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The map label for this gene is nagK [H]

Identifier: 119898712

GI number: 119898712

Start: 2674933

End: 2675643

Strand: Direct

Name: nagK [H]

Synonym: azo2421

Alternate gene names: 119898712

Gene position: 2674933-2675643 (Clockwise)

Preceding gene: 119898711

Following gene: 119898713

Centisome position: 61.13

GC content: 66.53

Gene sequence:

>711_bases
ATGTCCCAGACCCATTACCTGTGGAACCCCTCGCCGGTCTATTCGCTGCCGGTGAAGGGCGTCGATGCCCGCTTTCCGGT
CAAGCGCATCTTCTGCGTCGGCCGCAACTACCACGCCCACGCGGTGGAAATGGGCCGCCCGGTCGACAAATCGACCATGG
CCCCCTTCTACTTCCTGAAGGACGCCTCCACGCTGGTGGAGTCCGGCGCCACCGTGCCCTACCCCACCGGCACCAGCAAC
TACCACTACGAGATGGAACTGGTGGTGGCGATCGGCAAGGCGGGCTTCCGCGTCGCCGAGGCCGATGCGGACTCGCTCAT
CTACGGCTATGCCGCCGGGTTGGACATGACCCGCCGCGACCTGCAGCTGGTGGCCCGCGAACAGGGCCGCCCGTGGGACC
TCGGCAAGAACTTCGAGAACTCCGCGGTCTGCACCGAGATCATCCCCGCCGCCGGCGGCGCCGTGCTCGACAAGGGCGCG
ATCAACCTGCAGGTCAACGGCGAGACCAGGCAGAGCGCCGACCTCTCGATGCTGATCTGGAACATCCGCGAAATCATCGC
CGACCTGTCGAAGTTCTATCACCTGGAGCCGGGCGACCTGATCTACACCGGCACCCCGGAAGGCGTCGGCGCGGTCAAGA
GCGGCGACCGCATCACCGGCCATATCGACGGTGTGGGCGACGTCGCGCTGACGATCGGCGCCGCCGAGTAA

Upstream 100 bases:

>100_bases
AAGTCCGCTGCACAAGAAGTTGGGGCTGTACGAAGTGCGGACCTGAGCGACGCCCTCACCGGACCCACCGCACCCGAATC
CCAAATAACGGAGATACCCG

Downstream 100 bases:

>100_bases
TCCTGCGCGGCGCCGCAATCACCTCATCCGGAGGAGACAGACATGAGCGAACAACTTCCCGTCATCGTCATCGGCGGTGG
CATCGGCGGCCTGGCCGCCG

Product: fumarylpyruvate hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSQTHYLWNPSPVYSLPVKGVDARFPVKRIFCVGRNYHAHAVEMGRPVDKSTMAPFYFLKDASTLVESGATVPYPTGTSN
YHYEMELVVAIGKAGFRVAEADADSLIYGYAAGLDMTRRDLQLVAREQGRPWDLGKNFENSAVCTEIIPAAGGAVLDKGA
INLQVNGETRQSADLSMLIWNIREIIADLSKFYHLEPGDLIYTGTPEGVGAVKSGDRITGHIDGVGDVALTIGAAE

Sequences:

>Translated_236_residues
MSQTHYLWNPSPVYSLPVKGVDARFPVKRIFCVGRNYHAHAVEMGRPVDKSTMAPFYFLKDASTLVESGATVPYPTGTSN
YHYEMELVVAIGKAGFRVAEADADSLIYGYAAGLDMTRRDLQLVAREQGRPWDLGKNFENSAVCTEIIPAAGGAVLDKGA
INLQVNGETRQSADLSMLIWNIREIIADLSKFYHLEPGDLIYTGTPEGVGAVKSGDRITGHIDGVGDVALTIGAAE
>Mature_235_residues
SQTHYLWNPSPVYSLPVKGVDARFPVKRIFCVGRNYHAHAVEMGRPVDKSTMAPFYFLKDASTLVESGATVPYPTGTSNY
HYEMELVVAIGKAGFRVAEADADSLIYGYAAGLDMTRRDLQLVAREQGRPWDLGKNFENSAVCTEIIPAAGGAVLDKGAI
NLQVNGETRQSADLSMLIWNIREIIADLSKFYHLEPGDLIYTGTPEGVGAVKSGDRITGHIDGVGDVALTIGAAE

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI215422413, Length=202, Percent_Identity=41.0891089108911, Blast_Score=141, Evalue=4e-34,
Organism=Homo sapiens, GI13654274, Length=209, Percent_Identity=39.7129186602871, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI66348062, Length=198, Percent_Identity=41.4141414141414, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI156231349, Length=229, Percent_Identity=33.6244541484716, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI40786394, Length=213, Percent_Identity=32.8638497652582, Blast_Score=106, Evalue=2e-23,
Organism=Escherichia coli, GI1787428, Length=207, Percent_Identity=36.7149758454106, Blast_Score=137, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI17557057, Length=190, Percent_Identity=35.7894736842105, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324161, Length=224, Percent_Identity=30.3571428571429, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI28571789, Length=202, Percent_Identity=36.6336633663366, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI28572127, Length=221, Percent_Identity=31.2217194570136, Blast_Score=95, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 25566; Mature: 25435

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTHYLWNPSPVYSLPVKGVDARFPVKRIFCVGRNYHAHAVEMGRPVDKSTMAPFYFLK
CCCCCEEECCCCEEEECCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEC
DASTLVESGATVPYPTGTSNYHYEMELVVAIGKAGFRVAEADADSLIYGYAAGLDMTRRD
CHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEEECCCCCEEEEEECCCCHHHHH
LQLVAREQGRPWDLGKNFENSAVCTEIIPAAGGAVLDKGAINLQVNGETRQSADLSMLIW
HHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCEEEECCEEEEEECCCCCCCCCHHHHHH
NIREIIADLSKFYHLEPGDLIYTGTPEGVGAVKSGDRITGHIDGVGDVALTIGAAE
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEECCC
>Mature Secondary Structure 
SQTHYLWNPSPVYSLPVKGVDARFPVKRIFCVGRNYHAHAVEMGRPVDKSTMAPFYFLK
CCCCEEECCCCEEEECCCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCCEEEEC
DASTLVESGATVPYPTGTSNYHYEMELVVAIGKAGFRVAEADADSLIYGYAAGLDMTRRD
CHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEEECCCCCEEEEEECCCCHHHHH
LQLVAREQGRPWDLGKNFENSAVCTEIIPAAGGAVLDKGAINLQVNGETRQSADLSMLIW
HHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCEEEECCEEEEEECCCCCCCCCHHHHHH
NIREIIADLSKFYHLEPGDLIYTGTPEGVGAVKSGDRITGHIDGVGDVALTIGAAE
HHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10806384 [H]