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The map label for this gene is lpxK

Identifier: 119897761

GI number: 119897761

Start: 1602530

End: 1603555

Strand: Direct

Name: lpxK

Synonym: azo1470

Alternate gene names: 119897761

Gene position: 1602530-1603555 (Clockwise)

Preceding gene: 119897760

Following gene: 119897762

Centisome position: 36.62

GC content: 73.29

Gene sequence:

>1026_bases
ATGGCGGCTGCGCGCGGGGCCATGCCCACCGCCCCGTCGTACTGGCGCAGCCGCGGTCCGCGCGCGCTGCTGCTGTATCC
CCTGTCCCTGCTGTTCGGCCTGCTCGCCGCATTGCGACGCCGGCTCTACCGCGCCGGCCTGCTTTCGCAGGTGCGGCTGC
CGGTGAAGGTGATCGTCGTCGGCAACATCGCGGTCGGCGGCAGCGGCAAGACTCCGGTGGTCGCCTGGCTCGTCGAGCAG
TTGCGGGCGGCCGGCTGGCATCCGGGCATCATCAGCCGCGGGCACGGCGGCAGCGCGCGCGGCGTGCTCGAAGTGGTCGC
CTCCGGCGATGCCGGCGTATGCGGCGACGAGCCGCTGCTGCTTGCGCGCCTCACCGGCGTGCCGGTCTTCGTCGGGCGCG
ACCGCCCCGCGGCCGCCGCCGCGCTGCTGCAGGCCCACCCGGAATGCGATGTCATCGTCTCCGACGACGGCATGCAGCAC
TACCGCCTTGCCCGCGACCTGGAGCTGGCGGTGGTCGATCCCGCCACGCTGGGCAACCGCTGGCTGCTGCCCGCCGGGCC
GCTGCGCGAGCCGGTCGGCCGGCTCGACCGCGTGGACCTGGTGATCCGCCACGGCGACGAGGGGGAACTGCCGCCCCGGC
TGGGCGCGCGTGCGGTGCCGATGCGGCTGGTCGGCGACGGGTTCCGCGGCGTTGCCGACCCCGCCCGGCGCTGCGAGGCG
AGCGCCTTCCGCGGCCGCCGGGTCCATGCCGTTGCCGGCATCGGCCGTCCGCAGCGCTTCTTCGACCAGCTCGCGGCGAT
GGGTCTGGACGTGGTGCCGCATCCGTTTCCCGACCATCACCGCTTCGTTGCCGCCGATCTCGACTTCGCGCCCGGCGAGC
CCAAGCTGATGACCAGCAAGGATGCGGTAAAATGCGCGCCTTTCGCACCGGCCGACGCCTGGGAATTCCCGGTGACGGCC
GAAATCGGTTCGGGTGCCGCCGAACGCATCCTGGAGAGACTGCAACATGGACGCCCGCCTGCTTGA

Upstream 100 bases:

>100_bases
CAAGACCCCGCACCAGCGCGTCGTGGACGTCATGCAGGCGGCGCAGCGCGCCGGCCTTGCCCACATCACTTTCGCCACCC
AGACCCCGGCGAACTGACCC

Downstream 100 bases:

>100_bases
AATCCTCGTCTGCCCGCTGTGCAAGGGTCCGCTCGATTACCTCAAGGACAAGCAGGAGCTGGTCTGCAAGGCCGACCGCC
TCGCGTTCCCGATCCGCGAC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MAAARGAMPTAPSYWRSRGPRALLLYPLSLLFGLLAALRRRLYRAGLLSQVRLPVKVIVVGNIAVGGSGKTPVVAWLVEQ
LRAAGWHPGIISRGHGGSARGVLEVVASGDAGVCGDEPLLLARLTGVPVFVGRDRPAAAAALLQAHPECDVIVSDDGMQH
YRLARDLELAVVDPATLGNRWLLPAGPLREPVGRLDRVDLVIRHGDEGELPPRLGARAVPMRLVGDGFRGVADPARRCEA
SAFRGRRVHAVAGIGRPQRFFDQLAAMGLDVVPHPFPDHHRFVAADLDFAPGEPKLMTSKDAVKCAPFAPADAWEFPVTA
EIGSGAAERILERLQHGRPPA

Sequences:

>Translated_341_residues
MAAARGAMPTAPSYWRSRGPRALLLYPLSLLFGLLAALRRRLYRAGLLSQVRLPVKVIVVGNIAVGGSGKTPVVAWLVEQ
LRAAGWHPGIISRGHGGSARGVLEVVASGDAGVCGDEPLLLARLTGVPVFVGRDRPAAAAALLQAHPECDVIVSDDGMQH
YRLARDLELAVVDPATLGNRWLLPAGPLREPVGRLDRVDLVIRHGDEGELPPRLGARAVPMRLVGDGFRGVADPARRCEA
SAFRGRRVHAVAGIGRPQRFFDQLAAMGLDVVPHPFPDHHRFVAADLDFAPGEPKLMTSKDAVKCAPFAPADAWEFPVTA
EIGSGAAERILERLQHGRPPA
>Mature_340_residues
AAARGAMPTAPSYWRSRGPRALLLYPLSLLFGLLAALRRRLYRAGLLSQVRLPVKVIVVGNIAVGGSGKTPVVAWLVEQL
RAAGWHPGIISRGHGGSARGVLEVVASGDAGVCGDEPLLLARLTGVPVFVGRDRPAAAAALLQAHPECDVIVSDDGMQHY
RLARDLELAVVDPATLGNRWLLPAGPLREPVGRLDRVDLVIRHGDEGELPPRLGARAVPMRLVGDGFRGVADPARRCEAS
AFRGRRVHAVAGIGRPQRFFDQLAAMGLDVVPHPFPDHHRFVAADLDFAPGEPKLMTSKDAVKCAPFAPADAWEFPVTAE
IGSGAAERILERLQHGRPPA

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=331, Percent_Identity=41.9939577039275, Blast_Score=218, Evalue=7e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_AZOSB (A1K5I2)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932974.1
- STRING:   A1K5I2
- GeneID:   4608703
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo1470
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   GNIHAGG
- PhylomeDB:   A1K5I2
- ProtClustDB:   PRK00652
- BioCyc:   ASP62928:AZO1470-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36422; Mature: 36290

Theoretical pI: Translated: 10.13; Mature: 10.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAARGAMPTAPSYWRSRGPRALLLYPLSLLFGLLAALRRRLYRAGLLSQVRLPVKVIVV
CCCCCCCCCCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
GNIAVGGSGKTPVVAWLVEQLRAAGWHPGIISRGHGGSARGVLEVVASGDAGVCGDEPLL
EEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEE
LARLTGVPVFVGRDRPAAAAALLQAHPECDVIVSDDGMQHYRLARDLELAVVDPATLGNR
EEEECCCEEEEECCCCHHHHHHHHCCCCCCEEECCCCHHHHHHHCCCEEEEECCCCCCCE
WLLPAGPLREPVGRLDRVDLVIRHGDEGELPPRLGARAVPMRLVGDGFRGVADPARRCEA
EECCCCCHHHHHHHHCEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHH
SAFRGRRVHAVAGIGRPQRFFDQLAAMGLDVVPHPFPDHHRFVAADLDFAPGEPKLMTSK
HHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCEECCC
DAVKCAPFAPADAWEFPVTAEIGSGAAERILERLQHGRPPA
CCEEECCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AAARGAMPTAPSYWRSRGPRALLLYPLSLLFGLLAALRRRLYRAGLLSQVRLPVKVIVV
CCCCCCCCCCCHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
GNIAVGGSGKTPVVAWLVEQLRAAGWHPGIISRGHGGSARGVLEVVASGDAGVCGDEPLL
EEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEE
LARLTGVPVFVGRDRPAAAAALLQAHPECDVIVSDDGMQHYRLARDLELAVVDPATLGNR
EEEECCCEEEEECCCCHHHHHHHHCCCCCCEEECCCCHHHHHHHCCCEEEEECCCCCCCE
WLLPAGPLREPVGRLDRVDLVIRHGDEGELPPRLGARAVPMRLVGDGFRGVADPARRCEA
EECCCCCHHHHHHHHCEEEEEEEECCCCCCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHH
SAFRGRRVHAVAGIGRPQRFFDQLAAMGLDVVPHPFPDHHRFVAADLDFAPGEPKLMTSK
HHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCEECCC
DAVKCAPFAPADAWEFPVTAEIGSGAAERILERLQHGRPPA
CCEEECCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA