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The map label for this gene is prlC [H]

Identifier: 119899167

GI number: 119899167

Start: 3155906

End: 3157972

Strand: Direct

Name: prlC [H]

Synonym: azo2877

Alternate gene names: 119899167

Gene position: 3155906-3157972 (Clockwise)

Preceding gene: 119899166

Following gene: 119899168

Centisome position: 72.12

GC content: 67.44

Gene sequence:

>2067_bases
ATGACCGCTGCCGCCAATCCGCTGCTGGACTTCTCCGGCCTGCCCCGCTTCGATGCCGTCCGTCCCGAACACGTCGCGCC
CGCCATTCGCAGCCTGCTCGACGAATACCGCGCGCTGATCGAGCGCCTGACGGCCGACCCCGCCGCACCCACCTGGGACA
GCTTTGTCGCGCCGATGACCGAAACCGGCGAACGCATGGGGCGCGCCTGGGGCGTGGTCGGCCACCTGCACAGCGTGATG
GACGTGCCGGAGTGGCGCGAGGCCTATAACGCGATGCTGCCGGAGGTCTCGCGCTTCTACGCCGAGGTCGGCCAGAACCT
GGCGCTGTTCCACAAATACAAGGCGCTGCGCGACAGCGCCGAATACGCCACGCTGTCGCCGGCGCGCCGCCGCATCCTGG
ACAACGAAGTGCGCGACTTCCGCCTGTCCGGCGCGGAACTGCCGGACGAGGTCAAGCCGCGCTTCCAGGCCATCCAGGAA
GAACTCTCCCAGCTGGGCGCCAAGTTCTCCGAGAACCTGCTCGACTCCACCAATGCACACGCGGAGTGGATCACCGACGA
GGCCGCACTGGCCGGCATTCCGGAAGATGCGCGCGCTGCGGCACGCGCCGCCGCCGAGAAGGACGGCAAGCCGGGCTGGA
AATTCACGCTGCACATGCCGTCCTACCTGCCGGTGCTGCAATACGCCGACAACCGCGAACTGCGCGAACGCATGTACCGC
GCCTATGCCACCCGCGCGTCCGAACAGGGCAAGCCCGAATGGGACAACGGTCCGCTGATCGGCAAGATCCTCGCGCTGCG
CGAGGAGGAATCCCGCCTGCTCGGCTACAACAGCTTCGCCGAAGTGTCGCTGGTACCCAAGATGGCCGACACGCCGGCGC
AGGTGCTCGGCTTCCTGCGCGAACTCGCCGCCAAGGCCAAGCCTTTTGCCGAACGCGACCTCGCCGAACTCAAGGCCTTT
GCCGCGGAAGAACTCGGCCTGGATGACCTGCAGCCGTGGGACGCGTCGTGGGTGTCGGAAAAGCTGCGCCAGAAGCGCTA
CGACTATTCCGACCAGGAGGTGAAGCAATACTTCCCCGAACCCAAGGTGCTCGACGGCCTGTTCGGCGTGGTGCGCCGGC
TCTACGGCGTAGACATCCTGCCCGACGAGGCGCCGCGCTGGGACGCGGACGTGCGCTTCTTCCGCCTCGAGAAGGAAGGC
GACGTCGTCGGCCACTTCTACCTCGACCTGCACGCGCGCGAAACCAAGCGCGGCGGTGCCTGGATGGACTCCGCGCGCAG
CCGCCACGTCACCGTCAGCGGCACCGAAACCCCGGTGGCCTACCTGGTGTGCAACTTCCCCGGCCCGGTCAACGGCAAGC
CCGCCACCTTCACCCATGACGACGTGCTCACGCTGTTCCACGAGACCGGCCACGGCCTGCACCACCTGCTCACCCAGGTG
GACGAACTCGCGGTGTCCGGCATCCACGGCGTCGAATGGGATGCGGTGGAACTGCCCAGCCAGTTCATGGAGAACTTCTG
CTGGGAATGGGACGTGCTGCAAGGCATGACCGCCCATGCCGAAACCGGCGAACCGCTGCCGCGCGCGCTCTACGACAAGA
TGATCGCCGCCAAGAACTTCCAGAGCGGCATGCAGATGGTGCGCCAGCTGGAGTTCTCGATGTTCGACCTGCGTCTGCAC
GGCGAGGTGGAAGCCAATGGCCAGCCGGTCAGCATGGAGCGCGTGCTCGACCTGCTCGGCGAAGTGCGGCGCGAGGTGGC
GGTGCTGATTCCGCCCGCCTGGCACCGCTTCCCCAACAGCTTCTCGCACATCTTCGCCGGCGGCTACGCGGCGGGCTATT
ACAGCTACAAGTGGGCAGAAGTGCTGTCGGCCGACGCCTTCGAAGCCTTCGAGGAAGCCGGCGCCGGCAAGGGCAGCCTG
CTCGACCCGGAAACCGGCGCGCGCTTCTGGCGCGAGATCCTCGCGGTCGGCGGCAGCCGCCCGGCGATCGAATCCTTCAA
GGCCTTCCGCGGCCGTGAGCCGCGGGTCGACGCGCTGCTGCGCCACAACGGCATGGTGAGCGCATGA

Upstream 100 bases:

>100_bases
CTTTTGACCGGGGCGCCCATAGCGGCGCCCTTTGTACTTTTTCGGCACAATAGCCGCCATCACTTGCCATCCGACGCGTC
GCCGACGCCATACCGCCATC

Downstream 100 bases:

>100_bases
CGCGGCGCGCCGTCGCCCTTGCCCTGCTCGCGCTCGGCCTGACGGCCGGCGCGCAGGCACAGACCACCTACCGCTGGGTG
GACGAGCACGGCCGGGTGCA

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MTAAANPLLDFSGLPRFDAVRPEHVAPAIRSLLDEYRALIERLTADPAAPTWDSFVAPMTETGERMGRAWGVVGHLHSVM
DVPEWREAYNAMLPEVSRFYAEVGQNLALFHKYKALRDSAEYATLSPARRRILDNEVRDFRLSGAELPDEVKPRFQAIQE
ELSQLGAKFSENLLDSTNAHAEWITDEAALAGIPEDARAAARAAAEKDGKPGWKFTLHMPSYLPVLQYADNRELRERMYR
AYATRASEQGKPEWDNGPLIGKILALREEESRLLGYNSFAEVSLVPKMADTPAQVLGFLRELAAKAKPFAERDLAELKAF
AAEELGLDDLQPWDASWVSEKLRQKRYDYSDQEVKQYFPEPKVLDGLFGVVRRLYGVDILPDEAPRWDADVRFFRLEKEG
DVVGHFYLDLHARETKRGGAWMDSARSRHVTVSGTETPVAYLVCNFPGPVNGKPATFTHDDVLTLFHETGHGLHHLLTQV
DELAVSGIHGVEWDAVELPSQFMENFCWEWDVLQGMTAHAETGEPLPRALYDKMIAAKNFQSGMQMVRQLEFSMFDLRLH
GEVEANGQPVSMERVLDLLGEVRREVAVLIPPAWHRFPNSFSHIFAGGYAAGYYSYKWAEVLSADAFEAFEEAGAGKGSL
LDPETGARFWREILAVGGSRPAIESFKAFRGREPRVDALLRHNGMVSA

Sequences:

>Translated_688_residues
MTAAANPLLDFSGLPRFDAVRPEHVAPAIRSLLDEYRALIERLTADPAAPTWDSFVAPMTETGERMGRAWGVVGHLHSVM
DVPEWREAYNAMLPEVSRFYAEVGQNLALFHKYKALRDSAEYATLSPARRRILDNEVRDFRLSGAELPDEVKPRFQAIQE
ELSQLGAKFSENLLDSTNAHAEWITDEAALAGIPEDARAAARAAAEKDGKPGWKFTLHMPSYLPVLQYADNRELRERMYR
AYATRASEQGKPEWDNGPLIGKILALREEESRLLGYNSFAEVSLVPKMADTPAQVLGFLRELAAKAKPFAERDLAELKAF
AAEELGLDDLQPWDASWVSEKLRQKRYDYSDQEVKQYFPEPKVLDGLFGVVRRLYGVDILPDEAPRWDADVRFFRLEKEG
DVVGHFYLDLHARETKRGGAWMDSARSRHVTVSGTETPVAYLVCNFPGPVNGKPATFTHDDVLTLFHETGHGLHHLLTQV
DELAVSGIHGVEWDAVELPSQFMENFCWEWDVLQGMTAHAETGEPLPRALYDKMIAAKNFQSGMQMVRQLEFSMFDLRLH
GEVEANGQPVSMERVLDLLGEVRREVAVLIPPAWHRFPNSFSHIFAGGYAAGYYSYKWAEVLSADAFEAFEEAGAGKGSL
LDPETGARFWREILAVGGSRPAIESFKAFRGREPRVDALLRHNGMVSA
>Mature_687_residues
TAAANPLLDFSGLPRFDAVRPEHVAPAIRSLLDEYRALIERLTADPAAPTWDSFVAPMTETGERMGRAWGVVGHLHSVMD
VPEWREAYNAMLPEVSRFYAEVGQNLALFHKYKALRDSAEYATLSPARRRILDNEVRDFRLSGAELPDEVKPRFQAIQEE
LSQLGAKFSENLLDSTNAHAEWITDEAALAGIPEDARAAARAAAEKDGKPGWKFTLHMPSYLPVLQYADNRELRERMYRA
YATRASEQGKPEWDNGPLIGKILALREEESRLLGYNSFAEVSLVPKMADTPAQVLGFLRELAAKAKPFAERDLAELKAFA
AEELGLDDLQPWDASWVSEKLRQKRYDYSDQEVKQYFPEPKVLDGLFGVVRRLYGVDILPDEAPRWDADVRFFRLEKEGD
VVGHFYLDLHARETKRGGAWMDSARSRHVTVSGTETPVAYLVCNFPGPVNGKPATFTHDDVLTLFHETGHGLHHLLTQVD
ELAVSGIHGVEWDAVELPSQFMENFCWEWDVLQGMTAHAETGEPLPRALYDKMIAAKNFQSGMQMVRQLEFSMFDLRLHG
EVEANGQPVSMERVLDLLGEVRREVAVLIPPAWHRFPNSFSHIFAGGYAAGYYSYKWAEVLSADAFEAFEEAGAGKGSLL
DPETGARFWREILAVGGSRPAIESFKAFRGREPRVDALLRHNGMVSA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=626, Percent_Identity=31.9488817891374, Blast_Score=277, Evalue=3e-74,
Organism=Homo sapiens, GI14149738, Length=613, Percent_Identity=29.6900489396411, Blast_Score=252, Evalue=7e-67,
Organism=Homo sapiens, GI156105687, Length=684, Percent_Identity=24.4152046783626, Blast_Score=159, Evalue=1e-38,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=51.1661807580175, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=697, Percent_Identity=31.1334289813486, Blast_Score=268, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI71999758, Length=572, Percent_Identity=24.1258741258741, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32565901, Length=579, Percent_Identity=23.4887737478411, Blast_Score=108, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6319793, Length=659, Percent_Identity=26.1001517450683, Blast_Score=241, Evalue=4e-64,
Organism=Saccharomyces cerevisiae, GI6322715, Length=677, Percent_Identity=22.5997045790251, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21356111, Length=591, Percent_Identity=28.9340101522843, Blast_Score=224, Evalue=2e-58,
Organism=Drosophila melanogaster, GI20129717, Length=586, Percent_Identity=25.0853242320819, Blast_Score=138, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77293; Mature: 77162

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAANPLLDFSGLPRFDAVRPEHVAPAIRSLLDEYRALIERLTADPAAPTWDSFVAPMT
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHH
ETGERMGRAWGVVGHLHSVMDVPEWREAYNAMLPEVSRFYAEVGQNLALFHKYKALRDSA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
EYATLSPARRRILDNEVRDFRLSGAELPDEVKPRFQAIQEELSQLGAKFSENLLDSTNAH
HHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AEWITDEAALAGIPEDARAAARAAAEKDGKPGWKFTLHMPSYLPVLQYADNRELRERMYR
HHHHCCHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCHHHHHHHHH
AYATRASEQGKPEWDNGPLIGKILALREEESRLLGYNSFAEVSLVPKMADTPAQVLGFLR
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCHHHHHHHHH
ELAAKAKPFAERDLAELKAFAAEELGLDDLQPWDASWVSEKLRQKRYDYSDQEVKQYFPE
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCC
PKVLDGLFGVVRRLYGVDILPDEAPRWDADVRFFRLEKEGDVVGHFYLDLHARETKRGGA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEEEHHHCCCCCC
WMDSARSRHVTVSGTETPVAYLVCNFPGPVNGKPATFTHDDVLTLFHETGHGLHHLLTQV
HHHCCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
DELAVSGIHGVEWDAVELPSQFMENFCWEWDVLQGMTAHAETGEPLPRALYDKMIAAKNF
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
QSGMQMVRQLEFSMFDLRLHGEVEANGQPVSMERVLDLLGEVRREVAVLIPPAWHRFPNS
HHHHHHHHHHHHHHEEEEEECEEECCCCCCCHHHHHHHHHHHHHHHEEEECCHHHHCCCH
FSHIFAGGYAAGYYSYKWAEVLSADAFEAFEEAGAGKGSLLDPETGARFWREILAVGGSR
HHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCC
PAIESFKAFRGREPRVDALLRHNGMVSA
HHHHHHHHHCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
TAAANPLLDFSGLPRFDAVRPEHVAPAIRSLLDEYRALIERLTADPAAPTWDSFVAPMT
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHH
ETGERMGRAWGVVGHLHSVMDVPEWREAYNAMLPEVSRFYAEVGQNLALFHKYKALRDSA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCC
EYATLSPARRRILDNEVRDFRLSGAELPDEVKPRFQAIQEELSQLGAKFSENLLDSTNAH
HHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AEWITDEAALAGIPEDARAAARAAAEKDGKPGWKFTLHMPSYLPVLQYADNRELRERMYR
HHHHCCHHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCHHHHHHHHH
AYATRASEQGKPEWDNGPLIGKILALREEESRLLGYNSFAEVSLVPKMADTPAQVLGFLR
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHEECCCCCCCHHHHHHHHH
ELAAKAKPFAERDLAELKAFAAEELGLDDLQPWDASWVSEKLRQKRYDYSDQEVKQYFPE
HHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCC
PKVLDGLFGVVRRLYGVDILPDEAPRWDADVRFFRLEKEGDVVGHFYLDLHARETKRGGA
CHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEEEEHHHCCCCCC
WMDSARSRHVTVSGTETPVAYLVCNFPGPVNGKPATFTHDDVLTLFHETGHGLHHLLTQV
HHHCCCCCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHH
DELAVSGIHGVEWDAVELPSQFMENFCWEWDVLQGMTAHAETGEPLPRALYDKMIAAKNF
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHH
QSGMQMVRQLEFSMFDLRLHGEVEANGQPVSMERVLDLLGEVRREVAVLIPPAWHRFPNS
HHHHHHHHHHHHHHEEEEEECEEECCCCCCCHHHHHHHHHHHHHHHEEEECCHHHHCCCH
FSHIFAGGYAAGYYSYKWAEVLSADAFEAFEEAGAGKGSLLDPETGARFWREILAVGGSR
HHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCC
PAIESFKAFRGREPRVDALLRHNGMVSA
HHHHHHHHHCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]