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The map label for this gene is cusB [H]

Identifier: 119899244

GI number: 119899244

Start: 3240279

End: 3241874

Strand: Direct

Name: cusB [H]

Synonym: azo2954

Alternate gene names: 119899244

Gene position: 3240279-3241874 (Clockwise)

Preceding gene: 119899243

Following gene: 119899245

Centisome position: 74.05

GC content: 70.68

Gene sequence:

>1596_bases
GTGAAACCCGCCGTGCAACTTTCCCTTGCCGCGCTCGCGGTGGCCGTCGCACTCGGCGCCGGCTACTGGGCCGGCAGCCG
CAACGGCGGCCATCCCGCCGCAGCTCCCACAGGCGACAGCGCAGCACCGGCTGCCGGCAGCGGCGAGCGCAAGCCGCTCT
ACTACCGCAACCCGATGGGCCTGCCCGACACCTCGCCGGTGCCGAAGAAGGACTCGATGGGCATGGACTACATCCCGGTC
TATGCCGACGACACGCCCGACGACGCCGGCGTGGTCCGCGTCAGTCCGGCGCGGGTGCAGCTGCTCGGCGTCAAGACCGC
GCTCGCCGAGGAACGCATGGTCGACGCCGCGGTGCGCGCGGTCGGCCGCGTCGAACTCGACGAGCGCTCGGTGGTGGCGG
TGGCGCCGCGCTTCGAAGGCTGGATCGAGCGCCTCCACGTCAGCGCGGTCGGCGACCCGGTACGCAAGGGCCAACCCTTG
TTCACCGTCTACAGCCCGGAACTGCAATCGGCCGGCGAAGAATTGCGCATCGCCGAAAAACTGCAGCGCGACGCAGCCGC
CACCGACCCGACCGCTGCCGCGTCGGCCGCCCGGCTTGCCGATGCAACCCGCGAGCGCCTGAAGAATTGGGAGGTCGCGG
CCCCCGGCGCGGCCCCACGGACGACGCCGCCCGCCGCGGGGGTGGGCGCACCGTCCCAGGCGTCCACGCGACACACCTTC
CACGCCCCCGCCGACGGCATCGTGCTGGAGAAGAACGCGGTGCAGGGCGCGCGCTTCATGCCCGGCGAGGCGATCTACCG
CATCGCCGACCTTTCCCGCGTGTGGGTGATCGCCGATCTCTACGAGCAGGACCTCGCCCGCATCAAGGTGGGCCAGCCGG
CGAGCGTCAGCCTCGACGCTTTCCCCGGCCGCCGCTTCGACGCGAAGGTGGCCTACCTCTACCCGACGCTGAACGCCGCC
ACCCGCAGCACGCCGGTGCGGCTCGAACTCGACAACCGCGAACGCCTGCTGCGCCCCGGCATGTTCGCCCACGTCGAACT
CGCCGCCGGCCCCGCCGCGCCGCGGGTGACGGTGCCCGCGTCGGCAGTGATCGACGACGGCCATCGCCAGGTGGTGCTGA
TCGCGCTCGACGAAGGCCGCTACAAGCCGCAGCCGGTGAAGCTGGGCGCGCGCGGGCAGGACTACGTCGAGGTGACGGAA
GGCGTGCAGGCGGGCGAGCGCGTGGTGGTATCGGCCAACTTCCTGATCGACTCGGAAAGCCAGCTGAAGGCGGCGCTCTC
CAACCTGACCGAAGCGACCGCCGATACGTCCAAACCCGCGGCAGCGAAGGGTTTCGAAGCGGTCGGCGTGCTCGATGGCA
TCGACCTGGCGATGAACTCGATCACCGTCACCCACGAGCCGATCCCCGCGCTGCAGTGGCCGGAGATGACGATGGATTTC
GGTATCGCGTCGGCGGAGGTGGTGGCCGGGATGGCACCGGGGACGGCGATCCGGTTCAGTTTCGAACAACGGGCGCCGGG
GGAGTTTGTGGTGACGAAGGTTGAGCGGGTTGGAGCTACCGCGGAAGCGGACCACAGCGGTCACGGCAAACGCTGA

Upstream 100 bases:

>100_bases
CGGAACGCCAGTTGATCGACATCCGCATGCGCGCGCTGGAAACCGAGGTGGAAACCCGCTCCGCGCTCGCCGAGCTGGAA
AAACTCGCAGGAGAGGTGCA

Downstream 100 bases:

>100_bases
CGAGGCGGTTCTAGATCCTCCCCCTTCAAGGGGGAGGCTAGGAGGGGGATGGGGTCCGGCTCAGCGCCGCGATAACCCCA
TCCCCACCCCAGCCCTCCCC

Product: cation efflux transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MKPAVQLSLAALAVAVALGAGYWAGSRNGGHPAAAPTGDSAAPAAGSGERKPLYYRNPMGLPDTSPVPKKDSMGMDYIPV
YADDTPDDAGVVRVSPARVQLLGVKTALAEERMVDAAVRAVGRVELDERSVVAVAPRFEGWIERLHVSAVGDPVRKGQPL
FTVYSPELQSAGEELRIAEKLQRDAAATDPTAAASAARLADATRERLKNWEVAAPGAAPRTTPPAAGVGAPSQASTRHTF
HAPADGIVLEKNAVQGARFMPGEAIYRIADLSRVWVIADLYEQDLARIKVGQPASVSLDAFPGRRFDAKVAYLYPTLNAA
TRSTPVRLELDNRERLLRPGMFAHVELAAGPAAPRVTVPASAVIDDGHRQVVLIALDEGRYKPQPVKLGARGQDYVEVTE
GVQAGERVVVSANFLIDSESQLKAALSNLTEATADTSKPAAAKGFEAVGVLDGIDLAMNSITVTHEPIPALQWPEMTMDF
GIASAEVVAGMAPGTAIRFSFEQRAPGEFVVTKVERVGATAEADHSGHGKR

Sequences:

>Translated_531_residues
MKPAVQLSLAALAVAVALGAGYWAGSRNGGHPAAAPTGDSAAPAAGSGERKPLYYRNPMGLPDTSPVPKKDSMGMDYIPV
YADDTPDDAGVVRVSPARVQLLGVKTALAEERMVDAAVRAVGRVELDERSVVAVAPRFEGWIERLHVSAVGDPVRKGQPL
FTVYSPELQSAGEELRIAEKLQRDAAATDPTAAASAARLADATRERLKNWEVAAPGAAPRTTPPAAGVGAPSQASTRHTF
HAPADGIVLEKNAVQGARFMPGEAIYRIADLSRVWVIADLYEQDLARIKVGQPASVSLDAFPGRRFDAKVAYLYPTLNAA
TRSTPVRLELDNRERLLRPGMFAHVELAAGPAAPRVTVPASAVIDDGHRQVVLIALDEGRYKPQPVKLGARGQDYVEVTE
GVQAGERVVVSANFLIDSESQLKAALSNLTEATADTSKPAAAKGFEAVGVLDGIDLAMNSITVTHEPIPALQWPEMTMDF
GIASAEVVAGMAPGTAIRFSFEQRAPGEFVVTKVERVGATAEADHSGHGKR
>Mature_531_residues
MKPAVQLSLAALAVAVALGAGYWAGSRNGGHPAAAPTGDSAAPAAGSGERKPLYYRNPMGLPDTSPVPKKDSMGMDYIPV
YADDTPDDAGVVRVSPARVQLLGVKTALAEERMVDAAVRAVGRVELDERSVVAVAPRFEGWIERLHVSAVGDPVRKGQPL
FTVYSPELQSAGEELRIAEKLQRDAAATDPTAAASAARLADATRERLKNWEVAAPGAAPRTTPPAAGVGAPSQASTRHTF
HAPADGIVLEKNAVQGARFMPGEAIYRIADLSRVWVIADLYEQDLARIKVGQPASVSLDAFPGRRFDAKVAYLYPTLNAA
TRSTPVRLELDNRERLLRPGMFAHVELAAGPAAPRVTVPASAVIDDGHRQVVLIALDEGRYKPQPVKLGARGQDYVEVTE
GVQAGERVVVSANFLIDSESQLKAALSNLTEATADTSKPAAAKGFEAVGVLDGIDLAMNSITVTHEPIPALQWPEMTMDF
GIASAEVVAGMAPGTAIRFSFEQRAPGEFVVTKVERVGATAEADHSGHGKR

Specific function: Component of the sil cation efflux system that confers resistance to silver. May be part of a three-component cation/proton antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786787, Length=395, Percent_Identity=30.126582278481, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI87081796, Length=323, Percent_Identity=27.5541795665635, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 56082; Mature: 56082

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPAVQLSLAALAVAVALGAGYWAGSRNGGHPAAAPTGDSAAPAAGSGERKPLYYRNPMG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
LPDTSPVPKKDSMGMDYIPVYADDTPDDAGVVRVSPARVQLLGVKTALAEERMVDAAVRA
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCEEEEEEHHHHHHHHHHHHHHHHH
VGRVELDERSVVAVAPRFEGWIERLHVSAVGDPVRKGQPLFTVYSPELQSAGEELRIAEK
HCCEEECCCCEEEECCHHHHHHHHHHHHHCCCHHHCCCCEEEEECCHHHCCCHHHHHHHH
LQRDAAATDPTAAASAARLADATRERLKNWEVAAPGAAPRTTPPAAGVGAPSQASTRHTF
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEE
HAPADGIVLEKNAVQGARFMPGEAIYRIADLSRVWVIADLYEQDLARIKVGQPASVSLDA
ECCCCCEEEECCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHEECCCCCEEEEEC
FPGRRFDAKVAYLYPTLNAATRSTPVRLELDNRERLLRPGMFAHVELAAGPAAPRVTVPA
CCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCCCEEECCC
SAVIDDGHRQVVLIALDEGRYKPQPVKLGARGQDYVEVTEGVQAGERVVVSANFLIDSES
HHEECCCCCEEEEEEECCCCCCCCCEEECCCCCCHHHHHHHHCCCCEEEEEEEEEECCHH
QLKAALSNLTEATADTSKPAAAKGFEAVGVLDGIDLAMNSITVTHEPIPALQWPEMTMDF
HHHHHHHHHHHHHCCCCCCCHHCCCCEEEEECCHHHHHCEEEEECCCCCCCCCCCHHHHC
GIASAEVVAGMAPGTAIRFSFEQRAPGEFVVTKVERVGATAEADHSGHGKR
CCCHHHHHHCCCCCCEEEEEECCCCCCCEEEEEHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MKPAVQLSLAALAVAVALGAGYWAGSRNGGHPAAAPTGDSAAPAAGSGERKPLYYRNPMG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
LPDTSPVPKKDSMGMDYIPVYADDTPDDAGVVRVSPARVQLLGVKTALAEERMVDAAVRA
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCEEEEEEHHHHHHHHHHHHHHHHH
VGRVELDERSVVAVAPRFEGWIERLHVSAVGDPVRKGQPLFTVYSPELQSAGEELRIAEK
HCCEEECCCCEEEECCHHHHHHHHHHHHHCCCHHHCCCCEEEEECCHHHCCCHHHHHHHH
LQRDAAATDPTAAASAARLADATRERLKNWEVAAPGAAPRTTPPAAGVGAPSQASTRHTF
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEE
HAPADGIVLEKNAVQGARFMPGEAIYRIADLSRVWVIADLYEQDLARIKVGQPASVSLDA
ECCCCCEEEECCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHEECCCCCEEEEEC
FPGRRFDAKVAYLYPTLNAATRSTPVRLELDNRERLLRPGMFAHVELAAGPAAPRVTVPA
CCCCCCCCEEEEEEECCCCCCCCCCEEEEECCCHHHHCCCCEEEEEEECCCCCCEEECCC
SAVIDDGHRQVVLIALDEGRYKPQPVKLGARGQDYVEVTEGVQAGERVVVSANFLIDSES
HHEECCCCCEEEEEEECCCCCCCCCEEECCCCCCHHHHHHHHCCCCEEEEEEEEEECCHH
QLKAALSNLTEATADTSKPAAAKGFEAVGVLDGIDLAMNSITVTHEPIPALQWPEMTMDF
HHHHHHHHHHHHHCCCCCCCHHCCCCEEEEECCHHHHHCEEEEECCCCCCCCCCCHHHHC
GIASAEVVAGMAPGTAIRFSFEQRAPGEFVVTKVERVGATAEADHSGHGKR
CCCHHHHHHCCCCCCEEEEEECCCCCCCEEEEEHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9930866 [H]