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The map label for this gene is groEL [H]

Identifier: 119897514

GI number: 119897514

Start: 1316323

End: 1317960

Strand: Direct

Name: groEL [H]

Synonym: azo1223

Alternate gene names: 119897514

Gene position: 1316323-1317960 (Clockwise)

Preceding gene: 119897513

Following gene: 119897515

Centisome position: 30.08

GC content: 71.06

Gene sequence:

>1638_bases
ATGCCCAACATCATGCTGCACGACGACGAAGCCCGCGCCGCCCTGGCGCGCGGCGTCGCAAAGATGGCCCGCGCGGTGCG
CGGCACGCTTGGCCCGCGGGGGATGAACGCGATCATCGACCGCCCGATCGGCACGCCGATCATCTCGCGCGATGGCGTCA
GCATCGCCGCGGAAATCGAGCTGGAGGACCCGTTCGAGAACATCGGCGCCCAGGTGCTGCGCGAGGTATCGCGCCAGACC
AACGAGGTGGCCGGCGACGGCACCACCACCGCCACGGTGCTGGCCGATGCGCTGGTGCAGGAAGGGCTGGCCTGTGTGCA
GGCAGGCGTGAAGCCGGTCGAGCTGGTCAAGGGGCTGGAGCTGGCGGTGGATGAAACCGTCGCCGCGCTCAAGTCGATGG
CGATTCCCGTGCGCGGCCGCGAGGACGTGTTCTCGGTGGCCGTGGTGGCCGCCAATGAAGAGAGCACCGGCGCACTGGTA
GCCGAGGCGCTGGAGCGCGTGGGCCCGGACGGCATCGTGGACGTGGAATACGGCACCACCGTGGAGACCACGCTCGACGT
GCTCGATGGCATGGCCTTCGACCGCGGCTACCTGTCGCACCACATGGTGACCGACGTCGAGAAGATGCAGGTGGTGCTGG
ACGACCCCTGGATCCTGATGACCGACCAGCGCCTGCAGAGTCAGGAAGAAGTGGCGGTGCTGCAGAGCCTGCTCGCCGGC
AGCAAGCGGCCGCTGCTGATCATCGCCGACGAAGTGGCGCCCGCCTGCGTGGTCAGCCTGATGGCCTGGCGCGAGAAGAG
CGGGGTGCCGGTGGCCGCGATCCACCCGCCCGAGTACGGCCACTGGCGCAAGGCCATGCTGGACGACATCGCCATCGTCA
CCGGCGGCAAGGTGATCGCGCGCGATCTGGGCGGCAGCCTGAAGGACGTGAGCCTGGCCGAGCTGGGTTCGGCCCGCCAG
GTGCGGATCTCGTCCAACCAGACGGTGATCTCCGGCGGCGGCGGCACGCACGAGGCGATCGCCGCGCGGCGCAAGCAGGT
GCAGCGCCAGTACGAACTCGCGCCGCAGAACATCGAGCGCGACAAGTTCCAGGAGCGGCTCGCCAAGCTCACCGGCGGCA
CCGCGCTGATCCTCGCCGGCGGCGCCACGCCGGTGGAGCAGAAGCGCCGCCTGCTGCTGATCGAGGACGCGATCCACGCC
GCGCGCGCGGCGATCGAGGAGGGTATCGTGCCCGGCGGCGGCATCACGCTGCTGCAGGCCGCCGGCCGGCTCGAACACCT
GGTGGCGCAGACCAGCGGCGGCGTGCAGCAGGGCGTGCGCCTGCTGCAGCGCGCGCTGTCGCGGCCGCTGTACCACCTGG
CGGGCAACGCCGGGCTGGATAGCGAGCAGGTGGTCGACCGCGCGATGCGCGCCGAACCGGGCCACGGCCTGGACGTGCGC
AGCGGCGCCTTCGTCGATCTGGTGGCCGAAGGCGTGATCGACCCGGTGCGCGTGAGCTACACCGCGGTGCGCAACGCGGC
CTCGGTGGCGGGGCTGATCCTCACCACCCAGACGCTGGTGGCGAAGAAGCCGGAGATCATCGACCCGACCGCAGGCCCCG
CGACCGGCGGCGGGGCCGAGCTGTACGGCCGCCAGTAA

Upstream 100 bases:

>100_bases
AGCTTAAACCCCATCCCCACCCCCGCCCTCCCCTTGAAGGGGAGGGAGTTAAAACCCCTCCCCTGACCGGCAGGACAACA
AATACCGGAGGAGAGACAAA

Downstream 100 bases:

>100_bases
GGCGGGTCGGCCCGTTCGGGCCGGCTGTCTTCCCCGGCAAGCCCGCCGTGGCTTGCCGGGGTTTCCGCGCAACCCCGGGA
TGCTGCCACCATGAACGAGA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 4; Protein Cpn60 4 [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MPNIMLHDDEARAALARGVAKMARAVRGTLGPRGMNAIIDRPIGTPIISRDGVSIAAEIELEDPFENIGAQVLREVSRQT
NEVAGDGTTTATVLADALVQEGLACVQAGVKPVELVKGLELAVDETVAALKSMAIPVRGREDVFSVAVVAANEESTGALV
AEALERVGPDGIVDVEYGTTVETTLDVLDGMAFDRGYLSHHMVTDVEKMQVVLDDPWILMTDQRLQSQEEVAVLQSLLAG
SKRPLLIIADEVAPACVVSLMAWREKSGVPVAAIHPPEYGHWRKAMLDDIAIVTGGKVIARDLGGSLKDVSLAELGSARQ
VRISSNQTVISGGGGTHEAIAARRKQVQRQYELAPQNIERDKFQERLAKLTGGTALILAGGATPVEQKRRLLLIEDAIHA
ARAAIEEGIVPGGGITLLQAAGRLEHLVAQTSGGVQQGVRLLQRALSRPLYHLAGNAGLDSEQVVDRAMRAEPGHGLDVR
SGAFVDLVAEGVIDPVRVSYTAVRNAASVAGLILTTQTLVAKKPEIIDPTAGPATGGGAELYGRQ

Sequences:

>Translated_545_residues
MPNIMLHDDEARAALARGVAKMARAVRGTLGPRGMNAIIDRPIGTPIISRDGVSIAAEIELEDPFENIGAQVLREVSRQT
NEVAGDGTTTATVLADALVQEGLACVQAGVKPVELVKGLELAVDETVAALKSMAIPVRGREDVFSVAVVAANEESTGALV
AEALERVGPDGIVDVEYGTTVETTLDVLDGMAFDRGYLSHHMVTDVEKMQVVLDDPWILMTDQRLQSQEEVAVLQSLLAG
SKRPLLIIADEVAPACVVSLMAWREKSGVPVAAIHPPEYGHWRKAMLDDIAIVTGGKVIARDLGGSLKDVSLAELGSARQ
VRISSNQTVISGGGGTHEAIAARRKQVQRQYELAPQNIERDKFQERLAKLTGGTALILAGGATPVEQKRRLLLIEDAIHA
ARAAIEEGIVPGGGITLLQAAGRLEHLVAQTSGGVQQGVRLLQRALSRPLYHLAGNAGLDSEQVVDRAMRAEPGHGLDVR
SGAFVDLVAEGVIDPVRVSYTAVRNAASVAGLILTTQTLVAKKPEIIDPTAGPATGGGAELYGRQ
>Mature_544_residues
PNIMLHDDEARAALARGVAKMARAVRGTLGPRGMNAIIDRPIGTPIISRDGVSIAAEIELEDPFENIGAQVLREVSRQTN
EVAGDGTTTATVLADALVQEGLACVQAGVKPVELVKGLELAVDETVAALKSMAIPVRGREDVFSVAVVAANEESTGALVA
EALERVGPDGIVDVEYGTTVETTLDVLDGMAFDRGYLSHHMVTDVEKMQVVLDDPWILMTDQRLQSQEEVAVLQSLLAGS
KRPLLIIADEVAPACVVSLMAWREKSGVPVAAIHPPEYGHWRKAMLDDIAIVTGGKVIARDLGGSLKDVSLAELGSARQV
RISSNQTVISGGGGTHEAIAARRKQVQRQYELAPQNIERDKFQERLAKLTGGTALILAGGATPVEQKRRLLLIEDAIHAA
RAAIEEGIVPGGGITLLQAAGRLEHLVAQTSGGVQQGVRLLQRALSRPLYHLAGNAGLDSEQVVDRAMRAEPGHGLDVRS
GAFVDLVAEGVIDPVRVSYTAVRNAASVAGLILTTQTLVAKKPEIIDPTAGPATGGGAELYGRQ

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=518, Percent_Identity=35.3281853281853, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI31542947, Length=518, Percent_Identity=35.3281853281853, Blast_Score=338, Evalue=7e-93,
Organism=Escherichia coli, GI1790586, Length=518, Percent_Identity=40.9266409266409, Blast_Score=402, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17555558, Length=519, Percent_Identity=35.2601156069364, Blast_Score=332, Evalue=2e-91,
Organism=Caenorhabditis elegans, GI193210679, Length=219, Percent_Identity=35.1598173515982, Blast_Score=135, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI25144674, Length=128, Percent_Identity=30.46875, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=516, Percent_Identity=36.4341085271318, Blast_Score=347, Evalue=2e-96,
Organism=Saccharomyces cerevisiae, GI6322524, Length=155, Percent_Identity=27.741935483871, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322446, Length=546, Percent_Identity=23.6263736263736, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641193, Length=518, Percent_Identity=38.4169884169884, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24641191, Length=518, Percent_Identity=38.4169884169884, Blast_Score=363, Evalue=1e-100,
Organism=Drosophila melanogaster, GI45550936, Length=517, Percent_Identity=35.9767891682785, Blast_Score=338, Evalue=6e-93,
Organism=Drosophila melanogaster, GI45550132, Length=517, Percent_Identity=35.9767891682785, Blast_Score=338, Evalue=6e-93,
Organism=Drosophila melanogaster, GI45550935, Length=517, Percent_Identity=35.9767891682785, Blast_Score=338, Evalue=6e-93,
Organism=Drosophila melanogaster, GI17864606, Length=538, Percent_Identity=35.1301115241636, Blast_Score=311, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24584129, Length=518, Percent_Identity=30.1158301158301, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI19921262, Length=518, Percent_Identity=30.1158301158301, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24583944, Length=533, Percent_Identity=24.765478424015, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57533; Mature: 57401

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNIMLHDDEARAALARGVAKMARAVRGTLGPRGMNAIIDRPIGTPIISRDGVSIAAEIE
CCCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCEECCCCCEEEEEEE
LEDPFENIGAQVLREVSRQTNEVAGDGTTTATVLADALVQEGLACVQAGVKPVELVKGLE
ECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LAVDETVAALKSMAIPVRGREDVFSVAVVAANEESTGALVAEALERVGPDGIVDVEYGTT
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCC
VETTLDVLDGMAFDRGYLSHHMVTDVEKMQVVLDDPWILMTDQRLQSQEEVAVLQSLLAG
HHHHHHHHCCCHHCCHHHHHHHHHHHHHHEEEECCCEEEEECHHHCCHHHHHHHHHHHCC
SKRPLLIIADEVAPACVVSLMAWREKSGVPVAAIHPPEYGHWRKAMLDDIAIVTGGKVIA
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHEEEECCHHHH
RDLGGSLKDVSLAELGSARQVRISSNQTVISGGGGTHEAIAARRKQVQRQYELAPQNIER
HHHCCCCCCCHHHHCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCH
DKFQERLAKLTGGTALILAGGATPVEQKRRLLLIEDAIHAARAAIEEGIVPGGGITLLQA
HHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHH
AGRLEHLVAQTSGGVQQGVRLLQRALSRPLYHLAGNAGLDSEQVVDRAMRAEPGHGLDVR
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCC
SGAFVDLVAEGVIDPVRVSYTAVRNAASVAGLILTTQTLVAKKPEIIDPTAGPATGGGAE
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
LYGRQ
CCCCC
>Mature Secondary Structure 
PNIMLHDDEARAALARGVAKMARAVRGTLGPRGMNAIIDRPIGTPIISRDGVSIAAEIE
CCCEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCEECCCCCEEEEEEE
LEDPFENIGAQVLREVSRQTNEVAGDGTTTATVLADALVQEGLACVQAGVKPVELVKGLE
ECCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LAVDETVAALKSMAIPVRGREDVFSVAVVAANEESTGALVAEALERVGPDGIVDVEYGTT
HHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCC
VETTLDVLDGMAFDRGYLSHHMVTDVEKMQVVLDDPWILMTDQRLQSQEEVAVLQSLLAG
HHHHHHHHCCCHHCCHHHHHHHHHHHHHHEEEECCCEEEEECHHHCCHHHHHHHHHHHCC
SKRPLLIIADEVAPACVVSLMAWREKSGVPVAAIHPPEYGHWRKAMLDDIAIVTGGKVIA
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHEEEECCHHHH
RDLGGSLKDVSLAELGSARQVRISSNQTVISGGGGTHEAIAARRKQVQRQYELAPQNIER
HHHCCCCCCCHHHHCCCCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCH
DKFQERLAKLTGGTALILAGGATPVEQKRRLLLIEDAIHAARAAIEEGIVPGGGITLLQA
HHHHHHHHHHCCCCEEEEECCCCCHHHCCCEEEHHHHHHHHHHHHHHCCCCCCCHHHHHH
AGRLEHLVAQTSGGVQQGVRLLQRALSRPLYHLAGNAGLDSEQVVDRAMRAEPGHGLDVR
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCC
SGAFVDLVAEGVIDPVRVSYTAVRNAASVAGLILTTQTLVAKKPEIIDPTAGPATGGGAE
CCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
LYGRQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]