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The map label for this gene is moeA1 [H]

Identifier: 119897853

GI number: 119897853

Start: 1715261

End: 1716466

Strand: Direct

Name: moeA1 [H]

Synonym: azo1562

Alternate gene names: 119897853

Gene position: 1715261-1716466 (Clockwise)

Preceding gene: 119897852

Following gene: 119897854

Centisome position: 39.2

GC content: 71.14

Gene sequence:

>1206_bases
ATGAACGCCAGCATGCTCTCCTTCGACGAAGCGCTTGCCGCGCTCCTCGGTCACGCGCGTCCGGTTCGCGAGGTCGATCA
GGTTGACACCATGGTCGCCAACGGGCGCGTGCTCGCCGTGGCCCAGCACTCCCCGATCGACCAGCCGCCGATGGACAACT
CCGCCATGGACGGCTACGCGTTGCGCGTGGCCGACGTTGCCGCGGCCGGCACCCGGCTGCCGGTGAGCCAGCGCATTCCC
GCCGGCGGCACCGCGCATGCGCTGGCGGCCGGAACCGCCGCGCGCATCTTCACCGGCGCTCCGTTGCCGGCCGGTGCTGA
CGCCGTGGTGATGCAGGAATTCTGCGAACACGACGGTGAGAGCGTGATCGTCAACCGCGTTCCCCGCCTCGGTGAGGCGG
TGCGGCGCGCCGGCGAGGACATCCGCGCGGGCGCGGCGATTCTCCCTGCCGGCACGCGGCTGCGGCCGCAGGAGGTGGCG
CTGGCGGCCTCGGTCGGTCTCGCCCAGCTGCCCGTCTTCCGCCGCGTGCGGGTGGCGATGTTCTCCACGGGCAGCGAGCT
GGTGATGCCCGGCGAGCCGCTGCCGCCCGGCGGAATCTACAACTCGAACCGTTTCATGCTGCACGCACTGCTGGCCGGGA
TGGGCTGTGAAGTCACCGATTTCGGCATCGTGCCCGACCGGCTGGATGCGACCCGCGATGCGTTGCGCGCGGCCGCCGAG
GGCCACGACCTGATCCTCACCAGCGGCGGCGTGTCGATGGGCGAAGAAGACCACGTCAAGCCCGCGGTCGAGGCCGAGGG
CAGCCTGGACATGTGGAAGATCGCGATGAAGCCCGGCAAGCCGCTCGCCTATGGCCGCGTCCGCGGCGCGGCGTTCATCG
GCCTGCCCGGCAACCCGGTATCGAGTTTCGTCACCTTCCTGCTGATGGTCCGGCCCTTCCTGCTCGCCACCCAGGGCGTG
GCCGAGACGGTGCCGCTGGCGCTGTCCCTGCGCGCCGCGTTCGACTGGCCGAAGCCGGACCGTCGGCGCGAGTTCCTGCG
CGCACGGGTCAACGCCGCCGGTGAAGTCGAACTCTTCTCCAACCAGGGCGCCGCCGCGCTCGGCTCCACCGTTTGGGCGA
ACGGGCTGGTCGACGTGCCCGCCGATACCCCGATCCGCCAGGGCGACACCGTGCGCTTCCTGCCGTATGGCGAACTGCTT
GCCTGA

Upstream 100 bases:

>100_bases
CCGTGGCCACCGACGCAGACATCGCCTGTCCGCTGCCGCGCCTGCCGCTCAACGACGCCGCCGCGGTTGCGGCCTTCATC
CTCGAATTCACGGAGTCCAC

Downstream 100 bases:

>100_bases
CTATACTGAGCCATGAACGTCAAGATCCTGTTTTTTGCCAGCCTGCGTGAAGCGCTGGGAACCGCGTCCGAGTCCTATAC
GTTGCCGGCCGGCGGCCTCA

Product: molybdopterin cofactor biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MNASMLSFDEALAALLGHARPVREVDQVDTMVANGRVLAVAQHSPIDQPPMDNSAMDGYALRVADVAAAGTRLPVSQRIP
AGGTAHALAAGTAARIFTGAPLPAGADAVVMQEFCEHDGESVIVNRVPRLGEAVRRAGEDIRAGAAILPAGTRLRPQEVA
LAASVGLAQLPVFRRVRVAMFSTGSELVMPGEPLPPGGIYNSNRFMLHALLAGMGCEVTDFGIVPDRLDATRDALRAAAE
GHDLILTSGGVSMGEEDHVKPAVEAEGSLDMWKIAMKPGKPLAYGRVRGAAFIGLPGNPVSSFVTFLLMVRPFLLATQGV
AETVPLALSLRAAFDWPKPDRRREFLRARVNAAGEVELFSNQGAAALGSTVWANGLVDVPADTPIRQGDTVRFLPYGELL
A

Sequences:

>Translated_401_residues
MNASMLSFDEALAALLGHARPVREVDQVDTMVANGRVLAVAQHSPIDQPPMDNSAMDGYALRVADVAAAGTRLPVSQRIP
AGGTAHALAAGTAARIFTGAPLPAGADAVVMQEFCEHDGESVIVNRVPRLGEAVRRAGEDIRAGAAILPAGTRLRPQEVA
LAASVGLAQLPVFRRVRVAMFSTGSELVMPGEPLPPGGIYNSNRFMLHALLAGMGCEVTDFGIVPDRLDATRDALRAAAE
GHDLILTSGGVSMGEEDHVKPAVEAEGSLDMWKIAMKPGKPLAYGRVRGAAFIGLPGNPVSSFVTFLLMVRPFLLATQGV
AETVPLALSLRAAFDWPKPDRRREFLRARVNAAGEVELFSNQGAAALGSTVWANGLVDVPADTPIRQGDTVRFLPYGELL
A
>Mature_401_residues
MNASMLSFDEALAALLGHARPVREVDQVDTMVANGRVLAVAQHSPIDQPPMDNSAMDGYALRVADVAAAGTRLPVSQRIP
AGGTAHALAAGTAARIFTGAPLPAGADAVVMQEFCEHDGESVIVNRVPRLGEAVRRAGEDIRAGAAILPAGTRLRPQEVA
LAASVGLAQLPVFRRVRVAMFSTGSELVMPGEPLPPGGIYNSNRFMLHALLAGMGCEVTDFGIVPDRLDATRDALRAAAE
GHDLILTSGGVSMGEEDHVKPAVEAEGSLDMWKIAMKPGKPLAYGRVRGAAFIGLPGNPVSSFVTFLLMVRPFLLATQGV
AETVPLALSLRAAFDWPKPDRRREFLRARVNAAGEVELFSNQGAAALGSTVWANGLVDVPADTPIRQGDTVRFLPYGELL
A

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=419, Percent_Identity=33.890214797136, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI66932975, Length=419, Percent_Identity=33.890214797136, Blast_Score=181, Evalue=8e-46,
Organism=Escherichia coli, GI1787049, Length=388, Percent_Identity=42.5257731958763, Blast_Score=287, Evalue=9e-79,
Organism=Caenorhabditis elegans, GI25147659, Length=377, Percent_Identity=32.0954907161804, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=377, Percent_Identity=25.7294429708223, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17136978, Length=388, Percent_Identity=34.2783505154639, Blast_Score=161, Evalue=7e-40,
Organism=Drosophila melanogaster, GI24638841, Length=388, Percent_Identity=34.2783505154639, Blast_Score=161, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42214; Mature: 42214

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASMLSFDEALAALLGHARPVREVDQVDTMVANGRVLAVAQHSPIDQPPMDNSAMDGYA
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCEE
LRVADVAAAGTRLPVSQRIPAGGTAHALAAGTAARIFTGAPLPAGADAVVMQEFCEHDGE
EEEHHHHHCCCCCCHHCCCCCCCCHHHHHHCCHHHEEECCCCCCCCHHHHHHHHHHCCCC
SVIVNRVPRLGEAVRRAGEDIRAGAAILPAGTRLRPQEVALAASVGLAQLPVFRRVRVAM
EEEECCCHHHHHHHHHCCHHHHCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
FSTGSELVMPGEPLPPGGIYNSNRFMLHALLAGMGCEVTDFGIVPDRLDATRDALRAAAE
CCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCC
GHDLILTSGGVSMGEEDHVKPAVEAEGSLDMWKIAMKPGKPLAYGRVRGAAFIGLPGNPV
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCEEEEECCCCHH
SSFVTFLLMVRPFLLATQGVAETVPLALSLRAAFDWPKPDRRREFLRARVNAAGEVELFS
HHHHHHHHHHHHHHHHHCCHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEC
NQGAAALGSTVWANGLVDVPADTPIRQGDTVRFLPYGELLA
CCCCHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCHHHCC
>Mature Secondary Structure
MNASMLSFDEALAALLGHARPVREVDQVDTMVANGRVLAVAQHSPIDQPPMDNSAMDGYA
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCCEE
LRVADVAAAGTRLPVSQRIPAGGTAHALAAGTAARIFTGAPLPAGADAVVMQEFCEHDGE
EEEHHHHHCCCCCCHHCCCCCCCCHHHHHHCCHHHEEECCCCCCCCHHHHHHHHHHCCCC
SVIVNRVPRLGEAVRRAGEDIRAGAAILPAGTRLRPQEVALAASVGLAQLPVFRRVRVAM
EEEECCCHHHHHHHHHCCHHHHCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
FSTGSELVMPGEPLPPGGIYNSNRFMLHALLAGMGCEVTDFGIVPDRLDATRDALRAAAE
CCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHCC
GHDLILTSGGVSMGEEDHVKPAVEAEGSLDMWKIAMKPGKPLAYGRVRGAAFIGLPGNPV
CCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCEEEEECCCCHH
SSFVTFLLMVRPFLLATQGVAETVPLALSLRAAFDWPKPDRRREFLRARVNAAGEVELFS
HHHHHHHHHHHHHHHHHCCHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEEC
NQGAAALGSTVWANGLVDVPADTPIRQGDTVRFLPYGELLA
CCCCHHHHHHHHHCCCEECCCCCCCCCCCEEEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]