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The map label for this gene is hemF [H]

Identifier: 119899186

GI number: 119899186

Start: 3179160

End: 3180074

Strand: Direct

Name: hemF [H]

Synonym: azo2896

Alternate gene names: 119899186

Gene position: 3179160-3180074 (Clockwise)

Preceding gene: 119899185

Following gene: 119899187

Centisome position: 72.65

GC content: 67.32

Gene sequence:

>915_bases
ATGGTCGTCGATCTCACCGCCATCAAGCAGTATTTCACCGGCCTGCAGGGCCGCATCGTCGCCGGGCTCGAAGCCTTCGA
CGGCCAGACCTTCCGCAGCGACGGCTGGGAGCGCCCGGGCGGTGGCGGCGGCCTGACCCGTGTGATCGAGGAAGGCAACT
TCTTCGAGCGCGGCGGGGTGAATTTTTCGCACGTGATGGGCGACGGCCTGCCGGCGTCGGCCAGCGCGCACCGGCCCGAA
CTCGCGGGGCGCCGCTTCGAGGCGATGGGCGTGTCGCTCGTATTGCATCCGCGCAACCCCTACTGCCCCACCGTGCACAT
GAACGTGCGCTGCTTCGTCGCGCTCGCCGACGGCAAGCCTCCGGTGTGGTGGTTCGGTGGCGGCATGGATCTGACGCCCT
ATTACGGCTTCGAAGACGACGTTCGCCACTTCCACGCCACCTGCAAGGAAGCGGTGCTGCCCTTCGGCGGCGAAGCCGAG
TACCAGCGCTACAAGGCCTGGTGCGACCGCTACTTCTTCCTCAAGCACCGCAATGAGCCGCGCGGCGTTGGCGGACTGTT
CTTCGACGATCTCGGCGCCGACGGCGAAACCGATTTCGACACCGCCTTCGGCCTCACCCGCTCGGTCGGCAACGCCTTCC
TCGACGCCTACATCCCCATCGTCGAACGCCGTCGCGACTACGGCTACGGCGAGCGCGAACGCGACTTCCAGGCCTACCGG
CGCGGCCGCTACGTCGAGTTCAACCTGGTGTTCGACCGCGGCACCCTGTTCGGCCTGCAATCGGGCGGGCGTACCGAGTC
CATCCTGATGTCGATGCCGCCCATCGTGAAGTGGCGCTACGACTGGCAGCCGGAGCCGGGCTCCGCCGAAGCAGCGCTGT
ACGAACAATTCCTCGTCCCGCGCGACTGGGCCTGA

Upstream 100 bases:

>100_bases
GAAGCGTGCCTACGAACTCGCCGACGCGATCCAGTTCGAAGGCCGCCAGTTCCGCCGCGACATCGGCCACCGCGCCGTCG
CCCGCAAGAGCTGATCCGCC

Downstream 100 bases:

>100_bases
CTCGACCGCCCGCAAGCACGGGCATCAAATAGAAGCGTTTGCTAACATGGCGGCCCGCCCCTCGCCGCCACGCCGCATGT
CCGCGCCTGTCGAACGCCTG

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MVVDLTAIKQYFTGLQGRIVAGLEAFDGQTFRSDGWERPGGGGGLTRVIEEGNFFERGGVNFSHVMGDGLPASASAHRPE
LAGRRFEAMGVSLVLHPRNPYCPTVHMNVRCFVALADGKPPVWWFGGGMDLTPYYGFEDDVRHFHATCKEAVLPFGGEAE
YQRYKAWCDRYFFLKHRNEPRGVGGLFFDDLGADGETDFDTAFGLTRSVGNAFLDAYIPIVERRRDYGYGERERDFQAYR
RGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPIVKWRYDWQPEPGSAEAALYEQFLVPRDWA

Sequences:

>Translated_304_residues
MVVDLTAIKQYFTGLQGRIVAGLEAFDGQTFRSDGWERPGGGGGLTRVIEEGNFFERGGVNFSHVMGDGLPASASAHRPE
LAGRRFEAMGVSLVLHPRNPYCPTVHMNVRCFVALADGKPPVWWFGGGMDLTPYYGFEDDVRHFHATCKEAVLPFGGEAE
YQRYKAWCDRYFFLKHRNEPRGVGGLFFDDLGADGETDFDTAFGLTRSVGNAFLDAYIPIVERRRDYGYGERERDFQAYR
RGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPIVKWRYDWQPEPGSAEAALYEQFLVPRDWA
>Mature_304_residues
MVVDLTAIKQYFTGLQGRIVAGLEAFDGQTFRSDGWERPGGGGGLTRVIEEGNFFERGGVNFSHVMGDGLPASASAHRPE
LAGRRFEAMGVSLVLHPRNPYCPTVHMNVRCFVALADGKPPVWWFGGGMDLTPYYGFEDDVRHFHATCKEAVLPFGGEAE
YQRYKAWCDRYFFLKHRNEPRGVGGLFFDDLGADGETDFDTAFGLTRSVGNAFLDAYIPIVERRRDYGYGERERDFQAYR
RGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPIVKWRYDWQPEPGSAEAALYEQFLVPRDWA

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=308, Percent_Identity=43.1818181818182, Blast_Score=236, Evalue=2e-62,
Organism=Escherichia coli, GI1788777, Length=304, Percent_Identity=63.1578947368421, Blast_Score=391, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6320249, Length=320, Percent_Identity=45.3125, Blast_Score=259, Evalue=3e-70,
Organism=Drosophila melanogaster, GI17864388, Length=299, Percent_Identity=45.819397993311, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34367; Mature: 34367

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS01021 COPROGEN_OXIDASE ; PS00133 CARBOXYPEPT_ZN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVDLTAIKQYFTGLQGRIVAGLEAFDGQTFRSDGWERPGGGGGLTRVIEEGNFFERGGV
CEEEHHHHHHHHCCCCCEEEECEECCCCCEECCCCCCCCCCCCCHHHHHHCCCCEECCCC
NFSHVMGDGLPASASAHRPELAGRRFEAMGVSLVLHPRNPYCPTVHMNVRCFVALADGKP
CHHHHHCCCCCCCCCCCCCHHHCCEEEECCEEEEEECCCCCCCEEEECEEEEEEEECCCC
PVWWFGGGMDLTPYYGFEDDVRHFHATCKEAVLPFGGEAEYQRYKAWCDRYFFLKHRNEP
CEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEEECCCC
RGVGGLFFDDLGADGETDFDTAFGLTRSVGNAFLDAYIPIVERRRDYGYGERERDFQAYR
CCCCCEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPIVKWRYDWQPEPGSAEAALYEQFLVP
CCCEEEEEEEEECCEEEEECCCCCCHHEEECCCCCEEEEECCCCCCCCHHHHHHHHHCCC
RDWA
CCCC
>Mature Secondary Structure
MVVDLTAIKQYFTGLQGRIVAGLEAFDGQTFRSDGWERPGGGGGLTRVIEEGNFFERGGV
CEEEHHHHHHHHCCCCCEEEECEECCCCCEECCCCCCCCCCCCCHHHHHHCCCCEECCCC
NFSHVMGDGLPASASAHRPELAGRRFEAMGVSLVLHPRNPYCPTVHMNVRCFVALADGKP
CHHHHHCCCCCCCCCCCCCHHHCCEEEECCEEEEEECCCCCCCEEEECEEEEEEEECCCC
PVWWFGGGMDLTPYYGFEDDVRHFHATCKEAVLPFGGEAEYQRYKAWCDRYFFLKHRNEP
CEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEEECCCC
RGVGGLFFDDLGADGETDFDTAFGLTRSVGNAFLDAYIPIVERRRDYGYGERERDFQAYR
CCCCCEEHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPIVKWRYDWQPEPGSAEAALYEQFLVP
CCCEEEEEEEEECCEEEEECCCCCCHHEEECCCCCEEEEECCCCCCCCHHHHHHHHHCCC
RDWA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA