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The map label for this gene is lldD [H]

Identifier: 119898761

GI number: 119898761

Start: 2727286

End: 2728407

Strand: Reverse

Name: lldD [H]

Synonym: azo2470

Alternate gene names: 119898761

Gene position: 2728407-2727286 (Counterclockwise)

Preceding gene: 119898762

Following gene: 119898760

Centisome position: 62.35

GC content: 68.27

Gene sequence:

>1122_bases
ATGGATATCGATGACTTGCGCCGGCAGGCGCGGCGCTTCCTGCCCCGGTTCGTATTCGATTTTCTGGAGGGCGGGGCAGG
GGATGAAACCTGTCTGCAGGAGAACCTCGCCGCGCTGCGCAACATCAGGCTGTGGCCGAGCGTGCTGCGCGACACCTCCG
GGATCGATACCTCGATCGAAGTATTCGGTGAGCGTTGGCGCCTGCCGTTTGCCGTCGCGCCGACCGGGTTCAACGGACTG
TTCCGGCCCGACGGCGACATCCTGATCGCGCGCGCAGCGGCGCGTGCGGGCGTTCCCTTCAGCCTGTCCACCGCATCCAA
TACGCGCCTCGAGGAGGTGGCAAGGCAGGCGGACGGGCTCCGCTGGTTGCAGCTGTACGTGATGGGCGACCGTTCGATCG
CGGAGCAGATCATGCGGCGGGGTTGGGACGCCGGCTACCGGGTACTGGTGCTGACGGTGGATGTGCCTGTAAACGGGTAT
CGGAAGCGCGATATCCGCAACGGTTTCCGGCTGCCGTTCCGGCCGGGGCTGATGACCGCCCTCGATCTCGCCCGTCATCC
GCGCTGGATATTGCAGTTCGCGGGGCGGCGGTTCCCGAATTTCGCCAACCTCAGCGAACACCCGGATACCGCGGCTTCGG
CCCAGGTGCAGGCCGCACTGCTCAATCGCACCATGGACAGGACGCTGGCGTGGGAGAGCCTGAGCTGGGTACGGGCCCAC
TGGAAGGGGCCGGTCGTGGTCAAGGGCGTGCTGCACCCGGACGACGCCGCGCGGGCGGTCGCCGAAGGCGCGGACGGCAT
CGTGGTGTCCAACCACGGCGGCCGGCAGCTGAAGTCGGCGCCCGCCACCATCGAGGCCCTGCCGCTGGTGGTCGAGCGGG
TCGATGGCGCGGTTCCCGTGTTCGTGGATGGCGGATTCCGCTCCGGCGAGGATGTGGCGAAGGCGCTCGGCAGAGGGGCG
AAGGCGGTGTTCCTCGGTCGTCCCGTTCTGTACGGTCTGGCCGCCGCCGGCGAGGCCGGCGTGGAGCGGGTGTTCGACTG
GCTGCGGGAGGACCTGGAACGGACCATGATCCTGATGGGACGACGGCGCATTGACGAACTGGCCACCGGGTGGCGACCGT
GA

Upstream 100 bases:

>100_bases
GACCCGAGCCTTGCTGGCCCTGGTCAGGCTCGTCGAGGCTGGTCGCAGTACGCCCTCGGCCTGACCGGCCGAGATTCCCC
CGCTTTTGAATGAAGAATGA

Downstream 100 bases:

>100_bases
GGTGGGTTGCGAAGGCCGGCCCCAGGTCGAACGGCAATGGGTCGATCAGGGTGAAATCCACCGCCTAGACTCAAGGAGTC
CGACACTTCCCGGGAGCAGC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L(+)-mandelate dehydrogenase; MDH [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MDIDDLRRQARRFLPRFVFDFLEGGAGDETCLQENLAALRNIRLWPSVLRDTSGIDTSIEVFGERWRLPFAVAPTGFNGL
FRPDGDILIARAAARAGVPFSLSTASNTRLEEVARQADGLRWLQLYVMGDRSIAEQIMRRGWDAGYRVLVLTVDVPVNGY
RKRDIRNGFRLPFRPGLMTALDLARHPRWILQFAGRRFPNFANLSEHPDTAASAQVQAALLNRTMDRTLAWESLSWVRAH
WKGPVVVKGVLHPDDAARAVAEGADGIVVSNHGGRQLKSAPATIEALPLVVERVDGAVPVFVDGGFRSGEDVAKALGRGA
KAVFLGRPVLYGLAAAGEAGVERVFDWLREDLERTMILMGRRRIDELATGWRP

Sequences:

>Translated_373_residues
MDIDDLRRQARRFLPRFVFDFLEGGAGDETCLQENLAALRNIRLWPSVLRDTSGIDTSIEVFGERWRLPFAVAPTGFNGL
FRPDGDILIARAAARAGVPFSLSTASNTRLEEVARQADGLRWLQLYVMGDRSIAEQIMRRGWDAGYRVLVLTVDVPVNGY
RKRDIRNGFRLPFRPGLMTALDLARHPRWILQFAGRRFPNFANLSEHPDTAASAQVQAALLNRTMDRTLAWESLSWVRAH
WKGPVVVKGVLHPDDAARAVAEGADGIVVSNHGGRQLKSAPATIEALPLVVERVDGAVPVFVDGGFRSGEDVAKALGRGA
KAVFLGRPVLYGLAAAGEAGVERVFDWLREDLERTMILMGRRRIDELATGWRP
>Mature_373_residues
MDIDDLRRQARRFLPRFVFDFLEGGAGDETCLQENLAALRNIRLWPSVLRDTSGIDTSIEVFGERWRLPFAVAPTGFNGL
FRPDGDILIARAAARAGVPFSLSTASNTRLEEVARQADGLRWLQLYVMGDRSIAEQIMRRGWDAGYRVLVLTVDVPVNGY
RKRDIRNGFRLPFRPGLMTALDLARHPRWILQFAGRRFPNFANLSEHPDTAASAQVQAALLNRTMDRTLAWESLSWVRAH
WKGPVVVKGVLHPDDAARAVAEGADGIVVSNHGGRQLKSAPATIEALPLVVERVDGAVPVFVDGGFRSGEDVAKALGRGA
KAVFLGRPVLYGLAAAGEAGVERVFDWLREDLERTMILMGRRRIDELATGWRP

Specific function: Reduction of (S)-mandelate to benzoylformate [H]

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI54234014, Length=366, Percent_Identity=39.6174863387978, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI7705393, Length=366, Percent_Identity=39.6174863387978, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI11068137, Length=363, Percent_Identity=38.8429752066116, Blast_Score=258, Evalue=4e-69,
Organism=Escherichia coli, GI1790033, Length=364, Percent_Identity=36.8131868131868, Blast_Score=247, Evalue=7e-67,
Organism=Caenorhabditis elegans, GI193208036, Length=373, Percent_Identity=37.8016085790885, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI32566217, Length=290, Percent_Identity=34.4827586206897, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6323587, Length=378, Percent_Identity=32.010582010582, Blast_Score=179, Evalue=6e-46,
Organism=Drosophila melanogaster, GI78707188, Length=368, Percent_Identity=39.1304347826087, Blast_Score=249, Evalue=1e-66,
Organism=Drosophila melanogaster, GI281363140, Length=368, Percent_Identity=39.1304347826087, Blast_Score=249, Evalue=1e-66,
Organism=Drosophila melanogaster, GI78707190, Length=368, Percent_Identity=39.1304347826087, Blast_Score=249, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.99.31 [H]

Molecular weight: Translated: 41385; Mature: 41385

Theoretical pI: Translated: 10.27; Mature: 10.27

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDDLRRQARRFLPRFVFDFLEGGAGDETCLQENLAALRNIRLWPSVLRDTSGIDTSIE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHH
VFGERWRLPFAVAPTGFNGLFRPDGDILIARAAARAGVPFSLSTASNTRLEEVARQADGL
HHHHHHCCCEEECCCCCCCCCCCCCCEEEEEHHHHCCCCEEECCCCCHHHHHHHHHHCCC
RWLQLYVMGDRSIAEQIMRRGWDAGYRVLVLTVDVPVNGYRKRDIRNGFRLPFRPGLMTA
EEEEEEEECCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHCCCCCCCCCCHHHH
LDLARHPRWILQFAGRRFPNFANLSEHPDTAASAQVQAALLNRTMDRTLAWESLSWVRAH
HHHHHCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WKGPVVVKGVLHPDDAARAVAEGADGIVVSNHGGRQLKSAPATIEALPLVVERVDGAVPV
CCCCEEEEEEECCCHHHHHHHCCCCCEEEECCCCCCHHCCCCHHHHHHHHHHHHCCCCEE
FVDGGFRSGEDVAKALGRGAKAVFLGRPVLYGLAAAGEAGVERVFDWLREDLERTMILMG
EEECCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RRRIDELATGWRP
HHHHHHHHCCCCC
>Mature Secondary Structure
MDIDDLRRQARRFLPRFVFDFLEGGAGDETCLQENLAALRNIRLWPSVLRDTSGIDTSIE
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCCCCHHHH
VFGERWRLPFAVAPTGFNGLFRPDGDILIARAAARAGVPFSLSTASNTRLEEVARQADGL
HHHHHHCCCEEECCCCCCCCCCCCCCEEEEEHHHHCCCCEEECCCCCHHHHHHHHHHCCC
RWLQLYVMGDRSIAEQIMRRGWDAGYRVLVLTVDVPVNGYRKRDIRNGFRLPFRPGLMTA
EEEEEEEECCHHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHHHHHCCCCCCCCCCHHHH
LDLARHPRWILQFAGRRFPNFANLSEHPDTAASAQVQAALLNRTMDRTLAWESLSWVRAH
HHHHHCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WKGPVVVKGVLHPDDAARAVAEGADGIVVSNHGGRQLKSAPATIEALPLVVERVDGAVPV
CCCCEEEEEEECCCHHHHHHHCCCCCEEEECCCCCCHHCCCCHHHHHHHHHHHHCCCCEE
FVDGGFRSGEDVAKALGRGAKAVFLGRPVLYGLAAAGEAGVERVFDWLREDLERTMILMG
EEECCCCCHHHHHHHHCCCCCEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RRRIDELATGWRP
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2271624 [H]