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The map label for this gene is eutG [H]

Identifier: 119898990

GI number: 119898990

Start: 2978078

End: 2979187

Strand: Direct

Name: eutG [H]

Synonym: azo2700

Alternate gene names: 119898990

Gene position: 2978078-2979187 (Clockwise)

Preceding gene: 119898989

Following gene: 119898991

Centisome position: 68.05

GC content: 69.55

Gene sequence:

>1110_bases
GTGCCGCTTACCGCCTGGAGCTACCACAACCCGGTCAGGGTCGTCGGCGCCAGCCTGTCGACGCTGGCCCCGCAGTTGCC
GCACGGAAGGCGTGTATTGCTGGTGACCAGCCGCGGCGCCGCGGAGCGGGGAATCGCCCGTCAGCTCGAAGCGGCCCTGC
CCGGCCGGACGGTCGCGCTACTGGATGATGTCGCCCCCAACCCCGACCTCCGCTACCTGGACGAAACGGCTGCCCGCCTG
CGGGGTACGGAAATCGATCTGGTGATTGCGCTCGGCGGCGGCAGCGTTCTCGACGCGGGCAAGGTGCTCGCCCTCCTCCT
GCGCCGTCCGGAACCCGATCTGCTCGCGCAGTGCTTCCGCAACAGGCGCGATGTCGCGTGGACCGCGCGGCTGCCCTTGG
TCGCCATTCCGACCACGGCGGGCGCCGGTGCCGAAGTGACGCCGTTCGCGACGGTGTGGGATCACGAACGCAGCGCCAAG
CACTCGCTCGCCACCCCCTTCGCCTATCCAGACCTTGCGGTGCTGGACGCAGCGCTGACGCTGACGCTTCCGCCGGAGCA
CACCTTGTACCCGGCGCTGGACGCCCTGTCCCACGCACTGGAGTCGCTGTGGAACCGCAGCGCGACGCCGGTCAGCCGCG
GGCTGGCCCTTCAGGCCCTGGCGCTGGCCAGCCGCGCACTACCCGAGGTGCTTGCGCAGCCGGGCGATCTCGCGCGCCGG
GCAGACATGCAACACGCCAGCCTCCTTGCCGGCATGGCGATCAGTCAGACGAGGACCGCGGTCGCCCATGCGATCTCCTA
CCCCCTGACCCTCCACCACGGCGTTCCCCACGGGCTCGCCTGCAGCTTCACGCTGCCCACGCTCCTGCGCACCAACCTCG
ACCGCATTGCGCACAACCCGTCGGAACGTCTGCTGCTGGAAGCGGTGCTGGCGATGCTCGACACCTTCGGCCTGGGCCAG
CGCCTGCTCCAGTATCTGCAGCGCGATGACGTGCGGCGGCTGCATGGCGAAATGTTTACCGCCGAGCGCAGCAACAACTA
CAACGGGGTGCCGTTCGCCGACGTGGCCGAGATCATCGATTCCGCCCTTGCGCAGACGGGCAAGGACTAG

Upstream 100 bases:

>100_bases
TTGAAGCTGCGCTGCGGCTCGCGCAAGGATCTCGGACGGCCGACCACGAGCACCTGGGACAACAAGCAGGCCTTCATGGA
AGCCGCCGGTGACTGACACC

Downstream 100 bases:

>100_bases
CAAGCACGGCAAGACATGCTCGAGAAGACCCTTTTCGCAATCCTGCATCCGCTGTGGCGCCTCTACGACCTGATCGCCCC
GAAGCGGGCAGACCACTGGG

Product: alcohol dehydrogenase

Products: aldehyde; ketone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MPLTAWSYHNPVRVVGASLSTLAPQLPHGRRVLLVTSRGAAERGIARQLEAALPGRTVALLDDVAPNPDLRYLDETAARL
RGTEIDLVIALGGGSVLDAGKVLALLLRRPEPDLLAQCFRNRRDVAWTARLPLVAIPTTAGAGAEVTPFATVWDHERSAK
HSLATPFAYPDLAVLDAALTLTLPPEHTLYPALDALSHALESLWNRSATPVSRGLALQALALASRALPEVLAQPGDLARR
ADMQHASLLAGMAISQTRTAVAHAISYPLTLHHGVPHGLACSFTLPTLLRTNLDRIAHNPSERLLLEAVLAMLDTFGLGQ
RLLQYLQRDDVRRLHGEMFTAERSNNYNGVPFADVAEIIDSALAQTGKD

Sequences:

>Translated_369_residues
MPLTAWSYHNPVRVVGASLSTLAPQLPHGRRVLLVTSRGAAERGIARQLEAALPGRTVALLDDVAPNPDLRYLDETAARL
RGTEIDLVIALGGGSVLDAGKVLALLLRRPEPDLLAQCFRNRRDVAWTARLPLVAIPTTAGAGAEVTPFATVWDHERSAK
HSLATPFAYPDLAVLDAALTLTLPPEHTLYPALDALSHALESLWNRSATPVSRGLALQALALASRALPEVLAQPGDLARR
ADMQHASLLAGMAISQTRTAVAHAISYPLTLHHGVPHGLACSFTLPTLLRTNLDRIAHNPSERLLLEAVLAMLDTFGLGQ
RLLQYLQRDDVRRLHGEMFTAERSNNYNGVPFADVAEIIDSALAQTGKD
>Mature_368_residues
PLTAWSYHNPVRVVGASLSTLAPQLPHGRRVLLVTSRGAAERGIARQLEAALPGRTVALLDDVAPNPDLRYLDETAARLR
GTEIDLVIALGGGSVLDAGKVLALLLRRPEPDLLAQCFRNRRDVAWTARLPLVAIPTTAGAGAEVTPFATVWDHERSAKH
SLATPFAYPDLAVLDAALTLTLPPEHTLYPALDALSHALESLWNRSATPVSRGLALQALALASRALPEVLAQPGDLARRA
DMQHASLLAGMAISQTRTAVAHAISYPLTLHHGVPHGLACSFTLPTLLRTNLDRIAHNPSERLLLEAVLAMLDTFGLGQR
LLQYLQRDDVRRLHGEMFTAERSNNYNGVPFADVAEIIDSALAQTGKD

Specific function: May act on the acetaldehyde produced from the degradation of ethanolamine [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=272, Percent_Identity=26.8382352941176, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87082107, Length=268, Percent_Identity=35.8208955223881, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1787493, Length=284, Percent_Identity=30.9859154929577, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI48994951, Length=292, Percent_Identity=30.4794520547945, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1789163, Length=272, Percent_Identity=29.0441176470588, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1789386, Length=304, Percent_Identity=25.6578947368421, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=292, Percent_Identity=26.027397260274, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6321181, Length=266, Percent_Identity=29.3233082706767, Blast_Score=123, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24657991, Length=324, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: 1.1.1.1

Molecular weight: Translated: 39757; Mature: 39626

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTAWSYHNPVRVVGASLSTLAPQLPHGRRVLLVTSRGAAERGIARQLEAALPGRTVAL
CCCCCCCCCCCHHHHCCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
LDDVAPNPDLRYLDETAARLRGTEIDLVIALGGGSVLDAGKVLALLLRRPEPDLLAQCFR
ECCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHH
NRRDVAWTARLPLVAIPTTAGAGAEVTPFATVWDHERSAKHSLATPFAYPDLAVLDAALT
CCCCEEEEECCCEEEECCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCCCCCHHHHHHEEE
LTLPPEHTLYPALDALSHALESLWNRSATPVSRGLALQALALASRALPEVLAQPGDLARR
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ADMQHASLLAGMAISQTRTAVAHAISYPLTLHHGVPHGLACSFTLPTLLRTNLDRIAHNP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCC
SERLLLEAVLAMLDTFGLGQRLLQYLQRDDVRRLHGEMFTAERSNNYNGVPFADVAEIID
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
SALAQTGKD
HHHHHCCCC
>Mature Secondary Structure 
PLTAWSYHNPVRVVGASLSTLAPQLPHGRRVLLVTSRGAAERGIARQLEAALPGRTVAL
CCCCCCCCCCHHHHCCCHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEE
LDDVAPNPDLRYLDETAARLRGTEIDLVIALGGGSVLDAGKVLALLLRRPEPDLLAQCFR
ECCCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHH
NRRDVAWTARLPLVAIPTTAGAGAEVTPFATVWDHERSAKHSLATPFAYPDLAVLDAALT
CCCCEEEEECCCEEEECCCCCCCCCCCCCHHHHCCCHHHHHHCCCCCCCCCHHHHHHEEE
LTLPPEHTLYPALDALSHALESLWNRSATPVSRGLALQALALASRALPEVLAQPGDLARR
EECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ADMQHASLLAGMAISQTRTAVAHAISYPLTLHHGVPHGLACSFTLPTLLRTNLDRIAHNP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCC
SERLLLEAVLAMLDTFGLGQRLLQYLQRDDVRRLHGEMFTAERSNNYNGVPFADVAEIID
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
SALAQTGKD
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NAD+

Specific reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]