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The map label for this gene is dusC [H]

Identifier: 119897813

GI number: 119897813

Start: 1667410

End: 1668510

Strand: Direct

Name: dusC [H]

Synonym: azo1522

Alternate gene names: 119897813

Gene position: 1667410-1668510 (Clockwise)

Preceding gene: 119897809

Following gene: 119897814

Centisome position: 38.1

GC content: 71.57

Gene sequence:

>1101_bases
ATGTGGAAAACACGGGATTATCCGCGAGTCGGCGCGCTACCGCAAGGTTGCTGGCGCTGGCCGCGGAACGATGCACTACA
ATCGCGCGTTTTCCCGTTCCCGGAAGCCCCGATCTTGCGTCTGCTGCTTGCCCCGATGGAAGGCCTGCTCGATGACGTGT
TGCGCGCCGTGCTGACGCGCGACACGCGCTACGACTGCGCGGTCACCGAGTTCGTGCGGGTGTCGGGCGTAATGCTGCCG
CCGCGGACCTACCGGCGGATCGCGCCCGAGCTGGACAACGGCAGCCGCACCGTGGGTGGCACCCCGCTGCGGGTGCAACT
GCTCGGTTCCGATCCTGCCCTGCTGGCCGCGAACGCCGCGGTGCTGGCGCGCCTGGCGCCCACCGCGGTGGATCTGAACT
TCGGCTGTCCCGCCCCCACCGTCAACCGTCACCGCGGTGGCGCGGCGCTGCTGGACGAGCCCGAACTGCTGCACGAGATC
GCCTGCAGCGTGCGCGCCGCGCTGCCACCCGAAATGCCGCTGACCGCGAAGATGCGGTTGGGCATCGCCGATGCCGGGCG
CGCGCTCGACTGTGCCCGCGCCCTGGCCGATGGCGGGATTGCCGAACTCGTGGTGCATGCGCGTACCAAGCAGCAGGGCT
ACCGGCCGCCGGCGCACTGGGAGTGGGTGGGCCGCATCGCCAGCGAAGTGCAGGTGCCGGTGGTGGCCAACGGCGAGGTC
TGGAGCGCGGCCGACTGGCGGCGCTGCCGCGCGGTGTCCGGCGTGGCCGACGTGATGCTCGGGCGCGGCGCGGTGGCCGA
TCCCTTCCTTGCCGGGCGGATCCGGCGCGGCGAACTGGAACCACCGGAGCCGGCCGTCCGCGCCGAGGAATGGGCCGCGG
TGCTGGATCTGCTGGGCGATTTTCGCGTGCGGGTCCGGGCCAAGCTGCGGGCGGCGTTCGTGCCGGGGCGGATCAAGCAG
TGGCTCAACCTCCTGCGGCGCAGCTATCCGCAGGCCGAAAGCCTGTTTGCCGAAATCCGCACCCTGCGCCATCTGGCGGA
AATCGACCCGGTACTGGCCGCGCACGGCGTGCCGATGGCGGCCGCGCTGCGCGCTGCCTGA

Upstream 100 bases:

>100_bases
CCGCAGGAGCAGGTGACGTTCACTTCCGCGTACTTCGGATGGATATCGGCTTTCATGGTTCGGTCCTTGGTACGAGCGGG
CGGTGAATGTGGCCGCCCTG

Downstream 100 bases:

>100_bases
TGCCGCCTCTGTCCCGAGCACTGCATTCATGAGCTACGCCAATTCCCGCATTCCAGAAAGCGCGCAGACCGGCGTGCACG
AGAATCTCGCCCGCCTGGTG

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MWKTRDYPRVGALPQGCWRWPRNDALQSRVFPFPEAPILRLLLAPMEGLLDDVLRAVLTRDTRYDCAVTEFVRVSGVMLP
PRTYRRIAPELDNGSRTVGGTPLRVQLLGSDPALLAANAAVLARLAPTAVDLNFGCPAPTVNRHRGGAALLDEPELLHEI
ACSVRAALPPEMPLTAKMRLGIADAGRALDCARALADGGIAELVVHARTKQQGYRPPAHWEWVGRIASEVQVPVVANGEV
WSAADWRRCRAVSGVADVMLGRGAVADPFLAGRIRRGELEPPEPAVRAEEWAAVLDLLGDFRVRVRAKLRAAFVPGRIKQ
WLNLLRRSYPQAESLFAEIRTLRHLAEIDPVLAAHGVPMAAALRAA

Sequences:

>Translated_366_residues
MWKTRDYPRVGALPQGCWRWPRNDALQSRVFPFPEAPILRLLLAPMEGLLDDVLRAVLTRDTRYDCAVTEFVRVSGVMLP
PRTYRRIAPELDNGSRTVGGTPLRVQLLGSDPALLAANAAVLARLAPTAVDLNFGCPAPTVNRHRGGAALLDEPELLHEI
ACSVRAALPPEMPLTAKMRLGIADAGRALDCARALADGGIAELVVHARTKQQGYRPPAHWEWVGRIASEVQVPVVANGEV
WSAADWRRCRAVSGVADVMLGRGAVADPFLAGRIRRGELEPPEPAVRAEEWAAVLDLLGDFRVRVRAKLRAAFVPGRIKQ
WLNLLRRSYPQAESLFAEIRTLRHLAEIDPVLAAHGVPMAAALRAA
>Mature_366_residues
MWKTRDYPRVGALPQGCWRWPRNDALQSRVFPFPEAPILRLLLAPMEGLLDDVLRAVLTRDTRYDCAVTEFVRVSGVMLP
PRTYRRIAPELDNGSRTVGGTPLRVQLLGSDPALLAANAAVLARLAPTAVDLNFGCPAPTVNRHRGGAALLDEPELLHEI
ACSVRAALPPEMPLTAKMRLGIADAGRALDCARALADGGIAELVVHARTKQQGYRPPAHWEWVGRIASEVQVPVVANGEV
WSAADWRRCRAVSGVADVMLGRGAVADPFLAGRIRRGELEPPEPAVRAEEWAAVLDLLGDFRVRVRAKLRAAFVPGRIKQ
WLNLLRRSYPQAESLFAEIRTLRHLAEIDPVLAAHGVPMAAALRAA

Specific function: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs [H]

COG id: COG0042

COG function: function code J; tRNA-dihydrouridine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dus family. DusC subfamily [H]

Homologues:

Organism=Homo sapiens, GI40807366, Length=258, Percent_Identity=31.7829457364341, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI31742496, Length=171, Percent_Identity=29.2397660818713, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI239788483, Length=174, Percent_Identity=30.4597701149425, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI239788462, Length=177, Percent_Identity=31.0734463276836, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI8923374, Length=247, Percent_Identity=26.3157894736842, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788462, Length=311, Percent_Identity=42.443729903537, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI1789660, Length=251, Percent_Identity=31.0756972111554, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25144369, Length=173, Percent_Identity=31.7919075144509, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17507177, Length=193, Percent_Identity=31.0880829015544, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17543114, Length=176, Percent_Identity=27.8409090909091, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323560, Length=196, Percent_Identity=31.1224489795918, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323433, Length=199, Percent_Identity=24.6231155778894, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323437, Length=197, Percent_Identity=26.9035532994924, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585320, Length=189, Percent_Identity=32.2751322751323, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24580595, Length=171, Percent_Identity=34.5029239766082, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI19920448, Length=171, Percent_Identity=34.5029239766082, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI19921524, Length=284, Percent_Identity=26.056338028169, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45549423, Length=165, Percent_Identity=31.5151515151515, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001269
- InterPro:   IPR018517 [H]

Pfam domain/function: PF01207 Dus [H]

EC number: NA

Molecular weight: Translated: 40025; Mature: 40025

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: PS01136 UPF0034

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWKTRDYPRVGALPQGCWRWPRNDALQSRVFPFPEAPILRLLLAPMEGLLDDVLRAVLTR
CCCCCCCCCCCCCCHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DTRYDCAVTEFVRVSGVMLPPRTYRRIAPELDNGSRTVGGTPLRVQLLGSDPALLAANAA
CCCCHHHHHHHHHHCCEECCCHHHHHHCCCCCCCCEECCCCCEEEEEECCCCHHHHHHHH
VLARLAPTAVDLNFGCPAPTVNRHRGGAALLDEPELLHEIACSVRAALPPEMPLTAKMRL
HHHHHCCHHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHEEE
GIADAGRALDCARALADGGIAELVVHARTKQQGYRPPAHWEWVGRIASEVQVPVVANGEV
CCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCE
WSAADWRRCRAVSGVADVMLGRGAVADPFLAGRIRRGELEPPEPAVRAEEWAAVLDLLGD
ECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FRVRVRAKLRAAFVPGRIKQWLNLLRRSYPQAESLFAEIRTLRHLAEIDPVLAAHGVPMA
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHCCCCHH
AALRAA
HHHHCC
>Mature Secondary Structure
MWKTRDYPRVGALPQGCWRWPRNDALQSRVFPFPEAPILRLLLAPMEGLLDDVLRAVLTR
CCCCCCCCCCCCCCHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DTRYDCAVTEFVRVSGVMLPPRTYRRIAPELDNGSRTVGGTPLRVQLLGSDPALLAANAA
CCCCHHHHHHHHHHCCEECCCHHHHHHCCCCCCCCEECCCCCEEEEEECCCCHHHHHHHH
VLARLAPTAVDLNFGCPAPTVNRHRGGAALLDEPELLHEIACSVRAALPPEMPLTAKMRL
HHHHHCCHHEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHEEE
GIADAGRALDCARALADGGIAELVVHARTKQQGYRPPAHWEWVGRIASEVQVPVVANGEV
CCHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCE
WSAADWRRCRAVSGVADVMLGRGAVADPFLAGRIRRGELEPPEPAVRAEEWAAVLDLLGD
ECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FRVRVRAKLRAAFVPGRIKQWLNLLRRSYPQAESLFAEIRTLRHLAEIDPVLAAHGVPMA
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHCCCCHH
AALRAA
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9555876 [H]