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The map label for this gene is yxnA [H]

Identifier: 119898051

GI number: 119898051

Start: 1926417

End: 1927421

Strand: Direct

Name: yxnA [H]

Synonym: azo1760

Alternate gene names: 119898051

Gene position: 1926417-1927421 (Clockwise)

Preceding gene: 119898050

Following gene: 119898055

Centisome position: 44.02

GC content: 74.13

Gene sequence:

>1005_bases
ATGACAGCGCCGATCGTGGTGGTGACAGGGGGATCGGCCGGCGTGGGACGTGCCGTGGCACTGACGTTTGCGCGCCATGG
CTGGCGCGTGGCGGTGCTGGCGCGCGGCGAGGCGCGCCTGGACGACGCCTGCGCGCAGATCCGCGCGCTGGGCGCCGAAG
CCATGAAGCTGGTGGCCGACGTTGCCGACCCCGCGCAGGTGGAAGCGGCCGCCGACGAGGTGGAGCGCCGCTGGGGGCCG
ATCGCAGTGTGGGTGAACAACGCAATGGCCACGGTGTTCGGCGACCTTGCGCGCGTGCCCGCGGTGGACTTCCGGCGCGC
GACCGAAGTGACCTACCTCGGCGCGGTATGGGGGACGCAGGCCGCATTGCGCCACATGCGGCCCCGCAACCGGGGTTGCA
TCGTGCAGGTCGGGTCGGCGCTGGCCTACCGCTCGATCGCGCTGCAGTCCGCCTATTGCGGCGCCAAGTCGGCGTTGCGC
GGCTTCACCGATGCGCTGCGGCTGGAACTGCTGCATGCGCGCAGCGCGGTGCGGGTGACGATGGTGCACCTGCCGGCCTG
CAACACGCCGCAGTTCGACTGGAGCCGCAACTACATGGACGGACGCCCGCGCCCGCTGGGCTGGGTCTATCCACCGGACT
GGGTCGCGCGCGCCATCTATCGCGCCGCGGCGGGAACCCGGCGCGAACACTGGGTGGGCCTGCCGGCGGCCTTGGCCATC
GTCGGCGCGCGTTTTGCGCCCGGCTGGTTCAAGCACACGCTGGCCGAACAGACCTGGCACGGCCAGCTTGAGGAGGAGGG
GGAACGCGGCGCGGCGCACCACGCGCCCGACAACCTCTTCGCGCCTGCACCCGGGTGCCCCCGCGCGGAGGGTCGATTCG
GCCGCGCGGCGCAGGCGACGCGGGCGCGGCTGGTGGCGGGGCGCCTGCTGGCGCTCGGCGCGCTGCTCGTGGGGGCGAGC
CGCCTGCTGGCGCGGACGGCCCGGCAGCGCGACGGCGGCGGATGA

Upstream 100 bases:

>100_bases
CGCTGTTCTACCTTGCGGCGGGCGGCTGGCTGGTGTGGCGGCGGTTTGCGCGCACGGCGGAAGCGACCGCGGCGGTGTCG
CCGCAAGCAGGAGAGGGGCG

Downstream 100 bases:

>100_bases
GGGCGTCGGTGCCGGCTCAACGCGCCTCGGCTTCCAGCGCCAGCTCGGTACCCGGCTTGCCCCCGGCGGCGCTCGCGTCG
CGCAGCGTGATCCGCTCCGC

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MTAPIVVVTGGSAGVGRAVALTFARHGWRVAVLARGEARLDDACAQIRALGAEAMKLVADVADPAQVEAAADEVERRWGP
IAVWVNNAMATVFGDLARVPAVDFRRATEVTYLGAVWGTQAALRHMRPRNRGCIVQVGSALAYRSIALQSAYCGAKSALR
GFTDALRLELLHARSAVRVTMVHLPACNTPQFDWSRNYMDGRPRPLGWVYPPDWVARAIYRAAAGTRREHWVGLPAALAI
VGARFAPGWFKHTLAEQTWHGQLEEEGERGAAHHAPDNLFAPAPGCPRAEGRFGRAAQATRARLVAGRLLALGALLVGAS
RLLARTARQRDGGG

Sequences:

>Translated_334_residues
MTAPIVVVTGGSAGVGRAVALTFARHGWRVAVLARGEARLDDACAQIRALGAEAMKLVADVADPAQVEAAADEVERRWGP
IAVWVNNAMATVFGDLARVPAVDFRRATEVTYLGAVWGTQAALRHMRPRNRGCIVQVGSALAYRSIALQSAYCGAKSALR
GFTDALRLELLHARSAVRVTMVHLPACNTPQFDWSRNYMDGRPRPLGWVYPPDWVARAIYRAAAGTRREHWVGLPAALAI
VGARFAPGWFKHTLAEQTWHGQLEEEGERGAAHHAPDNLFAPAPGCPRAEGRFGRAAQATRARLVAGRLLALGALLVGAS
RLLARTARQRDGGG
>Mature_333_residues
TAPIVVVTGGSAGVGRAVALTFARHGWRVAVLARGEARLDDACAQIRALGAEAMKLVADVADPAQVEAAADEVERRWGPI
AVWVNNAMATVFGDLARVPAVDFRRATEVTYLGAVWGTQAALRHMRPRNRGCIVQVGSALAYRSIALQSAYCGAKSALRG
FTDALRLELLHARSAVRVTMVHLPACNTPQFDWSRNYMDGRPRPLGWVYPPDWVARAIYRAAAGTRREHWVGLPAALAIV
GARFAPGWFKHTLAEQTWHGQLEEEGERGAAHHAPDNLFAPAPGCPRAEGRFGRAAQATRARLVAGRLLALGALLVGASR
LLARTARQRDGGG

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4503817, Length=231, Percent_Identity=29.8701298701299, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI142976729, Length=260, Percent_Identity=27.6923076923077, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI40254992, Length=216, Percent_Identity=32.8703703703704, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI7706318, Length=174, Percent_Identity=33.3333333333333, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI210032110, Length=166, Percent_Identity=30.1204819277108, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI20149619, Length=265, Percent_Identity=27.5471698113208, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI157739938, Length=255, Percent_Identity=25.8823529411765, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI40807363, Length=236, Percent_Identity=22.8813559322034, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI31543615, Length=151, Percent_Identity=33.112582781457, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=197, Percent_Identity=29.9492385786802, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082100, Length=187, Percent_Identity=31.5508021390374, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786701, Length=179, Percent_Identity=29.0502793296089, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788459, Length=210, Percent_Identity=28.0952380952381, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787820, Length=180, Percent_Identity=30.5555555555556, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567345, Length=165, Percent_Identity=29.0909090909091, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI193203117, Length=188, Percent_Identity=27.6595744680851, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193203115, Length=188, Percent_Identity=27.6595744680851, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997402, Length=169, Percent_Identity=30.7692307692308, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=26.5917602996255, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17570069, Length=169, Percent_Identity=28.9940828402367, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=269, Percent_Identity=28.2527881040892, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17508895, Length=242, Percent_Identity=25.2066115702479, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=187, Percent_Identity=29.9465240641711, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=254, Percent_Identity=25.1968503937008, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=183, Percent_Identity=27.8688524590164, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281364892, Length=257, Percent_Identity=28.4046692607004, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21356301, Length=263, Percent_Identity=27.7566539923954, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24640492, Length=199, Percent_Identity=27.6381909547739, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI23397609, Length=229, Percent_Identity=30.5676855895196, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24581726, Length=243, Percent_Identity=26.3374485596708, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI21358495, Length=183, Percent_Identity=29.5081967213115, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355631, Length=273, Percent_Identity=23.8095238095238, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357041, Length=180, Percent_Identity=28.3333333333333, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 35896; Mature: 35764

Theoretical pI: Translated: 11.11; Mature: 11.11

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPIVVVTGGSAGVGRAVALTFARHGWRVAVLARGEARLDDACAQIRALGAEAMKLVAD
CCCCEEEEECCCCCCCHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
VADPAQVEAAADEVERRWGPIAVWVNNAMATVFGDLARVPAVDFRRATEVTYLGAVWGTQ
CCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHEEEHHHHHHH
AALRHMRPRNRGCIVQVGSALAYRSIALQSAYCGAKSALRGFTDALRLELLHARSAVRVT
HHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEE
MVHLPACNTPQFDWSRNYMDGRPRPLGWVYPPDWVARAIYRAAAGTRREHWVGLPAALAI
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCHHHHHHH
VGARFAPGWFKHTLAEQTWHGQLEEEGERGAAHHAPDNLFAPAPGCPRAEGRFGRAAQAT
HHHHCCCHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RARLVAGRLLALGALLVGASRLLARTARQRDGGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAPIVVVTGGSAGVGRAVALTFARHGWRVAVLARGEARLDDACAQIRALGAEAMKLVAD
CCCEEEEECCCCCCCHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
VADPAQVEAAADEVERRWGPIAVWVNNAMATVFGDLARVPAVDFRRATEVTYLGAVWGTQ
CCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHHHHHHHEEEHHHHHHH
AALRHMRPRNRGCIVQVGSALAYRSIALQSAYCGAKSALRGFTDALRLELLHARSAVRVT
HHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCEEEEE
MVHLPACNTPQFDWSRNYMDGRPRPLGWVYPPDWVARAIYRAAAGTRREHWVGLPAALAI
EEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCHHHHHHH
VGARFAPGWFKHTLAEQTWHGQLEEEGERGAAHHAPDNLFAPAPGCPRAEGRFGRAAQAT
HHHHCCCHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
RARLVAGRLLALGALLVGASRLLARTARQRDGGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]