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The map label for this gene is cysM [H]

Identifier: 119897368

GI number: 119897368

Start: 1160583

End: 1161473

Strand: Direct

Name: cysM [H]

Synonym: azo1077

Alternate gene names: 119897368

Gene position: 1160583-1161473 (Clockwise)

Preceding gene: 119897367

Following gene: 119897369

Centisome position: 26.52

GC content: 64.42

Gene sequence:

>891_bases
ATGGAATTCAAGACGCTCGAGGACTACGTCGGCAAGACCCCGCTGGTGCGCATGAAGCGGATCACCGCGGGGCATAACAA
CGTCATTCTCGCCAAGCTCGAGGGTAACAATCCGGCGGGATCGGTGAAGGACCGGCCGGCGTTGTCCATGGTCGTCCGCG
CAGAGGCACGGGGCGACATCAAGCCTGGCGACACGCTCATCGAGGCGACCAGCGGTAATACCGGCATCGCGCTTGCCATG
GCGGCGGCGATGCGCGGCTACCGGATGATCCTGGTGATGCCCGAGAACCAGAGCGTCGAGCGCCGGCAGACGATGCGCGC
TTTCGGGGCCGAACTCGTGCTGACGCCCAAGGAGGGCGGCATGGAGATGGCGCGTGACGTCGCCGAGAAGATGCGCGACG
AAGGCAAGGGCATCATCCTTGACCAGTTCGCCAACCCCGACAATCCGCTCGCCCACTACGAAGGAACCGGGCCCGAGTTG
TGGGAGCAGACGGCGGGACGCATCACTCATTTCGTCAGCAGCATGGGTACGACGGGGACCATCATGGGTACGTCCCGATT
CCTCAAGGAGATGAACCCGGCGATCCGGATCGTCGGGTGCCAGCCGGAGGAGGGATCCCAGATTCCGGGAATCCGCAAAT
GGCCCGAAGCCTATCTTCCGGCGATCTATCACCGCGAGTCGGTGGACAGCCTGGAGTACGTCAGCCAGGCCGATGCGGAG
GAGATGACCCGGCGGTTGGCGCGCGAAGAGGGGCTCTTTGCCGGCATTTCGTCCGGCGGTGCGATGCATGTCGCCCTGCG
TATCGCGGCACAGGTCGAAAACGCGGTGATCGTTTCGGTGATCTGCGACCGCGGCGACCGCTATCTCTCCACCGGGGTGT
TCCCCGCCTGA

Upstream 100 bases:

>100_bases
TCGGCAGCCCTGGCCTTCCGTAGCAGTGCGGGAACGAGTGCCTGGCGCGGCGCTTGCATCGGTTGCGGCACCATCGGTCA
CAGTAGCGGAAATGCGAGAA

Downstream 100 bases:

>100_bases
GCGGGCAGGCCGGGCAAGCTGGCCGCTAGAAAAAGGAAATGCGCGTGCCGGTACTGGTGTTCGACATCGAGACGATTCCG
GACGTGGCAGGCATCCGCGT

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MEFKTLEDYVGKTPLVRMKRITAGHNNVILAKLEGNNPAGSVKDRPALSMVVRAEARGDIKPGDTLIEATSGNTGIALAM
AAAMRGYRMILVMPENQSVERRQTMRAFGAELVLTPKEGGMEMARDVAEKMRDEGKGIILDQFANPDNPLAHYEGTGPEL
WEQTAGRITHFVSSMGTTGTIMGTSRFLKEMNPAIRIVGCQPEEGSQIPGIRKWPEAYLPAIYHRESVDSLEYVSQADAE
EMTRRLAREEGLFAGISSGGAMHVALRIAAQVENAVIVSVICDRGDRYLSTGVFPA

Sequences:

>Translated_296_residues
MEFKTLEDYVGKTPLVRMKRITAGHNNVILAKLEGNNPAGSVKDRPALSMVVRAEARGDIKPGDTLIEATSGNTGIALAM
AAAMRGYRMILVMPENQSVERRQTMRAFGAELVLTPKEGGMEMARDVAEKMRDEGKGIILDQFANPDNPLAHYEGTGPEL
WEQTAGRITHFVSSMGTTGTIMGTSRFLKEMNPAIRIVGCQPEEGSQIPGIRKWPEAYLPAIYHRESVDSLEYVSQADAE
EMTRRLAREEGLFAGISSGGAMHVALRIAAQVENAVIVSVICDRGDRYLSTGVFPA
>Mature_296_residues
MEFKTLEDYVGKTPLVRMKRITAGHNNVILAKLEGNNPAGSVKDRPALSMVVRAEARGDIKPGDTLIEATSGNTGIALAM
AAAMRGYRMILVMPENQSVERRQTMRAFGAELVLTPKEGGMEMARDVAEKMRDEGKGIILDQFANPDNPLAHYEGTGPEL
WEQTAGRITHFVSSMGTTGTIMGTSRFLKEMNPAIRIVGCQPEEGSQIPGIRKWPEAYLPAIYHRESVDSLEYVSQADAE
EMTRRLAREEGLFAGISSGGAMHVALRIAAQVENAVIVSVICDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=300, Percent_Identity=40, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI295821200, Length=300, Percent_Identity=40, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI4557415, Length=300, Percent_Identity=40, Blast_Score=191, Evalue=9e-49,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=63.3561643835616, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1788754, Length=313, Percent_Identity=42.1725239616613, Blast_Score=198, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17562970, Length=298, Percent_Identity=41.2751677852349, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI115535073, Length=296, Percent_Identity=42.2297297297297, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=40.9395973154362, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=41.9795221843003, Blast_Score=213, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=39.9328859060403, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17534315, Length=310, Percent_Identity=37.741935483871, Blast_Score=153, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=284, Percent_Identity=36.9718309859155, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=36.3207547169811, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=37.5796178343949, Blast_Score=169, Evalue=5e-43,
Organism=Saccharomyces cerevisiae, GI6321449, Length=326, Percent_Identity=30.9815950920245, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24643623, Length=302, Percent_Identity=39.7350993377483, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI20129101, Length=302, Percent_Identity=39.7350993377483, Blast_Score=175, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32267; Mature: 32267

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFKTLEDYVGKTPLVRMKRITAGHNNVILAKLEGNNPAGSVKDRPALSMVVRAEARGDI
CCCCCHHHHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHEEECCCCCCC
KPGDTLIEATSGNTGIALAMAAAMRGYRMILVMPENQSVERRQTMRAFGAELVLTPKEGG
CCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCC
MEMARDVAEKMRDEGKGIILDQFANPDNPLAHYEGTGPELWEQTAGRITHFVSSMGTTGT
HHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
IMGTSRFLKEMNPAIRIVGCQPEEGSQIPGIRKWPEAYLPAIYHRESVDSLEYVSQADAE
EHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCHH
EMTRRLAREEGLFAGISSGGAMHVALRIAAQVENAVIVSVICDRGDRYLSTGVFPA
HHHHHHHHHCCCEEEECCCCEEEEEEEHHHHHCCEEEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure
MEFKTLEDYVGKTPLVRMKRITAGHNNVILAKLEGNNPAGSVKDRPALSMVVRAEARGDI
CCCCCHHHHHCCCCHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHEEECCCCCCC
KPGDTLIEATSGNTGIALAMAAAMRGYRMILVMPENQSVERRQTMRAFGAELVLTPKEGG
CCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCC
MEMARDVAEKMRDEGKGIILDQFANPDNPLAHYEGTGPELWEQTAGRITHFVSSMGTTGT
HHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEE
IMGTSRFLKEMNPAIRIVGCQPEEGSQIPGIRKWPEAYLPAIYHRESVDSLEYVSQADAE
EHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHHHHCCHH
EMTRRLAREEGLFAGISSGGAMHVALRIAAQVENAVIVSVICDRGDRYLSTGVFPA
HHHHHHHHHCCCEEEECCCCEEEEEEEHHHHHCCEEEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]