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The map label for this gene is atoC [H]

Identifier: 119898103

GI number: 119898103

Start: 1988694

End: 1990121

Strand: Direct

Name: atoC [H]

Synonym: azo1812

Alternate gene names: 119898103

Gene position: 1988694-1990121 (Clockwise)

Preceding gene: 119898101

Following gene: 119898104

Centisome position: 45.45

GC content: 66.39

Gene sequence:

>1428_bases
ATGCCGCAGGTACTGTTGGTAGATGACGATCCGGAATCCATCGGATGGTTGAGCGAGTTCATCAAGGCCGAGGGTTACAC
CGTCGGTTCGGTCGATTCCTTGCGCGCGGCGCGGATACATCTGACGCGCTCGCGCCCCGAGGTGATCCTGACCGACCTGA
TGCTGCCGGACGGGCAGGGTATCGAACTCGTCAATGAATTTCCCGCGGGCGAGGCGCCCGAGCTGGTGGTGATCACCGGC
CACGCCAGCGTGGAGAGCGCGATCGAGGCGCTGCGCGCGGGCGCGACCGACTACCTGGTCAAGCCGGTCGATGTCGAGCG
GCTGCGCGGCATCCTGCAGCGCATTCCGAAGGCGGAGCACTTCCGCGCCGAGATCGGCGAGCTGCGCAACGAGCTGCTGC
GGCTGGGCCGCTTCGGCCACATCCTGGGCAATTCTCCGGTGATGCGAAGGCTGTACGACCAGCTCGCGCGCGTGGCCCCC
ACCTCGGCCTCGGTACTGCTGATCGGTGAAAGCGGCACCGGCAAGGAAGTCTGCGCGCAGACCATCCACGAACTCAGCCG
CCGCAAACGCCAGCCCTTCCTGCCGCTCAACTGCGGCGCGGTATCGCCGCAACTGGTGGAAAGCGAACTCTTCGGTCACG
AAAAGGGCAGCTTCACCGGCGCCGACCGCCAGCACCAGGGTTTCTTCGAGCGCGCCAACCGCGGCACGCTGTTCCTCGAC
GAAGTCACCGAGATGCGGCCCGACCTGCAGGTGAAGCTGCTGCGCGTGCTGGAAACCGGCAGCTTCATGCGCGTGGGCAC
CAACGATCCGATCGCCACCGACGTGCGCCTGATCGCCGCCACCAACCGCTCGCCGGAAAAGGCGGTATCCGAAGGCCGGC
TGCGCGAAGACCTGTATCACCGCCTCAACGTGTTTCCGATCCACCTGCCGCCGCTGCGCGAACGCGGCACCGACATCGAG
CTGCTCGCGGAGCATTTCCTTGCCGAACTGAACGAGCAGGAACAGACCGCCAAGCGCTTCTCGCCGGAGGCGATCGCCGC
GCTGTACGCCCATTCGTGGCCGGGCAACGTGCGCGAGCTGAAGAACTATGTGCACCGCGCCTTCATCCTGGCCGACGAGG
TCATCGAAGCCGACATGGCGCCCGAAGGCTTCCTGCAGCCGGCGCACAGCCCGGTGCTGACGATCCGCATCGGCACGCCG
CTGGACGAGGTCAACCGGCGGGTGATGGAGGCGACGCTGCTCGAATGCGGCAACGTCAAGCGCAAGGCGGCCGAGATTCT
CGGCATCAGCCTCAAGACCCTCTACAACCGGCTCGCCGCCTACAACGCCGGCAAGGTCGAGGGCGATGCAGAGGGGTTCG
ACGGCGAGGACATCGAGGAAGAGTACGAGGACGGCGCGGCCGAGGAATACCGCGGCAAGCGCGCCTGA

Upstream 100 bases:

>100_bases
CGACCGAAATAATTACAAAAAATGAAAACCGGGCGCCGAGTTCAGGACGCTAACATCGTCCCGATCGGCGTCGAGGACGC
GACGTCCTGAGGGAGGCCAG

Downstream 100 bases:

>100_bases
GCGCGCGCCATGTAAGTCCTACACATCGCGGGTAGGCCTTACCGCCGCCGGGCGCTGCGGGGGCCGGAAGCGGAGCCGGG
GCCGGCGAAACCGGCGGGAA

Product: transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MPQVLLVDDDPESIGWLSEFIKAEGYTVGSVDSLRAARIHLTRSRPEVILTDLMLPDGQGIELVNEFPAGEAPELVVITG
HASVESAIEALRAGATDYLVKPVDVERLRGILQRIPKAEHFRAEIGELRNELLRLGRFGHILGNSPVMRRLYDQLARVAP
TSASVLLIGESGTGKEVCAQTIHELSRRKRQPFLPLNCGAVSPQLVESELFGHEKGSFTGADRQHQGFFERANRGTLFLD
EVTEMRPDLQVKLLRVLETGSFMRVGTNDPIATDVRLIAATNRSPEKAVSEGRLREDLYHRLNVFPIHLPPLRERGTDIE
LLAEHFLAELNEQEQTAKRFSPEAIAALYAHSWPGNVRELKNYVHRAFILADEVIEADMAPEGFLQPAHSPVLTIRIGTP
LDEVNRRVMEATLLECGNVKRKAAEILGISLKTLYNRLAAYNAGKVEGDAEGFDGEDIEEEYEDGAAEEYRGKRA

Sequences:

>Translated_475_residues
MPQVLLVDDDPESIGWLSEFIKAEGYTVGSVDSLRAARIHLTRSRPEVILTDLMLPDGQGIELVNEFPAGEAPELVVITG
HASVESAIEALRAGATDYLVKPVDVERLRGILQRIPKAEHFRAEIGELRNELLRLGRFGHILGNSPVMRRLYDQLARVAP
TSASVLLIGESGTGKEVCAQTIHELSRRKRQPFLPLNCGAVSPQLVESELFGHEKGSFTGADRQHQGFFERANRGTLFLD
EVTEMRPDLQVKLLRVLETGSFMRVGTNDPIATDVRLIAATNRSPEKAVSEGRLREDLYHRLNVFPIHLPPLRERGTDIE
LLAEHFLAELNEQEQTAKRFSPEAIAALYAHSWPGNVRELKNYVHRAFILADEVIEADMAPEGFLQPAHSPVLTIRIGTP
LDEVNRRVMEATLLECGNVKRKAAEILGISLKTLYNRLAAYNAGKVEGDAEGFDGEDIEEEYEDGAAEEYRGKRA
>Mature_474_residues
PQVLLVDDDPESIGWLSEFIKAEGYTVGSVDSLRAARIHLTRSRPEVILTDLMLPDGQGIELVNEFPAGEAPELVVITGH
ASVESAIEALRAGATDYLVKPVDVERLRGILQRIPKAEHFRAEIGELRNELLRLGRFGHILGNSPVMRRLYDQLARVAPT
SASVLLIGESGTGKEVCAQTIHELSRRKRQPFLPLNCGAVSPQLVESELFGHEKGSFTGADRQHQGFFERANRGTLFLDE
VTEMRPDLQVKLLRVLETGSFMRVGTNDPIATDVRLIAATNRSPEKAVSEGRLREDLYHRLNVFPIHLPPLRERGTDIEL
LAEHFLAELNEQEQTAKRFSPEAIAALYAHSWPGNVRELKNYVHRAFILADEVIEADMAPEGFLQPAHSPVLTIRIGTPL
DEVNRRVMEATLLECGNVKRKAAEILGISLKTLYNRLAAYNAGKVEGDAEGFDGEDIEEEYEDGAAEEYRGKRA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=449, Percent_Identity=40.5345211581292, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=41.7977528089888, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1790299, Length=464, Percent_Identity=38.3620689655172, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI1788905, Length=455, Percent_Identity=37.1428571428571, Blast_Score=254, Evalue=9e-69,
Organism=Escherichia coli, GI1789233, Length=318, Percent_Identity=40.8805031446541, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1789087, Length=306, Percent_Identity=43.4640522875817, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI87082117, Length=254, Percent_Identity=46.4566929133858, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI87082152, Length=262, Percent_Identity=45.0381679389313, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI1787583, Length=313, Percent_Identity=38.0191693290735, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI87081872, Length=306, Percent_Identity=38.562091503268, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1786524, Length=335, Percent_Identity=39.7014925373134, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789828, Length=322, Percent_Identity=32.6086956521739, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI87081858, Length=317, Percent_Identity=29.6529968454259, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786838, Length=125, Percent_Identity=36, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786911, Length=118, Percent_Identity=32.2033898305085, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52814; Mature: 52683

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQVLLVDDDPESIGWLSEFIKAEGYTVGSVDSLRAARIHLTRSRPEVILTDLMLPDGQG
CCCEEEECCCCHHHHHHHHHHHHCCCEECCHHHHHHHHEEEECCCCCEEEEEEECCCCCC
IELVNEFPAGEAPELVVITGHASVESAIEALRAGATDYLVKPVDVERLRGILQRIPKAEH
CHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCCHHHEECCCCHHHHHHHHHHCCCHHH
FRAEIGELRNELLRLGRFGHILGNSPVMRRLYDQLARVAPTSASVLLIGESGTGKEVCAQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHH
TIHELSRRKRQPFLPLNCGAVSPQLVESELFGHEKGSFTGADRQHQGFFERANRGTLFLD
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEH
EVTEMRPDLQVKLLRVLETGSFMRVGTNDPIATDVRLIAATNRSPEKAVSEGRLREDLYH
HHHHCCCCHHHHHHHHHHCCCEEEECCCCCCHHCEEEEEECCCCHHHHHHHHHHHHHHHH
RLNVFPIHLPPLRERGTDIELLAEHFLAELNEQEQTAKRFSPEAIAALYAHSWPGNVREL
HHCEEEEECCCHHHCCCCHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHCCCCCCHHHH
KNYVHRAFILADEVIEADMAPEGFLQPAHSPVLTIRIGTPLDEVNRRVMEATLLECGNVK
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHH
RKAAEILGISLKTLYNRLAAYNAGKVEGDAEGFDGEDIEEEYEDGAAEEYRGKRA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHCCCCC
>Mature Secondary Structure 
PQVLLVDDDPESIGWLSEFIKAEGYTVGSVDSLRAARIHLTRSRPEVILTDLMLPDGQG
CCEEEECCCCHHHHHHHHHHHHCCCEECCHHHHHHHHEEEECCCCCEEEEEEECCCCCC
IELVNEFPAGEAPELVVITGHASVESAIEALRAGATDYLVKPVDVERLRGILQRIPKAEH
CHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCCHHHEECCCCHHHHHHHHHHCCCHHH
FRAEIGELRNELLRLGRFGHILGNSPVMRRLYDQLARVAPTSASVLLIGESGTGKEVCAQ
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHH
TIHELSRRKRQPFLPLNCGAVSPQLVESELFGHEKGSFTGADRQHQGFFERANRGTLFLD
HHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEEH
EVTEMRPDLQVKLLRVLETGSFMRVGTNDPIATDVRLIAATNRSPEKAVSEGRLREDLYH
HHHHCCCCHHHHHHHHHHCCCEEEECCCCCCHHCEEEEEECCCCHHHHHHHHHHHHHHHH
RLNVFPIHLPPLRERGTDIELLAEHFLAELNEQEQTAKRFSPEAIAALYAHSWPGNVREL
HHCEEEEECCCHHHCCCCHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHCCCCCCHHHH
KNYVHRAFILADEVIEADMAPEGFLQPAHSPVLTIRIGTPLDEVNRRVMEATLLECGNVK
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCHH
RKAAEILGISLKTLYNRLAAYNAGKVEGDAEGFDGEDIEEEYEDGAAEEYRGKRA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]