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The map label for this gene is pdhR [H]

Identifier: 119898553

GI number: 119898553

Start: 2479608

End: 2480288

Strand: Direct

Name: pdhR [H]

Synonym: azo2262

Alternate gene names: 119898553

Gene position: 2479608-2480288 (Clockwise)

Preceding gene: 119898552

Following gene: 119898554

Centisome position: 56.66

GC content: 72.54

Gene sequence:

>681_bases
ATGCCCAGCATCGCCAACATCGCCGCCCAGGCCCTGCAACGCCGGATCACCAACGGTGAATTCGCCGCCGGCGCCGCCCT
GCCCTCCCAGCGCGAACTCGCCGACCAGCTCGCCATCAGCCGCGCCTCGCTGCGCGAAGCCATCTCCACGCTGGAAGCGC
TCGGCCTCGTGCGCAGCCAGCCGGGCAAAGGCGTGTTCGTCACCGCCGGCAGCCAGCGCGACGCCACGCAGCCGCTGCGC
GGCACCGCCAGCATGACGCCGCAGGCGCTGATCGAATTCCGCGCCGCGCTCGAACCCGCCTGGGCTGCGCTCGCCGCCCA
GCGCATCGACGACGACGGCCGCGCCCGCCTCGCCGCCATCCAGGCCGGCATGGAAGACGCGCTCAAGGTCGGCGACCTGG
TGATGGCGGCCGACTGGGACCTGCAGTTCCACATGCTGCTCGCCGAACTCTGCGGCAACCCCGGCCTGATCGAGATTGCC
CACCAGTTCCGCGAACAGATCGGCCACAGCCTGCGGCTGCCGTTCTCGCGCTCGGCGAGCATCTGGGAACCGGCCGACGA
ACACCGCCTGATCATCGACGCCATCCTCGCCGGCGATGCCGCCGCCGCCGCCGCCGCGATGCATGCCCACCTCGGCGGCG
CCTCGCGCCGCATCGGCATCGACTACCGCCCGCCGCGCTGA

Upstream 100 bases:

>100_bases
CGTTCTTGATAGCCCTAATCGGCAAATGGGTCTGTTGGCACGCCATCTGCTTTTACTGGCCCAACTGGTCCGACCAGTCA
GAACACTCACCCGGAAAACC

Downstream 100 bases:

>100_bases
GCCCGACGTTTTTTCTTCCCTTCGCCCTTCTTTCCAAACGGAGCCCGCAACATGAACCACGCGCTGCACACCACCCGCCG
CCCCTTCCTGCGCAGCCTCT

Product: putative pyruvate dehydrogenase complex repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MPSIANIAAQALQRRITNGEFAAGAALPSQRELADQLAISRASLREAISTLEALGLVRSQPGKGVFVTAGSQRDATQPLR
GTASMTPQALIEFRAALEPAWAALAAQRIDDDGRARLAAIQAGMEDALKVGDLVMAADWDLQFHMLLAELCGNPGLIEIA
HQFREQIGHSLRLPFSRSASIWEPADEHRLIIDAILAGDAAAAAAAMHAHLGGASRRIGIDYRPPR

Sequences:

>Translated_226_residues
MPSIANIAAQALQRRITNGEFAAGAALPSQRELADQLAISRASLREAISTLEALGLVRSQPGKGVFVTAGSQRDATQPLR
GTASMTPQALIEFRAALEPAWAALAAQRIDDDGRARLAAIQAGMEDALKVGDLVMAADWDLQFHMLLAELCGNPGLIEIA
HQFREQIGHSLRLPFSRSASIWEPADEHRLIIDAILAGDAAAAAAAMHAHLGGASRRIGIDYRPPR
>Mature_225_residues
PSIANIAAQALQRRITNGEFAAGAALPSQRELADQLAISRASLREAISTLEALGLVRSQPGKGVFVTAGSQRDATQPLRG
TASMTPQALIEFRAALEPAWAALAAQRIDDDGRARLAAIQAGMEDALKVGDLVMAADWDLQFHMLLAELCGNPGLIEIAH
QFREQIGHSLRLPFSRSASIWEPADEHRLIIDAILAGDAAAAAAAMHAHLGGASRRIGIDYRPPR

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=218, Percent_Identity=32.1100917431193, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1790032, Length=208, Percent_Identity=32.2115384615385, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082208, Length=215, Percent_Identity=30.2325581395349, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI48994961, Length=219, Percent_Identity=30.1369863013699, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1790780, Length=223, Percent_Identity=28.2511210762332, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 24065; Mature: 23934

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSIANIAAQALQRRITNGEFAAGAALPSQRELADQLAISRASLREAISTLEALGLVRSQ
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGKGVFVTAGSQRDATQPLRGTASMTPQALIEFRAALEPAWAALAAQRIDDDGRARLAAI
CCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
QAGMEDALKVGDLVMAADWDLQFHMLLAELCGNPGLIEIAHQFREQIGHSLRLPFSRSAS
HHHHHHHHHHHCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEECCCCCCCC
IWEPADEHRLIIDAILAGDAAAAAAAMHAHLGGASRRIGIDYRPPR
CCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCCC
>Mature Secondary Structure 
PSIANIAAQALQRRITNGEFAAGAALPSQRELADQLAISRASLREAISTLEALGLVRSQ
CCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGKGVFVTAGSQRDATQPLRGTASMTPQALIEFRAALEPAWAALAAQRIDDDGRARLAAI
CCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
QAGMEDALKVGDLVMAADWDLQFHMLLAELCGNPGLIEIAHQFREQIGHSLRLPFSRSAS
HHHHHHHHHHHCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEECCCCCCCC
IWEPADEHRLIIDAILAGDAAAAAAAMHAHLGGASRRIGIDYRPPR
CCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]