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The map label for this gene is nuoL [H]

Identifier: 119897698

GI number: 119897698

Start: 1534446

End: 1536470

Strand: Direct

Name: nuoL [H]

Synonym: azo1407

Alternate gene names: 119897698

Gene position: 1534446-1536470 (Clockwise)

Preceding gene: 119897697

Following gene: 119897699

Centisome position: 35.06

GC content: 62.27

Gene sequence:

>2025_bases
ATGTCGGACATGCAGAAGCTCTATCTCCTCGTGCCGCTGGCCCCGCTGGCCGGCGCCATTCTGGCGGGCCTCTTCGGCAA
GCTCATCGGTCGCACGGGTGCGCACGTCGCCACCATCCTGGGCGTCGCCGTCGCGTTTGCGGCCTCGGTCCTGGTCTTCC
AGGACGTGCAGGCAGGAAACACCTTCAACGGCACGATCTACACCTGGATGAACGCCGGCGGGGTCAATTTCGAGGTCGGC
TTCCAGATCGACGCGCTCACCGTGATGATGATGCTGGTGGTGACCTTTGTGTCGCTGATGGTGCACATCTACACGATCGG
CTACATGCATGACGACCCGGGATACCAGCGCTTCTTCAGCTACATCTCGCTGTTTACCTTCTCGATGCTGATGCTGGTGA
TGTCCAACAACTTCCTCCAGCTGTTCTTCGGCTGGGAAGCTGTGGGCCTCGTCTCCTACCTGCTGATCGGCTTCTGGTAT
GACCGGCCGACCGCGATCTATGCCAACCTGAAGGCGTTCCTGGTCAACCGCGTCGGCGACTTCGGTTTCCTGCTCGGTAT
CGGTCTCATCGTGGCCTACACCGGCAGCCTCAACTACCAGGAAGTGTTCGCCAAGGCGCAGGAACTGTCGGCAATGGACA
TGGCGGTGACCGGCTGGCCGCTGCTGACCGCGATCTGCATCTGCCTCTTCATTGGCGCAATGGGCAAGTCGGCCCAGGTG
CCGCTACACGTCTGGCTGCCCGATTCCATGGAAGGCCCGACCCCGATCTCCGCGCTGATCCACGCGGCGACCATGGTGAC
CGCGGGCATCTTCATGGTGGCGCGCATGTCGCCGCTGTTCGAACTCTCCGACGTCGCGCTCTCCTTCGTGCTGGTGATCG
GCGCCACCACCGCGCTGTTCATGGGCTTCCTCGGCATCGTGCAGAACGACATCAAGCGCGTCGTGGCCTACTCGACGCTG
TCGCAGCTCGGCTACATGACCGTTGCGCTGGGTGTCTCCGCCTACTCGGCCGCGGTGTTCCACCTGATGACCCACGCGTT
CTTCAAGGCGCTGCTGTTCCTCGGTGCCGGCTCGGTGATCATCGGCATGCATCACGACCAGGACATGCGCAACATGGGCG
GCCTGTGGAAGTACATGCCGATCACCTGGTTTACCTCGCTGCTCGGCTCGCTGGCGCTGATCGGTTTCCCGTTCTTCTCC
GGCTTCTATTCCAAGGACTCGATCATCGAGGCAGTGCATGCCTCGACCATCCCGGGGGCGGGTTACGCGCTGTTCTGTGT
GATGGCGGGCGTGTTCGTCACCGCGTTCTACTCCTTCCGCATGTATTTCCTGGTGTTCCACGGCAAGGAGCGTTTTGGTC
ACAACGACCATGCGCATCACGACCACCACGGCGATCACGACGATGAAGAGCCGTCGGCCGATCATCATCACGGCCTCGCG
CCCGGCCAGAAGCCCCACGAGTCGCCCTGGGTCGTGACGCTGCCGCTGGTGCTGCTGGCCATCCCGTCGGTGCTGATCGG
TTTCTTCACGATCCAGCCGATGCTGTTCGGCGACTGGTTCAAGGGTGTGATCTTCGTCGGTGAGAACCACGTCGGCATCA
AGGAACTCGCCGAGCATTTCCACGGTTCGGTTGCGATGGCGGTGCACGGCCTGCAGACCGCGCCGTTCTGGCTGGCAATG
GGCGGTGTCGCGGTGGCCTGGTTCTTCTACATGGTCAAGCCCGGCATTCCGGCAGCGATCCAGCGCACCTTCAGCCCGCT
GCATACCCTGCTCGAGAACAAGTACTACTTCGACCGCTTCAACGAGATCTTCTTTGCCGGCGGGGCCCGCCTGCTCGGCA
AGGGGCTGTGGAAGGGCGGCGATCAGGCGCTGATCGACGGTGTTGCGATCAACGGCACCGCCAAGCTGGTCGGTTGGGTG
GCGCAGATTTCCCGCCTGTTCCAGACGGGGCATCTGTACCAGTACGCCTTCACGATGATCATCGGCGTGTTCGTGCTGCT
GACCTTCTGGTTCAACCGCGCCTAA

Upstream 100 bases:

>100_bases
ATCTGCGATCGGCCTCGCCATCCTGGTGGTGATGTTCCGCAATCTGCGGACCATCCATGTGGATGATCTGGACAGCCTCA
AGGGTTAAGGAAGCGTCACG

Downstream 100 bases:

>100_bases
ACAGCACGTCGCCCACCAGGCTTTAGACAACAAGATCGAACGCGCCAGGGACGGCGCATAGAACGGAAAGCAACGATGAC
GGACATTCCCTACCTTAGTC

Product: NADH-ubiquinone oxidoreductase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 674; Mature: 673

Protein sequence:

>674_residues
MSDMQKLYLLVPLAPLAGAILAGLFGKLIGRTGAHVATILGVAVAFAASVLVFQDVQAGNTFNGTIYTWMNAGGVNFEVG
FQIDALTVMMMLVVTFVSLMVHIYTIGYMHDDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWY
DRPTAIYANLKAFLVNRVGDFGFLLGIGLIVAYTGSLNYQEVFAKAQELSAMDMAVTGWPLLTAICICLFIGAMGKSAQV
PLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDVALSFVLVIGATTALFMGFLGIVQNDIKRVVAYSTL
SQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLWKYMPITWFTSLLGSLALIGFPFFS
GFYSKDSIIEAVHASTIPGAGYALFCVMAGVFVTAFYSFRMYFLVFHGKERFGHNDHAHHDHHGDHDDEEPSADHHHGLA
PGQKPHESPWVVTLPLVLLAIPSVLIGFFTIQPMLFGDWFKGVIFVGENHVGIKELAEHFHGSVAMAVHGLQTAPFWLAM
GGVAVAWFFYMVKPGIPAAIQRTFSPLHTLLENKYYFDRFNEIFFAGGARLLGKGLWKGGDQALIDGVAINGTAKLVGWV
AQISRLFQTGHLYQYAFTMIIGVFVLLTFWFNRA

Sequences:

>Translated_674_residues
MSDMQKLYLLVPLAPLAGAILAGLFGKLIGRTGAHVATILGVAVAFAASVLVFQDVQAGNTFNGTIYTWMNAGGVNFEVG
FQIDALTVMMMLVVTFVSLMVHIYTIGYMHDDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWY
DRPTAIYANLKAFLVNRVGDFGFLLGIGLIVAYTGSLNYQEVFAKAQELSAMDMAVTGWPLLTAICICLFIGAMGKSAQV
PLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDVALSFVLVIGATTALFMGFLGIVQNDIKRVVAYSTL
SQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLWKYMPITWFTSLLGSLALIGFPFFS
GFYSKDSIIEAVHASTIPGAGYALFCVMAGVFVTAFYSFRMYFLVFHGKERFGHNDHAHHDHHGDHDDEEPSADHHHGLA
PGQKPHESPWVVTLPLVLLAIPSVLIGFFTIQPMLFGDWFKGVIFVGENHVGIKELAEHFHGSVAMAVHGLQTAPFWLAM
GGVAVAWFFYMVKPGIPAAIQRTFSPLHTLLENKYYFDRFNEIFFAGGARLLGKGLWKGGDQALIDGVAINGTAKLVGWV
AQISRLFQTGHLYQYAFTMIIGVFVLLTFWFNRA
>Mature_673_residues
SDMQKLYLLVPLAPLAGAILAGLFGKLIGRTGAHVATILGVAVAFAASVLVFQDVQAGNTFNGTIYTWMNAGGVNFEVGF
QIDALTVMMMLVVTFVSLMVHIYTIGYMHDDPGYQRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYD
RPTAIYANLKAFLVNRVGDFGFLLGIGLIVAYTGSLNYQEVFAKAQELSAMDMAVTGWPLLTAICICLFIGAMGKSAQVP
LHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDVALSFVLVIGATTALFMGFLGIVQNDIKRVVAYSTLS
QLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDMRNMGGLWKYMPITWFTSLLGSLALIGFPFFSG
FYSKDSIIEAVHASTIPGAGYALFCVMAGVFVTAFYSFRMYFLVFHGKERFGHNDHAHHDHHGDHDDEEPSADHHHGLAP
GQKPHESPWVVTLPLVLLAIPSVLIGFFTIQPMLFGDWFKGVIFVGENHVGIKELAEHFHGSVAMAVHGLQTAPFWLAMG
GVAVAWFFYMVKPGIPAAIQRTFSPLHTLLENKYYFDRFNEIFFAGGARLLGKGLWKGGDQALIDGVAINGTAKLVGWVA
QISRLFQTGHLYQYAFTMIIGVFVLLTFWFNRA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=394, Percent_Identity=41.1167512690355, Blast_Score=301, Evalue=9e-82,
Organism=Escherichia coli, GI1788614, Length=491, Percent_Identity=42.5661914460285, Blast_Score=353, Evalue=3e-98,
Organism=Escherichia coli, GI1788829, Length=412, Percent_Identity=29.3689320388349, Blast_Score=145, Evalue=9e-36,
Organism=Escherichia coli, GI1788827, Length=414, Percent_Identity=29.2270531400966, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1788831, Length=348, Percent_Identity=29.5977011494253, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1788613, Length=345, Percent_Identity=25.7971014492754, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI145693160, Length=413, Percent_Identity=23.2445520581114, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI2367154, Length=190, Percent_Identity=28.4210526315789, Blast_Score=72, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 74047; Mature: 73916

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDMQKLYLLVPLAPLAGAILAGLFGKLIGRTGAHVATILGVAVAFAASVLVFQDVQAGN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
TFNGTIYTWMNAGGVNFEVGFQIDALTVMMMLVVTFVSLMVHIYTIGYMHDDPGYQRFFS
CCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHH
YISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYDRPTAIYANLKAFLVNRVGD
HHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
FGFLLGIGLIVAYTGSLNYQEVFAKAQELSAMDMAVTGWPLLTAICICLFIGAMGKSAQV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
PLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDVALSFVLVIGATTALF
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
MGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLGAGSVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IGMHHDQDMRNMGGLWKYMPITWFTSLLGSLALIGFPFFSGFYSKDSIIEAVHASTIPGA
EEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
GYALFCVMAGVFVTAFYSFRMYFLVFHGKERFGHNDHAHHDHHGDHDDEEPSADHHHGLA
HHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGQKPHESPWVVTLPLVLLAIPSVLIGFFTIQPMLFGDWFKGVIFVGENHVGIKELAEHF
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHH
HGSVAMAVHGLQTAPFWLAMGGVAVAWFFYMVKPGIPAAIQRTFSPLHTLLENKYYFDRF
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHH
NEIFFAGGARLLGKGLWKGGDQALIDGVAINGTAKLVGWVAQISRLFQTGHLYQYAFTMI
HHHHHCCCHHHHHHHHCCCCCHHHCCCEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
IGVFVLLTFWFNRA
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SDMQKLYLLVPLAPLAGAILAGLFGKLIGRTGAHVATILGVAVAFAASVLVFQDVQAGN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
TFNGTIYTWMNAGGVNFEVGFQIDALTVMMMLVVTFVSLMVHIYTIGYMHDDPGYQRFFS
CCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHH
YISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYDRPTAIYANLKAFLVNRVGD
HHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCH
FGFLLGIGLIVAYTGSLNYQEVFAKAQELSAMDMAVTGWPLLTAICICLFIGAMGKSAQV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
PLHVWLPDSMEGPTPISALIHAATMVTAGIFMVARMSPLFELSDVALSFVLVIGATTALF
CEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
MGFLGIVQNDIKRVVAYSTLSQLGYMTVALGVSAYSAAVFHLMTHAFFKALLFLGAGSVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IGMHHDQDMRNMGGLWKYMPITWFTSLLGSLALIGFPFFSGFYSKDSIIEAVHASTIPGA
EEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
GYALFCVMAGVFVTAFYSFRMYFLVFHGKERFGHNDHAHHDHHGDHDDEEPSADHHHGLA
HHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PGQKPHESPWVVTLPLVLLAIPSVLIGFFTIQPMLFGDWFKGVIFVGENHVGIKELAEHF
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHH
HGSVAMAVHGLQTAPFWLAMGGVAVAWFFYMVKPGIPAAIQRTFSPLHTLLENKYYFDRF
CCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHH
NEIFFAGGARLLGKGLWKGGDQALIDGVAINGTAKLVGWVAQISRLFQTGHLYQYAFTMI
HHHHHCCCHHHHHHHHCCCCCHHHCCCEEECCHHHHHHHHHHHHHHHHHCHHHHHHHHHH
IGVFVLLTFWFNRA
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]