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The map label for this gene is gltA [H]

Identifier: 119897845

GI number: 119897845

Start: 1701845

End: 1703140

Strand: Direct

Name: gltA [H]

Synonym: azo1554

Alternate gene names: 119897845

Gene position: 1701845-1703140 (Clockwise)

Preceding gene: 119897844

Following gene: 119897846

Centisome position: 38.89

GC content: 61.65

Gene sequence:

>1296_bases
ATGAGCACTGAACGCACCGCAACCCTAACCGTCGATGGCAAGACCGTCGATTTCCCCGTGATGACCGGCACCCATGGCCA
GGATGTCATCGACATCCGTACCCTGGGCGGGAAGACGGGCTTGTTCACCTACGATTCCGGTTTCCTCTCCACCGCCAGCT
GCAAGTCGAAGATCACCTTCATCGACGGCGACAAGGGTGAACTGCTGTACCGCGGCTACCCGATCGAGCAACTCGCCGAG
AAGTGCAACTTCCTCGAAGTCGCCTACCTGCTCAAGAACGGCGAACTGCCGAACGCGGCGCAGAAGCTGGATTTCGAAAA
CACCATCAAGAGCCACACGATGGTGCACGACCAGCTGACCCGCTTCTACAACGGCTTCCGCCGTGACGCCCACCCGATGG
CGATCATGGTGGGCGTGGTCGGCGCGCTGTCCGCGTTCTACCACGACGCGATGGACTTCTCCGACCAGGAGCACCGCAAC
GTCTCGATCAACCGCCTGATCGCGAAGCTGCCGACCATCGTCGCCATGGCCTACAAGTACAACACCGGCCAGCCGTTCAT
GTACCCGCGCAACGACCTCGACTACACGTCGAACTTCATGCACATGATGTTCGGTACGCCGTGCGAGGAGTACAAGCCGA
ACCCGGTGCTGGTGCGCGCGCTCGACGTCATCTTCACGCTGCACGCCGACCACGAGCAGAACGCCTCCACCTCCACGGTG
CGTCTGGCCGGCTCCTCGGGCGCAAACCCGTTCGCCTGCATCTCGGCCGGTATTGCCTGCCTGTGGGGCCCGGCCCACGG
CGGCGCGAACGAAGCCTGCCTGAACATGCTGGAAGAAATCGGCGACGTGTCCCGCGTCGGCGAGTACATCAAGCGTGCCA
AGGACAAGAACGACAGCTTCAAGCTGATGGGCTTCGGCCACCGCGTCTACAAGAACTTCGACCCGCGCGCCAAGCTGATG
GGCAAGGTCTGCAACGACGTGCTGACCGAACTCGGCCTCGAAGACGACCGCCTGTTCAAGCTGGCCAAGGAACTCGAAAA
GATCGCGCTGGAAGACGAGTACTTCGTCGAGAAGAAGCTCTACCCGAACGTCGACTTCTACTCGGGCATCGTGCAGAAGG
CACTGGGCATCCCGACTTCCATGTTCACCTGCATCTTCGCGCTCGCGCGCACGGTGGGCTGGATCACCCAGTGGGAAGAA
ATGATCACCGATCCGGAATACAAGATCGGCCGTCCGCGCCAGCTGTACATCGGCGCGGCACGTCGCGACGTTCCGGTCAT
CGGACAGCGTCCGTAA

Upstream 100 bases:

>100_bases
GGAGATGATTGGCTTGCTGCGTCAGAAGTGACGCAGGCAAGCCGGTCATGAACGAGGGAGTTAGCTTTAGAAAATCGGGC
AAAGCCACAAAGGGACGACC

Downstream 100 bases:

>100_bases
GAGACGATGGAGAGGGGAGGGAGGCTATCCCGGTTCTAGCCGTCGCGGGATGGTGGCCTTGTGTCGCCATCCCGTTTTTC
CTTCGACGTCTGGTGCCGGT

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSTERTATLTVDGKTVDFPVMTGTHGQDVIDIRTLGGKTGLFTYDSGFLSTASCKSKITFIDGDKGELLYRGYPIEQLAE
KCNFLEVAYLLKNGELPNAAQKLDFENTIKSHTMVHDQLTRFYNGFRRDAHPMAIMVGVVGALSAFYHDAMDFSDQEHRN
VSINRLIAKLPTIVAMAYKYNTGQPFMYPRNDLDYTSNFMHMMFGTPCEEYKPNPVLVRALDVIFTLHADHEQNASTSTV
RLAGSSGANPFACISAGIACLWGPAHGGANEACLNMLEEIGDVSRVGEYIKRAKDKNDSFKLMGFGHRVYKNFDPRAKLM
GKVCNDVLTELGLEDDRLFKLAKELEKIALEDEYFVEKKLYPNVDFYSGIVQKALGIPTSMFTCIFALARTVGWITQWEE
MITDPEYKIGRPRQLYIGAARRDVPVIGQRP

Sequences:

>Translated_431_residues
MSTERTATLTVDGKTVDFPVMTGTHGQDVIDIRTLGGKTGLFTYDSGFLSTASCKSKITFIDGDKGELLYRGYPIEQLAE
KCNFLEVAYLLKNGELPNAAQKLDFENTIKSHTMVHDQLTRFYNGFRRDAHPMAIMVGVVGALSAFYHDAMDFSDQEHRN
VSINRLIAKLPTIVAMAYKYNTGQPFMYPRNDLDYTSNFMHMMFGTPCEEYKPNPVLVRALDVIFTLHADHEQNASTSTV
RLAGSSGANPFACISAGIACLWGPAHGGANEACLNMLEEIGDVSRVGEYIKRAKDKNDSFKLMGFGHRVYKNFDPRAKLM
GKVCNDVLTELGLEDDRLFKLAKELEKIALEDEYFVEKKLYPNVDFYSGIVQKALGIPTSMFTCIFALARTVGWITQWEE
MITDPEYKIGRPRQLYIGAARRDVPVIGQRP
>Mature_430_residues
STERTATLTVDGKTVDFPVMTGTHGQDVIDIRTLGGKTGLFTYDSGFLSTASCKSKITFIDGDKGELLYRGYPIEQLAEK
CNFLEVAYLLKNGELPNAAQKLDFENTIKSHTMVHDQLTRFYNGFRRDAHPMAIMVGVVGALSAFYHDAMDFSDQEHRNV
SINRLIAKLPTIVAMAYKYNTGQPFMYPRNDLDYTSNFMHMMFGTPCEEYKPNPVLVRALDVIFTLHADHEQNASTSTVR
LAGSSGANPFACISAGIACLWGPAHGGANEACLNMLEEIGDVSRVGEYIKRAKDKNDSFKLMGFGHRVYKNFDPRAKLMG
KVCNDVLTELGLEDDRLFKLAKELEKIALEDEYFVEKKLYPNVDFYSGIVQKALGIPTSMFTCIFALARTVGWITQWEEM
ITDPEYKIGRPRQLYIGAARRDVPVIGQRP

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=404, Percent_Identity=26.4851485148515, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1786939, Length=418, Percent_Identity=65.311004784689, Blast_Score=586, Evalue=1e-168,
Organism=Escherichia coli, GI1786527, Length=372, Percent_Identity=30.6451612903226, Blast_Score=160, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17555174, Length=408, Percent_Identity=26.9607843137255, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6319850, Length=334, Percent_Identity=28.7425149700599, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324328, Length=331, Percent_Identity=26.8882175226586, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6325257, Length=403, Percent_Identity=28.5359801488834, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24640126, Length=408, Percent_Identity=25.7352941176471, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24640124, Length=408, Percent_Identity=25.7352941176471, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21356863, Length=434, Percent_Identity=26.4976958525346, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48296; Mature: 48165

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTERTATLTVDGKTVDFPVMTGTHGQDVIDIRTLGGKTGLFTYDSGFLSTASCKSKITF
CCCCCEEEEEECCCEEEEEEEECCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCEEEE
IDGDKGELLYRGYPIEQLAEKCNFLEVAYLLKNGELPNAAQKLDFENTIKSHTMVHDQLT
EECCCCCEEECCCCHHHHHHHCCHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHH
RFYNGFRRDAHPMAIMVGVVGALSAFYHDAMDFSDQEHRNVSINRLIAKLPTIVAMAYKY
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHEEEE
NTGQPFMYPRNDLDYTSNFMHMMFGTPCEEYKPNPVLVRALDVIFTLHADHEQNASTSTV
CCCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHEEECCCCCCCCCCEE
RLAGSSGANPFACISAGIACLWGPAHGGANEACLNMLEEIGDVSRVGEYIKRAKDKNDSF
EEECCCCCCCHHHHHHCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
KLMGFGHRVYKNFDPRAKLMGKVCNDVLTELGLEDDRLFKLAKELEKIALEDEYFVEKKL
EEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHC
YPNVDFYSGIVQKALGIPTSMFTCIFALARTVGWITQWEEMITDPEYKIGRPRQLYIGAA
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
RRDVPVIGQRP
CCCCCCCCCCC
>Mature Secondary Structure 
STERTATLTVDGKTVDFPVMTGTHGQDVIDIRTLGGKTGLFTYDSGFLSTASCKSKITF
CCCCEEEEEECCCEEEEEEEECCCCCCEEEEEECCCCCCEEEECCCCCCCCCCCCEEEE
IDGDKGELLYRGYPIEQLAEKCNFLEVAYLLKNGELPNAAQKLDFENTIKSHTMVHDQLT
EECCCCCEEECCCCHHHHHHHCCHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHH
RFYNGFRRDAHPMAIMVGVVGALSAFYHDAMDFSDQEHRNVSINRLIAKLPTIVAMAYKY
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHHHEEEE
NTGQPFMYPRNDLDYTSNFMHMMFGTPCEEYKPNPVLVRALDVIFTLHADHEQNASTSTV
CCCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHEEECCCCCCCCCCEE
RLAGSSGANPFACISAGIACLWGPAHGGANEACLNMLEEIGDVSRVGEYIKRAKDKNDSF
EEECCCCCCCHHHHHHCHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
KLMGFGHRVYKNFDPRAKLMGKVCNDVLTELGLEDDRLFKLAKELEKIALEDEYFVEKKL
EEEECCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHC
YPNVDFYSGIVQKALGIPTSMFTCIFALARTVGWITQWEEMITDPEYKIGRPRQLYIGAA
CCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECC
RRDVPVIGQRP
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8526514 [H]