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The map label for this gene is yegE [H]

Identifier: 119898170

GI number: 119898170

Start: 2061475

End: 2063547

Strand: Direct

Name: yegE [H]

Synonym: azo1879

Alternate gene names: 119898170

Gene position: 2061475-2063547 (Clockwise)

Preceding gene: 119898169

Following gene: 119898174

Centisome position: 47.11

GC content: 69.75

Gene sequence:

>2073_bases
ATGAAGGTATTCACCGCGCTGTCGCTCAAGCAGCGCCTGCTGATGGTGGTGCTGGTGCCGGCCGCCGTGCTGGCGGCGAC
GATCTCCGGCCTGCTGTTGATCCGCGACACGCAGGCGCTGGACGACGCGGCCACCGAGCGTGGCATCGCCATCGTCAGCT
TTCTCGCTCCCGCGGCGGAATACGGCGTCATTTCAGGCAACCGCACCAACCTCACCGCCCTCCTCCAGGCCGTGCTGGGC
CAGCGGGACGTGGCGGCGGTGGCGATCTACAACCCGGACGGCAGCGTGCTTGCCGTCAGTGGCAAACCGCGGCTGGACGA
TGTGTCGACGATGCGGCGGACGCACGGACCCACCACGCTCGAACGCGGCGACGACCGTATTTCCTTTGCGGCGCCAGTGC
AGCCCACCCCGCTCGTGATCGACGACCTGCCCGGCGGCGATGTCGACGGGACGGCGGCCGCGGGCGGCGGACCGCTGGGA
TGGGTGTACGTGGAGGTCGATACCCGTTCGCTGATCGAGCGCAAGCGCGACCTGGTGCTTGGCACGCTGGCCATCGTCGT
GCTGGGTCTCGCCCTCACCGCGGCCTTCGCGCTGCGTCTCGCGCGGTCGGTCGCAGAGCCCTTGGCCCGGCTGGTCGAGG
CCGTCAAGCAGATGGCCGCCGGCAACCTCGAAGTGTCGGTGCCGGACAGCGGGGCCGGTGCGGAACTGCAGGCACTGGAA
ACCGGCTTCAACGCGATGGCGCGCACCATGGCCGACGCCCACAAGACGCTGCAGGCGCGGGTGGACGAGGCGACGGAACT
CCTCGCGCATCAGGCGCTGCATGACCCCTTGACCGGCCTCCCCAATCGCCGCGCCTTCGAGCAGGCGCTGGAAGACGCGG
TGACGGCCTCGCGGCGTGCCGGCGACAGCGGCGTGCTGTGTTTCATCGACCTGGACCGCTTCAAGATCGTCAACGACACC
TGCGGCCACGCCGCGGGCGACGAACTGCTGCGGCGCATTGCGCGCCTGATCCGCCAGCGCGTCCGGGCCGAGGACCTGAT
CTGCCGCATCGGCGGTGACGAATTCGCGCTGATCCTGCATGGCTGCGGGCCGGAGGACGCGCACCGGATTGCCGAGAACA
TCCGCGAAGCCGTCGCGGCCTTCCGCTTTACCTGGGAGGGGCGGCGCTTCTCCGTCGGCGCGAGCATCGGGCTGGTCCGC
ATCGACGGCTCGCTCGCCACCGCTTCCGACGTTCTCGTGGCGGCGGACCTGGCCTGCTACGCCGCCAAGAAGAGCGGCCG
CAACCGGGTGGTGGAGCACGACGACGGTCCGGTCGGCGGTGCGGGCGACAGCGGGGATGCCGCCGTGCAAGCGGTGCAAC
CGGCCGCCATCCCCTACGATCAGTTGCTGCTCTACACTCAGGCGGTGGTGCCGGTGGGCGATGCCGCCACCGAGAGCTGG
AGCGAGATTCTGCTGCGCGTGGTCGGCCCAACCGGAGAAGTCGGTTCGGCCTCCGACCTGCTCGCCCGGCTGGAGCCCGG
CCGGCACCTGATCGAACTGGACGAGTGGGTGGCGGCGCAGGTATGCGCCGTGCTGGCTCGGGGCGCGGCGGGCGCGCCCT
TGCAGCGGGTCAGCCTCAATCTCAGTCGCAGTGCGGTGCTCGCATCCGGACGTTACGTCGCCCATCTCGAAACCCAGCTC
AAGCGCCATACGCTGGATCCGGACCTGGTGGTGCTGGAATTCCCCGCCTCGATGGTGGAGCAGGCGCCGGAGGAGTCGCG
CCATCTCGCCCGCGAGGCGCGCCGCGTCGGCTGCCGGATTGCGCTCGAGCGCATGGATGGTGGCGCCGTTGCGCTGCTGA
AGACCCTGCACCCGGACTACGTCAAGATCAGCCTCAAGCAACTGGTCGAAACCTACGGGCTGGAGGCCGGCTGCAATCTG
GCCCAGGCCTTGTGCGGCATGGCTGCGGCGCTGTCGATCCGGAGCGTGGCGTCCGAGGTGGAAGACGACCTGTTGCGCGA
CTCGCTGCGCGACTTCGGTTTCGATTTTGCGCAGGGCGCCCTCATCGCCGCCACCACCCCGCTGGAACGCTGA

Upstream 100 bases:

>100_bases
GCTTCGGGGTGGCGGTGAACCGCCAGGTTGCACGTTCGCTCGGGCTCACCGTGGCGGAAGATCTTGCGCTGGTGCGCGCG
ATGGGCTCGGGAGGTGGGCG

Downstream 100 bases:

>100_bases
CGAACCCTACATGCGCAGACGTTCCGCGTAGCCCGTCATTTCCAGGTAACCACGCCCTGCCTCGGTATGGTCGCGGTCTT
CGTCGAACAGACGCACAGCG

Product: putative signaling protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 690; Mature: 690

Protein sequence:

>690_residues
MKVFTALSLKQRLLMVVLVPAAVLAATISGLLLIRDTQALDDAATERGIAIVSFLAPAAEYGVISGNRTNLTALLQAVLG
QRDVAAVAIYNPDGSVLAVSGKPRLDDVSTMRRTHGPTTLERGDDRISFAAPVQPTPLVIDDLPGGDVDGTAAAGGGPLG
WVYVEVDTRSLIERKRDLVLGTLAIVVLGLALTAAFALRLARSVAEPLARLVEAVKQMAAGNLEVSVPDSGAGAELQALE
TGFNAMARTMADAHKTLQARVDEATELLAHQALHDPLTGLPNRRAFEQALEDAVTASRRAGDSGVLCFIDLDRFKIVNDT
CGHAAGDELLRRIARLIRQRVRAEDLICRIGGDEFALILHGCGPEDAHRIAENIREAVAAFRFTWEGRRFSVGASIGLVR
IDGSLATASDVLVAADLACYAAKKSGRNRVVEHDDGPVGGAGDSGDAAVQAVQPAAIPYDQLLLYTQAVVPVGDAATESW
SEILLRVVGPTGEVGSASDLLARLEPGRHLIELDEWVAAQVCAVLARGAAGAPLQRVSLNLSRSAVLASGRYVAHLETQL
KRHTLDPDLVVLEFPASMVEQAPEESRHLAREARRVGCRIALERMDGGAVALLKTLHPDYVKISLKQLVETYGLEAGCNL
AQALCGMAAALSIRSVASEVEDDLLRDSLRDFGFDFAQGALIAATTPLER

Sequences:

>Translated_690_residues
MKVFTALSLKQRLLMVVLVPAAVLAATISGLLLIRDTQALDDAATERGIAIVSFLAPAAEYGVISGNRTNLTALLQAVLG
QRDVAAVAIYNPDGSVLAVSGKPRLDDVSTMRRTHGPTTLERGDDRISFAAPVQPTPLVIDDLPGGDVDGTAAAGGGPLG
WVYVEVDTRSLIERKRDLVLGTLAIVVLGLALTAAFALRLARSVAEPLARLVEAVKQMAAGNLEVSVPDSGAGAELQALE
TGFNAMARTMADAHKTLQARVDEATELLAHQALHDPLTGLPNRRAFEQALEDAVTASRRAGDSGVLCFIDLDRFKIVNDT
CGHAAGDELLRRIARLIRQRVRAEDLICRIGGDEFALILHGCGPEDAHRIAENIREAVAAFRFTWEGRRFSVGASIGLVR
IDGSLATASDVLVAADLACYAAKKSGRNRVVEHDDGPVGGAGDSGDAAVQAVQPAAIPYDQLLLYTQAVVPVGDAATESW
SEILLRVVGPTGEVGSASDLLARLEPGRHLIELDEWVAAQVCAVLARGAAGAPLQRVSLNLSRSAVLASGRYVAHLETQL
KRHTLDPDLVVLEFPASMVEQAPEESRHLAREARRVGCRIALERMDGGAVALLKTLHPDYVKISLKQLVETYGLEAGCNL
AQALCGMAAALSIRSVASEVEDDLLRDSLRDFGFDFAQGALIAATTPLER
>Mature_690_residues
MKVFTALSLKQRLLMVVLVPAAVLAATISGLLLIRDTQALDDAATERGIAIVSFLAPAAEYGVISGNRTNLTALLQAVLG
QRDVAAVAIYNPDGSVLAVSGKPRLDDVSTMRRTHGPTTLERGDDRISFAAPVQPTPLVIDDLPGGDVDGTAAAGGGPLG
WVYVEVDTRSLIERKRDLVLGTLAIVVLGLALTAAFALRLARSVAEPLARLVEAVKQMAAGNLEVSVPDSGAGAELQALE
TGFNAMARTMADAHKTLQARVDEATELLAHQALHDPLTGLPNRRAFEQALEDAVTASRRAGDSGVLCFIDLDRFKIVNDT
CGHAAGDELLRRIARLIRQRVRAEDLICRIGGDEFALILHGCGPEDAHRIAENIREAVAAFRFTWEGRRFSVGASIGLVR
IDGSLATASDVLVAADLACYAAKKSGRNRVVEHDDGPVGGAGDSGDAAVQAVQPAAIPYDQLLLYTQAVVPVGDAATESW
SEILLRVVGPTGEVGSASDLLARLEPGRHLIELDEWVAAQVCAVLARGAAGAPLQRVSLNLSRSAVLASGRYVAHLETQL
KRHTLDPDLVVLEFPASMVEQAPEESRHLAREARRVGCRIALERMDGGAVALLKTLHPDYVKISLKQLVETYGLEAGCNL
AQALCGMAAALSIRSVASEVEDDLLRDSLRDFGFDFAQGALIAATTPLER

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=426, Percent_Identity=34.5070422535211, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI226510982, Length=588, Percent_Identity=24.1496598639456, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786584, Length=172, Percent_Identity=34.8837209302326, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI145693134, Length=166, Percent_Identity=34.9397590361446, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87081881, Length=177, Percent_Identity=38.9830508474576, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1787262, Length=175, Percent_Identity=34.8571428571429, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1787802, Length=266, Percent_Identity=29.3233082706767, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87081977, Length=165, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI1789149, Length=299, Percent_Identity=26.7558528428094, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI87082007, Length=179, Percent_Identity=36.3128491620112, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1788849, Length=434, Percent_Identity=22.1198156682028, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788956, Length=196, Percent_Identity=32.1428571428571, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1788085, Length=181, Percent_Identity=31.4917127071823, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1787541, Length=447, Percent_Identity=23.9373601789709, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87082096, Length=438, Percent_Identity=26.4840182648402, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87081974, Length=162, Percent_Identity=30.2469135802469, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787816, Length=181, Percent_Identity=31.4917127071823, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1787056, Length=164, Percent_Identity=29.2682926829268, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081921, Length=425, Percent_Identity=23.2941176470588, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 73116; Mature: 73116

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50885 HAMP ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVFTALSLKQRLLMVVLVPAAVLAATISGLLLIRDTQALDDAATERGIAIVSFLAPAAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHCCHHHHHHHHHHHH
YGVISGNRTNLTALLQAVLGQRDVAAVAIYNPDGSVLAVSGKPRLDDVSTMRRTHGPTTL
CCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHHHCCCCCC
ERGDDRISFAAPVQPTPLVIDDLPGGDVDGTAAAGGGPLGWVYVEVDTRSLIERKRDLVL
CCCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHH
GTLAIVVLGLALTAAFALRLARSVAEPLARLVEAVKQMAAGNLEVSVPDSGAGAELQALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHH
TGFNAMARTMADAHKTLQARVDEATELLAHQALHDPLTGLPNRRAFEQALEDAVTASRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCHHHHHHHHHHHHHHHHCC
GDSGVLCFIDLDRFKIVNDTCGHAAGDELLRRIARLIRQRVRAEDLICRIGGDEFALILH
CCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEE
GCGPEDAHRIAENIREAVAAFRFTWEGRRFSVGASIGLVRIDGSLATASDVLVAADLACY
CCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECCEEEEEEECCCCCCHHHHHHHHHHHHH
AAKKSGRNRVVEHDDGPVGGAGDSGDAAVQAVQPAAIPYDQLLLYTQAVVPVGDAATESW
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
SEILLRVVGPTGEVGSASDLLARLEPGRHLIELDEWVAAQVCAVLARGAAGAPLQRVSLN
HHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEC
LSRSAVLASGRYVAHLETQLKRHTLDPDLVVLEFPASMVEQAPEESRHLAREARRVGCRI
CCHHHHHHCCCEEEHHHHHHHHHCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHE
ALERMDGGAVALLKTLHPDYVKISLKQLVETYGLEAGCNLAQALCGMAAALSIRSVASEV
EEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EDDLLRDSLRDFGFDFAQGALIAATTPLER
HHHHHHHHHHHCCCHHHCCCEEEECCCCCC
>Mature Secondary Structure
MKVFTALSLKQRLLMVVLVPAAVLAATISGLLLIRDTQALDDAATERGIAIVSFLAPAAE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCHHHHHHHHHCCHHHHHHHHHHHH
YGVISGNRTNLTALLQAVLGQRDVAAVAIYNPDGSVLAVSGKPRLDDVSTMRRTHGPTTL
CCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHHHCCCCCC
ERGDDRISFAAPVQPTPLVIDDLPGGDVDGTAAAGGGPLGWVYVEVDTRSLIERKRDLVL
CCCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEECHHHHHHHHHHHHH
GTLAIVVLGLALTAAFALRLARSVAEPLARLVEAVKQMAAGNLEVSVPDSGAGAELQALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHH
TGFNAMARTMADAHKTLQARVDEATELLAHQALHDPLTGLPNRRAFEQALEDAVTASRRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCCHHHHHHHHHHHHHHHHCC
GDSGVLCFIDLDRFKIVNDTCGHAAGDELLRRIARLIRQRVRAEDLICRIGGDEFALILH
CCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEEEE
GCGPEDAHRIAENIREAVAAFRFTWEGRRFSVGASIGLVRIDGSLATASDVLVAADLACY
CCCCHHHHHHHHHHHHHHHHHHEEECCCEEEECCEEEEEEECCCCCCHHHHHHHHHHHHH
AAKKSGRNRVVEHDDGPVGGAGDSGDAAVQAVQPAAIPYDQLLLYTQAVVPVGDAATESW
HHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCCCCHHHHHH
SEILLRVVGPTGEVGSASDLLARLEPGRHLIELDEWVAAQVCAVLARGAAGAPLQRVSLN
HHHHHHHCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEC
LSRSAVLASGRYVAHLETQLKRHTLDPDLVVLEFPASMVEQAPEESRHLAREARRVGCRI
CCHHHHHHCCCEEEHHHHHHHHHCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHE
ALERMDGGAVALLKTLHPDYVKISLKQLVETYGLEAGCNLAQALCGMAAALSIRSVASEV
EEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EDDLLRDSLRDFGFDFAQGALIAATTPLER
HHHHHHHHHHHCCCHHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]