: 119899354

Gene position: 3373359-3373826 (Clockwise)

Preceding gene: 119899350

Following gene: 119899366

Centisome position: 77.09

GC content: 64.74

Gene sequence:

>468_bases
ATGAAGGAAGAACGCCTCGACGAGATCGACCGCAAGATCCTGCGCGAGCTGCGCAGCGACGGCCGCATCAGCAACCAGAA
GCTCGCCGAACGCATCGGCCTATCGCCCACGCCGTGCTGGAACCGGGTGCGCGCGCTGGAAGCGGCGGGCATCATCACCG
AGTACGTCGCAGTGCTGGACCAGCGCGCGCTCGGCATGCCCGACACGGTGATCATCGAAGTACAGCTGGAACGCCACGAC
GACGCGGTGTTCCAGGCCTTCGGCGACGCGCTGGTGGAATTGCCGGAGGTGATGGAGGCCTACCTGGTGACCGGCGAGTA
CGACTACCTGATCAAGGTGGCGGTGTCAGGCACCGAGGGTTATGAGCGCTTCCTGCGGCAGAAGCTGTACAAGATCCGCG
GGATACGGCACAGCCGGTCGACATTTGCGCTGCGGTGCTTGAAGCGGGCGCATTCGGTGGTGCCGTAG

Upstream 100 bases:

>100_bases
TTTCTTTATGGATTTCGCTGCCTTAGAGAATCTTTGTTTTTATTTTTCTCACAATGAGGAATAGTCTTCCTCGTCATCAG
ACTCCCGTGGAAAACCTGCG

Downstream 100 bases:

>100_bases
GGAGGGAGTTCGATCGGCGGAGAACGGTTTTGCCCCTCCCCCTTCAAGGGGGGCGGAACCGGGGTTTCGGCAAGCATGCT
TGCCGCCGGTGTAGCGGCGA

Product: leucine-responsive regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MKEERLDEIDRKILRELRSDGRISNQKLAERIGLSPTPCWNRVRALEAAGIITEYVAVLDQRALGMPDTVIIEVQLERHD
DAVFQAFGDALVELPEVMEAYLVTGEYDYLIKVAVSGTEGYERFLRQKLYKIRGIRHSRSTFALRCLKRAHSVVP

Sequences:

>Translated_155_residues
MKEERLDEIDRKILRELRSDGRISNQKLAERIGLSPTPCWNRVRALEAAGIITEYVAVLDQRALGMPDTVIIEVQLERHD
DAVFQAFGDALVELPEVMEAYLVTGEYDYLIKVAVSGTEGYERFLRQKLYKIRGIRHSRSTFALRCLKRAHSVVP
>Mature_155_residues
MKEERLDEIDRKILRELRSDGRISNQKLAERIGLSPTPCWNRVRALEAAGIITEYVAVLDQRALGMPDTVIIEVQLERHD
DAVFQAFGDALVELPEVMEAYLVTGEYDYLIKVAVSGTEGYERFLRQKLYKIRGIRHSRSTFALRCLKRAHSVVP

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=149, Percent_Identity=40.9395973154362, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI87081742, Length=148, Percent_Identity=35.1351351351351, Blast_Score=105, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17774; Mature: 17774

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEERLDEIDRKILRELRSDGRISNQKLAERIGLSPTPCWNRVRALEAAGIITEYVAVLD
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QRALGMPDTVIIEVQLERHDDAVFQAFGDALVELPEVMEAYLVTGEYDYLIKVAVSGTEG
HHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHH
YERFLRQKLYKIRGIRHSRSTFALRCLKRAHSVVP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKEERLDEIDRKILRELRSDGRISNQKLAERIGLSPTPCWNRVRALEAAGIITEYVAVLD
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QRALGMPDTVIIEVQLERHDDAVFQAFGDALVELPEVMEAYLVTGEYDYLIKVAVSGTEG
HHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHH
YERFLRQKLYKIRGIRHSRSTFALRCLKRAHSVVP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]