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The map label for this gene is apbA2

Identifier: 119898285

GI number: 119898285

Start: 2195039

End: 2196049

Strand: Direct

Name: apbA2

Synonym: azo1994

Alternate gene names: NA

Gene position: 2195039-2196049 (Clockwise)

Preceding gene: 119898284

Following gene: 119898286

Centisome position: 50.16

GC content: 68.15

Gene sequence:

>1011_bases
ATGACTTCTGCCCGAACCCCGAAAATCTGCATCGCCGGCGCCGGTGCCATCGGCTGCACCATTGCCGCCCGTCTCGCCAA
GGCCGACATGGATGTCACCGTGTTCGCCCGTGGCGCCACGCTCGATGTCCTGCGCCGCGACGGCATCACCCTGACCGATC
TGGAAGGCACGCATCAGGTGCCGGTGCGCGCCAGCGACCAGCCGGACTTTGGCGTGCAAGACGTGATCTTCGTCTGCGCC
AAGGCGCACGACCTGCCGGCGATGCTGCCGCGCCTCGCACCCTTGATCGGCGAGCACACCATCGTGGTGCCGGCGGTCAA
TGGCGTGCCCTGGTGGTACTTCCACGGCGAAGGCGGCCGCTTCGCCGACCAGCCGGTGCGCGCCACCGACCCCGAAGGCA
AGCTCGCCGCCGCCCTGCCCTTCAAGCACGTCATCGGCTGCGTGGTGTTCATCACCGCCGAGTCGCCGCAGCCCGGCCAC
GTGGTGGCGCGCAACCCGCACCTCATCATGTTCGGCGAGCCCGACAACAGCATGAGCGAGCGCTTGCGCGCGCTGTGCGC
CATCGTTGAGCGCGGCGGCATCGAGGCGCGGCCGCTGGAGCGCATCCGCGACAAGCTGTGGACCAAGATCATCGCCAACA
TCAGCACCAACCCGCTGTCGGTGATCTCCGGGGCGACGCTGGAAGAGCTGTACACCCAGCCGGAACTGCAGGAAACCGTG
GTTGCGATCATGCGCGAGGTGCTGCTGGTGGCCGCGAGCTACGGCGCGCGGGTCGAAATCGATCCGCTCACCTTCCTCGA
CCTCGGCGCCGCGATGGGGCCGGTGCGCACCTCGATGCTGCAGGACTTCGAGAAGAACCGTCCGCTGGAACTTGCGGCCA
TCGGCGACGCGGTGCTCGAACTGGCAGAACGCTTCGGCATCCCGATGCCGGTCACCCGCAAGGTGATCGCGCTGGCGCGC
TTCCGCGGCAAGCATCTGCACGACCCCCAGTCCGCTGCGGCGAAAGCCTGA

Upstream 100 bases:

>100_bases
AACCCACGTCAACATCTGCCGGGTGTACCACCCTCACCCCCGTGGCACGCCCCCAACACGAACGGCAGCCACCCTGCCCC
TCGCCCCACGGAGCCGAAAC

Downstream 100 bases:

>100_bases
TTTTCCGCGGGCTGGGCTCCCTCCTCCCCCTCCTCCCCCTCCCACCCTCGAACCAAGGAAACCGACATGAATGCAGCCAT
CAGCCCGGCGGTCGTCAAAC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MTSARTPKICIAGAGAIGCTIAARLAKADMDVTVFARGATLDVLRRDGITLTDLEGTHQVPVRASDQPDFGVQDVIFVCA
KAHDLPAMLPRLAPLIGEHTIVVPAVNGVPWWYFHGEGGRFADQPVRATDPEGKLAAALPFKHVIGCVVFITAESPQPGH
VVARNPHLIMFGEPDNSMSERLRALCAIVERGGIEARPLERIRDKLWTKIIANISTNPLSVISGATLEELYTQPELQETV
VAIMREVLLVAASYGARVEIDPLTFLDLGAAMGPVRTSMLQDFEKNRPLELAAIGDAVLELAERFGIPMPVTRKVIALAR
FRGKHLHDPQSAAAKA

Sequences:

>Translated_336_residues
MTSARTPKICIAGAGAIGCTIAARLAKADMDVTVFARGATLDVLRRDGITLTDLEGTHQVPVRASDQPDFGVQDVIFVCA
KAHDLPAMLPRLAPLIGEHTIVVPAVNGVPWWYFHGEGGRFADQPVRATDPEGKLAAALPFKHVIGCVVFITAESPQPGH
VVARNPHLIMFGEPDNSMSERLRALCAIVERGGIEARPLERIRDKLWTKIIANISTNPLSVISGATLEELYTQPELQETV
VAIMREVLLVAASYGARVEIDPLTFLDLGAAMGPVRTSMLQDFEKNRPLELAAIGDAVLELAERFGIPMPVTRKVIALAR
FRGKHLHDPQSAAAKA
>Mature_335_residues
TSARTPKICIAGAGAIGCTIAARLAKADMDVTVFARGATLDVLRRDGITLTDLEGTHQVPVRASDQPDFGVQDVIFVCAK
AHDLPAMLPRLAPLIGEHTIVVPAVNGVPWWYFHGEGGRFADQPVRATDPEGKLAAALPFKHVIGCVVFITAESPQPGHV
VARNPHLIMFGEPDNSMSERLRALCAIVERGGIEARPLERIRDKLWTKIIANISTNPLSVISGATLEELYTQPELQETVV
AIMREVLLVAASYGARVEIDPLTFLDLGAAMGPVRTSMLQDFEKNRPLELAAIGDAVLELAERFGIPMPVTRKVIALARF
RGKHLHDPQSAAAKA

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 36276; Mature: 36144

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSARTPKICIAGAGAIGCTIAARLAKADMDVTVFARGATLDVLRRDGITLTDLEGTHQV
CCCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCEEEECCCCCCC
PVRASDQPDFGVQDVIFVCAKAHDLPAMLPRLAPLIGEHTIVVPAVNGVPWWYFHGEGGR
CEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCC
FADQPVRATDPEGKLAAALPFKHVIGCVVFITAESPQPGHVVARNPHLIMFGEPDNSMSE
CCCCCCCCCCCCCCEEECCCHHHHEEEEEEEEECCCCCCEEEECCCEEEEEECCCCHHHH
RLRALCAIVERGGIEARPLERIRDKLWTKIIANISTNPLSVISGATLEELYTQPELQETV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCCHHHHH
VAIMREVLLVAASYGARVEIDPLTFLDLGAAMGPVRTSMLQDFEKNRPLELAAIGDAVLE
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
LAERFGIPMPVTRKVIALARFRGKHLHDPQSAAAKA
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCC
>Mature Secondary Structure 
TSARTPKICIAGAGAIGCTIAARLAKADMDVTVFARGATLDVLRRDGITLTDLEGTHQV
CCCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCCEEEECCCCCCC
PVRASDQPDFGVQDVIFVCAKAHDLPAMLPRLAPLIGEHTIVVPAVNGVPWWYFHGEGGR
CEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCC
FADQPVRATDPEGKLAAALPFKHVIGCVVFITAESPQPGHVVARNPHLIMFGEPDNSMSE
CCCCCCCCCCCCCCEEECCCHHHHEEEEEEEEECCCCCCEEEECCCEEEEEECCCCHHHH
RLRALCAIVERGGIEARPLERIRDKLWTKIIANISTNPLSVISGATLEELYTQPELQETV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCCHHHHH
VAIMREVLLVAASYGARVEIDPLTFLDLGAAMGPVRTSMLQDFEKNRPLELAAIGDAVLE
HHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHH
LAERFGIPMPVTRKVIALARFRGKHLHDPQSAAAKA
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]