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The map label for this gene is pepD [H]

Identifier: 119897550

GI number: 119897550

Start: 1358370

End: 1359830

Strand: Direct

Name: pepD [H]

Synonym: azo1259

Alternate gene names: 119897550

Gene position: 1358370-1359830 (Clockwise)

Preceding gene: 119897549

Following gene: 119897554

Centisome position: 31.04

GC content: 73.1

Gene sequence:

>1461_bases
ATGGACCTGAACCTGCTCCCTCCCGCCGCCGTCTGGCGCCATTTCGCCACCTTGTGCCGCATTCCGCGCCCGTCCGGGCA
CGAGCATGCGCTGCGCGAGGAAATCCTCGGCTGGGCGCGCCAGCGCGGGCTGGGGGCGGTGGTCGATGCCACCGGCAACC
TCATCCTCAGCAAGCCGGCGAGTCCCGGCCATGAGGATCGCCCGGGCGTGGTACTGCAGGGCCATCTCGACATGGTGTGC
CAGAAGAACGCCGGGTCGGCGCACGACTTCCTGCGCGACCCGATCCGCGCCGAACTGCGCGACGGCTGGCTGGTGGCGGA
CGACACCACGCTGGGGGCGGACAACGGCATCGGGGTGGCGATGGCGCTCGCGGTGCTGGAGGCAGACGACATCGCCCACC
CGGCGCTGGAGGTGCTGCTGACGGTGGACGAGGAAGCCGGGATGACCGGCGCGCGCGGCCTGCAGGCCGATGCGCTGCGC
GGGCGGCTGCTGATCAACATCGATACCGAGGACTGGGGCGAGTTCTACCTGGGCTGCGCGGGTGGCGCCGACGTGGTGGT
GGACGCGGTGCTCGATACCGTGGCGGCGCCTGCCGGGGGTGTGGCGCTGCGGCTGACGGTGGAAGGGCTGAAGGGCGGGC
ACTCCGGCGTGGATATCCACCTCCAGCGCGGCAATGCGATCAAGCTGCTGGTACGGGCGCTGCAGGGGCTGCGCGCGGCC
GGCGCCGGCTTTGCGCTGGCGACGCTGGAAGGCGGCACCGCGCGCAACGCACTGCCGCGCGAAGCGCAGGCGGTGATCGT
GGTGGACGCGGGCGATGTCGCGCCGCTGCACGAGGCGCTGGCGCGCATCGGCGCGGAGATTGCCGACGAACTTGCGGGCG
TGGACGACGGCTTCCGCCTGCACGCCGGGCCGGCGCCGCTGCCGGCGCGGGTATGTGCCGACGAGGCCGGACGCCGTGCG
CTCGCCGCGCTGCACGCCGCGCCGCATGGCGTGCGCCGGCTCAGCAGCCGGGTGCCCGGCGTCGTCGAAACCTCGGACAA
CCTCGGCGTCGTCCGGCTGGCCGAAGGCCGGCTGCAGGCCACGCTGATGGTGCGCTCGCTGCTGGACGCGGGCACCCGCG
AACTCGCCGCGGAGATCGTCGGCCTGTTCGGGTTGGCCGGCATGGCGGCGACCGTCAGCGAGCCCTATCCCGGTTGGGCG
CCGAATCCGCGCTCGGGCCTGCTGGCGCTGTTCCAGCAGGTGTATCAGCGCGAATTCGGCGGCGAGGCGGCGGTCAAGGT
GATCCACGCCGGGCTGGAGTGCGGCATCTTCACCGCCACCTGGCCGGACATGGACATGATCTCCTTCGGCCCCAGCATCC
GCGGCGCGCACGCGCCCGGCGAACGGGTGGAGGTGGCAAGCGTGGAGCGCGCGTGGCGTTTGCTGGTGGCGGTGCTCGCC
GCGGTGCCGGCGGCGCGTTAG

Upstream 100 bases:

>100_bases
GCCCCGGCGCGCGCCGTGCCGGTGGGCGCCGCGCCGGCCCGGCGCGAGGCCAACGCGCTATCCTCGATCACCCACTGATT
GCCCACATGCCGGAACCCCG

Downstream 100 bases:

>100_bases
CCCACCAGCGGGCGATCCGGCAGCTGGTTTTCGCGTGCTGCCGCGTCCGGCGGGAAGTGGCGCGCGAGCGCGGCGCCCAC
GCCATCGACCGCGCGCCCCA

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MDLNLLPPAAVWRHFATLCRIPRPSGHEHALREEILGWARQRGLGAVVDATGNLILSKPASPGHEDRPGVVLQGHLDMVC
QKNAGSAHDFLRDPIRAELRDGWLVADDTTLGADNGIGVAMALAVLEADDIAHPALEVLLTVDEEAGMTGARGLQADALR
GRLLINIDTEDWGEFYLGCAGGADVVVDAVLDTVAAPAGGVALRLTVEGLKGGHSGVDIHLQRGNAIKLLVRALQGLRAA
GAGFALATLEGGTARNALPREAQAVIVVDAGDVAPLHEALARIGAEIADELAGVDDGFRLHAGPAPLPARVCADEAGRRA
LAALHAAPHGVRRLSSRVPGVVETSDNLGVVRLAEGRLQATLMVRSLLDAGTRELAAEIVGLFGLAGMAATVSEPYPGWA
PNPRSGLLALFQQVYQREFGGEAAVKVIHAGLECGIFTATWPDMDMISFGPSIRGAHAPGERVEVASVERAWRLLVAVLA
AVPAAR

Sequences:

>Translated_486_residues
MDLNLLPPAAVWRHFATLCRIPRPSGHEHALREEILGWARQRGLGAVVDATGNLILSKPASPGHEDRPGVVLQGHLDMVC
QKNAGSAHDFLRDPIRAELRDGWLVADDTTLGADNGIGVAMALAVLEADDIAHPALEVLLTVDEEAGMTGARGLQADALR
GRLLINIDTEDWGEFYLGCAGGADVVVDAVLDTVAAPAGGVALRLTVEGLKGGHSGVDIHLQRGNAIKLLVRALQGLRAA
GAGFALATLEGGTARNALPREAQAVIVVDAGDVAPLHEALARIGAEIADELAGVDDGFRLHAGPAPLPARVCADEAGRRA
LAALHAAPHGVRRLSSRVPGVVETSDNLGVVRLAEGRLQATLMVRSLLDAGTRELAAEIVGLFGLAGMAATVSEPYPGWA
PNPRSGLLALFQQVYQREFGGEAAVKVIHAGLECGIFTATWPDMDMISFGPSIRGAHAPGERVEVASVERAWRLLVAVLA
AVPAAR
>Mature_486_residues
MDLNLLPPAAVWRHFATLCRIPRPSGHEHALREEILGWARQRGLGAVVDATGNLILSKPASPGHEDRPGVVLQGHLDMVC
QKNAGSAHDFLRDPIRAELRDGWLVADDTTLGADNGIGVAMALAVLEADDIAHPALEVLLTVDEEAGMTGARGLQADALR
GRLLINIDTEDWGEFYLGCAGGADVVVDAVLDTVAAPAGGVALRLTVEGLKGGHSGVDIHLQRGNAIKLLVRALQGLRAA
GAGFALATLEGGTARNALPREAQAVIVVDAGDVAPLHEALARIGAEIADELAGVDDGFRLHAGPAPLPARVCADEAGRRA
LAALHAAPHGVRRLSSRVPGVVETSDNLGVVRLAEGRLQATLMVRSLLDAGTRELAAEIVGLFGLAGMAATVSEPYPGWA
PNPRSGLLALFQQVYQREFGGEAAVKVIHAGLECGIFTATWPDMDMISFGPSIRGAHAPGERVEVASVERAWRLLVAVLA
AVPAAR

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=489, Percent_Identity=44.7852760736196, Blast_Score=400, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 50735; Mature: 50735

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNLLPPAAVWRHFATLCRIPRPSGHEHALREEILGWARQRGLGAVVDATGNLILSKPA
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCC
SPGHEDRPGVVLQGHLDMVCQKNAGSAHDFLRDPIRAELRDGWLVADDTTLGADNGIGVA
CCCCCCCCCEEEECCHHEEEECCCCCHHHHHHCHHHHHHCCCEEEECCCCCCCCCCHHHH
MALAVLEADDIAHPALEVLLTVDEEAGMTGARGLQADALRGRLLINIDTEDWGEFYLGCA
HHHHHHHHHHCCHHHHHEEEEECHHCCCCCCCCCCHHCCCCEEEEEECCCCCCCEEEECC
GGADVVVDAVLDTVAAPAGGVALRLTVEGLKGGHSGVDIHLQRGNAIKLLVRALQGLRAA
CCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHC
GAGFALATLEGGTARNALPREAQAVIVVDAGDVAPLHEALARIGAEIADELAGVDDGFRL
CCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEE
HAGPAPLPARVCADEAGRRALAALHAAPHGVRRLSSRVPGVVETSDNLGVVRLAEGRLQA
CCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEECCCCCCEEEECCCHHHH
TLMVRSLLDAGTRELAAEIVGLFGLAGMAATVSEPYPGWAPNPRSGLLALFQQVYQREFG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GEAAVKVIHAGLECGIFTATWPDMDMISFGPSIRGAHAPGERVEVASVERAWRLLVAVLA
CHHHHHHHHHCCCCCEEEECCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AVPAAR
HCCCCC
>Mature Secondary Structure
MDLNLLPPAAVWRHFATLCRIPRPSGHEHALREEILGWARQRGLGAVVDATGNLILSKPA
CCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCEEEECCC
SPGHEDRPGVVLQGHLDMVCQKNAGSAHDFLRDPIRAELRDGWLVADDTTLGADNGIGVA
CCCCCCCCCEEEECCHHEEEECCCCCHHHHHHCHHHHHHCCCEEEECCCCCCCCCCHHHH
MALAVLEADDIAHPALEVLLTVDEEAGMTGARGLQADALRGRLLINIDTEDWGEFYLGCA
HHHHHHHHHHCCHHHHHEEEEECHHCCCCCCCCCCHHCCCCEEEEEECCCCCCCEEEECC
GGADVVVDAVLDTVAAPAGGVALRLTVEGLKGGHSGVDIHLQRGNAIKLLVRALQGLRAA
CCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHC
GAGFALATLEGGTARNALPREAQAVIVVDAGDVAPLHEALARIGAEIADELAGVDDGFRL
CCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEE
HAGPAPLPARVCADEAGRRALAALHAAPHGVRRLSSRVPGVVETSDNLGVVRLAEGRLQA
CCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCEEECCCCCCEEEECCCHHHH
TLMVRSLLDAGTRELAAEIVGLFGLAGMAATVSEPYPGWAPNPRSGLLALFQQVYQREFG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
GEAAVKVIHAGLECGIFTATWPDMDMISFGPSIRGAHAPGERVEVASVERAWRLLVAVLA
CHHHHHHHHHCCCCCEEEECCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AVPAAR
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]