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The map label for this gene is aer [H]

Identifier: 119898490

GI number: 119898490

Start: 2408503

End: 2410050

Strand: Direct

Name: aer [H]

Synonym: azo2199

Alternate gene names: 119898490

Gene position: 2408503-2410050 (Clockwise)

Preceding gene: 119898489

Following gene: 119898491

Centisome position: 55.04

GC content: 66.34

Gene sequence:

>1548_bases
ATGGAGCCCGGCCGCCCGATTGTCACCAAGACCGACCTGGCAGGACGGATCACCTACGCCAACCCGGCCTTCGTCGCCAT
CAGCGGATTCAGCCGCGACGAACTGATCGGTCAAAACCACAACATCGTGCGTCACCCCGACATGCCAGCGGAGGCTTTCG
CCGACTTATGGCGGACGATACAGGCGGGCCGCCCCTGGCGCGGCATCGTCAAGAACCGCGCGAAGAATGGCGATTTCTAC
TGGGTTGAAGCCTACGTCACGCCGCTGACCGAAAACGGCCAGCGGGTGGGCTACATGTCGGTCCGTACGCCACCATCAAC
AGAAGCCCGGGAGCGCGCCGAAGCCTTGTACGGCCGCCTGCGCACGGGCAGCGCCACACTTCCGCCCACCCGCCTCTCGC
ATGGCAGTTCGCTGTCCGTCACCACCGGCGCGGGATTGGCCCTGACGCTGTTGTTTGGCGCCGCGGCCGCTTTTTTCGAC
GGACTGCCGGCGGCCCTGCTGGTGGGGGCACAGGCCGTGGTGGCCGCCGGGCTGTGGCTGCTCCTGCAGCGCCGCGTGCA
GGTGCCGCTGCATACGCTGCTCGGTCTGCTCGCCGACATCGGCGAAGGCCGCTTGAAAGGCGAGCCGCCGCAGGAAGGCT
GCAGCGAGATGCAGACGCTCGGCAGTGCGGTGATGTCGATGCAGGTGAGCCTGCGCGCGCTGATCGGTGACGTGGTCGCG
TCCGCCAACGACACCGCGCGCGAGGCGGCACGTCTGCATACCAGCGCACAACGGCTCCAACGCGGGTCGCACAGCCAGGC
CGACCAGCTTGCCTCGTCCGCATCCGCCATGGAGGAACTGGCGGTTTCGGTCAGCGAAATCGCCGGCGCCACCGACAACA
GCGCCGATCAGGCCCGCACCGCGCAGAGCATCACGGCCGACGGCCAGCGCAACATGTCCAACGCCGCCGAGTCGACTCAT
CGCGTGGTCGCGGCGGTGGAAGAGAACAACCGCATGCTCGAAGCGCTCTCCGATTCGGTCGAAAAGATCGGCGTCGTGGC
CGCAGCCATCAGCGAAATCGCCAAGCGCACCAACCTGCTCGCACTCAACGCCGCCATCGAAGCTGCACGCGCCGGCGAAC
AGGGCCGCGGCTTCGCGGTGGTTGCCGGCGAGGTCACCGAACTCGCTGGGCAAACCCAGCACAGCACGGAGGACATCGCC
CGCCTGATCGCCGAGATTTCCGAGCGGAAAACCAGCGTCATCCAGACCATGCAGACCCTGCGCGAGGGCGTGAGCGGCAG
TGTGAACACCATACGGACCGTGGCAGAAGAACTGGAACAGATATCCAGCGCCAACACGGCCGTGGCCAACAACTCCGAGG
AAATCCGCCACATGCTCAGGCAGCAGGAGCAGGCCTCCGCGGAGGTGGCGAACATCATGGAGCGCATGAGCGGGCTGACC
GAGGACAACCTGCAAACCGTGACCGATGTGGAGGAAGCCGCCGCGGCGCTGGAGACGACTGCGCGCGAACTGCAATTGCT
GGTCGCCCATTTCGAAACCCGACTTTGA

Upstream 100 bases:

>100_bases
GCCCTACCCCACGAGATTGACGCTTCACATGGACTTGCGCGCACAGAACCGCCCCTCGCCCCACACCCCTTCGCCGTCCA
GCTCCCCGCGAGAACGCTTC

Downstream 100 bases:

>100_bases
TCCGCGGCAACGCAAGCGGACCACTCCGAGAACAGCGCCCATGCTGAAGGCCCAATTCATCTCCCCGTCGCCGCCCCCTT
CCACGCGAGAAAACCTTTCC

Product: aerotaxis receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 515; Mature: 515

Protein sequence:

>515_residues
MEPGRPIVTKTDLAGRITYANPAFVAISGFSRDELIGQNHNIVRHPDMPAEAFADLWRTIQAGRPWRGIVKNRAKNGDFY
WVEAYVTPLTENGQRVGYMSVRTPPSTEARERAEALYGRLRTGSATLPPTRLSHGSSLSVTTGAGLALTLLFGAAAAFFD
GLPAALLVGAQAVVAAGLWLLLQRRVQVPLHTLLGLLADIGEGRLKGEPPQEGCSEMQTLGSAVMSMQVSLRALIGDVVA
SANDTAREAARLHTSAQRLQRGSHSQADQLASSASAMEELAVSVSEIAGATDNSADQARTAQSITADGQRNMSNAAESTH
RVVAAVEENNRMLEALSDSVEKIGVVAAAISEIAKRTNLLALNAAIEAARAGEQGRGFAVVAGEVTELAGQTQHSTEDIA
RLIAEISERKTSVIQTMQTLREGVSGSVNTIRTVAEELEQISSANTAVANNSEEIRHMLRQQEQASAEVANIMERMSGLT
EDNLQTVTDVEEAAAALETTARELQLLVAHFETRL

Sequences:

>Translated_515_residues
MEPGRPIVTKTDLAGRITYANPAFVAISGFSRDELIGQNHNIVRHPDMPAEAFADLWRTIQAGRPWRGIVKNRAKNGDFY
WVEAYVTPLTENGQRVGYMSVRTPPSTEARERAEALYGRLRTGSATLPPTRLSHGSSLSVTTGAGLALTLLFGAAAAFFD
GLPAALLVGAQAVVAAGLWLLLQRRVQVPLHTLLGLLADIGEGRLKGEPPQEGCSEMQTLGSAVMSMQVSLRALIGDVVA
SANDTAREAARLHTSAQRLQRGSHSQADQLASSASAMEELAVSVSEIAGATDNSADQARTAQSITADGQRNMSNAAESTH
RVVAAVEENNRMLEALSDSVEKIGVVAAAISEIAKRTNLLALNAAIEAARAGEQGRGFAVVAGEVTELAGQTQHSTEDIA
RLIAEISERKTSVIQTMQTLREGVSGSVNTIRTVAEELEQISSANTAVANNSEEIRHMLRQQEQASAEVANIMERMSGLT
EDNLQTVTDVEEAAAALETTARELQLLVAHFETRL
>Mature_515_residues
MEPGRPIVTKTDLAGRITYANPAFVAISGFSRDELIGQNHNIVRHPDMPAEAFADLWRTIQAGRPWRGIVKNRAKNGDFY
WVEAYVTPLTENGQRVGYMSVRTPPSTEARERAEALYGRLRTGSATLPPTRLSHGSSLSVTTGAGLALTLLFGAAAAFFD
GLPAALLVGAQAVVAAGLWLLLQRRVQVPLHTLLGLLADIGEGRLKGEPPQEGCSEMQTLGSAVMSMQVSLRALIGDVVA
SANDTAREAARLHTSAQRLQRGSHSQADQLASSASAMEELAVSVSEIAGATDNSADQARTAQSITADGQRNMSNAAESTH
RVVAAVEENNRMLEALSDSVEKIGVVAAAISEIAKRTNLLALNAAIEAARAGEQGRGFAVVAGEVTELAGQTQHSTEDIA
RLIAEISERKTSVIQTMQTLREGVSGSVNTIRTVAEELEQISSANTAVANNSEEIRHMLRQQEQASAEVANIMERMSGLT
EDNLQTVTDVEEAAAALETTARELQLLVAHFETRL

Specific function: Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a r

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789453, Length=509, Percent_Identity=32.4165029469548, Blast_Score=218, Evalue=8e-58,
Organism=Escherichia coli, GI1788195, Length=268, Percent_Identity=31.7164179104478, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI2367378, Length=321, Percent_Identity=31.1526479750779, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1788194, Length=339, Percent_Identity=29.4985250737463, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1787690, Length=314, Percent_Identity=29.9363057324841, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF08447 PAS_3 [H]

EC number: NA

Molecular weight: Translated: 54900; Mature: 54900

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPGRPIVTKTDLAGRITYANPAFVAISGFSRDELIGQNHNIVRHPDMPAEAFADLWRTI
CCCCCCCEEECCCCCEEEECCCCEEEEECCCHHHHCCCCCCEEECCCCCHHHHHHHHHHH
QAGRPWRGIVKNRAKNGDFYWVEAYVTPLTENGQRVGYMSVRTPPSTEARERAEALYGRL
HCCCCHHHHHHCCCCCCCEEEEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
RTGSATLPPTRLSHGSSLSVTTGAGLALTLLFGAAAAFFDGLPAALLVGAQAVVAAGLWL
CCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LLQRRVQVPLHTLLGLLADIGEGRLKGEPPQEGCSEMQTLGSAVMSMQVSLRALIGDVVA
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SANDTAREAARLHTSAQRLQRGSHSQADQLASSASAMEELAVSVSEIAGATDNSADQART
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AQSITADGQRNMSNAAESTHRVVAAVEENNRMLEALSDSVEKIGVVAAAISEIAKRTNLL
HHHHHCCCHHHHHHHHHHHHHHHEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALNAAIEAARAGEQGRGFAVVAGEVTELAGQTQHSTEDIARLIAEISERKTSVIQTMQTL
HHHHHHHHHHCCCCCCCEEEEECHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
REGVSGSVNTIRTVAEELEQISSANTAVANNSEEIRHMLRQQEQASAEVANIMERMSGLT
HHCCCCCHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EDNLQTVTDVEEAAAALETTARELQLLVAHFETRL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEPGRPIVTKTDLAGRITYANPAFVAISGFSRDELIGQNHNIVRHPDMPAEAFADLWRTI
CCCCCCCEEECCCCCEEEECCCCEEEEECCCHHHHCCCCCCEEECCCCCHHHHHHHHHHH
QAGRPWRGIVKNRAKNGDFYWVEAYVTPLTENGQRVGYMSVRTPPSTEARERAEALYGRL
HCCCCHHHHHHCCCCCCCEEEEEEEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHH
RTGSATLPPTRLSHGSSLSVTTGAGLALTLLFGAAAAFFDGLPAALLVGAQAVVAAGLWL
CCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LLQRRVQVPLHTLLGLLADIGEGRLKGEPPQEGCSEMQTLGSAVMSMQVSLRALIGDVVA
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SANDTAREAARLHTSAQRLQRGSHSQADQLASSASAMEELAVSVSEIAGATDNSADQART
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
AQSITADGQRNMSNAAESTHRVVAAVEENNRMLEALSDSVEKIGVVAAAISEIAKRTNLL
HHHHHCCCHHHHHHHHHHHHHHHEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALNAAIEAARAGEQGRGFAVVAGEVTELAGQTQHSTEDIARLIAEISERKTSVIQTMQTL
HHHHHHHHHHCCCCCCCEEEEECHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
REGVSGSVNTIRTVAEELEQISSANTAVANNSEEIRHMLRQQEQASAEVANIMERMSGLT
HHCCCCCHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
EDNLQTVTDVEEAAAALETTARELQLLVAHFETRL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9190831; 9380671 [H]