Click here to switch to the map view.

The map label for this gene is bioA [H]

Identifier: 119898179

GI number: 119898179

Start: 2073125

End: 2074477

Strand: Direct

Name: bioA [H]

Synonym: azo1888

Alternate gene names: 119898179

Gene position: 2073125-2074477 (Clockwise)

Preceding gene: 119898176

Following gene: 119898180

Centisome position: 47.37

GC content: 69.18

Gene sequence:

>1353_bases
ATGCCCTTCCAGTCCAGTTCCGACCTTCTGCAGCGCTCGCTCGCCGCAGTCTGGCACCCGTGCACCCAGATGAAGCACCA
CGAAACGCTGCCGCTGGTGCCCATCGTCCGCGGTGAAGGCGCCTGGCTGATCGACGCCGACGGACGCCGCCTGCTCGACG
GCATCAGCTCGTGGTGGGTCAATCTCTTCGGACACTGCAACCGCCGCATCAACGCCGCGCTGCGCGAACAGCTGGAAACG
CTGGAACACGTGATGCTGGCCGGCTTCACCCATCCGCCCGCGGTGGAACTGGCCGAACGGCTGGCCGCGCTGACCGGCCA
CCGTCTGGGCCACGCCTTCTATGCTTCCGACGGCGCCTCGGCGACCGAGATCGCGCTGAAGATGAGCGTGCATTACTGGC
GAAACCGGGGCGAAGCCGGCAAGAACCGTTTCATCAGCCTCGCCGGCAGCTATCACGGCGAAACCGCCGGCGCGCTGGCC
GTGACCGATGTGGCCTTGTTCCGCGACGCCTATGCGCCGCTGGTGCGGCCGGGCGCAACCGTGCCCACGCCCGATATCCG
CCTGGCGGTGGCGGGCGAATCGGCATCCAGCCTGGCCCGGCGCGCGGCGCAAGCGCTGGAAGCGCACCTGGCCGAGCACC
ACGCCGAAACCGCCGCACTGATCGTGGAGCCGCTGGTGCAGGGGGCGTCCGGCATGGTGATGTACGACGCCGAGTACCTG
CGCCAGGCCCGGGCGCTGTGCGACCACTACCAGGTGCACCTGATTGCCGACGAGATCGCCGTGGGCTGCGGGCGCACCGG
CACCTTCTTCGCGTGGGAGCAGGTCGCGGCGGATGACGCGGCGGGCTGGCCGGATTTCATCTGCCTCTCCAAAGGCATCT
CGGGCGGCTATCTGCCGCTGTCGCTGGTGCTCTCCAGCGACGATATCTACGCCGCGTTCTACGACGACAGCAGCACGCGC
GCCTTTCTGCATTCGCACTCCTACACGGGTAATCCGCTGGCCTGCCGCGCCGCGCTGGCAACGCTGGACATCTTCCGCGA
GGACGACGTCGTGGCCGAGAACCGGGGCCGCGCCGAGCGCATGCGGCGACAGGCGGACGAGCGTTTCGCCAACCATCCGG
CGGTCCGTCACCTGCGCCAGCAGGGGATGATCCTGGCCTTCGATGTCGATACCGGCACGCTCGGTGCCGGCGAGTTTGCG
CGCCGCTTCTTCGCCGCGGCGCTGGACCACGGCCTGCTGCTGCGGCCGATCGGCAACACGGTCTACTTCATGCCGCCCTA
CGTGCTGGGCGAGGACGAACTGCGTCACCTCGTCGACGGCGCGGCCGCCGCGCTAGAGCGGGCGCTGCGCTGA

Upstream 100 bases:

>100_bases
CTGGATGGATGGGGCGATGTTAGCAAAGTCGGCGGTTTGACAGCCCCTTCCCGATTGCGCACCATTGGCCGGTTTCGCCC
TGCCCCAGACCCTGCATCCG

Downstream 100 bases:

>100_bases
TGTCCGCCCTGCTGGACCGCCTGCGCACCGACCTCTCCGCGCTTGCCGGCCAGGGCCTGCGGCGGGTGCGCCGCAGCAAC
GCCCTGCCCTGCGCGCCGCG

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MPFQSSSDLLQRSLAAVWHPCTQMKHHETLPLVPIVRGEGAWLIDADGRRLLDGISSWWVNLFGHCNRRINAALREQLET
LEHVMLAGFTHPPAVELAERLAALTGHRLGHAFYASDGASATEIALKMSVHYWRNRGEAGKNRFISLAGSYHGETAGALA
VTDVALFRDAYAPLVRPGATVPTPDIRLAVAGESASSLARRAAQALEAHLAEHHAETAALIVEPLVQGASGMVMYDAEYL
RQARALCDHYQVHLIADEIAVGCGRTGTFFAWEQVAADDAAGWPDFICLSKGISGGYLPLSLVLSSDDIYAAFYDDSSTR
AFLHSHSYTGNPLACRAALATLDIFREDDVVAENRGRAERMRRQADERFANHPAVRHLRQQGMILAFDVDTGTLGAGEFA
RRFFAAALDHGLLLRPIGNTVYFMPPYVLGEDELRHLVDGAAAALERALR

Sequences:

>Translated_450_residues
MPFQSSSDLLQRSLAAVWHPCTQMKHHETLPLVPIVRGEGAWLIDADGRRLLDGISSWWVNLFGHCNRRINAALREQLET
LEHVMLAGFTHPPAVELAERLAALTGHRLGHAFYASDGASATEIALKMSVHYWRNRGEAGKNRFISLAGSYHGETAGALA
VTDVALFRDAYAPLVRPGATVPTPDIRLAVAGESASSLARRAAQALEAHLAEHHAETAALIVEPLVQGASGMVMYDAEYL
RQARALCDHYQVHLIADEIAVGCGRTGTFFAWEQVAADDAAGWPDFICLSKGISGGYLPLSLVLSSDDIYAAFYDDSSTR
AFLHSHSYTGNPLACRAALATLDIFREDDVVAENRGRAERMRRQADERFANHPAVRHLRQQGMILAFDVDTGTLGAGEFA
RRFFAAALDHGLLLRPIGNTVYFMPPYVLGEDELRHLVDGAAAALERALR
>Mature_449_residues
PFQSSSDLLQRSLAAVWHPCTQMKHHETLPLVPIVRGEGAWLIDADGRRLLDGISSWWVNLFGHCNRRINAALREQLETL
EHVMLAGFTHPPAVELAERLAALTGHRLGHAFYASDGASATEIALKMSVHYWRNRGEAGKNRFISLAGSYHGETAGALAV
TDVALFRDAYAPLVRPGATVPTPDIRLAVAGESASSLARRAAQALEAHLAEHHAETAALIVEPLVQGASGMVMYDAEYLR
QARALCDHYQVHLIADEIAVGCGRTGTFFAWEQVAADDAAGWPDFICLSKGISGGYLPLSLVLSSDDIYAAFYDDSSTRA
FLHSHSYTGNPLACRAALATLDIFREDDVVAENRGRAERMRRQADERFANHPAVRHLRQQGMILAFDVDTGTLGAGEFAR
RFFAAALDHGLLLRPIGNTVYFMPPYVLGEDELRHLVDGAAAALERALR

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=441, Percent_Identity=29.7052154195011, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI13994255, Length=376, Percent_Identity=27.9255319148936, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI284507298, Length=330, Percent_Identity=30.6060606060606, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI37574042, Length=418, Percent_Identity=24.6411483253589, Blast_Score=119, Evalue=7e-27,
Organism=Homo sapiens, GI226442705, Length=418, Percent_Identity=24.1626794258373, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI226442709, Length=388, Percent_Identity=24.2268041237113, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI24119277, Length=441, Percent_Identity=23.5827664399093, Blast_Score=102, Evalue=7e-22,
Organism=Escherichia coli, GI1786991, Length=441, Percent_Identity=37.4149659863946, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI145693181, Length=404, Percent_Identity=28.4653465346535, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=27.455919395466, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1789016, Length=448, Percent_Identity=27.0089285714286, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788044, Length=423, Percent_Identity=27.4231678486998, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1787560, Length=422, Percent_Identity=28.9099526066351, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786349, Length=405, Percent_Identity=25.9259259259259, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI32564660, Length=439, Percent_Identity=24.6013667425968, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=418, Percent_Identity=25.1196172248804, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI25144274, Length=237, Percent_Identity=27.8481012658228, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71992977, Length=473, Percent_Identity=21.1416490486258, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324386, Length=464, Percent_Identity=28.8793103448276, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6323470, Length=431, Percent_Identity=29.6983758700696, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6324432, Length=427, Percent_Identity=25.0585480093677, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21357415, Length=419, Percent_Identity=28.4009546539379, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI28574759, Length=450, Percent_Identity=27.3333333333333, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI161085790, Length=451, Percent_Identity=27.4944567627494, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI21356575, Length=328, Percent_Identity=25, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49167; Mature: 49036

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFQSSSDLLQRSLAAVWHPCTQMKHHETLPLVPIVRGEGAWLIDADGRRLLDGISSWWV
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHH
NLFGHCNRRINAALREQLETLEHVMLAGFTHPPAVELAERLAALTGHRLGHAFYASDGAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCC
ATEIALKMSVHYWRNRGEAGKNRFISLAGSYHGETAGALAVTDVALFRDAYAPLVRPGAT
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
VPTPDIRLAVAGESASSLARRAAQALEAHLAEHHAETAALIVEPLVQGASGMVMYDAEYL
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHH
RQARALCDHYQVHLIADEIAVGCGRTGTFFAWEQVAADDAAGWPDFICLSKGISGGYLPL
HHHHHHHHHHEEEEEHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEE
SLVLSSDDIYAAFYDDSSTRAFLHSHSYTGNPLACRAALATLDIFREDDVVAENRGRAER
EEEEECCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHH
MRRQADERFANHPAVRHLRQQGMILAFDVDTGTLGAGEFARRFFAAALDHGLLLRPIGNT
HHHHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCE
VYFMPPYVLGEDELRHLVDGAAAALERALR
EEECCCEEECHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PFQSSSDLLQRSLAAVWHPCTQMKHHETLPLVPIVRGEGAWLIDADGRRLLDGISSWWV
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHH
NLFGHCNRRINAALREQLETLEHVMLAGFTHPPAVELAERLAALTGHRLGHAFYASDGAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCEEEECCCCC
ATEIALKMSVHYWRNRGEAGKNRFISLAGSYHGETAGALAVTDVALFRDAYAPLVRPGAT
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
VPTPDIRLAVAGESASSLARRAAQALEAHLAEHHAETAALIVEPLVQGASGMVMYDAEYL
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHH
RQARALCDHYQVHLIADEIAVGCGRTGTFFAWEQVAADDAAGWPDFICLSKGISGGYLPL
HHHHHHHHHHEEEEEHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEE
SLVLSSDDIYAAFYDDSSTRAFLHSHSYTGNPLACRAALATLDIFREDDVVAENRGRAER
EEEEECCCEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHH
MRRQADERFANHPAVRHLRQQGMILAFDVDTGTLGAGEFARRFFAAALDHGLLLRPIGNT
HHHHHHHHHCCCHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCE
VYFMPPYVLGEDELRHLVDGAAAALERALR
EEECCCEEECHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]