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The map label for this gene is butA [H]

Identifier: 119898150

GI number: 119898150

Start: 2042142

End: 2042897

Strand: Direct

Name: butA [H]

Synonym: azo1859

Alternate gene names: 119898150

Gene position: 2042142-2042897 (Clockwise)

Preceding gene: 119898149

Following gene: 119898151

Centisome position: 46.67

GC content: 73.54

Gene sequence:

>756_bases
ATGAAATCACAACAGGAAACGGCAGTTGTCGTCGGCGCCACCGGCGCTTTCGGCCAGGCCATCGTCTCGCGGCTGGTGGG
GCAGGGGCTGGCGGTGGTGGCGGTGGCGCGCTCGGTGGATGCGCTGGACGCGCTGCGCGAGCGCTGCCCGGGCCTGCGGG
CGTGCGCCGCCGACATCGCGTCGGACAGCGCCATCGCGGCGATCGGCGCCGCGGTCGATGGGCCGGTGCGGATGGTGGTG
CACGGCCCCGGGGTGGCGGTGGCGGGCGGCATTCTCAGCGCACCGACGGCGTCGATGACCGAGGCGGTGAACATCAAGGT
GGGCGGGCTGCTGCGCCTGGTGCGAGCGGTCGATGACCGGCTGGCGAGGGGAGGGCGCATCGTCGCCATCGGCGGCCATT
ACGGGCTGGAACCGACCGCCTACGCCGCCGCGGCCGGGGTGGCCAACGCGGCGCTGATGAACGTGGTGCGCCAGTTGAGC
CTGGCCTACGGCGAGCGCGGCATCACCGCCCACACCATCGCCCCCGGCCCGGCCGACACCGAGCGCCTGCACCGTGTTGC
CGCCGACCGGGCCGCGCTGCGCGGCATCAGCGTGGATGCGGTGCTGGATGAAATGCGCTGCGAATCCTCGATCGGCGCGC
TGACCACGCCGGAGCAGGTGGCCTGGGCGGTATCGCTGCTGCTGGCGCGCGAAGCCGACGCGATGACCGGTTCCACGCTG
ATGCTGGACGCCGGCCGTCGCCGCGGCCTGCCCTGA

Upstream 100 bases:

>100_bases
ACAAGCGAGTTGGGGGCGGCGACCTTTGCGCAGGACAACATCCCGCGCGAAAGCTTCCTGACCGTGCTCACCTGAGTTGC
CACCGGAAGGACGAAAACGC

Downstream 100 bases:

>100_bases
GGAGGCGGCGATGCCCATCCTGCATTTTCATCTCGCCGAAGGGCAGTACACCGCGGAACAGCACGAGGCGCTGCTGCTGG
AATCCAGCTGCTTCTTCGCC

Product: short-chain dehydrogenase family protein

Products: NA

Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MKSQQETAVVVGATGAFGQAIVSRLVGQGLAVVAVARSVDALDALRERCPGLRACAADIASDSAIAAIGAAVDGPVRMVV
HGPGVAVAGGILSAPTASMTEAVNIKVGGLLRLVRAVDDRLARGGRIVAIGGHYGLEPTAYAAAAGVANAALMNVVRQLS
LAYGERGITAHTIAPGPADTERLHRVAADRAALRGISVDAVLDEMRCESSIGALTTPEQVAWAVSLLLAREADAMTGSTL
MLDAGRRRGLP

Sequences:

>Translated_251_residues
MKSQQETAVVVGATGAFGQAIVSRLVGQGLAVVAVARSVDALDALRERCPGLRACAADIASDSAIAAIGAAVDGPVRMVV
HGPGVAVAGGILSAPTASMTEAVNIKVGGLLRLVRAVDDRLARGGRIVAIGGHYGLEPTAYAAAAGVANAALMNVVRQLS
LAYGERGITAHTIAPGPADTERLHRVAADRAALRGISVDAVLDEMRCESSIGALTTPEQVAWAVSLLLAREADAMTGSTL
MLDAGRRRGLP
>Mature_251_residues
MKSQQETAVVVGATGAFGQAIVSRLVGQGLAVVAVARSVDALDALRERCPGLRACAADIASDSAIAAIGAAVDGPVRMVV
HGPGVAVAGGILSAPTASMTEAVNIKVGGLLRLVRAVDDRLARGGRIVAIGGHYGLEPTAYAAAAGVANAALMNVVRQLS
LAYGERGITAHTIAPGPADTERLHRVAADRAALRGISVDAVLDEMRCESSIGALTTPEQVAWAVSLLLAREADAMTGSTL
MLDAGRRRGLP

Specific function: Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI109715829, Length=255, Percent_Identity=28.2352941176471, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI23397609, Length=255, Percent_Identity=25.0980392156863, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014007
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.304 [H]

Molecular weight: Translated: 25429; Mature: 25429

Theoretical pI: Translated: 8.09; Mature: 8.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSQQETAVVVGATGAFGQAIVSRLVGQGLAVVAVARSVDALDALRERCPGLRACAADIA
CCCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
SDSAIAAIGAAVDGPVRMVVHGPGVAVAGGILSAPTASMTEAVNIKVGGLLRLVRAVDDR
CCCHHHHHHHCCCCCEEEEEECCCHHHHCCHHCCCCHHHHHEEEEEHHHHHHHHHHHHHH
LARGGRIVAIGGHYGLEPTAYAAAAGVANAALMNVVRQLSLAYGERGITAHTIAPGPADT
HHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
ERLHRVAADRAALRGISVDAVLDEMRCESSIGALTTPEQVAWAVSLLLAREADAMTGSTL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEE
MLDAGRRRGLP
EEECCHHCCCC
>Mature Secondary Structure
MKSQQETAVVVGATGAFGQAIVSRLVGQGLAVVAVARSVDALDALRERCPGLRACAADIA
CCCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
SDSAIAAIGAAVDGPVRMVVHGPGVAVAGGILSAPTASMTEAVNIKVGGLLRLVRAVDDR
CCCHHHHHHHCCCCCEEEEEECCCHHHHCCHHCCCCHHHHHEEEEEHHHHHHHHHHHHHH
LARGGRIVAIGGHYGLEPTAYAAAAGVANAALMNVVRQLSLAYGERGITAHTIAPGPADT
HHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
ERLHRVAADRAALRGISVDAVLDEMRCESSIGALTTPEQVAWAVSLLLAREADAMTGSTL
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEE
MLDAGRRRGLP
EEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA