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The map label for this gene is cysK [H]

Identifier: 119898690

GI number: 119898690

Start: 2639458

End: 2640438

Strand: Direct

Name: cysK [H]

Synonym: azo2399

Alternate gene names: 119898690

Gene position: 2639458-2640438 (Clockwise)

Preceding gene: 119898689

Following gene: 119898691

Centisome position: 60.32

GC content: 68.81

Gene sequence:

>981_bases
ATGACCCACTGGTACGAAGACAACGCCCGCTCCATCGGCCATACGCCGCTGGTGCGCCTCAACCGCGTCACCGACGGCGC
GCCCGCCACCATCCTGGCCAAGATCGAGGGCCGCAACCCCGGCTACTCGGTCAAGTGCCGCCTTGGTGCGGCGCTGATCT
GGGATGCCGAGAAGCGTGGCCTGCTCGGCCCCGGCAAGGAACTGGTGGAGCCGACCTCCGGCAATACCGGCATCGCGCTC
GCCTTCGTCGCCGCCGCGCGCGGCATCCCCATCACGCTGACGATGCCGGAAACGATGAGCATCGAGCGCCGCAAGCTGCT
GCTCGCCTACGGCGCCAAGCTGGTGCTGACGGAGGGCCCCAAGGGCATGAGCGGCGCGGTCGCCAAGGCCGAGGAAATCG
CCGCGTCCGACCCCTCGCGCTACGTGCTGCTGCAGCAGTTCAAGAACCCGGCCAACCCGGCCATCCATGAAGAAACCACC
GGCCCGGAAATCTGGAACGACACCGAAGGGGCGGTGGACATCTTCGTCTCCGGCGTCGGCACCGGCGGCACCATCACCGG
CGTCAGCCGCTACCTGAAGAAGACGCGCGGCAAGGACGTGCTGTCGGTTGCGGTCGAACCCGCTGCGAGCCCCATCCTCA
CCCAAAAGCGCAGCGGCCAGGAACTGAAGCCCGCCCCGCACAAGATCCAGGGTATCGGCGCCGGCTTCGTGCCCGAGGTG
CTGGATCTGTCGCTGGTCGACCAGGTGGAAACCGTGGGCAACGAGGAAGCGGTGGACTACGCCCGCCGCCTCGCCCGCGA
AGAAGGCATCCTGTCCGGCATCTCCAGCGGCGCCGCGGTGGCCGCCGCGGTGCGTCTGGCGCGCGACCCGCAGCATGCCG
GCAAGACCATCGTCGTCGTGCTGCCCGACTCCGGCGAACGCTATCTCAGCTCGGTGCTGTTCGAAGGCGTGTTCGACGCC
ACCGGCCTGCCCACCGCCTGA

Upstream 100 bases:

>100_bases
ACGTTTGATATTCTCCGAAATCCGGGTGCAGCAACGCCGCCCGCCTCGATGACGGCATCCCCTGCCCCCGGCGCCCCAAC
CATACCGACAAGGACCCGCC

Downstream 100 bases:

>100_bases
GTTTTTTCGCCAGCTGCGCCGCGCCCGCCATTCCGCATGGCCGGCGCGGCGTTTTTGTTTCTACGCGGTATCCGCTCCGC
GTCAGCGCTGCGACGCGCGT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTHWYEDNARSIGHTPLVRLNRVTDGAPATILAKIEGRNPGYSVKCRLGAALIWDAEKRGLLGPGKELVEPTSGNTGIAL
AFVAAARGIPITLTMPETMSIERRKLLLAYGAKLVLTEGPKGMSGAVAKAEEIAASDPSRYVLLQQFKNPANPAIHEETT
GPEIWNDTEGAVDIFVSGVGTGGTITGVSRYLKKTRGKDVLSVAVEPAASPILTQKRSGQELKPAPHKIQGIGAGFVPEV
LDLSLVDQVETVGNEEAVDYARRLAREEGILSGISSGAAVAAAVRLARDPQHAGKTIVVVLPDSGERYLSSVLFEGVFDA
TGLPTA

Sequences:

>Translated_326_residues
MTHWYEDNARSIGHTPLVRLNRVTDGAPATILAKIEGRNPGYSVKCRLGAALIWDAEKRGLLGPGKELVEPTSGNTGIAL
AFVAAARGIPITLTMPETMSIERRKLLLAYGAKLVLTEGPKGMSGAVAKAEEIAASDPSRYVLLQQFKNPANPAIHEETT
GPEIWNDTEGAVDIFVSGVGTGGTITGVSRYLKKTRGKDVLSVAVEPAASPILTQKRSGQELKPAPHKIQGIGAGFVPEV
LDLSLVDQVETVGNEEAVDYARRLAREEGILSGISSGAAVAAAVRLARDPQHAGKTIVVVLPDSGERYLSSVLFEGVFDA
TGLPTA
>Mature_325_residues
THWYEDNARSIGHTPLVRLNRVTDGAPATILAKIEGRNPGYSVKCRLGAALIWDAEKRGLLGPGKELVEPTSGNTGIALA
FVAAARGIPITLTMPETMSIERRKLLLAYGAKLVLTEGPKGMSGAVAKAEEIAASDPSRYVLLQQFKNPANPAIHEETTG
PEIWNDTEGAVDIFVSGVGTGGTITGVSRYLKKTRGKDVLSVAVEPAASPILTQKRSGQELKPAPHKIQGIGAGFVPEVL
DLSLVDQVETVGNEEAVDYARRLAREEGILSGISSGAAVAAAVRLARDPQHAGKTIVVVLPDSGERYLSSVLFEGVFDAT
GLPTA

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=316, Percent_Identity=40.1898734177215, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI295821200, Length=316, Percent_Identity=40.1898734177215, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI4557415, Length=316, Percent_Identity=40.1898734177215, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=68.9655172413793, Blast_Score=429, Evalue=1e-122,
Organism=Escherichia coli, GI2367138, Length=306, Percent_Identity=43.1372549019608, Blast_Score=218, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17535051, Length=309, Percent_Identity=49.1909385113269, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI115535073, Length=313, Percent_Identity=53.0351437699681, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17562970, Length=315, Percent_Identity=46.6666666666667, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI32566674, Length=305, Percent_Identity=47.8688524590164, Blast_Score=258, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17561720, Length=328, Percent_Identity=46.9512195121951, Blast_Score=240, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI32566672, Length=225, Percent_Identity=47.1111111111111, Blast_Score=193, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI17534315, Length=328, Percent_Identity=39.0243902439024, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI25147552, Length=316, Percent_Identity=34.4936708860759, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17561716, Length=138, Percent_Identity=42.0289855072464, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321594, Length=320, Percent_Identity=37.1875, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=32.8220858895706, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24643623, Length=320, Percent_Identity=36.5625, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20129101, Length=320, Percent_Identity=36.5625, Blast_Score=172, Evalue=2e-43,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 34363; Mature: 34231

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHWYEDNARSIGHTPLVRLNRVTDGAPATILAKIEGRNPGYSVKCRLGAALIWDAEKRG
CCCEECCCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEEEEEECEEEEEECCCCC
LLGPGKELVEPTSGNTGIALAFVAAARGIPITLTMPETMSIERRKLLLAYGAKLVLTEGP
CCCCCHHHCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCC
KGMSGAVAKAEEIAASDPSRYVLLQQFKNPANPAIHEETTGPEIWNDTEGAVDIFVSGVG
CCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
TGGTITGVSRYLKKTRGKDVLSVAVEPAASPILTQKRSGQELKPAPHKIQGIGAGFVPEV
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHCCCCCCCCCCCCCEEECCCCCHHHH
LDLSLVDQVETVGNEEAVDYARRLAREEGILSGISSGAAVAAAVRLARDPQHAGKTIVVV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCEEEEE
LPDSGERYLSSVLFEGVFDATGLPTA
ECCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
THWYEDNARSIGHTPLVRLNRVTDGAPATILAKIEGRNPGYSVKCRLGAALIWDAEKRG
CCEECCCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEEEEEECEEEEEECCCCC
LLGPGKELVEPTSGNTGIALAFVAAARGIPITLTMPETMSIERRKLLLAYGAKLVLTEGP
CCCCCHHHCCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCC
KGMSGAVAKAEEIAASDPSRYVLLQQFKNPANPAIHEETTGPEIWNDTEGAVDIFVSGVG
CCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCC
TGGTITGVSRYLKKTRGKDVLSVAVEPAASPILTQKRSGQELKPAPHKIQGIGAGFVPEV
CCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHCCCCCCCCCCCCCEEECCCCCHHHH
LDLSLVDQVETVGNEEAVDYARRLAREEGILSGISSGAAVAAAVRLARDPQHAGKTIVVV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCEEEEE
LPDSGERYLSSVLFEGVFDATGLPTA
ECCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7603442 [H]