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The map label for this gene is kdpD1 [H]

Identifier: 119899089

GI number: 119899089

Start: 3082083

End: 3083501

Strand: Direct

Name: kdpD1 [H]

Synonym: azo2799

Alternate gene names: 119899089

Gene position: 3082083-3083501 (Clockwise)

Preceding gene: 119899088

Following gene: 119899090

Centisome position: 70.43

GC content: 70.19

Gene sequence:

>1419_bases
GTGACCGCCGCGCCTCCCGTACCGCCCACCCCGCTGCAGCGCGCCCGCCCCTACCTGGCAGCGGTCGCCGGCAGTGTGCT
GGTCACCGTCTGCGCAGCCCCGCTGCGCCACGTGCTCGACCCCGCCAACATCGCCATGCTGTTCCTGCTGGCGGTCTTTC
TGGCCGCCCTGCGGCTGGGGCGCGGGCCCGCGGTGGCGATGGCCTTCGCCAACACCGTGCTGCTCGACTACGTCATCGTC
CCGCCGCACTTCGCCTTCATCCCCACCGATCTGCAATACCTCGTCACCCTCGTGGTGATGCTGACGGTGGGCTTGGTCAC
CGCACGGCTGAGCACCGGCCTGGGGCGCCAGACGCGATTGAGCGCCAGCCAGGAGCGCGACACCTCCGCCCTCTATGAAC
TGGCGCACGAACTCGCCGGCTGCATCACCCTGGAGCAGATCCGCCGCGCACTCGATGGCTACCTGACCCGCCAGCCGCGT
GAGGTGCGCCTGCTGCTGCCGGACGATCCCCCCGCCGCAGCGGCCAGCGTGGCGATCTTCCCGCTGCAGGGCACCGACCC
CAGCCGCGGCGAGCTGCACGTGCGCCTCGCCCCGCGCGAGGCCGCCCTCCCCGCGCCCGACTCCGAACGCTTCCGCACCG
TCGCGTCGCTGCTGGCCACGGCGATCGAACGCGTGCGTTACGTGGAACTGGCCGAAAGCCACGCCGTGGCGATTTCGTCC
GAGCGCTTGCGTACCTCGGTGCTCGCGGCGCTGTCGCACGACCTGCGCACGCCGATGACGGTACTGATCGGGCTCGCCGA
CAGCCTGGTGATGTCGCGCGACCCGCTGCCCCCGGAAGCCCACCAGACCGCCACCTCGCTGCTGCATCAGGCGCGCGCCC
TCAGCGGCATCCTCAACAACGTGCTCGACATGGCGCGCCTGCACAGCGGCACGATACGGCCGCGGCGCGAATGGCACCTG
CTCGACGACGTCATCGCAGCCAGCGTGCGCCTGCTCAAACCACAGTTGTCCGACCACCCGATCCGGGTGCGACTGGAGCC
CGACCTGCCGCTGGTGGAGTTCGACGCAACGTTGCTCGAACGCGTGGTGTGCAACCTGATCGACAACGCCGCCAAGTATT
CGCCCGCCGGCGCGCCGATCGAGATCACGGCCTTTGTCGATGCAGGGGGAAATCAGGCCTGCATCGAGGTCTGCGACCAG
GGCGAGGGTTTCCCTGCGGGCAACATCGACCGCCTGTTCGAACTGTTCGAGCGCGGCAACACCGAATCCAGCGTGCCGGG
CATGGGCCTCGGGCTCTCCATCTGCCAGCGCATCATGGCCGCCCACGGCGGCAGCATCGCGGTCCGCAACCGCGAACGCG
GCGCCTGCGTCCAGTTGCGGCTGCCCCTCGGCACCCCCCCGGTCATCTACGAAGAGTGA

Upstream 100 bases:

>100_bases
GCGCGGCGGCAGGACGGTGCAGGAATTAACGGCTTTTTTACAGCGCGTGCGACGGGCTCCGCTACCGTTCCGGCTCCCGT
CGCTTCTTCCACCGCCAGAC

Downstream 100 bases:

>100_bases
CAGCGATCATGGACATCACCGTGCTGGTGGTCGAGGACGAGCCGCAAATCCGCCGCCTGGTGCGCAACGCACTGGAAGGC
GAGAACTACCGCGTCTTCAC

Product: two component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MTAAPPVPPTPLQRARPYLAAVAGSVLVTVCAAPLRHVLDPANIAMLFLLAVFLAALRLGRGPAVAMAFANTVLLDYVIV
PPHFAFIPTDLQYLVTLVVMLTVGLVTARLSTGLGRQTRLSASQERDTSALYELAHELAGCITLEQIRRALDGYLTRQPR
EVRLLLPDDPPAAAASVAIFPLQGTDPSRGELHVRLAPREAALPAPDSERFRTVASLLATAIERVRYVELAESHAVAISS
ERLRTSVLAALSHDLRTPMTVLIGLADSLVMSRDPLPPEAHQTATSLLHQARALSGILNNVLDMARLHSGTIRPRREWHL
LDDVIAASVRLLKPQLSDHPIRVRLEPDLPLVEFDATLLERVVCNLIDNAAKYSPAGAPIEITAFVDAGGNQACIEVCDQ
GEGFPAGNIDRLFELFERGNTESSVPGMGLGLSICQRIMAAHGGSIAVRNRERGACVQLRLPLGTPPVIYEE

Sequences:

>Translated_472_residues
MTAAPPVPPTPLQRARPYLAAVAGSVLVTVCAAPLRHVLDPANIAMLFLLAVFLAALRLGRGPAVAMAFANTVLLDYVIV
PPHFAFIPTDLQYLVTLVVMLTVGLVTARLSTGLGRQTRLSASQERDTSALYELAHELAGCITLEQIRRALDGYLTRQPR
EVRLLLPDDPPAAAASVAIFPLQGTDPSRGELHVRLAPREAALPAPDSERFRTVASLLATAIERVRYVELAESHAVAISS
ERLRTSVLAALSHDLRTPMTVLIGLADSLVMSRDPLPPEAHQTATSLLHQARALSGILNNVLDMARLHSGTIRPRREWHL
LDDVIAASVRLLKPQLSDHPIRVRLEPDLPLVEFDATLLERVVCNLIDNAAKYSPAGAPIEITAFVDAGGNQACIEVCDQ
GEGFPAGNIDRLFELFERGNTESSVPGMGLGLSICQRIMAAHGGSIAVRNRERGACVQLRLPLGTPPVIYEE
>Mature_471_residues
TAAPPVPPTPLQRARPYLAAVAGSVLVTVCAAPLRHVLDPANIAMLFLLAVFLAALRLGRGPAVAMAFANTVLLDYVIVP
PHFAFIPTDLQYLVTLVVMLTVGLVTARLSTGLGRQTRLSASQERDTSALYELAHELAGCITLEQIRRALDGYLTRQPRE
VRLLLPDDPPAAAASVAIFPLQGTDPSRGELHVRLAPREAALPAPDSERFRTVASLLATAIERVRYVELAESHAVAISSE
RLRTSVLAALSHDLRTPMTVLIGLADSLVMSRDPLPPEAHQTATSLLHQARALSGILNNVLDMARLHSGTIRPRREWHLL
DDVIAASVRLLKPQLSDHPIRVRLEPDLPLVEFDATLLERVVCNLIDNAAKYSPAGAPIEITAFVDAGGNQACIEVCDQG
EGFPAGNIDRLFELFERGNTESSVPGMGLGLSICQRIMAAHGGSIAVRNRERGACVQLRLPLGTPPVIYEE

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=493, Percent_Identity=35.4969574036511, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI145693157, Length=257, Percent_Identity=29.1828793774319, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI48994928, Length=255, Percent_Identity=27.843137254902, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789149, Length=257, Percent_Identity=28.4046692607004, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1788279, Length=229, Percent_Identity=26.6375545851528, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1790861, Length=239, Percent_Identity=29.2887029288703, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=253, Percent_Identity=26.8774703557312, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788713, Length=221, Percent_Identity=23.9819004524887, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789808, Length=218, Percent_Identity=30.2752293577982, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=25.1121076233184, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790551, Length=222, Percent_Identity=31.0810810810811, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1788393, Length=231, Percent_Identity=24.6753246753247, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1787894, Length=248, Percent_Identity=28.6290322580645, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50906; Mature: 50775

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAPPVPPTPLQRARPYLAAVAGSVLVTVCAAPLRHVLDPANIAMLFLLAVFLAALRLG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
RGPAVAMAFANTVLLDYVIVPPHFAFIPTDLQYLVTLVVMLTVGLVTARLSTGLGRQTRL
CCCHHHHHHHHHHHHHEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
SASQERDTSALYELAHELAGCITLEQIRRALDGYLTRQPREVRLLLPDDPPAAAASVAIF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEE
PLQGTDPSRGELHVRLAPREAALPAPDSERFRTVASLLATAIERVRYVELAESHAVAISS
EECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHH
ERLRTSVLAALSHDLRTPMTVLIGLADSLVMSRDPLPPEAHQTATSLLHQARALSGILNN
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VLDMARLHSGTIRPRREWHLLDDVIAASVRLLKPQLSDHPIRVRLEPDLPLVEFDATLLE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEHHHHHHHH
RVVCNLIDNAAKYSPAGAPIEITAFVDAGGNQACIEVCDQGEGFPAGNIDRLFELFERGN
HHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
TESSVPGMGLGLSICQRIMAAHGGSIAVRNRERGACVQLRLPLGTPPVIYEE
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TAAPPVPPTPLQRARPYLAAVAGSVLVTVCAAPLRHVLDPANIAMLFLLAVFLAALRLG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCC
RGPAVAMAFANTVLLDYVIVPPHFAFIPTDLQYLVTLVVMLTVGLVTARLSTGLGRQTRL
CCCHHHHHHHHHHHHHEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHC
SASQERDTSALYELAHELAGCITLEQIRRALDGYLTRQPREVRLLLPDDPPAAAASVAIF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEE
PLQGTDPSRGELHVRLAPREAALPAPDSERFRTVASLLATAIERVRYVELAESHAVAISS
EECCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHH
ERLRTSVLAALSHDLRTPMTVLIGLADSLVMSRDPLPPEAHQTATSLLHQARALSGILNN
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
VLDMARLHSGTIRPRREWHLLDDVIAASVRLLKPQLSDHPIRVRLEPDLPLVEFDATLLE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEHHHHHHHH
RVVCNLIDNAAKYSPAGAPIEITAFVDAGGNQACIEVCDQGEGFPAGNIDRLFELFERGN
HHHHHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
TESSVPGMGLGLSICQRIMAAHGGSIAVRNRERGACVQLRLPLGTPPVIYEE
CCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1532388; 8905232; 9278503; 7499326 [H]