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The map label for this gene is pcaK [H]

Identifier: 119898834

GI number: 119898834

Start: 2810683

End: 2812047

Strand: Reverse

Name: pcaK [H]

Synonym: azo2543

Alternate gene names: 119898834

Gene position: 2812047-2810683 (Counterclockwise)

Preceding gene: 119898835

Following gene: 119898833

Centisome position: 64.26

GC content: 68.64

Gene sequence:

>1365_bases
ATGAATCAGCAGCGGCCTGTCGATGTGCAGGCTTTCATCAACCAGCATCCCTTCTCGCGCTTCCAGTGGTCGGTGTTCGC
GCTGTGCTTCGTCATCGTGCTGCTCGATGGTTTCGATACCGCCGCCATCGGTTACATCGCGCCGTCGCTGATCAATGAAT
GGGGCGTCTCGCGCCCGGCACTGGCGCCGGTGCTGAGCGCCGCGCTGTTCGGCCTGGCCGGCGGCGCGCTGTCCGCCGGG
CCGCTGGCGGACCGCTTCGGGCGCAAGGAAGTGCTGGTGGGCTCGGTGCTGCTGTTCGGCGTCGCCTGCCTTGCGTCGGC
TTTCGTGGCCGACCTGACGATGCTGACCGCGATGCGTTTCGTCACCGGGCTCGGCCTGGGCGCCGCGATGCCCAACGCGG
TGACGCTGATGAGCGAATACTGCCCCGACCAGCGCCGCGCGATGCTGACCAACGCGATGTTCTGCGGCTTTCCGCTCGGC
GCCGCCTTCGGCGGCTTCCTCGCCTCGTGGATGATTCCCCACTTCGGCTGGCGCAGCGTGTTGATGCTGGGCGGCATCGC
GCCGCTGGTGCTGGTGCTGCTGCTGGTGCTGGTGCTGCCGGAATCGGTGCGCTACATGGTGGCGCGCGCCTATCCGGCCG
AACGCATCCGCGCGGTGCTGAGCCGCATCTCCGCCACCGCGGCGCAGGCCGGCAGCTTCGTGATGAGTGAAACCCGTCCC
GCGGCCAACGGGCGGCGCGGCCTGGGCGTGGTGTTCTCGCGCGAGTACCGCGTCGGCTCGCTGATGCTGTGGCTGGCCTA
CTTCATGGGGCTGGTGATCTTCTACGCGCTGATCAACTGGATGCCGATCCTGTTCAAGGACGCAGGCCTCGAACCGCAGC
ACGCCACGCTGATCTCCGCGCTGTTCCCGCTCGGCGGCGTGGGCGCGGTGTTTTTCGGCTGGCTGATGGACCGCTTCAAC
GGCAACTTCATCATCGCCGTCGGCTATGCCTTCACCGCGGTGTCGATCTACGCGATCGGCCAGGTCGCCGGCAATGTGGG
TGCGCTGGTGGTGCTGGTGTTCGTCGCCGGCACCATCATGAACACCGCGCAGTCGTCGATGCCCGCGCTCGCCGCCGGCT
TCTATCCCACGGCGGGGCGCGCCACCGGCGTGGCCTGGATGCTCGGCATCGGCCGCTTCGGCGGCATCGCCGGCTCCTTC
CTGGTGGCCGAACTGTCCCGCCGCCAGCTCGCCTTCGACCAGATCTTCATGGTGGTCGCGCTGCCCGGGGCGATCGCCGC
GATCGCGCTGCTGGTCAAGCAGTCCTCCCACCCCGAAACGCCGGACGAAGCCGGGGCGACCCGCGCCGAAGCGCACGCCC
ACTGA

Upstream 100 bases:

>100_bases
CGAATTCGATCCACACCCAAGCCCGAGGGGTCCGCCGCCGCGGCGGGCCTGCGAGGCGCCGCAGAGCGCCCTTCACCCAT
CACGCTTTCGGAGACGCGTA

Downstream 100 bases:

>100_bases
AGCGCCATGCCCGCATCCACGCCCATTCGATAAAGGACCAGAACATGATCATCGATTGCCACGGCCACTACACCACCGCG
CCCAAGGCGCTGGAAGAATG

Product: putative 4-hydroxybenzoate transporter protein

Products: Proton [Cytoplasm]; 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MNQQRPVDVQAFINQHPFSRFQWSVFALCFVIVLLDGFDTAAIGYIAPSLINEWGVSRPALAPVLSAALFGLAGGALSAG
PLADRFGRKEVLVGSVLLFGVACLASAFVADLTMLTAMRFVTGLGLGAAMPNAVTLMSEYCPDQRRAMLTNAMFCGFPLG
AAFGGFLASWMIPHFGWRSVLMLGGIAPLVLVLLLVLVLPESVRYMVARAYPAERIRAVLSRISATAAQAGSFVMSETRP
AANGRRGLGVVFSREYRVGSLMLWLAYFMGLVIFYALINWMPILFKDAGLEPQHATLISALFPLGGVGAVFFGWLMDRFN
GNFIIAVGYAFTAVSIYAIGQVAGNVGALVVLVFVAGTIMNTAQSSMPALAAGFYPTAGRATGVAWMLGIGRFGGIAGSF
LVAELSRRQLAFDQIFMVVALPGAIAAIALLVKQSSHPETPDEAGATRAEAHAH

Sequences:

>Translated_454_residues
MNQQRPVDVQAFINQHPFSRFQWSVFALCFVIVLLDGFDTAAIGYIAPSLINEWGVSRPALAPVLSAALFGLAGGALSAG
PLADRFGRKEVLVGSVLLFGVACLASAFVADLTMLTAMRFVTGLGLGAAMPNAVTLMSEYCPDQRRAMLTNAMFCGFPLG
AAFGGFLASWMIPHFGWRSVLMLGGIAPLVLVLLLVLVLPESVRYMVARAYPAERIRAVLSRISATAAQAGSFVMSETRP
AANGRRGLGVVFSREYRVGSLMLWLAYFMGLVIFYALINWMPILFKDAGLEPQHATLISALFPLGGVGAVFFGWLMDRFN
GNFIIAVGYAFTAVSIYAIGQVAGNVGALVVLVFVAGTIMNTAQSSMPALAAGFYPTAGRATGVAWMLGIGRFGGIAGSF
LVAELSRRQLAFDQIFMVVALPGAIAAIALLVKQSSHPETPDEAGATRAEAHAH
>Mature_454_residues
MNQQRPVDVQAFINQHPFSRFQWSVFALCFVIVLLDGFDTAAIGYIAPSLINEWGVSRPALAPVLSAALFGLAGGALSAG
PLADRFGRKEVLVGSVLLFGVACLASAFVADLTMLTAMRFVTGLGLGAAMPNAVTLMSEYCPDQRRAMLTNAMFCGFPLG
AAFGGFLASWMIPHFGWRSVLMLGGIAPLVLVLLLVLVLPESVRYMVARAYPAERIRAVLSRISATAAQAGSFVMSETRP
AANGRRGLGVVFSREYRVGSLMLWLAYFMGLVIFYALINWMPILFKDAGLEPQHATLISALFPLGGVGAVFFGWLMDRFN
GNFIIAVGYAFTAVSIYAIGQVAGNVGALVVLVFVAGTIMNTAQSSMPALAAGFYPTAGRATGVAWMLGIGRFGGIAGSF
LVAELSRRQLAFDQIFMVVALPGAIAAIALLVKQSSHPETPDEAGATRAEAHAH

Specific function: Transporter for 4-hydroxybenzoate. Also required for chemotaxis to aromatic acids [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=480, Percent_Identity=24.7916666666667, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI166064021, Length=361, Percent_Identity=25.4847645429363, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI8923870, Length=380, Percent_Identity=26.0526315789474, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI7662270, Length=330, Percent_Identity=20.9090909090909, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87081723, Length=379, Percent_Identity=34.0369393139842, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87082231, Length=449, Percent_Identity=25.6124721603563, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1789207, Length=280, Percent_Identity=29.2857142857143, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788068, Length=402, Percent_Identity=23.6318407960199, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1788074, Length=426, Percent_Identity=23.0046948356808, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082404, Length=387, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI87082159, Length=287, Percent_Identity=27.5261324041812, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI48994889, Length=121, Percent_Identity=33.0578512396694, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1789312, Length=280, Percent_Identity=28.9285714285714, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI32564663, Length=459, Percent_Identity=23.7472766884532, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19922874, Length=445, Percent_Identity=24.2696629213483, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24640198, Length=463, Percent_Identity=23.5421166306695, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24640196, Length=463, Percent_Identity=23.5421166306695, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24640200, Length=463, Percent_Identity=23.5421166306695, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004746
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48187; Mature: 48187

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 3-(3-hydroxyphenyl)propionate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 3-(3-hydroxyphenyl)propionate [Periplasm] = Proton [Cytoplasm] + 3-(3-hydroxyphenyl)propionate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7961399 [H]