Click here to switch to the map view.

The map label for this gene is rppH

Identifier: 119899054

GI number: 119899054

Start: 3044471

End: 3044998

Strand: Reverse

Name: rppH

Synonym: azo2764

Alternate gene names: 119899054

Gene position: 3044998-3044471 (Counterclockwise)

Preceding gene: 119899057

Following gene: 119899053

Centisome position: 69.58

GC content: 61.93

Gene sequence:

>528_bases
ATGCTCGACCGCGAAGGCTATCGCCCGAACGTCGGCATCATTCTGGTGAACGCGCGCAACGAGGTGTTCTGGGGCAAACG
GATCCGCGAACATTCCTGGCAGTTTCCGCAAGGCGGCATCAAGCACGGCGAGTCGCCGGAGCAGGCCATGTACCGGGAAC
TGTACGAAGAAGTCGGATTGCGTCCCGAGCACGTGAAGATTCTCGGTCGCACGCGTGGCTGGTTGAGGTACGACGTTCCC
AAGCACTGGATCAGGCGGGAGTGGCGCAACACGTATCGCGGGCAGAAGCAGATCTGGTATCTGCTCCGCCTCGTCGGTCG
CGATACCGACGTTTGCCTTCGGGCCAGCACGCATCCGGAATTCGATGCCTGGCGCTGGAGCGAATACTGGGTGCCACTGG
AAGCGGTGATCGAGTTCAAGCGGCAGGTGTATCAGCAGGCGCTGACCGAGTTGTCGCGTCTGCTGTTCCGCAGCAAGCCG
GCCGAATTGCCGGAAGGCTATCGCCAAGGCACTGCCTCGCAGGCGTGA

Upstream 100 bases:

>100_bases
CAACGGCCGCTGCGGCGCGGAACCGCCCTCCCGGCGCGCTTTCCAAGCACGGGCAAGTGTGAAAAAATCCGACACAGTCA
AAGAAATCTGAAGGTTCATC

Downstream 100 bases:

>100_bases
TGCCGAGCGGGGCGCCGCGGTCCGCGGGTCCCGCCTGTTCCTACTCTTGGAGCATTCCCTTGAAGCGTTGCATTACTGGT
GTGCTGACCCTCGCGCTGCT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MLDREGYRPNVGIILVNARNEVFWGKRIREHSWQFPQGGIKHGESPEQAMYRELYEEVGLRPEHVKILGRTRGWLRYDVP
KHWIRREWRNTYRGQKQIWYLLRLVGRDTDVCLRASTHPEFDAWRWSEYWVPLEAVIEFKRQVYQQALTELSRLLFRSKP
AELPEGYRQGTASQA

Sequences:

>Translated_175_residues
MLDREGYRPNVGIILVNARNEVFWGKRIREHSWQFPQGGIKHGESPEQAMYRELYEEVGLRPEHVKILGRTRGWLRYDVP
KHWIRREWRNTYRGQKQIWYLLRLVGRDTDVCLRASTHPEFDAWRWSEYWVPLEAVIEFKRQVYQQALTELSRLLFRSKP
AELPEGYRQGTASQA
>Mature_175_residues
MLDREGYRPNVGIILVNARNEVFWGKRIREHSWQFPQGGIKHGESPEQAMYRELYEEVGLRPEHVKILGRTRGWLRYDVP
KHWIRREWRNTYRGQKQIWYLLRLVGRDTDVCLRASTHPEFDAWRWSEYWVPLEAVIEFKRQVYQQALTELSRLLFRSKP
AELPEGYRQGTASQA

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=156, Percent_Identity=51.2820512820513, Blast_Score=179, Evalue=7e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_AZOSB (A1K975)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_934267.1
- ProteinModelPortal:   A1K975
- SMR:   A1K975
- STRING:   A1K975
- GeneID:   4607604
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo2764
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- PhylomeDB:   A1K975
- ProtClustDB:   PRK00714
- BioCyc:   ASP62928:AZO2764-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 21069; Mature: 21069

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDREGYRPNVGIILVNARNEVFWGKRIREHSWQFPQGGIKHGESPEQAMYRELYEEVGL
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
RPEHVKILGRTRGWLRYDVPKHWIRREWRNTYRGQKQIWYLLRLVGRDTDVCLRASTHPE
CHHHHHHEECCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCC
FDAWRWSEYWVPLEAVIEFKRQVYQQALTELSRLLFRSKPAELPEGYRQGTASQA
CCCEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCC
>Mature Secondary Structure
MLDREGYRPNVGIILVNARNEVFWGKRIREHSWQFPQGGIKHGESPEQAMYRELYEEVGL
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
RPEHVKILGRTRGWLRYDVPKHWIRREWRNTYRGQKQIWYLLRLVGRDTDVCLRASTHPE
CHHHHHHEECCCCCEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEECCCCCC
FDAWRWSEYWVPLEAVIEFKRQVYQQALTELSRLLFRSKPAELPEGYRQGTASQA
CCCEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA