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The map label for this gene is bioA [C]

Identifier: 119898391

GI number: 119898391

Start: 2305593

End: 2306900

Strand: Reverse

Name: bioA [C]

Synonym: azo2100

Alternate gene names: 119898391

Gene position: 2306900-2305593 (Counterclockwise)

Preceding gene: 119898392

Following gene: 119898388

Centisome position: 52.72

GC content: 66.51

Gene sequence:

>1308_bases
ATGGAACATGAGCAGGCCCTGTGGCTGCCCTTCACGGCGAACCGGGCGTTCTGGAAGCAGCCGCGCGTCATCTCGGGCGC
GCGCGGCCACTACTACACCACCGCCGATGGGCGCGAGTTGCTGGACGGGTTTTCAGGGTTGTGGAGTTGCGGGCTGGGGC
ACGCCCACCCGGGTATCGTCGCAGCCGTCCAGCAACAGGTGGCTACGCTCGATTTCAGCATGACCTTCCAGGCCACCAAC
GACAAGGCGATCGCGCTTGCGCGTGAGGTGGCGTCGATGGCGCCCCCAGGGCTTCACAAGGTGTTCTTCACCAACTCCGG
TTCCGAATCGGTGGATACCGCGCTGAAGATCGCACTCGCCTATCACCGGGCGCGTGGAGACGGGCACCGCACCCGGTTGA
TCGGCCGGGAGCGTGGCTACCACGGCGTCAACCTGGGCGGCACGTCCGTGGGCGGGATTGCGGTCAATCGCAAGGCCTTC
GGTGCCGTGCTGACGCCCGGGGTGGACCACATCCGTCACACCCTCAGTCTGCCCGACATGGCGTTCAGCCGTGGGCAGCC
GAGTTGGGGCGCTCATCTCGCCGACGATCTGGAGCGGCTTGCCGCGCTGCACGACCCCAGCACCATCGCCGCAGTCATCG
TCGAACCCGTCGCCGGCTCCACGGGCATCCTGGTGCCGCCGGTGGGGTATCTGGAACGCCTGCGCGCAATCTGCGACCAG
CACGGCTTTCTGCTGATCTTTGATGAAGTGATCAATGCGTTCGGCCGGCTCGGCGCACCGTTCGCGGCGACCCGCTTCGG
CGTCACGCCCGACCTCATCACGACCGCCAAGGGCCTGACCAACGGCGTGGTGCCGATGGGCGCAGTCATCGTGCGTCAGG
ACATCTACGACGCCCTGATGCAGGGCCCGGAGCATGCAGTGGAGTTCTTCCACGGCTACACCTATTCGGGCCATCCGCTC
GCTGCTGCGGCAGGGCTGGCGGCGCTGCGTGCCTATCGCGAGGAGGACAGCTTCGCCCGCGTCCGGGCGCTCGAACCCGT
GTTCGAGGACGGCTTGCACAGCCTGCGCGACGAACCCAACGTGGTGGATATCCGCAACTTCGGCCTGATGGGCGGGGTGG
AACTGGCGCCTCGCGACGGGGTACTGGGAGTGCGCGGATTCGAGGTGTTCCTGAAGTGCTTCGAAGCCGGAGTCGTCATT
CGCAATGGTGGCGACATCCTGCAATTCGCGCCGTTCTTCGACAGCACCGAGGATGAACTCGCACGCATCTTCGAAACCGT
GCGCGCCGCGCTGCGGGCCACGGCCTGA

Upstream 100 bases:

>100_bases
GCGCTCCCGCCCAAGGTCACGTGCCGGCGAAGCCGAACCGAGCCGGTGTCTGTCTATGTTCCTGTGCTCCCCTTGATACG
GAGGCGAGGTGATGGACCCC

Downstream 100 bases:

>100_bases
GCAGAACGGCAAGCGGCCGCAACCCATCAGGCTGCGGCCGCAGGGAACACGTTACCGCCGGGTTGGCGGCGGCGAAGTGC
TTAAAGGTTGCCCTTGGCCC

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MEHEQALWLPFTANRAFWKQPRVISGARGHYYTTADGRELLDGFSGLWSCGLGHAHPGIVAAVQQQVATLDFSMTFQATN
DKAIALAREVASMAPPGLHKVFFTNSGSESVDTALKIALAYHRARGDGHRTRLIGRERGYHGVNLGGTSVGGIAVNRKAF
GAVLTPGVDHIRHTLSLPDMAFSRGQPSWGAHLADDLERLAALHDPSTIAAVIVEPVAGSTGILVPPVGYLERLRAICDQ
HGFLLIFDEVINAFGRLGAPFAATRFGVTPDLITTAKGLTNGVVPMGAVIVRQDIYDALMQGPEHAVEFFHGYTYSGHPL
AAAAGLAALRAYREEDSFARVRALEPVFEDGLHSLRDEPNVVDIRNFGLMGGVELAPRDGVLGVRGFEVFLKCFEAGVVI
RNGGDILQFAPFFDSTEDELARIFETVRAALRATA

Sequences:

>Translated_435_residues
MEHEQALWLPFTANRAFWKQPRVISGARGHYYTTADGRELLDGFSGLWSCGLGHAHPGIVAAVQQQVATLDFSMTFQATN
DKAIALAREVASMAPPGLHKVFFTNSGSESVDTALKIALAYHRARGDGHRTRLIGRERGYHGVNLGGTSVGGIAVNRKAF
GAVLTPGVDHIRHTLSLPDMAFSRGQPSWGAHLADDLERLAALHDPSTIAAVIVEPVAGSTGILVPPVGYLERLRAICDQ
HGFLLIFDEVINAFGRLGAPFAATRFGVTPDLITTAKGLTNGVVPMGAVIVRQDIYDALMQGPEHAVEFFHGYTYSGHPL
AAAAGLAALRAYREEDSFARVRALEPVFEDGLHSLRDEPNVVDIRNFGLMGGVELAPRDGVLGVRGFEVFLKCFEAGVVI
RNGGDILQFAPFFDSTEDELARIFETVRAALRATA
>Mature_435_residues
MEHEQALWLPFTANRAFWKQPRVISGARGHYYTTADGRELLDGFSGLWSCGLGHAHPGIVAAVQQQVATLDFSMTFQATN
DKAIALAREVASMAPPGLHKVFFTNSGSESVDTALKIALAYHRARGDGHRTRLIGRERGYHGVNLGGTSVGGIAVNRKAF
GAVLTPGVDHIRHTLSLPDMAFSRGQPSWGAHLADDLERLAALHDPSTIAAVIVEPVAGSTGILVPPVGYLERLRAICDQ
HGFLLIFDEVINAFGRLGAPFAATRFGVTPDLITTAKGLTNGVVPMGAVIVRQDIYDALMQGPEHAVEFFHGYTYSGHPL
AAAAGLAALRAYREEDSFARVRALEPVFEDGLHSLRDEPNVVDIRNFGLMGGVELAPRDGVLGVRGFEVFLKCFEAGVVI
RNGGDILQFAPFFDSTEDELARIFETVRAALRATA

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=414, Percent_Identity=28.0193236714976, Blast_Score=138, Evalue=8e-33,
Organism=Homo sapiens, GI13994255, Length=451, Percent_Identity=27.4944567627494, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI37574042, Length=434, Percent_Identity=25.5760368663594, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=25.8145363408521, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI284507298, Length=330, Percent_Identity=28.1818181818182, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI226442705, Length=434, Percent_Identity=25.1152073732719, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI24119277, Length=368, Percent_Identity=27.1739130434783, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI188536080, Length=283, Percent_Identity=24.0282685512367, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679950, Length=283, Percent_Identity=24.0282685512367, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI38679946, Length=283, Percent_Identity=24.0282685512367, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786991, Length=438, Percent_Identity=31.9634703196347, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI145693181, Length=403, Percent_Identity=30.7692307692308, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789759, Length=380, Percent_Identity=33.4210526315789, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=29.6758104738155, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1789016, Length=350, Percent_Identity=32, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1787560, Length=344, Percent_Identity=30.8139534883721, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786349, Length=364, Percent_Identity=30.4945054945055, Blast_Score=116, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=458, Percent_Identity=28.3842794759825, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71992977, Length=437, Percent_Identity=27.9176201372998, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=394, Percent_Identity=24.6192893401015, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=206, Percent_Identity=30.0970873786408, Blast_Score=96, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323470, Length=419, Percent_Identity=27.4463007159904, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324432, Length=410, Percent_Identity=27.3170731707317, Blast_Score=121, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324386, Length=432, Percent_Identity=25.6944444444444, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI161085790, Length=447, Percent_Identity=28.4116331096197, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI21357415, Length=416, Percent_Identity=25.7211538461538, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574759, Length=426, Percent_Identity=29.1079812206573, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21356575, Length=374, Percent_Identity=28.8770053475936, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 46875; Mature: 46875

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHEQALWLPFTANRAFWKQPRVISGARGHYYTTADGRELLDGFSGLWSCGLGHAHPGIV
CCCCCEEEEEEECCCHHHCCCCEECCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCHHH
AAVQQQVATLDFSMTFQATNDKAIALAREVASMAPPGLHKVFFTNSGSESVDTALKIALA
HHHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHH
YHRARGDGHRTRLIGRERGYHGVNLGGTSVGGIAVNRKAFGAVLTPGVDHIRHTLSLPDM
HHHHCCCCCHHEEEECCCCCCCCCCCCCCCCCEEECHHHHCHHCCCCHHHHHHHHCCCHH
AFSRGQPSWGAHLADDLERLAALHDPSTIAAVIVEPVAGSTGILVPPVGYLERLRAICDQ
HHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHHHCC
HGFLLIFDEVINAFGRLGAPFAATRFGVTPDLITTAKGLTNGVVPMGAVIVRQDIYDALM
CCEEEEHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QGPEHAVEFFHGYTYSGHPLAAAAGLAALRAYREEDSFARVRALEPVFEDGLHSLRDEPN
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
VVDIRNFGLMGGVELAPRDGVLGVRGFEVFLKCFEAGVVIRNGGDILQFAPFFDSTEDEL
EEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCEEEECCCCCCCHHHH
ARIFETVRAALRATA
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MEHEQALWLPFTANRAFWKQPRVISGARGHYYTTADGRELLDGFSGLWSCGLGHAHPGIV
CCCCCEEEEEEECCCHHHCCCCEECCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCHHH
AAVQQQVATLDFSMTFQATNDKAIALAREVASMAPPGLHKVFFTNSGSESVDTALKIALA
HHHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHH
YHRARGDGHRTRLIGRERGYHGVNLGGTSVGGIAVNRKAFGAVLTPGVDHIRHTLSLPDM
HHHHCCCCCHHEEEECCCCCCCCCCCCCCCCCEEECHHHHCHHCCCCHHHHHHHHCCCHH
AFSRGQPSWGAHLADDLERLAALHDPSTIAAVIVEPVAGSTGILVPPVGYLERLRAICDQ
HHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEECCHHHHHHHHHHHCC
HGFLLIFDEVINAFGRLGAPFAATRFGVTPDLITTAKGLTNGVVPMGAVIVRQDIYDALM
CCEEEEHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
QGPEHAVEFFHGYTYSGHPLAAAAGLAALRAYREEDSFARVRALEPVFEDGLHSLRDEPN
CCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
VVDIRNFGLMGGVELAPRDGVLGVRGFEVFLKCFEAGVVIRNGGDILQFAPFFDSTEDEL
EEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHCCEEEECCCCEEEECCCCCCCHHHH
ARIFETVRAALRATA
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]